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Secondary adrenocortical insufficiency occurs when exogenous steroids have suppressed the hypothalamic-pituitary-adrenal (HPA) axis. Too rapid withdrawal of exogenous steroid may precipitate adrenal crisis
[adrenal] crisis can be fatal. It is a medical emergency, usually requiring hospitalization. Characteristic symptoms are:Sudden penetrating pain in the legs, lower back or abdomen Severe vomiting and diarrhea, resulting in dehydration Low blood pressure Loss of consciousness/Syncope Hypoglycemia Confusion, psychosis Severe lethargy Convulsions Fever