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quote:Originally posted by dont_panicHow do nerve agents actually work? Presumably attacking the nervous system; but after doing research on the internet all i seem to come up with is how the Nazi's used them. Its terribly frustrating. Hope you lot can help, Thank you all.
quote:WHAT IS CHOLINESTERASE?Cholinesterase (ko-li-nes-ter-ace) is one of many important enzymes needed for the proper functioning of the nervous systems of humans, other vertebrates, and insects. Certain chemical classes of pesticides, such as organophosphates (OPs) and carbamates (CMs) work against undesirable bugs by interfering with, or 'inhibiting' cholinesterase. While the effects of cholinesterase inhibiting products are intended for insect pests, these chemicals can also be poisonous, or toxic, to humans in some situations. Human exposure to cholinesterase inhibiting chemicals can result from inhalation, ingestion, or eye or skin contact during the manufacture, mixing, or applications of these pesticides. HOW DOES IT WORK?Electrical switching centers, called 'synapses' are found throughout the nervous systems of humans, other vertebrates, and insects. Muscles, glands, and nerve fibers called 'neurons' are stimulated or inhibited by the constant firing of signals across these synapses. Stimulating signals are usually carried by a chemical called 'acetylcholine' (a-see-till-ko-leen). Stimulating signals are discontinued by a specific type of cholinesterase enzyme, acetylcholinesterase, which breaks down the acetylcholine. These important chemical reactions are usually going on all the time at a very fast rate, with acetylcholine causing stimulation and acetylcholinesterase ending the signal. If cholinesterase-affecting insecticides are present in the synapses, however, this situation is thrown out of balance. The presence of cholinesterase inhibiting chemicals prevents the breakdown of acetylcholine. Acetylcholine can then build up, causing a "jam" in the nervous system. Thus, when a person receives to great an exposure to cholinesterase inhibiting compounds, the body is unable to break down the acetylcholine. Let us look at a typical synapse in the body's nervous system, in which a muscle is being directed by a nerve to move. An electrical signal, or nerve impulse, is conducted by acetylcholine across the junction between the nerve and the muscle (the synapse) stimulating the muscle to move. Normally, after the appropriate response is accomplished, cholinesterase is released which breaks down the acetylcholine terminating the stimulation of the muscle. The enzyme acetylcholine accomplishes this by chemically breaking the compound into other compounds and removing them from the nerve junction. If acetylcholinesterase is unable to breakdown or remove acetylcholine, the muscle can continue to move uncontrollably.
quote:Originally posted by padfoot89Nerve agents are also found in nature.Certain snakes' poison also contain nerve agents.It kills by affecting the nervous system.HISSlobo
quote:Originally posted by dont_panicWould it be possible to make a nerve agent that mearly stunning the nervous system, rendering the person paralysed for a while, but they could then recover either with time or an antidote?
quote:Originally posted by dont_panicDid the Russian public know they were planning on using nerve agents?
quote:Originally posted by Soul SurferMuse are you by any remote chance a surfer from belgium?