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"Aztec Cactus Salve" has been previously shown to do just the same thing for $2 less
OK. Let's open this article and ask ourselves questions like real scientists would...1. This is a news blurb in a publication of the American Chemical Society. (a) Why is it not in a critically reviewed medical Journal?(b) What do chemists know about wound healing or mice with diabetes?(c) How did it come to be in this journal? (i.e. was it sent to them by some huckster, I mean "Marketing Consultant"?2. The premise of this article presumes that NO gas freely passes thru the skin?(a) If that is true, why do we need lungs?(b) Why doesn't the Oxygen all leak out and we die of suffocation as we read this?(c) Why isn't Viagra supplied in topical form?3. The only real therapeutic use of these stockings is in (possibly) treating diabetic foot ulcers.(a) Would you put a pair of socks on an open foot ulcer ( In a diabetic with compromised healing in the first place!) and then lace up your shoes for a walk to the market?Good news Mother! I met a man on the way to market and I have traded the cow for this pair of magic socks which will cure your diabetic ulcers!
like whoever told you that fairy story about NO crossing the epidermis freely? I wonder if you would kindly oblige me with some sort of factual reference outside the realm of Science Fiction.
OK.Your prof is flogging a book on Amazon called "Nitric Acid Protocols". Oooooh! Shiny! But I'm from Missouri (or at least I drove thru it last June)
ow kindly show me a critically reviewed article in a reputable medical journal to support your frankly incredible claim that NO freely passes through the human epidermis.
Are you sure you're a graduate student? When I was in my graduate seminars in Pharmacology (back in the day) we learned how to support our arguments without inviting people to kiss our a**. The way we did that was to politely say, "show me the facts to support your most remarkable assertion." When they couldn't do that then they were fair game to be asked if they had recently visited fairyland and maybe had a toot with the little people.
Healthyhuman skin does produce nitric oxide, at verylow levels, as a result of chemical reactions withinsweat (Weller et al., 1996b). However, productionis about ten times higher in non-lesional skin ofpsoriatics, and about ten times higher again inthe plaques themselves (Weller& Ormerod, 1997;Orem et al., 1997; Ormerod et al., 1998). Theseobservations are highly suggestive of a role fornitric oxide in the development of psoriasis, althoughno mechanism has yet been established.From a clinical viewpoint, this is an excitingpossibility, because nitric oxide levels can be alteredrelatively easily, by topical application ofnitric oxide donors or inhibitors.
The nitric oxide molecule is small and is solublein phospholipid membranes and thus willdiffuse at approximately the same (high) rate indifferent layers of the skin, unimpeded by cells,extracellular matrix components, etc.
The high production rates of nitric oxide inpsoriatic plaques have been established bymeasuring release rates of nitric oxide from theskin surface.
The epidermis is composed of dead cells...your arguments about what happens in live cells do not apply to the case at hand. Why are you working so hard to try to confuse people? It is extremely dishonorable.
You are promoting untried therapy based on a preposterous idea.
Does your Mother know what you're up to?
It was your original claim that NO crossed the skin barrier.
have thrice asked you to show some reputable source to support your claim and the best you can come up with is to ask me to prove that it doesn't.
I personally believe you, little buddy. (thousands wouldn't) I'm sure you will have a most interesting career in science
hope that this tiresome exchange has at least caused people to question the junk science behind these wretched socks.
A slightly more obscure variation on the nicotine patch is the glyceryl trinitrate patch used in the treatment of angina. They work quite well. As it happens they work because the GTN gets converted to nitric oxide.
Why isn't Viagra supplied in topical form?
Alprostadil is sold in the United States as urethral suppositories, under the brand name MUSE (Medicated Urethral Suppository for Erection) by Vivus ... Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection will be needed.
"The presently available scientific documentation, although less extensive, indicates that NO donors, such as topically applied nitroglycerin (GTN; for example, 1-2 puffs of an ordinary GTN spray applied to the shaft of the penis), might be a reasonable alternative. Further larger-scale research on the efficacy and tolerability of topical GTN is needed to establish its full therapeutic potential in the treatment of erectile dysfunction."
Martin,I suspect you don't have other user's signatures visible. You might find it revealing if you enable them.
Now that is a concrete reproducible fact that can be verified easily by anybody who cares to give it a try. NTG applied topically simply does not provide effective levels of NO sufficient to work..I don't care what kind of phony and poorly designed study may say differently. Ask the man that owns one, why don't you?
Now then, if slathering NTG directly on the skin doesn't deliver NO...just maybe I am justifiably skeptical of these preposterous socks' ridiculous claims.
Finally as to the suggestion that I should be mindful of the identities of the other parties in this discussion,how is that scientific?
NTG doesn't reverse ED because it just plain doesn't put enough NO across the skin to do that. All the King's horses and all the King's men don't change that simple, concrete and easily verifiable fact.
BC,When you said "yardstick", were you referring to the US Yard or the Imperial Yard?
Quote from: Geezer on 06/09/2010 21:17:19BC,When you said "yardstick", were you referring to the US Yard or the Imperial Yard?Either way, if a any man here has a penis that is comparable to a yard stick I want his number... 
Res Ipsa Loquitur
Quote from: Variola on 07/09/2010 08:02:57Biggus Dickus. You can't drag Palin into this! Don't you realize that could destabilize the entire Western World?
But have you met his wife? Incontinentia Buttockus?