There have in fact been a few people who have won major lotteries twice, or even more, although many of the multiple wins are smaller lotteries with under $1 Million in prize money.

http://abcnews.go.com/blogs/business/2013/02/arkansas-couple-wins-lottery-twice-in-one-weekend/http://www.lotterypost.com/tag/Won_multiple_timeshttps://www.thelotter.com/blog/2014/10/twice-three-times-lottery-winner/Most of those individuals winning multiple times also spend A LOT OF MONEY on tickets.

As far as whether there is a bias towards certain numbers, if the system is truly random, then there should not be.

For something like selecting balls from a cage. Perhaps even a few milligrams difference in the weight of the balls, or a few cubic millimeters in volume would make a difference. Or, perhaps the lottery commission has a verification phase in which all balls are ordered before dumping into the cage, and for some reason they don't get fully mixed.

Thus, there are people trying to calculate the statistics for the perfect card. But, the differences SHOULD BE extremely minimal. Physical characteristics of the balls might also change over time, so data from 10 years ago may not be applicable today.

It is best to consider a lottery as a tax. If the payout is 50%, then if you invest $1,000,000, you should expect to get less than $500,000 back. But, it is worse than that. If the payments are spread out over time, then the lost investment income should be significant. And, taxes also take a chunk out of it.

So, your $1,000,000 investment starts looking a lot like a $100,000 return.

So, can you "beat the odds"? If there is a long streak of no winners, the lotteries often reach a point where the expected payout is greater than the odds. So, for example, it reaches a point where the odds are 1:1,000,000 to win $2,000,000. Outwardly the odds look favorable. But, the payouts are often greater than what is needed. But, also, considering time amortization, and taxes, the actual break even point may be much higher.