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It's about whether to strongly and officially recommend a nontoxic nutrient when data to prove its efficacy are still unconfirmed.In the case of diseases of unknown cause and poor treatment results ...unsatisfactory results, or 'suboptimal' if you prefer.It's Philosophy of Science and practical medicine altogetherikod [^] thanks to the >100000 viewers (just unbelievable!)
Quote from: iko on 01/05/2007 22:13:37Click above if you want to read my grandfather's story...
Click above if you want to read my grandfather's story...
Facts do not cease to exist because they are ignoredAldous Huxley
...Vitamin D was used to treat a variety of skin diseases including psoriasis in the 1930s. However, it was not until the mid-1980s that the terapeutic potential of vitamin D in skin diseases reemerged.A dramatic improvement was seen in the psoriatic lesions in a patient receiving oral 1alpha-hydroxyvitamin D3 to treat severe osteoporosis (171).
"Is it your considered opinion that CLO is a good thing to take for the young and old ?.........Do the advantages outweigh the disadvantages ?neilep
quote:Note:fish liver oils contain vit.A+Vit.D3+omega-3 fatty acids.fish oils contain omega-3 fatty acids mainly.Vit.A&Vit.D3 are fat-soluble and do accumulate in the body: doses higher than reccomended may lead to toxicity.iko
quote:Control of the nervous systemVitamin D3 actions in the nervous system include induction of Vitamin D Receptor content (VDR is expressed in the brain and on several regions of the central and peripheral nervous system), the conductance velocity of motor neurons, and the synthesis of neurotrophic factors, such as nerve growth factors and neurotrophyns, that prevent the loss of injured neurons. Vit.D3 also enhances the expression of glial cell line-derived neurotrophic factor, a potential candidate for treatment of Parkinson's disease.In addition to increased nerve growth factor, combined treatment with Vit.D3 and 17beta-estradiol in rats elicits neuroprotective effects after focal cortical ischemia induced through the photothrombosis model.Vit.D3 influences critical components of orderly brain development. In the embrionic rat brain, the VDR increases steadly from day 15 to day 23, and Vit.D3 induces the expression of nerve growth factor and stimulates neurite outgrowth in embryonic hippocampal explants and primary cultures. Low prenatal Vitamin D in utero leads to increased brain size, brain shape, enlarged ventricles, and reduced expression of nerve growth factor in the neonatal rat.The association of vit.D deficiency and abnormal brain development makes Vitamin D an attractive candidate for tretment of schizophrenia, a disorder resulting from gene-environment interactions that disrupt brain development.Also, transient prenatal vitamin D deficiency in rats induces hyperlocomotion in adulthood with sever motor abnormalities.
quote: Vitamin D deficiency is associated with an increased risk for cancer, particularly gastrointestinal tract cancer, according to the results of a study of men reported in the April 5 issue of the Journal of the National Cancer Institute.What the study found was that with the first incremental increase in blood plasma levels of Vitamin D, compared to a lower baseline, there was an associated 17% reduction in total cancer incidence, a 29% reduction in total cancer mortality and a 45 % reduction in digestive-system cancer mortality. There was also some reduced incidence of leukemia.The authors were quoted as saying, “The vitamin D supplementation necessary to achieve this (incremental increase) may be at least 1500IU/day.” Current recommendations are adequate only to prevent the disease entity associated with a deficiency of vitamin D, or rickets.Sun exposure was one of the selected study determinants for calculating the expected serum vitamin D levels and was probably the most important source. The authors state, ” If the promise of vitamin D holds, a brief walk in the sun may turn out to be a step toward cancer prevention.” Further, they state “Although melanomas (skin cancer) account for approximately 7000 deaths annually in males in the United States, 295,000 men die annually of all cancers. We estimate a 29% lower cancer mortality rate (i.e., 85,550 fewer deaths annually) if the predicted (serum vitamin D) levels are increased.”“What does this all mean, Doc?” It means that while getting a regular dose of UVB via the sun is good, don’t get burned. Repeat; don’t get even a little red. You don’t get to have immunity from stupidity by over doing it. It means that while there are some deleterious effects to sun exposure and some people should minimize their exposure, sunlight (vitamin D) may substantially reduce your risk of certain cancers. And not just a little bit. 45%-decreased death rate is not a little bit. Yes, the rate for skin cancer may rise, but if the overall mortality rate drops even half the estimated amount of 85,550 per year and the mortality rate for melanoma doubles you are talking about a net decrease in the mortality stats of 28,775 men’s lives saved or a net drop from 295,000 per year by almost 10% for all cancer. While this study was directed toward men, a reasonable assumption is there would be some benefit for women as well.This is big, big news! This journal doesn’t print nutritional studies similar to this often.And the percentages of decrease in mortality rates are momentous. For me this is the earliest stage of substantiation of sunlight as a powerful preventive measure. Sunlight may not be the best or only way to get your D. And our placement on earth (short days in the winter in our latitude) may not allow us the sun exposure we all need. Some may have to supplement with a tablet or capsule. Those in the high risk for deficiency include vegetarians, couch potatoes, women with closely spaced pregnancies, persons with fat malabsorption syndromes and surgical gall bladder removal, certain medications, diabetes, osteoporosis and the elderly. For those that are in the high risk of deficiency group or don’t get the sunlight you need in the winter, 800 I.U.’s per day from the vitamin form D-3 is best. If you use a cod liver oil, keep track of the D in it and your multiple vitamins. If you have questions about Vitamin D, ask me.May 3, 2006
quote:Scientists crack cod liver oil secretCod liver oil can help arthritis sufferersScientists have identified exactly why cod liver oil is effective in easing the pain and inflammation associated with arthritis. Researchers at Cardiff University have pinpointed unusual fatty acids, called Omega or n-3 fatty acids, as the crucial factor.These fatty acids are present in fish oils but not other oils common in the diet. These findings provide some very interesting explanations as to why granny's cod liver oil therapies have some benefits to arthritis sufferers. Once incorporated into the cells, the fatty acids reduce the activity of enzymes that are responsible for damaging the cells and causing arthritis.The fatty acids also cause the "switching off" of another recently-discovered enzyme that causes much of the pain and inflammation in arthritis. Lead researcher Professor Bruce Caterson said: "This is a particularly interesting finding because there is intense activity in the pharmaceutical industry to find specific drug inhibitors of Cyclooxygenase-2." Pain and inflammation The fatty acids also switch off the long-term production of other chemicals known as inflammatory cytokines that prolong the pain and inflammation associated with arthritis. Professor Caterson said: "These findings provide some very interesting explanations as to why granny's cod liver oil therapies have some benefits to arthritis sufferers. "The good thing about modern day dietary supplements is that fish oil is available in capsules, thus preventing the most obvious deterrent to this treatment - the smell that precedes the terrible taste!" Dr Madeline Devey, scientific secretary of the Arthritis Research Campaign, said the research was "terrifically exciting". She said: "Taking fish oil is something that lots of people do because it makes them feel better, but we had had no idea why. "Any good science that can be thrown at a common self-medication is a really good idea, and it might enable us to manipulate diet in a slightly more rational way than we do at the moment." Sunday, 16 January, 2000, 01:03 GMThttp://news.bbc.co.uk/2/hi/health/604014.stm
"Cod liver oil is in the forefront of children's remedies.For long it has been struggling against the scepticism of exact science" Rosenstern: Berl. klin. Wchuschr. 47;822, 1910.
The manner in which M. Bretonneau, of Tours, was induced to give the oil in this disease deserves notice.He had treated the rachitic child of a rich Dutch merchant with preparations of iodine and other means, for some time, without success.He was then told by the father that the elder children had previously suffered under the same malady, and had been cured by the cod liver oil, which, in Holland, was a popular remedy. Bretonneau gave the same substance to his young patient, and was much struck with the very rapid and successful result which followed.He commenced making researches with it on other patients, and it was only then that he learnt for the first time what had been written by the German authors on this subject.He has since given it extensively in rachitis, with the happiest results.This fact was communicated to the Societe de Medicine de Paris, in 1837, by M. Roche. 10. Trousseau: Clinical Medicine, Philadelphia 2: 734, 1882.
How did the cod deficiency affect the evolution of the culture?Zoey