How do bacteria become resistant to phages?

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How do bacteria become resistant to phages?
« on: 23/11/2010 21:30:03 »
Gita asked the Naked Scientists:

I am looking to understand how bacteria develops resistance to phages, if (and how) it is possible to 'enhance' or develop new phages that bacteria would not be resistant to, and what the best strategy would be to avoid or delay resistance development

I have a personal interest in the subject because I am undergoing phage therapy for an e-coli & enterococcus antibiotic resistant kidney infection.  Initial response was excellent, however, there is now resistance to phages.  I would like to learn as much as possible before I have another conversation with my treating physician.  This seems to be my last resort and I may be able to influence the outcome into the positive, at least hoping to.

It is my understanding from your website that Professor Nick Mann, from Warwick University is developing bacteriophages.  Would it be possible to hear back from him or another scientist who is familiar with bacteriophages & bacterial resistance issues?

Thank you

What do you think?
« Last Edit: 11/12/2010 18:53:35 by chris »