0 Members and 1 Guest are viewing this topic.
Telomere Theory Telomeres (structures at the ends of chromosomes) have experimentally been shown to shorten with each successive cell division. Shortened telomeres activate a mechanism that prevents further cell multiplication. This may be an important mechanism of ageing in tissues like bone marrow and the arterial lining where active cell division is necessary. Importantly though, mice lacking telomerase do not show a dramatically reduced lifespan, as the simplest version of this theory would predict.Reproductive-Cell Cycle Theory The idea that ageing is regulated by reproductive hormones that act in an antagonistic pleiotropic manner via cell cycle signalling, promoting growth and development early in life in order to achieve reproduction, but later in life, in a futile attempt to maintain reproduction, become dysregulated and drive senescence (dyosis). At the same time, castrated animals, although living somewhat longer, still experience senescence, even in the absence of reproductive hormones.Wear-and-Tear Theory The very general idea that changes associated with ageing are the result of chance damage that accumulates over time.Somatic Mutation Theory The biological theory that ageing results from damage to the genetic integrity of the body’s cells.Error Accumulation Theory The idea that ageing results from chance events that escape proof reading mechanisms, which gradually damages the genetic code.Evolutionary Theories See Theories of ageing in Senescence. These are by far the most theoretical; however, their usefulness is somewhat limited as they do not provide readily testable biochemically based interventions.Accumulative-Waste Theory The biological theory of ageing that points to a buildup of cells of waste products that presumably interferes with metabolism.Autoimmune Theory The idea that ageing results from an increase in autoantibodies that attack the body's tissues. A number of diseases associated with ageing, such as atrophic gastritis and Hashimoto's thyroiditis, are probably autoimmune in this way. While inflammation is very much evident in old mammals, even SCID mice in SPF colonies still senescence.Ageing-Clock Theory The theory that ageing results from a preprogrammed sequence, as in a clock, built into the operation of the nervous or endocrine system of the body. In rapidly dividing cells the shortening of the telomeres would provide just such a clock. This idea is indirect contradiction with the Evolutionary Based Theory of Aging.Cross-Linkage Theory The idea that ageing results from accumulation of cross-linked compounds that interfere with normal cell function.Free-Radical Theory The idea that free radicals (unstable and highly reactive organic molecules, also named reactive oxygen species or oxidative stress) create damage that gives rise to symptoms we recognize as ageing.Mitohormesis It has been known since the 1930s that restricting calories while maintaining adequate amounts of other nutrients prevents ageing across a broad range of organism. Recently, Michael Ristow has shown that this delay of ageing is due to increased formation of free radicals within the mitochondria causing a secondary induction of increased antioxidant defence capacity.Misrepair-Accumulation Theory This very recent novel theory by Wang et al.  suggests that ageing is the result of the accumulation of "Misrepair"...
As you can see, Telemere theory is just one of a dosen other ones. Of course as always the most likely is that they are all true in to some extent.
QuoteAs you can see, Telemere theory is just one of a dosen other ones. Of course as always the most likely is that they are all true in to some extent.So which one of those does Oil of Olay work against??