Post Orgasmic Illness Syndrome (POIS)

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Offline GoingCrazy

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« Reply #14550 on: 04/09/2011 05:30:19 »
I don't think that thoughts can trigger an allergy.

It has been found that in people with multi-personality disorder, they will test positive allergic to a substance in one personality, and negative to the same substance when in their other personality.

Many doctors/medicine in general are now moving away from the old Newtonian physics that drugs are the answer to chronic problems, and more towards the quantum physics way of thinking that, the mind and energy fields are the key to chronic illness, if watch you the whole of the living matrix you'll get the idea, which is why NLP & reiki etc are good for chronic illhealth.
The Living Matrix http://www.youtube.com/watch?v=Bl2DiT6jg88

Anyways, it has been known since 1899 that everybody are probably allergic to their semen.

1899-1900 Sperm recognized as immunogenic (will cause an autoimmune reaction if transplanted from the testis into a different area of the body) by Lansteiner (1899) and Metchinikoff, (1900)
Immune privilege in the testis
Sperm are immunogenic - that is they will cause an autoimmune reaction if transplanted from the testis into a different part of the body. This has been demonstrated in experiments using rats by Lansteiner (1899) and Metchinikoff (1900) , mice and guinea pigs . The likely reason for this is that sperm first mature at puberty, after immune tolerance is established, therefore the body recognizes them as foreign and mounts an immune reaction against them. Since sperm do not die in the testis, mechanisms for their protection must exist in this organ. The blood-testis barrier is likely to contribute to the survival of sperm. However, it is believed in the field of testicular immunology that the blood-testis barrier cannot account for all immune suppression in the testis, due to (1) its incompleteness at a region called the rete testis and (2) the presence of immunogenic molecules outside the blood-testis barrier, on the surface of spermatogonia . Another mechanism which is likely to protect sperm is the suppression of immune responses in the testis . Both the suppression of immune responses and the increased survival of grafts in the testis have led to its recognition as an immunologically privileged site. Other immunologically privileged sites include the eye, brain and uterus.

http://www.reference.com/browse/testicular+immunology


referring to your quote about the people already being allergic to semen:

Thanks that's what I needed to see.  when I think of sperm allergy I think of sneezing, runny nose, etc. not the mental affects.

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Offline daveman

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« Reply #14551 on: 04/09/2011 15:35:30 »
Even though Niacin / XN / vitamin B3 seems to be working well for most, it has it's side effects. The flush is uncomfortable for some, prolonged use could do damage to the liver, which should be monitored, and others, for combinations of other drugs they may be taking or certain other physical problems can't even take it.

But what is more important is what it points to. At risk of being repetitive, "A failure is not a failure with good data, and success is not a success without".

It seems, if properly taken, at minimal doses and ONLY just before orgasm, the risks are minimized, and it works fairly well for a good percentage of us.

But it is a big step in moving towards confirmation of potential autoimmune causes for severe cognitive symptoms. For those who do not believe that an "allergy" can make you feel "out of it", "depressed", even "suicidal", the effects that niacin has over the reduction of symptoms points to the mechanism which causes those symptoms.

It's really hard to have an intuitive feel for what is causing a cognitive disorder, because the very part of you that is "screwed up" is the part that generates that perspective.

But when you feel niacin working, it's evident. Where once there was hell, it is now smooth. You wait for the bottom to fall out, but it doesn't.

For sure, you are not CURED. But the evidence is there, both in the flesh AND in th data.

How does Murphey do it??

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Offline baboo

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« Reply #14552 on: 04/09/2011 16:30:09 »
Hi everyone. I've posted on here briefly some time ago but not much since. I kind of avoided thinking much about POIS as I have other issues going on in my life.

My POIS was triggered by starting on an SSRI medication. I don't know how or why, but I never noticed having this problem prior to taking it. I take Escitalopram. I also know of someone who took Citalopram who suffered brainfog after orgasm.

My symptoms are mainly attention difficulties, difficulty focusing, aswell as motivation problems. It is very hard to be around people when in this state. I get minor body aches too.
I think in my case it may be connected to the SSRI depleting my dopamine levels, which get further depleted after orgasm. Just my guess.

So, from what I can see reading the last few pages, niacin seems popular? Can this be taken after an orgasm?
« Last Edit: 04/09/2011 16:33:23 by baboo »

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Offline makrofag

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« Reply #14553 on: 04/09/2011 16:45:51 »
But it may be a big step in moving towards confirmation of potential autoimmune causes for severe cognitive symptoms. For those who do not believe that an "allergy" can make you feel "out of it", "depressed", even "suicidal", the effects that niacin has over the reduction of symptoms may point to the mechanism which maybe cause those symptoms.

Just a little correction.

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Offline Quasar

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« Reply #14554 on: 04/09/2011 19:02:16 »
Hi everyone. I've posted on here briefly some time ago but not much since. I kind of avoided thinking much about POIS as I have other issues going on in my life.

My POIS was triggered by starting on an SSRI medication. I don't know how or why, but I never noticed having this problem prior to taking it. I take Escitalopram. I also know of someone who took Citalopram who suffered brainfog after orgasm.

My symptoms are mainly attention difficulties, difficulty focusing, aswell as motivation problems. It is very hard to be around people when in this state. I get minor body aches too.
I think in my case it may be connected to the SSRI depleting my dopamine levels, which get further depleted after orgasm. Just my guess.

So, from what I can see reading the last few pages, niacin seems popular? Can this be taken after an orgasm?

Hi Babou! I also took for 6 months Escitalopram. My Pois before taking the drug was negligible. In fact, i didn't know i had Pois before taking the SSRI.

But thinking about it, i remember i was having brain fog and low energy issues for some years before taking the SSRI. So, it seems i already had Pois.

However, i also think Escitalopram made it much worse. I remember when i was under Escitalopram i was nearly impossible for me to reach an orgasm.

I think it may not be only related to dopamine, because SSRI's modify more neurotransmitters, not just dopamine.

Who knows, maybe the issue is with serotonin. SSRI's may have caused to deplete your serotonin levels post-SSRI.

So, if you really want to check if that is the issue, you could talk to your doctor, and try some drug to reverse the SSRI effect.

Maybe something similar to Wellbutrin, Requip, or serotonin antagonists. Or maybe something different that increases serotonin, like MAOI's.

But please take care, and always talk to your doctor. Some drugs are dangerours and can have side effects.

Aso, a blood test about neurotransmitters could be of some help.

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Offline daveman

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« Reply #14555 on: 04/09/2011 22:36:36 »
But it may be a big step in moving towards confirmation of potential autoimmune causes for severe cognitive symptoms. For those who do not believe that an "allergy" can make you feel "out of it", "depressed", even "suicidal", the effects that niacin has over the reduction of symptoms may point to the mechanism which maybe cause those symptoms.

Just a little correction.

That's fine if you want to see I that way! I guess we'll just have to wait and see.




How does Murphey do it??

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Offline Pharaoh

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« Reply #14556 on: 05/09/2011 05:47:50 »
Niacin seems to be working for me.  I started taking 100 mg in the morning yesterday.  Made me agressive and sexually aroused.  Had an O, then took 200 mg.  Had another O.  Not 100% by any means, but definitely feeling better than I would under the circumstances.  We'll see what tomorrow brings. 

A few questions:

1.  Many of us were normal at one point, and then experienced POIS.  Sometimes the development was gradual.  Some have identified specific substances that maybe the trigger, e.g. Animus's herbal male enhancement and baboo's Escitalopram.  So, the question is, how did they become allergic to their own semen?  I suppose I have trouble with idea that one can suddenly become allergic to their own semen.  If it was a birth disorder, then it would be more acceptable.  But, the idea that SSRI's or other neurochemical altering substances can "trigger" POIS leads me to believe there is more to it than a very intense allergic reaction.

2. The quote Horizon provided from reference.com is fascinating.  It basically states that all people can be allergic to their own semen: "Sperm are immunogenic - that is they will cause an autoimmune reaction if transplanted from the testis into a different part of the body."  This raises the question of whether intradermal tests actually tell us anything.  Furthermore, as many have pointed out, and as one allergy dr. my endocrinologist phoned during my appointment immediately identified, there is no control group in Waldinger's work.  According to the research cited, the photos Habibou shared do not show anything unexpected. 

3.  The symptoms of sexual exhaustion seem to be very similar, if not identical, to those of POIS.  This may also explain why multiple O's will lead to more severe POIS symptoms.  Simply because many people can have multiple O's in one day without any consequences does not rule out that some can become extremely fatigued after one.  But, I do believe there is more to POIS than just exhaustion.  I would like more investigation into the condition of the blood-testis barrier and the rete testis in POIS sufferers.  Could it be that we have damaged this mechanism?  This may explain why some people develop POIS after years of normality.  But, why would SSRI's or herbal male enhancements lead to this?  Maybe they are red herrings.  Or, they effected the mechanism in a way that made it more vulnerable to damage. 

My endocrinologist can not make sense of why anti-histamines have no effect whatsoever.  He's gone so far as to recommend I make the trip to Holland.  He also recommended I see Dr. Arthur Burnett.  He's a big shot urologist at John's Hopkins.  Let's see what he thinks. 

Looking forward to your thoughts.


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Offline EDS

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« Reply #14557 on: 05/09/2011 12:39:26 »
I have a question for everyone!!

If a very respected medical institution approached you and offered you a magic pill that would cure you of this hideous disease called POIS, would you pay $100, $1,000, or even $10,000 for it?!!
OF COURSE YOU WOULD!!!
I certainly would pay as much as possible to be able to live a normal life - be able to interact, feel good, enjoy intimate time with my wife, not have achy joints or worry about NE's, etc., etc.

The way I figure it - There are at least 350 of us (I think many more) viewing this site on a regular basis. If each of us gave only $100, we would have the necessary funding to start the NORD study. Some of us have already given or pledged more, so even if it is only $50, I think we can get there. Think about it - for less than the cost of a nice meal out, we may find relief from misery!

NORD may very well offer the "magic pill" of which I spoke! We will never know if we don't take a small leap of faith and support ourselves to get the necessary funding. A lot of the questions and speculation we discuss here will be answered when we get a world class institution like NORD on our side.

So PLEASE, PLEASE, PLEASE, give what you can to the fund. We simply have to support ourselves... so let's start today! We will surely benefit!! And we all know how much better our quality of life will be if we can beat this plague!!!

It is very easy to give with a credit card. Just click on the link below and donate for the betterment of us all.
https://rarediseases.org/about/support/research-donations/fg_base_view_p3

To quote a famous advertising slogan "JUST DO IT"
« Last Edit: 05/09/2011 20:28:16 by EDS »

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Offline horizon

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« Reply #14558 on: 05/09/2011 13:44:49 »
everyone dont forget the Niacin poll at http://poiscenter.com/forums/index.php?topic=200.0

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Offline daveman

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« Reply #14559 on: 05/09/2011 20:57:49 »
Niacin seems to be working for me.  I started taking 100 mg in the morning yesterday.  Made me agressive and sexually aroused.  Had an O, then took 200 mg.  Had another O.  Not 100% by any means, but definitely feeling better than I would under the circumstances.  We'll see what tomorrow brings. 

A few questions:

1.  Many of us were normal at one point, and then experienced POIS.  Sometimes the development was gradual.  Some have identified specific substances that maybe the trigger, e.g. Animus's herbal male enhancement and baboo's Escitalopram.  So, the question is, how did they become allergic to their own semen?  I suppose I have trouble with idea that one can suddenly become allergic to their own semen.  If it was a birth disorder, then it would be more acceptable.  But, the idea that SSRI's or other neurochemical altering substances can "trigger" POIS leads me to believe there is more to it than a very intense allergic reaction.

2. The quote Horizon provided from reference.com is fascinating.  It basically states that all people can be allergic to their own semen: "Sperm are immunogenic - that is they will cause an autoimmune reaction if transplanted from the testis into a different part of the body."  This raises the question of whether intradermal tests actually tell us anything.  Furthermore, as many have pointed out, and as one allergy dr. my endocrinologist phoned during my appointment immediately identified, there is no control group in Waldinger's work.  According to the research cited, the photos Habibou shared do not show anything unexpected. 

3.  The symptoms of sexual exhaustion seem to be very similar, if not identical, to those of POIS.  This may also explain why multiple O's will lead to more severe POIS symptoms.  Simply because many people can have multiple O's in one day without any consequences does not rule out that some can become extremely fatigued after one.  But, I do believe there is more to POIS than just exhaustion.  I would like more investigation into the condition of the blood-testis barrier and the rete testis in POIS sufferers.  Could it be that we have damaged this mechanism?  This may explain why some people develop POIS after years of normality.  But, why would SSRI's or herbal male enhancements lead to this?  Maybe they are red herrings.  Or, they effected the mechanism in a way that made it more vulnerable to damage. 

My endocrinologist can not make sense of why anti-histamines have no effect whatsoever.  He's gone so far as to recommend I make the trip to Holland.  He also recommended I see Dr. Arthur Burnett.  He's a big shot urologist at John's Hopkins.  Let's see what he thinks. 

Looking forward to your thoughts.



Pharaoh,

A good post, with reassonable doubts. I think you basically answer point 1 with point 3.

And, I think as you do, that we need more on the blood-testes-brain barrier.

It is almost assumed that the barrier is inpenertrable, and so, for that reason many experts discount the hypothesis.

The whole area of vasectomies and especially reversals demonstrates this. If the blood testes barrier were not so solid, these things would not be possible. But when you think about it, vasectomy side effects and reversal side effects only have a history of about 45 yrs. Sounds like a lot, but if we take my case as an example for instance: I had a vasectomy for 21 yrs, before I had a reversal, and then only after about 10 yrs I started to have POIS.

For things the doctor said, 5 yrs of vasectomy before a reversal is nothing, but 20 yrs is a different story for reasons of anti-body development and damages to the system that might result. Later once the reversal is done, there is a different and stronger reaction that causes damage. Also this may take several years to eventually weaken the barrier.

So there isn't a large history supporting the real resilience of the barrier. Few have both the vasectomy AND the reversal, and few have had the combination for 30 or 40 yrs, so any number would be low, and most likely those that show, are covered as a result of any attempt to cover the doctors' butts.

So it is rare..... but so is POIS.

Dr. Goldmeier, who is a good friend of POIS, and is very well respected, saw CFS (similar to Sexual Exhaustion) in Habibou as the result of the beating that POIS was imposing on his system.

What beating? He apparantly believes that it is allergy (autoimmune), but it could be something else. If I had to believe a doctor with Dr. Goldmeier's credenciales and experience over a local endocrinologist, guess who I'm going to go with?

As far as antihistamines, I've tried them, as have a couple of others, and I can't say they haven't had no effect whatsoever. For sure, they may only provide temporary and light relief, maybe as good as no effect, but there are many reasons for that. POIS is not just a low grade "type I" sniffles allergy. One member has found a couple of stronger antihistamines that help him quite a bit. And there are types of antihistamines, for H1, H2 etc.

The attack (if we can permit an immune system attack for the moment) is heavy. More than pollen in the air. It's living critteres in the blood. But even so, after orgasm, the normal person even emits histamines, naturally. Heavy histamine requirements an a fatigued system (or perhaps even normal histimine requirements on a failed system) will leave depletions of the precursors to elements that we need to think properly and concentrate and be incentivated.

Perhaps this is why we confuse POIS with CFS or S/E. Yes the symptoms are very similar, but in our case POIS leads to the others, lasts an average of 6 days and doesn't recuperate with pure abstention. With abstention it can temporarily be easier on isolated "Os" following the abstention but comes back to "normal" after just a few. This temporary and slight recuperation is probably because the CFS or S/E consequences of POIS are relieved.

« Last Edit: 05/09/2011 21:11:10 by daveman »
How does Murphey do it??

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Offline Vincent M

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« Reply #14560 on: 05/09/2011 21:40:28 »
"Saw palmetto is used by natural health practitioners to treat a variety of ailments in men and women, such as testicular inflammation, urinary tract inflammation, coughs, and respiratory congestion. It is also used to strengthen the thyroid gland, balance the metabolism, stimulate appetite, and aid digestion."

http://medical-dictionary.thefreedictionary.com/saw+palmetto

Since saw palmetto makes my testicles much less tender and takes away the burning feeling that usually accompanies urination, these facts provide evidence of actual inflammation in my body resulting from orgasm. Saw palmetto also reduces the bloating I have during POIS and makes bowel movements less painful which is evidence that POIS causes my intestines to become inflamed or my digestion to become hindered in some way.
Taking fenugreek+tea/garlic, saw palmetto, huperzine, niacin, boswellia, and nutmeg.

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Offline B_Daniel

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« Reply #14561 on: 05/09/2011 22:22:21 »
"Saw palmetto is used by natural health practitioners to treat a variety of ailments in men and women, such as testicular inflammation, urinary tract inflammation, coughs, and respiratory congestion. It is also used to strengthen the thyroid gland, balance the metabolism, stimulate appetite, and aid digestion."

http://medical-dictionary.thefreedictionary.com/saw+palmetto

Since saw palmetto makes my testicles much less tender and takes away the burning feeling that usually accompanies urination, these facts provide evidence of actual inflammation in my body resulting from orgasm. Saw palmetto also reduces the bloating I have during POIS and makes bowel movements less painful which is evidence that POIS causes my intestines to become inflamed or my digestion to become hindered in some way.

I'm glad to hear it's helping you.  There are 3 glands that produce the seminal fluid.  The seminal vescicles, cowpers, and the prostate.  The seminal vescicles and the prostate produce 90% of it.  Saw Palmetto helps to shrink the prostate.  Our pois is quite possibly caused by one of those glands... so it's makes sense by me that our pois is helped by shrinking the prostate
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline B_Daniel

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« Reply #14562 on: 05/09/2011 22:27:01 »
I have a question for everyone!!

If a very respected medical institution approached you and offered you a magic pill that would cure you of this hideous disease called POIS, would you pay $100, $1,000, or even $10,000 for it?!!
OF COURSE YOU WOULD!!!
I certainly would pay as much as possible to be able to live a normal life - be able to interact, feel good, enjoy intimate time with my wife, not have achy joints or worry about NE's, etc., etc.

The way I figure it - There are at least 350 of us (I think many more) viewing this site on a regular basis. If each of us gave only $100, we would have the necessary funding to start the NORD study. Some of us have already given or pledged more, so even if it is only $50, I think we can get there. Think about it - for less than the cost of a nice meal out, we may find relief from misery!

NORD may very well offer the "magic pill" of which I spoke! We will never know if we don't take a small leap of faith and support ourselves to get the necessary funding. A lot of the questions and speculation we discuss here will be answered when we get a world class institution like NORD on our side.

So PLEASE, PLEASE, PLEASE, give what you can to the fund. We simply have to support ourselves... so let's start today! We will surely benefit!! And we all know how much better our quality of life will be if we can beat this plague!!!

It is very easy to give with a credit card. Just click on the link below and donate for the betterment of us all.
https://rarediseases.org/about/support/research-donations/fg_base_view_p3

To quote a famous advertising slogan "JUST DO IT"

EDS you're exactly right!  Not everyone can afford $100, but also some people can afford more.  If we all give $100 we'll have the NORD money raised in no time. 

If you factor in your happiness, your lost wages/ work potential, quality of life, etc, then Getting rid of this thing is worth a 100 times more than that to EACH of us!
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline CertainlyPOIS

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« Reply #14563 on: 06/09/2011 04:00:24 »
Bdaniel am sure you meant to say at least 10000 times more

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Offline demografx

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« Reply #14564 on: 06/09/2011 06:49:44 »

I have a question for everyone!!

If a very respected medical institution approached you and offered you a magic pill that would cure you of this hideous disease called POIS, would you pay $100, $1,000, or even $10,000 for it?!!
OF COURSE YOU WOULD!!!
I certainly would pay as much as possible to be able to live a normal life - be able to interact, feel good, enjoy intimate time with my wife, not have achy joints or worry about NE's, etc., etc.

The way I figure it - There are at least 350 of us (I think many more) viewing this site on a regular basis. If each of us gave only $100, we would have the necessary funding to start the NORD study. Some of us have already given or pledged more, so even if it is only $50, I think we can get there. Think about it - for less than the cost of a nice meal out, we may find relief from misery!

NORD may very well offer the "magic pill" of which I spoke! We will never know if we don't take a small leap of faith and support ourselves to get the necessary funding. A lot of the questions and speculation we discuss here will be answered when we get a world class institution like NORD on our side.

So PLEASE, PLEASE, PLEASE, give what you can to the fund. We simply have to support ourselves... so let's start today! We will surely benefit!! And we all know how much better our quality of life will be if we can beat this plague!!!

It is very easy to give with a credit card. Just click on the link below and donate for the betterment of us all.
https://rarediseases.org/about/support/research-donations/fg_base_view_p3

To quote a famous advertising slogan "JUST DO IT"



EDS you're exactly right!  Not everyone can afford $100, but also some people can afford more.  If we all give $100 we'll have the NORD money raised in no time. 

If you factor in your happiness, your lost wages/ work potential, quality of life, etc, then Getting rid of this thing is worth a 100 times more than that to EACH of us!



B_Daniel am sure you meant to say at least 10000 times more



EDS, B_DANIEL, AND CCCONFUCIUS....THANK YOU!!!!

 [:)]   [:)]   [:)]
« Last Edit: 06/09/2011 06:53:56 by demografx »

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Offline Itsthatskater

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« Reply #14565 on: 06/09/2011 07:22:16 »
Honestly guys I dont see what else this could be rather than an allergic reaction.

I mean obviously its something in our semen that is making our body act like this, Masturbation without ejaculation doesnt harm but with Ejaculation causes a world of problems!

It it just me or when you ejaculate do you feel like a wave through your  body that kind of just wipes away your strenght that you dont get back, and you dont feel it get back, I get that back in my sleep 48 hours later.

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Offline B_Daniel

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« Reply #14566 on: 06/09/2011 08:59:36 »

B_Daniel am sure you meant to say at least 10000 times more



EDS, B_DANIEL, AND CCCONFUCIUS....THANK YOU!!!!

 [:)]   [:)]   [:)]

Haha!  Whatever my left arm is worth... THAT many times more!
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline mellivora

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« Reply #14567 on: 06/09/2011 18:36:07 »
Flipping POIS! I pledge $500 now to the NORD fund, maybe more in future.
I suspect one of the problems with the NORD system is...what happens to the money donated if we don't actually make it to the required amount? I'm not suggesting we won't make it but its not surprising to me that people aren't making that many donations. However, pledging is a different matter. My only hope is that when the pledged total is actually enough to get the ball rolling, people actually cough up a real donation to make it happen. I think they will.

If the donation system were set up such that money would be refunded if the required total for NORD POIS research wasn't reached after say 5 years, people might be more forthcoming with real donations - a sort of guarantee that money donated would only be used for POIS and be refunded if no POIS research was forthcoming. Please don't let it take 5 years to get started though!! Roll up people. As EDS and others have so brilliantly written, it should be easy to get this total. If you don't want to actually part with your money now until you know we're close to $33,500 then at least pledge something...and stick to it. That's where I'm at just now.  I know, as usual, I've not been posting very frequently on here... Thanks everyone for carrying on the battle so persistently, I really am grateful to you all.

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Offline Quasar

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« Reply #14568 on: 06/09/2011 19:35:07 »
Honestly guys I dont see what else this could be rather than an allergic reaction.

I mean obviously its something in our semen that is making our body act like this, Masturbation without ejaculation doesnt harm but with Ejaculation causes a world of problems!

It it just me or when you ejaculate do you feel like a wave through your  body that kind of just wipes away your strenght that you dont get back, and you dont feel it get back, I get that back in my sleep 48 hours later.

Yes, but it could also be that the brain detects when you have a real ejaculation, and the reward system could be different. Maybe the brain only releases certain neurotransmittes and hormones if it detects that the ejactulation has been 100% real.

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Offline Quasar

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« Reply #14569 on: 06/09/2011 19:40:06 »
"Saw palmetto is used by natural health practitioners to treat a variety of ailments in men and women, such as testicular inflammation, urinary tract inflammation, coughs, and respiratory congestion. It is also used to strengthen the thyroid gland, balance the metabolism, stimulate appetite, and aid digestion."

http://medical-dictionary.thefreedictionary.com/saw+palmetto

Since saw palmetto makes my testicles much less tender and takes away the burning feeling that usually accompanies urination, these facts provide evidence of actual inflammation in my body resulting from orgasm. Saw palmetto also reduces the bloating I have during POIS and makes bowel movements less painful which is evidence that POIS causes my intestines to become inflamed or my digestion to become hindered in some way.

I'm glad to hear it's helping you.  There are 3 glands that produce the seminal fluid.  The seminal vescicles, cowpers, and the prostate.  The seminal vescicles and the prostate produce 90% of it.  Saw Palmetto helps to shrink the prostate.  Our pois is quite possibly caused by one of those glands... so it's makes sense by me that our pois is helped by shrinking the prostate

I've got one question. I don't know if it's because of POIS, but lately i have the urge to pee more than usual. Is that a symptom of prostate inflammation?

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Offline demografx

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« Reply #14570 on: 06/09/2011 20:41:28 »

I pledge $500 now to the NORD fund







Mellivora, thank you so much!!!
« Last Edit: 06/09/2011 20:44:40 by demografx »

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Offline demografx

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« Reply #14571 on: 07/09/2011 07:14:37 »

People,

Please don't forget there is another POIS-forum (supported and created by this community), where we can discuss in topics (instead of in one long thread).

http://www.poiscenter.com/forums/index.php

Please have a look.

Rocky


« Last Edit: 07/09/2011 08:11:11 by demografx »

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Offline demografx

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« Reply #14572 on: 07/09/2011 07:27:56 »
For those of you not yet familiar.....


We started a POIS Medical Research Fund to accelerate our finding a POIS cure! It is explained here in detail:
http://poiscenter.com/forums/index.php?topic=125.0


We've raised nearly $3,000.....with much more $$$ pledged!


And your POIS fund donation is most welcome here:
http://rarediseases.org/about/support/research-donations


Helping the Fund will help YOU to a faster cure for YOUR POIS!!


If you can't contribute now, post your PLEDGE ! Knowledge of your "future funding" intentions will be very uplifting and will affect us all!!


$ Large or small $ !! THANK YOU!!!

« Last Edit: 07/09/2011 07:56:56 by demografx »

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Offline Quasar

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« Reply #14573 on: 07/09/2011 11:28:58 »
Would it be dangerous to insert natural lemon juice with water into my urethra? I want to know if it stings, maybe i have some little urethra infection. It may not do any harm, and may clean something.

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Offline B_Daniel

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« Reply #14574 on: 07/09/2011 15:12:57 »
Flipping POIS! I pledge $500 now to the NORD fund, maybe more in future.
I suspect one of the problems with the NORD system is...what happens to the money donated if we don't actually make it to the required amount? I'm not suggesting we won't make it but its not surprising to me that people aren't making that many donations. However, pledging is a different matter. My only hope is that when the pledged total is actually enough to get the ball rolling, people actually cough up a real donation to make it happen. I think they will.

If the donation system were set up such that money would be refunded if the required total for NORD POIS research wasn't reached after say 5 years, people might be more forthcoming with real donations - a sort of guarantee that money donated would only be used for POIS and be refunded if no POIS research was forthcoming. Please don't let it take 5 years to get started though!! Roll up people. As EDS and others have so brilliantly written, it should be easy to get this total. If you don't want to actually part with your money now until you know we're close to $33,500 then at least pledge something...and stick to it. That's where I'm at just now.  I know, as usual, I've not been posting very frequently on here... Thanks everyone for carrying on the battle so persistently, I really am grateful to you all.

Thank you sincerely for your donation, Mellivora.  With your pledge, we've surpassed the 1/3 marker and are closer than ever!

In regards to your points above, I'll tell you what I'm doing.  I'm donating my money on a schedule.  So I've given the first portion now.  When our donation tally reaches $5K, I'll give another bit, and so on and so forth.  I know rob58, EDS, and some others have similar strategies.  That being said, I think there's also an unspoken agreement that when the total pledged amount exceeds the $33.5K, it'll be time for us all to go all in.  Then we can celebrate!   
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline demografx

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« Reply #14575 on: 07/09/2011 17:31:57 »

Would it be dangerous to insert natural lemon juice with water into my urethra? I want to know if it stings, maybe i have some little urethra infection. It may not do any harm, and may clean something.


Quasar, PLEASE ask this of a physician!

None of us here are qualified to respond !
« Last Edit: 07/09/2011 17:35:14 by demografx »

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Offline demografx

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« Reply #14576 on: 07/09/2011 17:38:08 »

Flipping POIS! I pledge $500 now to the NORD fund, maybe more in future.
I suspect one of the problems with the NORD system is...what happens to the money donated if we don't actually make it to the required amount? I'm not suggesting we won't make it but its not surprising to me that people aren't making that many donations. However, pledging is a different matter. My only hope is that when the pledged total is actually enough to get the ball rolling, people actually cough up a real donation to make it happen. I think they will.

If the donation system were set up such that money would be refunded if the required total for NORD POIS research wasn't reached after say 5 years, people might be more forthcoming with real donations - a sort of guarantee that money donated would only be used for POIS and be refunded if no POIS research was forthcoming. Please don't let it take 5 years to get started though!! Roll up people. As EDS and others have so brilliantly written, it should be easy to get this total. If you don't want to actually part with your money now until you know we're close to $33,500 then at least pledge something...and stick to it. That's where I'm at just now.  I know, as usual, I've not been posting very frequently on here... Thanks everyone for carrying on the battle so persistently, I really am grateful to you all.


Thank you sincerely for your donation, Mellivora.  With your pledge, we've surpassed the 1/3 marker and are closer than ever!

In regards to your points above, I'll tell you what I'm doing.  I'm donating my money on a schedule.  So I've given the first portion now.  When our donation tally reaches $5K, I'll give another bit, and so on and so forth.  I know rob58, EDS, and some others have similar strategies.  That being said, I think there's also an unspoken agreement that when the total pledged amount exceeds the $33.5K, it'll be time for us all to go all in.  Then we can celebrate!  



B_Daniel, this is simply wonderful!!! Thank you, thank you, thank you!!!!

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Offline Quasar

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« Reply #14577 on: 07/09/2011 18:05:06 »

Would it be dangerous to insert natural lemon juice with water into my urethra? I want to know if it stings, maybe i have some little urethra infection. It may not do any harm, and may clean something.


Quasar, PLEASE ask this of a physician!

None of us here are qualified to respond !

Thanks Demo. You're right. I should ask to my doctor. But i was talking about just inserting some drops to the tip of my penis. So, it would be just a small part of the urethra. If i can, i will ask it to my doctor, although is quite a rare question.

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Offline Willem

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« Reply #14578 on: 07/09/2011 19:18:38 »
I have the same concerns as mellivora.  If I knew that we'd reach the goal, I would be happy to donate $1,000.  If you want to make the pledges more legit, we can open up a cause at thepoint (started by the founder of Groupon) and they will only charge our credit cards if a preset amount is reached.  I checked it out earlier and the main drawback I saw was that if it "tips" then it releases our real names.

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Offline Habibou

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« Reply #14579 on: 07/09/2011 20:05:46 »
It is very important that mellivora underlined his personal concerns because it seems to be shared by many other secretly ! Let s hope it will be the trigger for our Nord programme :)

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Offline Limejuice

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« Reply #14580 on: 07/09/2011 20:10:53 »
I feel the same as both of you, and my initial pledge will be honored.

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Offline demografx

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« Reply #14581 on: 07/09/2011 22:24:12 »
Mellivora, B_Daniel, Willem, Limejuice, Habibou and all: your concerns are well expressed and legitimate. Daveman and I will bring this up with Stefanie when she returns from a leave of absence in a few weeks. Many thanks for speaking your mind!

Demo
« Last Edit: 07/09/2011 22:26:32 by demografx »

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Offline demografx

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« Reply #14582 on: 08/09/2011 18:05:52 »
Is Vandemolen still around? I haven't read any posts from him in a while... especially interesting are his updates on the desensitization he was getting at Dr Waldinger's!

I got this message from him:
I am fine. Thanks. I feel relief. I think I have 40 % less symptoms. Now I have only 2 days of POIS. Before the therapy 4 days. Now day 1 is like how day 2 used to be. And day 2 is like day 4.
I am now on 1/70 of dillution. Next Thursday I will have a 1/50 shot. And about 6 weeks I will be on the maximum: 1/20. Then the relief should go faster.


In light of these great results by vandemolen, those of you still looking for doctors to do semen allergy shouldnt give up.  Within my small state i have found two doctors that are willing to do the therapy. One of them changed his mind though because of distance but another one has agreed to do it (hopefully he dosnt change his mind).

my advice for searching; 
check every nook and corner
try university hospital doctors
try independent doctors(the ones that have agreed to do it were independent doctors)
whenever i sent them messages: i included dr waldingers papers and other papers, my psychologist letter proving my mental symptoms, and results from dr bewtra in creighton university, and a sob letter discribing how pois is destroying my life and now you can  add proofs that it is helping others you know.



CC, excellent advice, thank you!

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Offline Willem

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« Reply #14583 on: 08/09/2011 18:43:50 »
Mellivora, B_Daniel, Willem, Limejuice, Habibou and all: your concerns are well expressed and legitimate. Daveman and I will bring this up with Stefanie when she returns from a leave of absence in a few weeks. Many thanks for speaking your mind!

Demo

Thanks for your understanding Demo.  I don't think it's reasonable to expect NORD to return donations received from hither and yon, and so wonder if we couldn't run a complimentary system on the side and if we raise the funds on thepoint and it tips then the check gets cut to NORD.  We'd have to make sure that we could adjust the tipping amount in case more donations are received through NORD and a lower amount is needed from thepoint.

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Offline Ryuk

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« Reply #14584 on: 08/09/2011 19:53:46 »
Oh my god...I thought I was alone with this!

Ever since I was 13, every time I orgasmed, I felt the usual relaxation which I assumed was normal. But hours later and even the next day or two, the tiredness stayed. Post-orgasm, I feel lethargic, I can't think as clear as usual, time feels like it's moving too fast, I feel physically sore, I'm also prone to migraines and acne in the days following. I always thought I was crazy for thinking there was an actual problem and doctors said it was all in my head, but I knew it wasn't.

I'm 18 now, and it's been a constant internal battle. I fight with myself to not masturbate or have sex, but every once in awhile I give in and I'm finished for 2 days. I always thought how unfair it was how other guys could have sex/masturbate 5 times in a night and still have energy, while if I do it once, I'm mentally and physically exhausted for days. I'm so glad I finally found out there's more people like me xD

Does anybody have any recommendations on something to take/do to get rid of these debilitating symptoms? And could someone explain what's even going on?

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Offline Quasar

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« Reply #14585 on: 09/09/2011 00:47:01 »
Oh my god...I thought I was alone with this!

Ever since I was 13, every time I orgasmed, I felt the usual relaxation which I assumed was normal. But hours later and even the next day or two, the tiredness stayed. Post-orgasm, I feel lethargic, I can't think as clear as usual, time feels like it's moving too fast, I feel physically sore, I'm also prone to migraines and acne in the days following. I always thought I was crazy for thinking there was an actual problem and doctors said it was all in my head, but I knew it wasn't.

I'm 18 now, and it's been a constant internal battle. I fight with myself to not masturbate or have sex, but every once in awhile I give in and I'm finished for 2 days. I always thought how unfair it was how other guys could have sex/masturbate 5 times in a night and still have energy, while if I do it once, I'm mentally and physically exhausted for days. I'm so glad I finally found out there's more people like me xD

Does anybody have any recommendations on something to take/do to get rid of these debilitating symptoms? And could someone explain what's even going on?

Welcome Ryuk!

I've got similar symptoms as you. About recommendations, some meds have worked for some users are: Niacin, Testosterone replace therapy, and desensitization. The main theory is that we suffer from an allergy to our own semen. Please, always consult your doctor before taking any medication.

Lately i'm having lots of trouble with my stomach post-Pois. It becomes bloated and i have diarrhea.  [:(!]

I'd also like to ask a question to all of you: Apart from other symptoms, if we only take into account the sexual exhaustion post-Pois, do you lose sexual potency while in Pois?

I mean, if we suppose Pois is a kind of extended refractory period. I mean, a lot of people becomes tired for some hours after sex. What if Pois makes us tired for days instead of hours?

I know Pois has other symptoms like migraine, stomach symptoms, etc.

But if we speak only about the refractory period, if it's true that Pois makes the refractory period longer, what can be done to make the refractory period shorter and recover sooner the lost sexual potency?


Has anyone experienced in medications with this objective in mind?

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Offline demografx

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« Reply #14586 on: 09/09/2011 02:09:15 »
Ryuk, welcome to the POIS thread of The Naked Science Forum!




Here are some POIS resources which may be helpful to you:

Our new POIS Forum - architectural genius: "daveman" - for detailed subject-by-subject discussion!
http://www.POISCenter.com/forums/index.php
Our 4-year-old POIS thread here at Naked Science Forum will also always remain open for newcomers, for general unstructured discussion, and historical research of the 10,000+ postings here since 2007.

The Learning Channel's (TLC)  feature TV presentation on POIS, featuring our member here at this forum, "Animus". It was aired on May 22, 2011. Here is a link to the file for that TV documentary, "Desperate Measures", which can be downloaded and played. The segment starts at about 12:20..
http://www.fileserve.com/file/cUtJa9R/TITLE01.mp4

Our POIS Information Website, built by "mat780", is here:
http://sites.google.com/site/POISwebsite/

The POIS Information Website is home to the famous POIS Forum Compendium, written by "Pyropeach", and contains theories already discussed here and treatments that have both worked and failed.

Please see "B_Jim"'s POIS Summary of All Cases, here as well as others on the Web. This includes remedies that we have tested, and results.
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

"Girlwind" has created an excellent POIS Video:
http://www.youtube.com/watch?v=UWBxAUC9k1g

Our new POIS chatroom (realtime chat). Invite or visit another member(s) there, ANY TIME. We can all get to know each other better:
http://forums.delphiforums.com/POIS/chat

Post Orgasmic Illness Syndrome "POIS": Case report

Authors:
Abdalla M Attia*, Magda H Al-Ziny, Hossam A Yasien
*Corresponding author: Andrology Unit, Minoufiya University, Shibin El Kom, Eygpt

For more info, check out emi_b's  SMF POIS thread:
http://poiscenter.com/forums/index.php?topic=191.0;topicseen


Available Upon Request:

1. and 2. POIS Research Studies, 2011

These 2 papers reveal Dr. Waldinger's POIS autoimmune hypothesis and suggests one possible avenue of treatment.

3. First POIS Research Study, 2002

We have a copy of the first formal medical investigation on POIS by Prof. dr. Marcel D. Waldinger,MD,PhD, and Dr. Dave Schweitzer, MD.

  
4. Recent POIS Research Study, 2010

CASE REPORT
Postorgasm Illness Syndrome - A Spectrum of Illnesses
Jane Ashby, MRCP, and David Goldmeier, MRCP
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg316781#msg316781


5. British Medical Journal Case Report, 2010

Case study by Dr. Selwyn Dexter of a patient with a headache-featured POIS symptom treated with progesterone/norethisterone.
http://casereports.bmj.com/content/2010/bcr.10.2009.2359.short?rss=1


How to get any or all of the above 5 studies: send me or "daveman" a Private Message (PM) with your regular email address (use "AT" instead of "@" ) and we'll send you back the PDF(s).

To send a Private Message, click on "Messages" at the top of this page. At the Messages page, click on "New Message". From that point on, it works just like posting a message here, except that it only goes to the person(s) you designate.

Remember to put a quote around the recipient's name, i.e., "demografx", or "daveman".


New York Times article,

January 20, 2009
Mind
Sex and Depression: In the Brain, if Not the Mind
By RICHARD A. FRIEDMAN, M.D.
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

In addition to serving our own informational interests, the resources listed above can be useful for you to show our credibility to the medical world - which often shows little understanding and is sometimes skeptical of our condition: POIS has scientific underpinnings and POIS is not "just another psychological problem" related to sex - to be treated by the psychiatric/psychotherapeutic community. All of this information can greatly help you to fight the immediate reaction of some doctors: so just tell them, "IT'S NOT 'ALL IN OUR HEADS'! "

Also, it can be helpful when dealing with medical professionals to point out the successful existence of our rapidly growing forum, which has already been referenced in respectable sources such as the Journal of Sexual Medicine (Dr. Waldinger's study), British Medical Journal and wikipedia:
http://en.wikipedia.org/wiki/Postorgasmic_illness_syndrome

For over 4 years, our POIS forum has attracted over 200 POIS sufferers worldwide who have posted here, research on an additional 200 sufferers elsewhere on the internet, plus over 1,300,000 page visits. Not bad for a rare malady!



SEARCH THE FORUM WITH GOOGLE

We have an overwhelming amount of data: more than 4 years' worth of posts (over  10,000 posts!) from 200+ Forum members, and an additional 200 POIS sufferers found elsewhere on the Internet by Member B_Jim.

In the Google search box, type
whatever-it-is-you're-interested-in-finding-out[space]POIS[space]site:http://thenakedscientists.com/

for example, I tried
nocturnal emission POIS site:http://thenakedscientists.com/

and 740 results came up for "nocturnal emission" within the Forum.

be careful with spaces (you can use them before the word "site") and no-spaces (everything after the word "site")

Google even provides you results with the Message# for each result. But Message #'s do change, so be patient and look for the approximate Message#.





« Last Edit: 09/09/2011 02:22:36 by demografx »

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Offline Willem

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« Reply #14587 on: 09/09/2011 19:54:24 »
Oh my god...I thought I was alone with this!

Ever since I was 13, every time I orgasmed, I felt the usual relaxation which I assumed was normal. But hours later and even the next day or two, the tiredness stayed. Post-orgasm, I feel lethargic, I can't think as clear as usual, time feels like it's moving too fast, I feel physically sore, I'm also prone to migraines and acne in the days following. I always thought I was crazy for thinking there was an actual problem and doctors said it was all in my head, but I knew it wasn't.

I'm 18 now, and it's been a constant internal battle. I fight with myself to not masturbate or have sex, but every once in awhile I give in and I'm finished for 2 days. I always thought how unfair it was how other guys could have sex/masturbate 5 times in a night and still have energy, while if I do it once, I'm mentally and physically exhausted for days. I'm so glad I finally found out there's more people like me xD

Does anybody have any recommendations on something to take/do to get rid of these debilitating symptoms? And could someone explain what's even going on?

Welcome Ryuk!  We're here to help you and I'm assuming you'll learn a lot about our condition in the coming months.  It's an exciting time for POIS with several people reporting positive results from treatments like Niacin (many members) and desensitization (Vandemolen and myself), and some confirmed cases of testosterone (Demo), desensitization (2 cases in Waldinger's paper) and "male hysterectomy" (Animus) working.  There's hope!
« Last Edit: 09/09/2011 20:00:01 by Willem »

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Offline demografx

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« Reply #14588 on: 09/09/2011 20:25:42 »

It's an exciting time for POIS with several people reporting positive results from treatments like Niacin (many members) and desensitization (Vandemolen and myself), and some confirmed cases of testosterone (Demo), desensitization (2 cases in Waldinger's paper) and "male hysterectomy" (Animus) working.  There's hope!


Willem, terrific state-of-the-art summary of POIS treatment! Thank you.
« Last Edit: 10/09/2011 01:59:14 by demografx »

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Offline carlitto

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« Reply #14589 on: 09/09/2011 22:16:12 »
Oh my god...I thought I was alone with this!

Ever since I was 13, every time I orgasmed, I felt the usual relaxation which I assumed was normal. But hours later and even the next day or two, the tiredness stayed. Post-orgasm, I feel lethargic, I can't think as clear as usual, time feels like it's moving too fast, I feel physically sore, I'm also prone to migraines and acne in the days following. I always thought I was crazy for thinking there was an actual problem and doctors said it was all in my head, but I knew it wasn't.

I'm 18 now, and it's been a constant internal battle. I fight with myself to not masturbate or have sex, but every once in awhile I give in and I'm finished for 2 days. I always thought how unfair it was how other guys could have sex/masturbate 5 times in a night and still have energy, while if I do it once, I'm mentally and physically exhausted for days. I'm so glad I finally found out there's more people like me xD

Does anybody have any recommendations on something to take/do to get rid of these debilitating symptoms? And could someone explain what's even going on?

Welcome Ryuk!  We're here to help you and I'm assuming you'll learn a lot about our condition in the coming months.  It's an exciting time for POIS with several people reporting positive results from treatments like Niacin (many members) and desensitization (Vandemolen and myself), and some confirmed cases of testosterone (Demo), desensitization (2 cases in Waldinger's paper) and "male hysterectomy" (Animus) working.  There's hope!

Hello Willem,
could you please again summarize a bit your desensitization treatment
1- when did you start and where
2- how many injections have you received till now and concentrations
3- percent of improvement you are feeling
4- fresh or frozen samples each time?

can't wait to hear it is working for you!
thanks

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Offline B_Daniel

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« Reply #14590 on: 09/09/2011 22:37:12 »

But if we speak only about the refractory period, if it's true that Pois makes the refractory period longer, what can be done to make the refractory period shorter and recover sooner the lost sexual potency?[/b]

Has anyone experienced in medications with this objective in mind?

So i did some reading on the refractory period a few months ago.  I don't know how many hormones/whatnot are part of this process, but I read from a few different sources that one of the main ones is Prolactin.  Prolactin makes you feel tired and groggy.  It's what drug addicts experience pretty badly when they're going cold-turkey away from drugs.  The body elevates prolactin after sex, which in turn decreases oxytocin "cuddle hormone" and dopamine.  So, from an evolutionary standpoint, after a male has sex, Prolactin levels are raised to decrease the male's appetite for more sex.  It's a signal to the man that he has spread his seed and now the job is over.

I took Vitex berry for a couple months, which is the foremost supplement known to reduce prolactin.  I also had  bloodwork to check my Prolactin levels, and I had it checked during a terrible POIS episode.  It was within the normal range.  

That experience has helped me to conclude that POIS is not just a lengthened refractory period.

I'm just one data point though.
« Last Edit: 10/09/2011 02:24:48 by B_Daniel »
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline CertainlyPOIS

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« Reply #14591 on: 09/09/2011 22:37:33 »
Answer to quasar's question still excited even while in pois
All my prolactin test came back normal.

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Offline B_Daniel

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« Reply #14592 on: 09/09/2011 22:40:27 »

Hello Willem,
could you please again summarize a bit your desensitization treatment
1- when did you start and where
2- how many injections have you received till now and concentrations
3- percent of improvement you are feeling
4- fresh or frozen samples each time?

can't wait to hear it is working for you!
thanks

Willem -You're doing the sublingual immunotherapy at home.  I know there's probably some risk of shock and perhaps it's against medical advice to do this on your own so pls be as safe as possible about it, but I just wanted to personally say that I'm very excited for your results.  I know you're waiting for conclusive evidence to share with us, so I'm waiting patiently until then.  Also, i think you're a crazy pioneer/maverick for treating yourself with this and I give you a ton of credit for undertaking such an experiment!
« Last Edit: 09/09/2011 23:19:38 by B_Daniel »
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline B_Daniel

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« Reply #14593 on: 09/09/2011 22:46:42 »
Oh my god...I thought I was alone with this!.....


Hahaha!  Ryuk - i felt the same way when i found this place 4 months ago.  Only difference is I'm 27 and have been living with this sh1t condition so much longer!  You're lucky to have found us!

Demo's welcome post to you includes a lot of great resources which will help get you caught up to speed as quickly as possibly.  We don't yet have a POIS 101 introductory course to give you everything you probably want to know, but do a bunch of reading and you'll get there.  Welcome!   
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline rock27

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« Reply #14594 on: 09/09/2011 23:36:15 »
Ryuk,
Welcome!

I can imagine it is almost impossible to go through the 600 pages here;
This community has therefore created a forum to discuss in topics,
for example about the recent niacin solution:
http://poiscenter.com/forums/index.php?topic=174.0
then just click home to see the other topics, it's the best pois overview we have right now.
POIS, fatigue, brain fog, can't find words, irritated, can't concentrate.

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Offline Quasar

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« Reply #14595 on: 09/09/2011 23:42:35 »

But if we speak only about the refractory period, if it's true that Pois makes the refractory period longer, what can be done to make the refractory period shorter and recover sooner the lost sexual potency?[/b]

Has anyone experienced in medications with this objective in mind?

So i did some reading on the refractory period.  I don't know how many hormones/whatnot are part of this process, but I read from a few different sources that one of the main ones is Prolactin.  Prolactin makes you feel tired and groggy.  It's what some drug addicts experience pretty badly when they're going cold-turkey away from drugs.  The body elevates prolactin after sex, which in turn decreases oxytocin "cuddle hormone" and dopamine.  So, from an evolutionary standpoint, after a male has sex, Prolactin levels are raised to decrease the male's appetite for more sex.  It's a signal to the man that he has spread his seed and now the job is over.

I took Vitex berry for a couple months, which is the foremost supplement known to reduce prolactin.  I also had  bloodwork to check my Prolactin levels, and I had it checked during a terrible POIS episode.  It was within the normal range.  

That experience has helped me to conclude that POIS is not just a lengthened refractory period.

I'm just one data point though.

Thanks a lot B_Daniel!

So, if we suppose we have no trouble with the refractory period, then...what is causing the lose of sexual potency in Pois? I mean, at least in me, when i'm under Pois i become nearly-impotent. So, even if we don't have a problem with the refractory period, we have a problem somewhere else, and closely related to sexual potency and other symptoms, of course. I think demografx has had some success with Levitra.

I mean, it may not cure Pois, but at least it's a good option in terms of relationships, and sexual potency. And it may help Pois symptoms.

What i'm thinking is that i can notice a severe muscular contraction after having an orgasm in my whole body. Also, what i was saying about sexual potency, i mean, i not only become nearly-impotent in Pois, but also i can see and feel my penis becomes quite, quite small for days!! Too small.

When i'm without Pois, my penis looks more normal, more dilated.

I usually do body stretches, because of some back pain. And i can tell you that before Pois i can nearly touch my feet with my hand, and some minutes after orgasm, i can barely do it. My back leg and back muscles become more contracted.

So, if we get these two symptoms together, i'm starting to think, that a general muscular contraction is making worse the peripheral arterial system -arterioles-. This is well documented. For example, Calcium Channel Blockers are used to prevent the muscular contraction around arterioles, so they prevent their contraction. They also prevent cerebral vasospasm.

"Calcium channel blockers work by blocking voltage-gated calcium channels (VGCCs) in cardiac muscle and blood vessels. This decreases intracellular calcium leading to a reduction in muscle contraction. In the heart, a decrease in calcium available for each beat results in a decrease in cardiac contractility. In blood vessels, a decrease in calcium results in less contraction of the vascular smooth muscle and therefore an increase in arterial diameter (CCBs do not work on venous smooth muscle), a phenomenon called vasodilation. Vasodilation decreases total peripheral resistance, while a decrease in cardiac contractility decreases cardiac output. Since blood pressure is determined by cardiac output and peripheral resistance, blood pressure drops. Calcium channel blockers are especially effective against large vessel stiffness, one of the common causes of elevated systolic blood pressure in elderly patients.[2]"

Please, consult your doctor before taking a Calcium Channel Blocker, or any other drug, because they can be dangerous and have side effects. Thanks.

Some alpha and beta blockers also prevent smooth muscle contraction. So, i don't really know what could be better for us: a calcium channel blocker, an alpha blocker or a beta blocker.  [???] Some members have reported that aplha blockers did nothing for them, and beta blockers also did not reduce Pois symptoms....

The problem i see with Calcium Channel Blockers and alpha/beta blockers (except Yohimbine) is that they don't improve erectile dysfunction, in fact, some of them make it worse.

Magnesium also can help: "Ionic calcium is antagonized by magnesium ions in the nervous system. Because of this, bioavailable supplements of magnesium, possibly including magnesium chloride, magnesium lactate and magnesium aspartate, may increase or enhance the effects of calcium channel blockade.[3]"
« Last Edit: 10/09/2011 00:58:00 by Quasar »

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Offline demografx

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« Reply #14596 on: 10/09/2011 02:01:52 »

I'm just one data point though.


Gee.....and here I thought you were a swell human being.....where did I go wrong??? [;D]

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Offline B_Daniel

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« Reply #14597 on: 10/09/2011 03:01:38 »

I'm just one data point though.


Gee.....and here I thought you were a swell human being.....where did I go wrong??? [;D]

haha demo this where you went wrong... you missed the 1st question !  [;D]  just joking!

2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline demografx

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« Reply #14598 on: 10/09/2011 06:55:18 »
B_Daniel, in that case I will double up on my efforts till I get it RIGHT!!!

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Offline Zoop

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« Reply #14599 on: 10/09/2011 15:14:30 »
2. The quote Horizon provided from reference.com is fascinating.  It basically states that all people can be allergic to their own semen: "Sperm are immunogenic - that is they will cause an autoimmune reaction if transplanted from the testis into a different part of the body."  This raises the question of whether intradermal tests actually tell us anything.  Furthermore, as many have pointed out, and as one allergy dr. my endocrinologist phoned during my appointment immediately identified, there is no control group in Waldinger's work.  According to the research cited, the photos Habibou shared do not show anything unexpected. 

This is not sure. Most male can be allergic to their semen but since their blood has never been in contact with it, the skinprick could be different to one done on a man with POIS, whose allergic reaction could be enhanced by multiple contact with the allergen. This may let physicians to do the difference between the POISed man and the non-POISed man. Just thoughts, I'm not allergist.
« Last Edit: 10/09/2011 15:16:02 by Zoop »