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quote:Originally posted by chrisOk, good question.5' and 3' ends of DNA are relative terms. Mostly we speak in terms of in the 5' to 3' direction meaning that in the case of a circular piece of DNA the polymerase always works 5' to 3', no matter where it starts. When it copies the complementary (3 to 5) strand, at low resolution it looks as though synthesis is progressing the wrong way (3 to 5) but if you look closely the DNA is actually being copied in short 200bp segments each in the 5 to 3 direction. These are called Okazaki fragments after the guy who first described themChris"I never forget a face, but in your case I'll make an exception" - Groucho Marx