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there doesn't appear to have been a significant helpful mutation for many thousands of years
The processing of the genetic information within DNA is facilitated by highly discriminatory and strong protein binding. It has been shown that the interfacial water molecules can serve as 'hydration fingerprints' of a given DNA sequence .The normal 'hydration fingerprint' of the DNA will clearly be disrupted by DNA damage and this will facilitate repair protein attachment. The hydration spine (see above) is capable of carrying messages, as facilitated proton movement down the water wire, between binding sites in a similar, if complementary, manner to the electron transfer through the DNA residues  and so coordinate the repair process.
Lamarck's alternative theory has been discredited
the pepper moth which switches from one completely perfect camouflage to another completely different perfect camouflage
I am aware that minor mutations occur within species. My question and it is a question, relates to mutations that fundamentally change a species.