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When Thomas Addison described the disease that now bears his name , bilateral adrenal destruction by tuberculosis was its most common cause. Now tuberculosis accounts for only 7 to 20 percent of cases; autoimmune disease is responsible for 70 to 90 percent, with the remainder being caused by other infectious diseases, replacement by metastatic cancer or lymphoma, adrenal hemorrhage or infarction, or drugs
Although carcinoma frequently metastasizes to the adrenal,development of adrenal insufficiency is rare and recognition occurs even less frequently.
Hi Andrew,Answer to your QuestionsSymptoms vary, but mine include......Tiredness.... general feeling of constant exhaustion....feeling nauseous..frequent various infections of chest, kidney etcpalpitations....confusion (brain fog)...insomnia (it is 5.30am as I write this).... discolouration of skin (healthy looking tan)constant aches and pains... rheumatoid arthritis....swelling of arms and legs (fluid retention) these are but a few symptoms.In answer to your other questions The feeling of being unwell is a constant, there is no specific time of day when it feels worse, but if I did have to put a time on it, it would have to be, shortly before my first lot of medication is due in the morning. yes the weather does have an impact. cold weather plays havoc with joint and mobility, also more prone to colds which nearly always end up with hospitalisation as they progress to pneumonia. Hot weather effects hydration, I dehydrate very quickly, and have had to be put on a saline drip on frequent occasions. Maintaining body temp is weird, I can be hot when everyone else is cold and vica versa, sweating is bad even when body temp is low, (again dehydration) my hands and feet are always hot to touch. B.P is also strange. I have a constant low B.P norm around 85/60 sitting which drops on standing. dizzy spells are a way of life now and you learn never to stand up quickly or you end up in a heap on the floor. lol. I could write a book on the symptoms, I just wish there was more research and info available on the causes of this disease. Su
Rheumatic fever is an inflammatory disease which may develop after a Group A streptococcal infection (such as strep throat or scarlet fever) and can involve the heart, joints, skin, and brain.
Hi R.D. Thank you for the reply, The Oncologist said that the Addisons played a factor in my contracting the Cancer.(I had Addison's before the cancer appeared) Pre Addison's I was super fit, apart from Pregnancy, I never needed to see a Dr. I had never had any illness, apart from general childhood illnesses, including Scarlet fever. I have read up on Thos Addison and possible causes of the disease, but none of them seem to fit my profile. The Endo I have seems to have very little time to answer my questions or he just may not know the answers, and seems to fob me off with non commital answers. I know that he is a very busy man and has a very large surgery and his dept is small and very over stretched. 2 of the links that you have mentioned I have never seen before. Thank you.I am going to check these out.
... A year ago, I suffered severe eye pain in my left eye ... I began fainting!! ... I lost my voice, the pains in my joints and muscles were beyond painful ... My joints ache so bad that it exhausts me and I too, workout everyday. I dump salt on my food because I can't taste anything. I am irritable and feel jumpy at times.