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There's nothing wrong with empty calories as such.However, in any sensible diet you need enough calories and also things like fats, proteins, vitamins etc.If you eat lots of sweets (candy for those across the pond) you get a lot of calories and, if you don't get enough exercise those calories are stored as fat (they would be, no matter whether they were eaten as fat protein or sugar because that's what the body does with spare energy; it hoards it for later).The problem is that, having eaten the sweets, you still need to eat other things to ensure that you get the vitamins and such and those other things also have calories in them.This is likely to lead to eating more calories than you actually use and, therfore, to weight gain.Of course, if you are doing lots of exercise the problem is somewhat reduced.
Glucose is just glucose. But if it happens to be part of an orange you get the aded benefit of some fibre and vitamin C etc.Without those "added extras" it's described as empty. The calorie count is exactly the same from a gram of glucose as a pure white powder or as part of an orange.