DNA Polymerase needs Mn2+?

  • 1 Replies
  • 2432 Views

0 Members and 1 Guest are viewing this topic.

*

Offline vj_tu

  • Jr. Member
  • **
  • 29
    • View Profile
DNA Polymerase needs Mn2+?
« on: 20/01/2006 18:56:22 »
I was wondering if DNA polymerase specifically requires Mg2+ for its activity or it can work with any kinds of divalent cations eg. Mn2+ or Co2+?
 

*

Offline rosy

  • Neilep Level Member
  • ******
  • 1018
  • Chemistry
    • View Profile
Re: DNA Polymerase needs Mn2+?
« Reply #1 on: 20/01/2006 20:17:46 »
Usually, a requirement for a metal atom is specific (I don't know of any counterexamples), different atoms have different sizes and therefore fit different sized gaps and they also have different electron orbital occupancies and energies.
We're talking about a chemical reaction here, and they tend to be pretty subtle, especially the biological ones!