Could vitamin D kill viruses?

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Offline Bored chemist

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Could vitamin D kill viruses?
« Reply #50 on: 01/09/2009 19:33:20 »
So Diabetes is related to the weather? That's interesing.
Of course, if it were caused by a virus it would be expected to occur in "outbreaks" like 'flu or chickenpox.
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Offline Kevan Gelling

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« Reply #51 on: 03/09/2009 14:46:20 »
I'm unable to access the research document in order to find out if any outbreaks were identified

The BBC News article on viruses and diabetes type 1 [nofollow] links diabetes to enteroviruses, although the researchers were unable to identify which type.

From the article:
Quote
... enteroviruses - a common family of viruses which cause symptoms such as vomiting and diarrhoea

Here some more information on enteroviruses from Wikipedia [nofollow]:
Quote
Human enteroviruses (family Picornaviridae) infect millions of people worldwide each year, resulting in a wide range of clinical outcomes ranging from unapparent infection to mild respiratory illness (common cold), hand, foot and mouth disease, acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis.

From Wikipedia [nofollow] on hand, foot and mouth disease:
Quote
It typically occurs in small epidemics in nursery schools or kindergartens, usually during the summer and autumn months.

So maybe it does occur in outbreaks.  A statistician is needed to take the researchers' seasonal diabetes figures and quickly identify whether they have such a pattern or not.

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Offline Kevan Gelling

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« Reply #52 on: 08/09/2009 14:07:11 »
Another one, this time prostate cancer

From Science Daily - First Evidence Of Virus In Malignant Prostate Cells: XMRV Retrovirus Linked To More Aggressive Tumors [nofollow]

From Medline [nofollow]:
Quote
Life course sun exposure and risk of prostate cancer: population-based nested case-control study and meta-analysis

...

Our data and meta-analyses provide limited support for the hypothesis that increased exposure to sunlight may reduce prostate cancer risk. The findings warrant further investigation because of their implications for vitamin D chemoprevention trials.

2009 UICC

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Offline Bored chemist

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Could vitamin D kill viruses?
« Reply #53 on: 08/09/2009 19:27:47 »
"Our data and meta-analyses provide limited support "
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Offline Kevan Gelling

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« Reply #54 on: 15/09/2009 13:00:51 »
And another for multiple sclerosis

From Science Daily - Linking Epstein-Barr Virus To Multiple Sclerosis [nofollow]

From Times - Vitamin D is ray of sunshine for multiple sclerosis patients [nofollow]

From PubMed [nofollow]

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Vitamin D and multiple sclerosis

Recently, it has been clearly demonstrated that exogenous 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D3, can completely prevent experimental autoimmune encephalomyelitis (EAE), a widely accepted mouse model of human multiple sclerosis (MS).

This finding has focused attention on the possible relationship of this disease to vitamin D. Although genetic traits certainly contribute to MS susceptibility, an environmental factor is also clearly involved. It is our hypothesis that one crucial environmental factor is the degree of sunlight exposure catalyzing the production of vitamin D3 in skin, and, further, that the hormonal form of vitamin D3 is a selective immune system regulator inhibiting this autoimmune disease.

Thus, under low-sunlight conditions, insufficient vitamin D3 is produced, limiting production of 1,25-dihydroxyvitamin D3, providing a risk for MS. Although the evidence that vitamin D3 is a protective environmental factor against MS is circumstantial, it is compelling. This theory can explain the striking geographic distribution of MS, which is nearly zero in equatorial regions and increases dramatically with latitude in both hemispheres.

It can also explain two peculiar geographic anomalies, one in Switzerland with high MS rates at low altitudes and low MS rates at high altitudes, and one in Norway with a high MS prevalence inland and a lower MS prevalence along the coast. Ultraviolet (UV) light intensity is higher at high altitudes, resulting in a greater vitamin D3 synthetic rate, thereby accounting for low MS rates at higher altitudes. On the Norwegian coast, fish is consumed at high rates and fish oils are rich in vitamin D3.

Further, experimental work on EAE provides strong support for the importance of vitamin D3 in reducing the risk and susceptibility for MS. If this hypothesis is correct, then 1,25-dihydroxyvitamin D3 or its analogs may have great therapeutic potential in patients with MS.

More importantly, current research together with data from migration studies opens the possibility that MS may be preventable in genetically susceptible individuals with early intervention strategies that provide adequate levels of hormonally active 1,25-dihydroxyvitamin D3 or its analogs.

More MS research can be found here [nofollow]

« Last Edit: 15/09/2009 13:09:45 by Kevan Gelling »

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Offline Bored chemist

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Could vitamin D kill viruses?
« Reply #55 on: 15/09/2009 19:41:24 »
From time to time I get a cold- It's a viral infection.
I get a headache and a runny nose so I take one of the over-the-counter remedies that are on the market. The symptoms are reduced.
Nobody claims that the aspirin and decongestant are killing the cold virus.

Vitamin D may well cure the symptoms of MS and (at least some cases of) MS may be caused by a virus. (And if that's generally true then it's certainly interesting, in spite of the toxicity of vitamin D.)
That doesn't mean that vitamin D kills the virus.
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Offline rhade

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Could vitamin D kill viruses?
« Reply #56 on: 16/09/2009 15:50:52 »
Call me ultra picky, but I don't think that "cure" the symptoms is a good choice of word. I think "treat" the symptoms is better, as, if I am interpretting your meaning correctly, Boredchemist, you are stating that the virus is still present, but you feel a certain amount of relief from the symptoms.

Also, with most of these over the counter cold remedies, any relief is probably largely a placebo effect. Have you ever noticed how the wording on the package always says "remedy", not "cure"? No breaking the law by making totally false advertising claims!
As the great man said, "love your neighbour as you would love yourself- But first be able to love yourself."

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Offline Bored chemist

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Could vitamin D kill viruses?
« Reply #57 on: 16/09/2009 19:19:39 »
I agree that remmedies (which offer symptomatic relief) are different from cures (which remove the root cause of the problem).
I'm not sure which category this falls into "Recently, it has been clearly demonstrated that exogenous 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D3, can completely prevent experimental autoimmune encephalomyelitis (EAE)".
It's asserted to be preventative but I doubt they mean "take Vitamin D once and never get troubled by EAE" in the way that a measles jab is preventative- take it once and forget about measles forever.
It's difficult to know, from that quote, what this effect really is. I'm pleased to see that some progress is being made in this field.
Anyway this thread's about Vit D killing viruses and that report isn't an answer to that question.
« Last Edit: 16/09/2009 19:23:38 by Bored chemist »
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Offline Kevan Gelling

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Could vitamin D kill viruses?
« Reply #58 on: 18/09/2009 12:35:51 »
From time to time I get a cold- It's a viral infection.
I get a headache and a runny nose so I take one of the over-the-counter remedies that are on the market. The symptoms are reduced.
Nobody claims that the aspirin and decongestant are killing the cold virus.

Vitamin D may well cure the symptoms of MS and (at least some cases of) MS may be caused by a virus. (And if that's generally true then it's certainly interesting, in spite of the toxicity of vitamin D.)
That doesn't mean that vitamin D kills the virus.

My intention hasn't been to suggest that vitamin D3 literally kills the virus rather that it is improves the killing mechanism.  In this respect, the thread title is a tad misleading.

Maybe the title should have been "Does a high level (>50ng/mL) of 25-hydroxyvitamin D [25(OH)D] modulate the immune system such that it can better fight bacterial and viral infections?  Thus do the empirical correlations that exist between 25(OH)D levels and certain diseases - MS, certain cancers, diabetes, heart disease, schizophrenia, and others - allow us to infer that those diseases are caused by infection?" but it's not as catchy.


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Offline rhade

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Could vitamin D kill viruses?
« Reply #59 on: 22/09/2009 15:51:56 »
Of course, it is possible to overdose on vitamins.
As the great man said, "love your neighbour as you would love yourself- But first be able to love yourself."

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Offline Variola

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Could vitamin D kill viruses?
« Reply #60 on: 23/09/2009 09:23:14 »
Perhaps the angle would have been better if it had focussed on reported cases of high Vit D3 levels having some significant benefit on a condition? With subsequent discussion and analysis after. 
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Offline Kevan Gelling

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Could vitamin D kill viruses?
« Reply #61 on: 10/11/2009 22:58:35 »
The answer to the question "Could vitamin D kill viruses?" is YES

As iko [nofollow] pointed out in this post [nofollow], vitamin D is involved in the production of human cathelicidin - LL-37.

Quote


We report for the first time that LL-37 demonstrates significant antiviral inhibitory activity (>98% inhibition) against HSV-1 [Herpes Simplex Virus Type 1], the leading viral cause of corneal blindness in industrialized countries.

Additionally, we report for the first time that LL- 37 demonstrated statistically significant inhibitory activity in vitro against Ad19 [Adenovirus], a major cause of conjunctivitis and epidemic keratoconjunctivitis in local and global epidemics.


Quote


The current study is the first to identify human and murine cathelicidins as innate antimicrobial peptides capable of interfering in vitro and in vivo with replication of vaccinia virus.



Quote


Here we demonstrate that LL-37 inhibits HIV-1 replication in PBMC, including primary CD4+ T cells



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Offline Bored chemist

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Could vitamin D kill viruses?
« Reply #62 on: 11/11/2009 07:09:22 »
LL37 isn't vit D.
Imagine someone who's body failed to make LL37 for some reason. All the Vit D in the world wouldn't help him by killing viruses.
Clearly someone who is deficient in Vit D is going to be in poor health and less able to fight infection but that's hardly the same as saying vitamin D kills viruses.

Sadly there are many people in the world who do not get enough to eat. This leaves them open to all sorts of infections including viruses.
It's fair to say that chocolate cake would help them simply because it would provide calories (and some vitamins + proteins etc).

Do you claim that chocolate cake kills viruses?
« Last Edit: 11/11/2009 18:51:20 by Bored chemist »
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Offline iko

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Could vitamin D kill viruses?
« Reply #63 on: 12/11/2009 20:53:31 »
Bored lawyer,

We are playing with words, aren't we?
I could find many examples to justify that someone somewhere might dare say:
"Vitamin D kills viruses"
We agree with you: it may do it INDIRECTLY.
Vaccinations kill diseases, eliminating them by immune activation as well.
Don't be too fussy. Please  [;)]

ikod
« Last Edit: 12/11/2009 20:57:55 by iko »

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Offline Bored chemist

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« Reply #64 on: 12/11/2009 21:42:58 »
So, you do think that, albeit indirectly, chocolate cake kills viruses.
Fair enough. My opinion is different.
Incidentally, I think that many aspects of the immune system depend on one or more vitamins in one way or another. For example it's fair to say that without our skin we wuld be much more susceptible to viral attack. Vitamin C is vital in the production of the collagen which holds that skin together.
Without vitamin C we would be more prone to viral infection.
Does that make vitamin C a viruscide?
Do all vitamins kill viruses?
In the end, what doesn't kill them?

The problem with accepting Kevan's post as evidence thet Vit D kills viruses is that it leads to the view that damned near everything else does. That rather reduces the meaning of the statement.
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Offline Kevan Gelling

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Could vitamin D kill viruses?
« Reply #65 on: 23/11/2009 20:19:27 »
"I didn't kill him, your honour, it was the bullet.  I only pulled the trigger!"

VDRs (vitamin D receptors) occur next to CAMP (cathelicidin anti-microbial peptide) genes and up-regulate them (turn them on) in response to infection.

Guilty!

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Offline Bored chemist

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Could vitamin D kill viruses?
« Reply #66 on: 24/11/2009 07:08:15 »
 The statement "I didn't kill him, your honour, it was the bullet.  I only pulled the trigger!"
Might be made in court by the accused- but it's not going to get him very far.

On the other hand, the statement "Your honour, the cause of death was a gunshot wound to chest." is likely to come from a scientist and would be accepted.
There's a difference between cause and culpability which is why we generally accept that very young children and people with mental health problems may not be guilty of murder, even when it's clear they killed someone. Of course, unless you claim that vitamin D has free will and is responsible for its actions this whole idea is a strawman.


I guess it's entirely possible that someone could fatally shoot someone accidentally because the bullet was faulty.
For example the security services sometimes use hollow point amunition - the idea being that it doesn't generally go through someone.
Imagine that a security officer on a plane shot a terrorist but, unfortunately, because the bullet was faulty, it went through the terrorist and also killed a bystander.
In that instance, the claim "it wasn't me; it was the bullet", would be a legitimate reason.

I take it you are planning to prescribe chocolate cake as a viruscide.
« Last Edit: 24/11/2009 20:14:20 by Bored chemist »
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Offline iko

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Could vitamin D kill viruses?
« Reply #67 on: 24/11/2009 22:07:12 »
So, you do think that, albeit indirectly, chocolate cake kills viruses.
Fair enough. My opinion is different.
Incidentally, I think that many aspects of the immune system depend on one or more vitamins in one way or another. For example it's fair to say that without our skin we wuld be much more susceptible to viral attack. Vitamin C is vital in the production of the collagen which holds that skin together.
Without vitamin C we would be more prone to viral infection.
Does that make vitamin C a viruscide?
Do all vitamins kill viruses?
In the end, what doesn't kill them?


Few vitamin deficiencies lead to an infection as cause of death.
Scurvy is one: either infection or cardiac arrest (not hemorrhage as commonly thought).
Thiamine (B1) deficiency (beri-beri) gives you heart failure or nervous system damage from confusion to paralysis and coma. Immune defense still works fine, but cell 'batteries' run out of energy in crucial organs, so patients die before suffering any viral or bacterial attack.
When rickets was common in children, a 13times higher incidence of pneumonia had been reported.

Help.  Few years ago I posted a question about vitD deficiency in leukemia:
"Could vitamin D HELP in leukemia treatment?"
Similarly, "could vitamin D help in killing viruses?"
should be the new title of this thread...  [;)]
To have a proper discussion around here.

Dear Kevan, it's up to you, this is your topic. 
« Last Edit: 24/11/2009 22:44:43 by iko »

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Offline Kevan Gelling

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« Reply #68 on: 25/11/2009 12:53:47 »
And a change of title would placate BC?  I suspect his mind is made up (vitamin = alternative medicine = cr*p) which is why he is playing Pendantic Semantics.

The dictionary definition of kill is 'cause the death of'.  No free will or culpability is required.  And in the example, the security officer did 'cause the death of', i.e. kill, the bystander.

BC aside, if anyone is interested reading more on vitamin D and cathelicidin try this recent article on the genetic history of the CAMP gene - Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates (Gombart et al., 2009) [nofollow] - "VDR-signaling increases production of hCAP18/LL-37 protein (encoded by the CAMP gene) to kill the pathogen".  The References section contains a comprehensive list of recent research in the field.

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Offline iko

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« Reply #69 on: 25/11/2009 18:18:34 »
Thank you so much Kevan,

I'm going to print the whole article for a good reading...

"1,25(OH)(2)D(3) thus directly regulates antimicrobial peptide gene expression, revealing
 the potential of its analogues in treatment of opportunistic infections."

...a promising conclusion indeed!   [:)]

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Offline Bored chemist

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Could vitamin D kill viruses?
« Reply #70 on: 25/11/2009 18:51:44 »
"I suspect his mind is made up (vitamin = alternative medicine = cr*p)"
An odd thing for you to suspect. I have made it quite clear that I know that vitamins have a vital role.
What my mind is made up about is the assertion that "vitamins can do magic" is crap.
Take some suitable virus, lets say ebola. Shake it up with some vitamin D then mix it into some saline and inject it. Feel free to extract the excess vitamin D if you are worried about its toxicity.

If you do that then if you ask me a week later, I will do the same using bleach (which does kill viruses) rather than Vit D.

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Offline Kevan Gelling

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Could vitamin D kill viruses?
« Reply #71 on: 29/11/2009 20:15:52 »
What my mind is made up about is the assertion that "vitamins can do magic" is crap.

Vitamin D is unique amongst vitamins because it's a pre-hormone and is part of the endocrine system.  Genetic research from the last 10-20 years has revealed that vitamin D (as calcitriol) regulates many important functions throughout the body, including immunity, inflammation and cell propagation.  These functions are linked to a number of morbidities.

Ecological studies link latitude and skin colour to 'vitamin D' morbidities; cohort studies link low vitamin D levels with 'vitamin D' morbidities; epidemiological studies show high levels of vitamin D deficiency by latitude and by skin colour; the few RCTs involving large dose supplementation show that vitamin D significantly reduces 'vitamin D' morbidities.

Not "vitamins", just vitamin D; not magic, just science.

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Offline iko

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Could vitamin D kill viruses?
« Reply #72 on: 29/11/2009 22:13:27 »
What my mind is made up about is the assertion that "vitamins can do magic" is crap.

Vitamin D is unique amongst vitamins because it's a pre-hormone and is part of the endocrine system.  Genetic research from the last 10-20 years has revealed that vitamin D (as calcitriol) regulates many important functions throughout the body, including immunity, inflammation and cell propagation.  These functions are linked to a number of morbidities.

Ecological studies link latitude and skin colour to 'vitamin D' morbidities; cohort studies link low vitamin D levels with 'vitamin D' morbidities; epidemiological studies show high levels of vitamin D deficiency by latitude and by skin colour; the few RCTs involving large dose supplementation show that vitamin D significantly reduces 'vitamin D' morbidities.

Not "vitamins", just vitamin D; not magic, just science.


You are exactly right Kevan,

but we have to tell the whole story:
why such a simple and cheap remedy is coming so late in modern medicine?
I can give you some good reasons to 'justify' such a delay:
- Vitamin D is not a vitamin, but a steroid hormone acting on specific cell receptors.
- The dosage in serum is tricky and expensive: large studies are coming out only now.
- Normal levels are expressed in ng/mL or nmol/ml, just for the fun of it...
- The active form, calcitriol, has been improperly used instead of replenishing 25-OHvitD pool.
- Toxicity has been overestimated: 400U/day failed where 2000U/day are making the trick.
- Cholecalciferol or vitamin D3 is a 'generic' drug, too cheap to support clinical trials.

Do you want to play the doctor?
Just read this amazing case report, free-fulltext from Canada:


Now look for a chronic-back-pain patient, get a history of lack of sunlight exposure, no cod liver oil or vitamin D supplements and suggest her/him to have 25-OHvitaminD tested.
If the result is below 20 ng/ml...Bingo!  Send her/him to a doctor for a 50kU/week x 8weeks prescription.  A clinician will exclude any condition of vitD toxicity or intolerance and monitor calcium levels if necessary.
The following two-three weeks might be really magic for that patient...
Unbelievable? On my part, I don't think so anymore!  [;)]



Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series.

Schwalfenberg G.

Department of Family Medicine, University of Alberta, Canada. gschwalf@telus.net

This article reviews 6 selected cases of improvement/resolution of chronic back pain or failed back surgery after vitamin D repletion in a Canadian family practice setting. Pub Med was searched for articles on chronic back pain, failed back surgery, and vitamin D deficiency. Chronic low back pain and failed back surgery may improve with repletion of vitamin D from a state of deficiency/insufficiency to sufficiency. Vitamin D insufficiency is common; repletion of vitamin D to normal levels in patients who have chronic low back pain or have had failed back surgery may improve quality of life or, in some cases, result in complete resolution of symptoms.

J Am Board Fam Med.2009 Jan-Feb;22(1):69-74.
« Last Edit: 30/11/2009 12:00:40 by iko »

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Offline Bored chemist

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« Reply #73 on: 30/11/2009 18:26:59 »
Just in case you all missed this the first time I posted it.
Take some suitable virus, lets say Ebola. Shake it up with some vitamin D then mix it into some saline and inject it. Feel free to extract the excess vitamin D if you are worried about its toxicity.

If you do that then if you ask me a week later, I will do the same using bleach (which does kill viruses) rather than Vit D

Unless you are prepared to take part in this experiment you are accepting that vitamin D doesn't kill viruses.
What you need is a thread called something like "Vitmin D odes some really interesting things including modifying the human immune response."
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Offline iko

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« Reply #74 on: 30/11/2009 22:16:34 »
"Vitmin D odes"...oh sure!  [;D]


« Last Edit: 30/11/2009 22:20:32 by iko »

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Offline Kevan Gelling

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« Reply #75 on: 02/12/2009 21:19:54 »
Unless you are prepared to take part in this experiment you are accepting that vitamin D doesn't kill viruses.

Give it up BC!

Beside the glaring false dichotomy, it has never suggested that vitamin D can kill all viruses or that it could kill a particular virus with 100% certainty.  Only that vitamin D is part of the innate immune system, via the production of cathelicidin, and can 'cause the death of' some viruses.  And the comparison with bleach is nonsense.

Retort with science rather than the ridiculous, please!
« Last Edit: 02/12/2009 21:44:58 by Kevan Gelling »

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Offline Kevan Gelling

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« Reply #76 on: 02/12/2009 21:33:31 »
This post was originally an private email to Dr Chris.  It was highly speculative and I sent it to him because he is a living, breathing virologist.

Evidence has since been documented in this post that shows vitamin D is part of the innate immune system via the production of the anti-microbial peptides and that, in particular, cathelicidin has anti-viral properties.  There is also evidence that viruses may be the cause of some 'vitamin D deficient' morbidities - hypertension, MS, pancreatic cancer, prostate cancer.  Is it possible the reason for the correlation is that a sufficient vitamin D level can prevent viral infections and thus prevent the onset of said morbidities?

Dr Chris, what is your view?
« Last Edit: 02/12/2009 21:44:15 by Kevan Gelling »

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Offline Bored chemist

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Could vitamin D kill viruses?
« Reply #77 on: 03/12/2009 19:28:35 »
"Beside the glaring false dichotomy, it has never suggested that vitamin D can kill all viruses"
Please provide the details of any virus that it kills in the sort of experiment I described.
Even any virus where there's a reduction of the titre by a few log units would do.

My point is that it has not (at least here) been shown to kill any virus. It really is a viruscide in that same way that chocolate cake is.
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Offline iko

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« Reply #78 on: 11/12/2009 17:48:11 »
Allow me a cut&paste: Historical notes about vitamin D 'power'!  [;D]

...even if you were a young lion, without proper sunlight exposure...you would be just dead.

Some recent discussion about ancient reports of cod liver oil use...




Rickets in Lion Cubs at the London Zoo in 1889: Some New Insights.


Chesney RW, Hedberg G.
aDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

In 1889, when Dr John Bland-Sutton, a prominent surgeon in London, England, was consulted concerning fatal rickets in more than 20 successive litters of lion cubs at the London Zoo, he evaluated the role of diet relative to the development of rickets. He prescribed goat meat and bones and cod-liver oil to be added to the lean horse-meat diet of the cubs and their mothers. Rickets reversed, the cubs survived, and litters were reared successfully. In classic controlled studies conducted in puppies and young rats 3 decades later, the crucial role of calcium, phosphate, and vitamin D in both prevention and therapy of rickets was elucidated. Later studies led to the identification of the structural features of vitamin D. Although the Bland-Sutton interventional diet obviously provides calcium and phosphate from bones and vitamin D from cod-liver oil, other benefits of this diet were not initially recognized.
Chewing bones promotes tooth and gum health and removes bacteria-laden tartar.
Cod-liver oil also contains vitamin A, which is essential for the prevention of infection and for epithelial cell health. Taurine-conjugated bile salts are also necessary for the intestinal absorption of fat-soluble vitamins, including A and D. Moreover, unlike dogs and rats, all feline species are unable to synthesize taurine yet can only conjugate bile acids with taurine. This sulfur-containing beta-amino acid must be provided in the carnivorous diet of a large cat.
Taurine-conjugated bile salts were provided in the oil cold-pressed from cod liver.
The now famous Bland-Sutton "experiment of nature," namely, fatal rickets in lion cubs, was cured by the addition of minerals and vitamin D. However, gum health and the presence of taurine-conjugated bile salts undoubtedly permitted absorption of vitamin A and D, the latter promoting the cure of rickets.

Pediatrics. 2009 Apr 6. [Epub ahead of print]


« Last Edit: 12/12/2009 13:27:06 by iko »

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Offline alanan

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Could vitamin D kill viruses?
« Reply #79 on: 30/12/2009 05:09:41 »
During the last winter,when people all around me were contacting various strains of influenza I took 4,000 units of vitamin d per day. I did not have any flu vaccinations, and I went through the winter without catching a cold or Flu. That's good enough for me. alanan

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Offline iko

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« Reply #80 on: 30/12/2009 12:04:25 »
You did the right thing...but this is not enough, scientifically speaking:
fortunately flu epidemics hit a relatively small percentage of people.
I'm sure you know Dr. John Cannell's story:


...and if you decide to go on with your 'treatment' in the near future, you might enjoy other more important benefits of D-vitamin, which is not a vitamin but a hormone produced by proper sunlight exposure: the sunshine hormone.  [;)]

« Last Edit: 31/12/2009 15:01:32 by iko »

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Offline alanan

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Could vitamin D kill viruses?
« Reply #81 on: 03/01/2010 07:29:52 »
you would not absorb much sunlight with that ski suit on!!~

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Offline iko

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Offline Kevan Gelling

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« Reply #83 on: 15/01/2010 13:47:24 »
Good to see the results from some trials coming through.

From Haaretz [nofollow] (Israeli newspaper)

Quote
Vitamin D could help fight hepatitis C

A new study has found that administering vitamin D to hepatitis C patients dramatically reduces the presence of the virus in the blood.

The study, carried out at Rebecca Sieff Hospital in Safed and Hillel Yaffeh Medical Center in Hadera by Dr. Assy Nimer and Dr. Saif Abu-Mouch covered 90 hepatitis C patients.

The findings were presented in late November at a conference of the American Association for the Study of Liver Diseases.

For six months, in addition to the standard treatment, which included Interferon once a week and a daily dose of the antiviral drug Ribavirin, 30 patients were also treated with 1,000 units of vitamin D a day. A control group of 60 patients went without the vitamin.

In order to assess the impact of vitamin D on the treatment of the disease, before starting the study, all patients, including those from the control group and those who were found to have a vitamin D deficiency, were given supplements, so that all participants began the study from the same point.

A month after the start of treatment, the virus had disappeared from the blood in 44 percent of the group receiving vitamin D supplements, as opposed to just 18 percent among the control group.

After three months, the success rate for the group getting the supplement rose to 96 percent, compared to 48 percent in the control group.

Other findings from the study, which will be presented next month in Kfar Blum at a conference of the Israeli Association for the Study of the Liver, indicate that this trend continues even after the end of drug treatment.

The initial results show that six months after the end of treatment, 90 percent of patients treated with drug therapy and vitamin D supplements had the virus disappear and completely recovered.

"The drug treatment for hepatitis C patients is usually administered for around a year, and occasionally the virus disappears from the blood, but remains in other places, for example, in the liver and lymph glands," explained Nimer, the director of the Liver Disease Unit at Rebecca Sieff Hospital. "At the end of the treatment, the virus may return to the blood, but we found that in patients who were also given the vitamin D supplement, the virus did not return, that is, it was excreted by the body."

How vitamin D helps improve the condition of hepatitis patients is not entirely clear. However, according to Nimer, "It has already been proven that vitamin D benefits the immune system by increasing the activity of T cells [white blood cells that help in the fight against pathogens], improves the body's reaction to the insulin hormone, and reduces the level of pro-inflammatory proteins that cause liver infections caused by viruses."

...



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Offline ch3ls3a

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« Reply #84 on: 20/01/2010 17:35:21 »
Hello,
Im not sure about viruses but psoriasis (a disease which affects the skin) can be almost cured when the affected skin is in direct sunlight which contains big amounts of vitamin D so this could help kill viruses  [???]

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Offline syhprum

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« Reply #85 on: 06/02/2010 18:17:31 »
As a boy in the thirties suffering fro asthma I used to visit Great Ormand street hospital to be irradiated with UV presumably to create vitamin D.
I cannot recall if it did any good.
syhprum

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Offline iko

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« Reply #86 on: 18/02/2010 14:21:56 »
As a boy in the thirties suffering fro asthma I used to visit Great Ormond street hospital to be irradiated with UV presumably to create vitamin D.
I cannot recall if it did any good.



...vitamin d and asthma: new studies for a new century!!!   [:D]


Vitamin D, the immune system and asthma.

Lange NE, Litonjua A, Hawrylowicz CM, Weiss S.

Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham & Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA Tel.: +1 617 525 0874 nlange@partners.org.

The effects of vitamin D on bone metabolism and calcium homeostasis have long been recognized. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. Vitamin D deficiency has been found to be associated with several immune-mediated diseases, susceptibility to infection and cancer. Recently, there has been increasing interest in the possible link between vitamin D and asthma. Further elucidation of the role of vitamin D in lung development and immune system function may hold profound implications for the prevention and treatment of asthma.

Expert Rev Clin Immunol. 2009 Nov;5(6):693-702.


« Last Edit: 06/03/2010 11:08:19 by iko »

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Offline Kevan Gelling

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« Reply #88 on: 09/03/2010 20:34:59 »
Here's the abstract from Nature Immunology [nofollow]

Quote
Vitamin D controls T cell antigen receptor signaling and activation of human T cells

Abstract

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-γ1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of ~75-fold in PLC-γ1 expression, which correlated with greater TCR responsiveness. Induction of PLC-γ1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-γ1, which are required for subsequent classical TCR signaling and T cell activation.


From the Copenhagen University press release [nofollow]

Quote

"We have discovered that the first stage in the activation of a T cell involves vitamin D, explains Professor Carsten Geisler from the Department of International Health, Immunology and Microbiology. When a T cell is exposed to a foreign pathogen, it has an immediate biochemical reaction and extends a signaling device or ‘antenna' known as a vitamin D receptor, with which it search for vitamin D. This means that the T cell must have vitamin D or activation of the cell will cease. If the T cells cannot find enough vitamin D in the blood, they won't even begin to mobilise."




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Offline Kevan Gelling

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« Reply #89 on: 09/03/2010 20:43:19 »

Get out in that frosty morning sunshine...!


Unfortunately at a latitude of 52o (Birmingham) and above, the winter sun is too low in the sky for UVB light to create vitamin D in the skin for 6 months of the year (October to March) 1.


1. Webb, A. R., Kline, L. &  Holick, M. F. Influence of season and latitude on the cutaneous synthesis of vitamin d3: Exposure to winter sunlight in boston and edmonton will not promote vitamin d3 synthesis in human skin. J Clin Endocrinol Metab  67, 373-378 (1988). http://dx.doi.org/10.1210/jcem-67-2-373 [nofollow]

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Offline Joe.X

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« Reply #90 on: 10/03/2010 05:11:10 »
Vitamin D have been vertificated to be a activator in T cell immunology by Denmarkish

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Offline alanan

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« Reply #91 on: 12/03/2010 05:56:48 »
Try looking at this site newbielink:http://abcnews.go.com/GMA/OnCall/study-vitamin-kills-cancer-cells/story?id=9904415 [nonactive]

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Offline iko

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« Reply #92 on: 13/03/2010 19:11:15 »
Try looking at this site http://abcnews.go.com/GMA/OnCall/study-vitamin-kills-cancer-cells/story?id=9904415
Exciting and quite promising, alanan...
...nevertheless: "In Tests, Vitamin D Shrinks Breast Cancer Cells.
Results Encouraging, But Don't Read Too Much Into Them, Says Dr. Richard Besser".

There is something new about vitamin D and influenza viruses...
a bit closer to the title of this very thread:


Randomized trial of vitamin D supplementation
 to prevent seasonal influenza A in schoolchildren.

Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H.
Division of Molecular Epidemiology Jikei University School of Medicine Minato-ku Tokyo Japan.

BACKGROUND: To our knowledge, no rigorously designed clinical trials have evaluated the relation between vitamin D and physician-diagnosed seasonal influenza.
OBJECTIVE: We investigated the effect of vitamin D supplements on the incidence of seasonal influenza A in schoolchildren.
DESIGN: From December 2008 through March 2009, we conducted a randomized, double-blind, placebo-controlled trial comparing vitamin D(3) supplements (1200 IU/d) with placebo in schoolchildren. The primary outcome was the incidence of influenza A, diagnosed with influenza antigen testing with a nasopharyngeal swab specimen.
RESULTS: Influenza A occurred in 18 of 167 (10.8%) children in the vitamin D(3) group compared with 31 of 167 (18.6%) children in the placebo group [relative risk (RR), 0.58; 95% CI: 0.34, 0.99; P = 0.04]. The reduction in influenza A was more prominent in children who had not been taking other vitamin D supplements (RR: 0.36; 95% CI: 0.17, 0.79; P = 0.006) and who started nursery school after age 3 y (RR: 0.36; 95% CI: 0.17, 0.78; P = 0.005). In children with a previous diagnosis of asthma, asthma attacks as a secondary outcome occurred in 2 children receiving vitamin D(3) compared with 12 children receiving placebo (RR: 0.17; 95% CI: 0.04, 0.73; P = 0.006).

CONCLUSION: This study suggests that vitamin D(3) supplementation during the winter may reduce the incidence of influenza A, especially in specific subgroups of schoolchildren.

This trial was registered at https://center.umin.ac.jp as UMIN000001373.

Am J Clin Nutr. 2010 Mar 10. [Epub ahead of print]


« Last Edit: 30/03/2010 16:57:56 by iko »

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Offline linda5508

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« Reply #93 on: 03/06/2010 19:35:06 »
well yes vitamin d can help prevent illnesses but i'm not too sure about curing illnesses

newbielink:http://www.vitaminddeficiencysymptoms.org [nonactive]

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Offline iko

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« Reply #94 on: 20/06/2010 09:33:38 »
D-vitamin newsletter!  [;D] [;D] [;D]



Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults.

Sabetta JR, Depetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML.

Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.

Abstract
BACKGROUND: Declining serum concentrations of 25-hydroxyvitamin D seen in the fall and winter as distance increases from the equator may be a factor in the seasonal increased prevalence of influenza and other viral infections. This study was done to determine if serum 25-hydroxyvitamin D concentrations correlated with the incidence of acute viral respiratory tract infections. METHODOLOGY/FINDINGS: In this prospective cohort study serial monthly concentrations of 25-hydroxyvitamin D were measured over the fall and winter 2009-2010 in 198 healthy adults, blinded to the nature of the substance being measured. The participants were evaluated for the development of any acute respiratory tract infections by investigators blinded to the 25-hydroxyvitamin D concentrations. The incidence of infection in participants with different concentrations of vitamin D was determined. One hundred ninety-five (98.5%) of the enrolled participants completed the study. Light skin pigmentation, lean body mass, and supplementation with vitamin D were found to correlate with higher concentrations of 25-hydroxyvitamin D. Concentrations of 38 ng/ml or more were associated with a significant (p<0.0001) two-fold reduction in the risk of developing acute respiratory tract infections and with a marked reduction in the percentages of days ill.
CONCLUSIONS/SIGNIFICANCE: Maintenance of a 25-hydroxyvitamin D serum concentration of 38 ng/ml or higher should significantly reduce the incidence of acute viral respiratory tract infections and the burden of illness caused thereby, at least during the fall and winter in temperate zones. The findings of the present study provide direction for and call for future interventional studies examining the efficacy of vitamin D supplementation in reducing the incidence and severity of specific viral infections, including influenza, in the general population and in subpopulations with lower 25-hydroxyvitamin D concentrations, such as pregnant women, dark skinned individuals, and the obese.

PLoS One. 2010 Jun 14;5(6):e11088



« Last Edit: 20/06/2010 10:10:16 by iko »

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Offline Bored chemist

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« Reply #95 on: 20/06/2010 11:21:02 »
There's an important word in that.
"Declining serum concentrations of 25-hydroxyvitamin D seen in the fall and winter as distance increases from the equator may be a factor in the seasonal increased prevalence of influenza and other viral infections".

Correlation does not imply causation.
It seems to me to be at least as likely that colds are correlated with low vitamin D levels simply because both tend to happen in Winter. In any group some people will be affected more than others by Winter.
The other obvious potential cause  for the correlation is that poor diet drops vitamin D levels and promotes infections.

Even if the correlation in this case is due to causation it still doesn't show that vitamin D kills viruses any better than chocolate cake does.
Please disregard all previous signatures.

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Offline iko

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« Reply #96 on: 20/06/2010 13:18:50 »
Hi B.C.,

May be
You are right.
But a previous post reported an RCT, the 'gold standard' in modern medicine:

Try looking at this site http://abcnews.go.com/GMA/OnCall/study-vitamin-kills-cancer-cells/story?id=9904415
Exciting and quite promising, alanan...
...nevertheless: "In Tests, Vitamin D Shrinks Breast Cancer Cells.
Results Encouraging, But Don't Read Too Much Into Them, Says Dr. Richard Besser".

There is something new about vitamin D and influenza viruses...
a bit closer to the title of this very thread:


Randomized trial of vitamin D supplementation
 to prevent seasonal influenza A in schoolchildren.

Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H.
Division of Molecular Epidemiology Jikei University School of Medicine Minato-ku Tokyo Japan.

BACKGROUND: To our knowledge, no rigorously designed clinical trials have evaluated the relation between vitamin D and physician-diagnosed seasonal influenza.
OBJECTIVE: We investigated the effect of vitamin D supplements on the incidence of seasonal influenza A in schoolchildren.
DESIGN: From December 2008 through March 2009, we conducted a randomized, double-blind, placebo-controlled trial comparing vitamin D(3) supplements (1200 IU/d) with placebo in schoolchildren. The primary outcome was the incidence of influenza A, diagnosed with influenza antigen testing with a nasopharyngeal swab specimen.
RESULTS: Influenza A occurred in 18 of 167 (10.8%) children in the vitamin D(3) group compared with 31 of 167 (18.6%) children in the placebo group [relative risk (RR), 0.58; 95% CI: 0.34, 0.99; P = 0.04]. The reduction in influenza A was more prominent in children who had not been taking other vitamin D supplements (RR: 0.36; 95% CI: 0.17, 0.79; P = 0.006) and who started nursery school after age 3 y (RR: 0.36; 95% CI: 0.17, 0.78; P = 0.005). In children with a previous diagnosis of asthma, asthma attacks as a secondary outcome occurred in 2 children receiving vitamin D(3) compared with 12 children receiving placebo (RR: 0.17; 95% CI: 0.04, 0.73; P = 0.006).

CONCLUSION: This study suggests that vitamin D(3) supplementation during the winter may reduce the incidence of influenza A, especially in specific subgroups of schoolchildren.

This trial was registered at https://center.umin.ac.jp as UMIN000001373.

Am J Clin Nutr. 2010 Mar 10. [Epub ahead of print]



« Last Edit: 20/06/2010 13:20:29 by iko »

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Offline Bored chemist

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« Reply #97 on: 20/06/2010 14:26:03 »
So, it does as good a job as chocolate cake.
For those people who are poorly nourished, improving their diet improves their health.
Not exactly rocket science and not evidence for vitamin D killing the virus.
Please disregard all previous signatures.

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Offline iko

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« Reply #98 on: 20/06/2010 16:22:41 »
So, it does as good a job as chocolate cake.
For those people who are poorly nourished, improving their diet improves their health.
Not exactly rocket science and not evidence for vitamin D killing the virus.

Chocolate cake has much better taste than vitamin D.
I agree, but you seem to have missed a basic point here:
Vitamin D does NOT come from your diet mostly (90-95%).
Consequently, this hormone is NOT a vitamin.
« Last Edit: 20/06/2010 16:26:45 by iko »

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Offline Bored chemist

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« Reply #99 on: 20/06/2010 19:39:30 »
As one of those papers points out "Light skin pigmentation, lean body mass, and supplementation with vitamin D were found to correlate with higher concentrations of 25-hydroxyvitamin D." so eating the stuff raises your levels of it. It might not be a dominant route for the production of the stuff in plasma, but it's certainly measurable.

The name vitamin originally only referred to amines, ("Vital amines" in particular) so vitamins  A, C, D, E, and K are not vitamins.

No matter what you call the stuff, it doesn't kill viruses.
Please disregard all previous signatures.