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Could be a number of factors. Higher temperatures in storage, along with large temperature storage swings in both the trip there and in storage in the space environment. A more conservative approach to shelf life will result from this high temperature storage, and the space suppliers are traditionally more conservative in this respect. In packaging there traditionally is an autoclave cycle, to kill bacteria, and this will reduce shelf life. All this degrades the active ingredients, and will result in creation of undesirable breakdown products.
what is shelf life based on? main ingredient,additives, or preservatives? i've eaten some post dated stuff just fine= methinx mfr. wants to sell more
an irradiated drug is considered potentially a different drug than the un-irradiated version.
The “bends” rarely occurs with a rapid drop in air pressure below altitudes of 25,000 to 30,000 feet and should not be a problem in airline operations.