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Our observations of about 300 planetary systems seem to actually preclude, at least, advanced life form on in any of them.
Further, the structures of these planetary systems are remarkably similar in that all but one of them, I believe, have gas giant planets close to their suns.
We know what constituent chemistry is required, but we have never come close to moving from chemistry to molecular reproductive life. In some ways it is an embarrassment.
And no one has even a clue, not even a theory, as to how this transition came about.