How does the body adapt to low oxygen?

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Offline Detective L Ryuzaki

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How does the body adapt to low oxygen?
« on: 22/11/2015 06:23:25 »
I recently got a urinary tract infection which then later on caused me some symptoms that I thought were quite serious.  I got chills, felt weak and fatigue, and had a little bit of a hard time breathing.  I think my body was lacking some oxygen due to the chronic inflammation that followed after that infection.  But now I notice that my body has adapted to that lack of oxygen in which I no longer notice those symptoms anymore.  But question is, can my body remain adapted to this?  Or will this adaptive mechanism eventually go downhill over time and result in something serious and fatal?

I am quite sure I have chronic inflammation which is what is causing this lack of oxygen in my body.  So that is why it is vital that not only does this adaptive mechanism stay fully in place and doesn't fail over time, but it is also vital that I ask if I don't have to worry about this adaptive mechanism failing eventually or if I do have to worry since it might actually fail over time and result in something fatal.  Now I am thinking that maybe the reason why I have chronic inflammation is because of a neurological issue and not any issue with my body.

The reason I think this is because I have anhedonia.  During anhedonia, you have a dysregulated HPA axis that causes your pleasure (good moods) to turn off.  The HPA axis also happens to be the brain region that is responsible for triggering inflammation.  So I figured that since I have a dysregulated stress response due to my anhedonia which is chronic and 24/7, that I also now have a dysregulated chronic inflammatory response as well.  I notice that my good moods have turned off even further and that the dysregulated stress response has become even greater after that infection.  So that is the reason why I am really thinking here that this additional activity is the result of a chronic inflammatory response in addition to the stress activity.

Like I said before, I am really hoping here that this adaptive mechanism can stay fully in place.  I need to know right now if this mechanism could very well fail over time and that I might die or if I don't have to worry and that I will live.
« Last Edit: 22/11/2015 10:07:10 by chris »


Offline Colin2B

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Re: Adaptation to low oxygen
« Reply #1 on: 22/11/2015 10:03:15 »
When our daughter was preparing to climb (walk) Kilimanjaro we spent a lot of time reading research on altitude sickness and high altitude nutrition. There isn't a lot out there on de-acclimatisation but one study did say that native people living at high altitude showed signs of changes in red blood cells after 10 days at sea level.
It might not be relevant to your situation but it gives an indication.
Did you check your blood oxygen level?
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Offline puppypower

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Re: How does the body adapt to low oxygen?
« Reply #2 on: 22/11/2015 12:49:39 »
The two types of anaerobic energy systems are: 1) high energy phosphates, ATP adenosine triphosphate and CP creatine phosphate; and 2) anaerobic glycolysis. High energy phosphates are stored in limited quantities within muscle cells. Anaerobic glycolysis exclusively uses glucose (and glycogen) as a fuel in the absence of oxygen, or more specifically when ATP is needed at rates that exceed those provided by aerobic metabolism.

When I was younger, I used to do anaerobic training, such as super setting with weights (1 minute rest between sets),  sprinting and hills. Anaerobic training conditions your body to function with limited oxygen; being winded The body adjusts, over time, by storing more and more high energy phosphate in the muscles, which can be burned for fuel without the need of oxygen.

In anaerobic glycolysis, there is a build up of lactic acid in muscles. But as time goes by the body is able to absorb this quicker so you don't get tired from it. After a workout I would do some aerobics; walk and jog, to change the energy pathways until they start to include oxygen. This would clear my body of lactic acid and allow the anaerobic phosphate fuel to build back up in my muscles for later. 

« Last Edit: 22/11/2015 12:51:45 by puppypower »


Offline evan_au

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Re: How does the body adapt to low oxygen?
« Reply #3 on: 22/11/2015 16:57:26 »
Climbing high mountains, traveling in an unpressurized jet or pneumonia can reduce the oxygen levels in your blood. All these interfere with the ability of oxygen to pass into your lungs and bloodstream.

I would be surprised if the slightly increased energy consumption of a mild fever could do the same. This has less energy consumption than other forms of exercise.

Perhaps you were feeling the general malaise that comes with an infection and fever. Now the infection and fever have passed, you once again feel "normal"?