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One of the problems with this is the same that was found for filtered cigarettes.It "made sense" that filtered cigarettes would be safer than the unfiltered cigarettes.However, long-term studies have in fact shown that is not the case. The current theory is that the extra pressure used for dragging on a filtered cigarette increases its potential harm to being equivalent, or perhaps greater than that of the unfiltered cigarette.As far as the E-Cigs. There are no long-term studies about their safety... And thus any conclusions about safety would all be speculative. They should reduce the chemicals being inhaled into the lungs, but they also are increasing the water vapor that these are being inhaled with, as well as potentially selecting new chemicals that are not commonly found in the pulmonary system.One other thing. I'm not sure about the packaging and delivery system for the refills. Burning a cigarette will sterilize the vapors being inhaled, although it does burn from the end towards the person, thus it is filtered through the rest of the (dry) cigarette. The E-Cigs may have an aqueous environment which could promote the growth of bacteria that may not be sterilized before inhalation. Obviously we inhale microbes, but... this could potentially lead to respiratory disease not associated with cigarettes.Anyway, outwardly it appears as if the E-Cigs should be safer than cigarettes, pipes, and cigars, but I doubt that has been proven. And, anything that promotes continuing smoking is a potential problem.