Can gene therapy be used to treat depression?

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Offline thedoc

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Can gene therapy be used to treat depression?
« on: 24/10/2010 10:22:43 »
A gene injected into one region of the brain might hold the key to treating depressed patients who fail to respond to conventional therapies.

Read the whole story on our website by clicking here

  
« Last Edit: 24/10/2010 10:22:43 by _system »

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Offline thedoc

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Can gene therapy be used to treat depression?
« Reply #1 on: 10/12/2010 15:29:25 »
Read the whole story on our website by clicking here, or go to the podcast page
[chapter podcast=2822 track=10.10.24/Naked_Scientists_Show_10.10.24_7389.mp3] Listen to the Story[/chapter] or [download as MP3]
« Last Edit: 10/12/2010 15:29:25 by _system »

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SteveFish

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Can gene therapy be used to treat depression?
« Reply #2 on: 26/10/2010 20:43:20 »
Thedoc:

This article is confusing. The mice in the study were missing a gene, but the article says-- "Intriguingly, brains from depressed humans studied post mortem show that the human p11 gene is also present at much lower levels in the same brain regions of these subjects, suggesting that what works in the mice might also work in man." This says that the gene is present at lower levels. However, except for certain early development problems, the gene complement for every cell in one person will be identical. So, the depressed human subjects in the study were either missing a gene, or there was evidence that the gene was present but not expressed as much as in normal humans, or you just meant that the gene was present in a lower proportion of the subject group than in a control group. Please Clarify.

Steve

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Offline chris

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Can gene therapy be used to treat depression?
« Reply #3 on: 29/10/2010 00:16:23 »
Hello Steve

I agree that I could have written that more clearly; what I meant to say is that the gene product is present at lower levels i.e. the expression level of the gene is lower in depressed people.

Chris
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SteveFish

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Can gene therapy be used to treat depression?
« Reply #4 on: 29/10/2010 01:22:44 »
Chris:

Thanks for the response. I, of course, have never written anything that wasn't perfectly clear, but then I tend to be selectively forgetful.

Steve