How does asbestos get into the pleural lining?

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Offline DoctorBeaver

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How does asbestos get into the pleural lining?
« on: 04/02/2009 00:14:21 »
Mesothelioma is caused by asbestos fibres in the pleural lining. But how does it get there? Asbestos can be breathed into the lungs, but how does it pass through the lungs into the lining?
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Offline Chemistry4me

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Offline DoctorBeaver

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How does asbestos get into the pleural lining?
« Reply #2 on: 04/02/2009 00:51:59 »
Thank you for that link.
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Offline Chemistry4me

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How does asbestos get into the pleural lining?
« Reply #3 on: 04/02/2009 00:53:16 »
But did it even help? Be honest. Please.

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Offline lancenti

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How does asbestos get into the pleural lining?
« Reply #4 on: 04/02/2009 03:05:33 »
I'd go with diffusion, micro punctures, and pure dumb luck.

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Offline DoctorBeaver

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How does asbestos get into the pleural lining?
« Reply #5 on: 04/02/2009 13:04:35 »
C4M - yes it did.
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Offline iko

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How does asbestos get into the pleural lining?
« Reply #6 on: 04/02/2009 18:41:54 »
C4M - yes it did.

Tiny asbestos crystals are "engulfed" by scavenger white cells (defense: 'macrophages') but cannot be digested enzymatically because of their size and shape. Macrophages die exausted, so other soldiers come to help, creating a persistent (chronic) state of reaction-inflammation, locally, for years and years...

« Last Edit: 04/02/2009 18:59:23 by iko »

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Offline DoctorBeaver

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How does asbestos get into the pleural lining?
« Reply #7 on: 20/02/2009 23:26:23 »
iko - That's very interesting & explains why it takes so long to present. Thank you.
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