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It was pointed out by Schiff (1959) that it positrons had a negative gravitational mass ("fall upward"), then we would expect the nucleus to have anomalous ratios of mG/mI. The reason for this is that a nucleus is surrounded by a fluctuating cloud of virtual electron-positron pairs, a condition known as vacuum polarization. The number of pairs depends on the charge distribution of the nucleus, and if the gravitational mass of positrons were negative, nuclei surrounded by more pairs would appear to have lower gravitational mass. This effect would lead to a difference in mG/mI between platinum and aluminum amounting to a few parts in 107, in clear contradiction to Eotvos's experimental results.