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quote:Originally posted by bezoarIf by megaloblastic anemia, you mean pernicious anemia, then you would do better to take the B12 by injection. Pernicious anemia means you are missing the intrinsic factors needed to absorb the B12 from you digestive tract. A bone marrow biopsy isn't necessary at first. A Schilling test would give the answer to whether or not you're able to absorb B12 from your GI tract. This involves a 24 hour urine collection, and provided you collect all your urine, and don't have any problems with your kidneys or the lining of your small intestine, you'll get your answer. You need to know the cause of the anemia before you know how to treat it, but probably, it is pernicious.