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In mammals, erythrocytes also lose all other cellular organelles such as their mitochondria, golgi apparatus and endoplasmic reticulum. As a result of not containing mitochondria, these cells use none of the oxygen they transport; instead they produce the energy carrier ATP from glucose by a glycolysis pathway that ends with lactic acid production. Furthermore, red blood cells do not have an insulin receptor and thus their glucose uptake is not regulated by insulin. Because of the lack of nuclei and organelles, mature red blood cells do not contain DNA and cannot synthesize any RNA, and consequently cannot divide and have limited repair capabilities.
lactic acid (the stuff that makes muscles feel tired after sustained exercise)
What advantage does losing the nucleus and the mitochondria bring to the red blood cells? ...
What advantage does losing the nucleus and the mitochondria bring to the red blood cells?