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Natural insecticides, such as nicotine ... are made by plants as defenses against insects. Nicotine-based insecticides are widely used in the US and Canada, but are barred in the European Union
7.2 Toxicity 7.2.1 Human data 126.96.36.199 Adults The mean lethal dose has been estimated to be 30 to 60 mg (0.5-1.0 mg/kg) (Gosselin, 1988). 188.8.131.52 Children The lethal dose is considered to be about 10 mg of nicotine (Arena, 1974). 7.2.2 Relevant animal data Dog: oral LD50: 9.2 mg/kg mouse: oral LD50: 3.3 mg/kg (RTECS, 1985-86) rat: oral LD50: 50 mg/kg