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Antihistamine nasal spraysDo they work?Yes. There's a good chance that using an antihistamine nasal spray will help to reduce your hayefver symptoms. The only antihistamine nasal spray you can get in the UK contains the drug azelastine. Some research suggests that antihistamine nasal sprays containing azelastine works just as well antihistamine tablets.What are they?Antihistamines are drugs that block histamine, one of the chemicals that cause your hay fever symptoms. The only antihistamine that you can get as a spray is called azelastine. You breathe it in through your nose twice a day. The brand name is Rhinolast. You can get it on prescription from your doctor. How can they help?Antihistamines can help you feel better by relieving the symptoms of hay fever. Breathing in a spray that contains azelastine through your nose can help to reduce symptoms such as sneezing, and having a runny nose, an itchy nose, a blocked nose and itchy, watery eyes. Antihistamine nasal spray containing azelastine seems to work as well as antihistamine tablets.