[badgerstripe]

jferr, I can relate to what you said about being paranoid around people.  I guess you can call this social anxiety.  I believe it is probably some guilt-type reaction that your subconscious sets off after orgasm.  Sort of like you sense that people know what you did.  I usually get this after having orgasmed, especially to porn.  That is why I try to stay away from porn.  I don't really get the effects if i just masturbate without any material.  You don't have to look at porn to masturbate, but you can masturbate without looking at porn.  If i do get this feeling,I will have the anxious feeling for that day and maybe the next, the day after that it goes away.  After discovering Niacin I am a lot better too, but I also make the mistake of taking niacin after O because I really do not plan my orgasms.

I too have noticed a mild paranoia that seems to corresponds with the POIS period, most severe the day after O, then fading gradually in the next two or three days. This is nothing like in the psychotic range but it does make me feel more inclined to think people might be talking about me or looking at me strangely and make me defensive. A couple of people close to me have noticed this as well. This could be hormonal but could also be linked to guilt feelings about sex, though i can't really say i have many of those nowadays.

[badgerstripe]

There is no doubt that zinc supplements have hastened the recovery period from pois but hasn't prevented it. The best results have come from recent use of niacin. Hope everyone had happy holidays.

They're relatively cheap so I take both. 2 ZMA supps at night and the niacin first thing in the morning to get a good flush. Throw in a high strength multi-vitamin & mineral (I use the Quest one if that isn't breaking forum rules) for all my other vit needs and 4g of Vit C during the day and I feel almost bouncy. Actually, I'm still remembering quite vivid dreams and waking up much happier. And that's in a 7 day period where for various reasons, all of them good , I ended up having 3 O's. So I broke my own rules & still feel good.

Sounds great kurtosis. Do you (and others who take it) take Niacin every day or just before an O?

[GoingCrazy]

jferr, how long have you been battling POIS?  For me the paranoia was also there mostly all the time, but the longer I have battled POIS the less severe my symptoms have been and the shorter duration they have lasted.  I also believe it to be some neurochemical hangover or imbalance.  Over just about 3 years I've managed to bring my POIS down from lasting about a week, to just about a day.  I am saying that maybe if you just realized about POIS that you may need to wait some time before your "constant symptoms" gradually lessen in severity.

[GoingCrazy]

There is no doubt that zinc supplements have hastened the recovery period from pois but hasn't prevented it. The best results have come from recent use of niacin. Hope everyone had happy holidays.

They're relatively cheap so I take both. 2 ZMA supps at night and the niacin first thing in the morning to get a good flush. Throw in a high strength multi-vitamin & mineral (I use the Quest one if that isn't breaking forum rules) for all my other vit needs and 4g of Vit C during the day and I feel almost bouncy. Actually, I'm still remembering quite vivid dreams and waking up much happier. And that's in a 7 day period where for various reasons, all of them good , I ended up having 3 O's. So I broke my own rules & still feel good.

Sounds great kurtosis. Do you (and others who take it) take Niacin every day or just before an O?

I've been taking Niacin about twice every week, once on Sunday, and once on Wednesday or Thursday.  I still need to see the difference between taking it pre-O versus post-O.  I've only been taking it post-O and that does not do as much as I would like.  I'm pretty sure I have taken it pre-O maybe once on a Thursday morning and I O'd on a Thursday night.  I remember experiencing no symptoms.  But my question is why does the Niacin really only work pre-O as opposed to post-O?

[observercenter]

I remember experiencing no symptoms.  But my question is why does the Niacin really only work pre-O as opposed to post-O?

GoingCrazy, stop taking the niacin after the O. It is useless. You could get relief for 2-3-4 hours - but you are going to get symptoms again after this time passes by.
Niacin pre-O *-1-2-3hour before or 15-20 min after you get the flush* and better in non-full stomach has COMPLETELY blocked my POIS symptoms(No digestive problems, no brain fog, no straw berry shaped hair, no fatigue, no lethargy...). We could discuss why is the reason that it is working, it could be that the histamine release is blocking the later inmune response against semen -misleading your organism- or maybe it is producing the necesary histamine to fight against POIS. We really do not know.
I have found that if i take an anti-histamine(H1) during the day and i take the niacin on this same day and have an Orgasm, it is not going to work completely, maybe i could have a very mild brain fog and slighty fatigue. I think this could be discussed here.
I suggest you to CRUSH the niacin into powder before taking it. It will be more effective*fast.

Oh... and i nearly forgot:
Happy new year for all of you!! O8)

[jferr]

jferr, how long have you been battling POIS?  For me the paranoia was also there mostly all the time, but the longer I have battled POIS the less severe my symptoms have been and the shorter duration they have lasted.  I also believe it to be some neurochemical hangover or imbalance.  Over just about 3 years I've managed to bring my POIS down from lasting about a week, to just about a day.  I am saying that maybe if you just realized about POIS that you may need to wait some time before your "constant symptoms" gradually lessen in severity.

GoingCrazy, I have been battling POIS for 8 years. It started suddenly with dulled emotions one day at orgasm when I was 16 and has not since lifed. Only has gotten worse. Paranoia came about around 2 years ago. I have waited months without orgasm before but only recover to a certain level which has gotten less and less over time. When this suddenly started at that moment when I was 16 it physically felt like an engine turned off in my head, I then developed my POIS on top of it not long after. It has been hell. The symptoms have just become more wide spread. Thankfully since the niacin I have had some minor relief but I am desperately searching for more.

Best wishes.

[demografx]

If the sophisticated testing you did includes things I somehow haven't tested for it would be greatly appreciated to get a list of the items to present to my doctor, If you wouldn't mind.

MY ENDOCRINOLOGIST'S LABWORK ORDERED FOR POIS


Out of reference range

-PROLACTIN

Extremely high (reason for MRI of the pituitary gland - all turned out ok)

-TESTOSTERONE(Bioavailable Testosterone, Free Testosterone, Total Testosterone, Sex Hormone Globulin Binding)

"Free T" is low; others I don't have reference range on summary.

In reference range
-DHEA-SULFATE

-FSH (Follicle Stimulating Hormone)

-LH (Luteinizing Hormone)

-TSH (Thyroid-Stimulating Hormone)

jferr, the "sophisticated testing" meant two things to me: 1. a major university research laboratory vs. my GP's local lab and 2. Working with an endocrinologist vs. urologist or GP.

You probably have covered much of this testing, yours sounds very thorough.

[demografx]

Best wishes, everyone, for a POIS-free 2012!

  daveman                                   demografx

[badgerstripe]

There is no doubt that zinc supplements have hastened the recovery period from pois but hasn't prevented it. The best results have come from recent use of niacin. Hope everyone had happy holidays.

They're relatively cheap so I take both. 2 ZMA supps at night and the niacin first thing in the morning to get a good flush. Throw in a high strength multi-vitamin & mineral (I use the Quest one if that isn't breaking forum rules) for all my other vit needs and 4g of Vit C during the day and I feel almost bouncy. Actually, I'm still remembering quite vivid dreams and waking up much happier. And that's in a 7 day period where for various reasons, all of them good , I ended up having 3 O's. So I broke my own rules & still feel good.

Sounds great kurtosis. Do you (and others who take it) take Niacin every day or just before an O?

I've been taking Niacin about twice every week, once on Sunday, and once on Wednesday or Thursday.  I still need to see the difference between taking it pre-O versus post-O.  I've only been taking it post-O and that does not do as much as I would like.  I'm pretty sure I have taken it pre-O maybe once on a Thursday morning and I O'd on a Thursday night.  I remember experiencing no symptoms.  But my question is why does the Niacin really only work pre-O as opposed to post-O?

My recent experimentation in the last 3 weeks or so has shown me the following.

Niacin:
Post O has made my symptoms worse than ever
1.5 hours before O on an empty stomach with a flush - no symptoms at all!
1 hour before O with a full stomach, barely noticeable flush. Symptoms which were probably half as severe as normal.

There were no other circumstances i can spot which would have effected my symptoms and clearly longer-term experimentation is needed with this but so far it looks promising. I can only speculate on *why* this appears to work and the answers must lie with the sort of testing that demografx and others on this forum have undergone.

The explanation that the Niacin-induced flush is producing the necesary histamine release for an orgasm makes sense to me, especially as my symptoms were so much worse when taking Niacin after an orgasm which suggests over-depletion of histamine but i imagine the process is much more complex than this.

Thankyou for the suggestion of crushing of the Niacin tab observercenter!

[John21 (OP)]

I just spoke on the phone with the center at Harvard.

http://alzheimersweekly.com/content/alzheimers-disease-research-center-harvard-medical-school

They want me to put together an email describing the correlation between POIS, relatives who have Alzheimers, and the similarity in mental symptoms one gets from POIS to the symptoms one gets from Alzheimers.

This is who I am to send the email to:

http://madrc.mgh.harvard.edu/liang-yap-phd


So I am going to ask one last time, just in case, do any of your relatives, for those who have POIS, have or had Alzheimer's? If you dont know for sure, please check and post here if so. After a few days I will compose the email and send it out.

My grandmother died with Alzheimers, but a connection to POIS seems improbable to me.

[kurtosis]

POISers who had parents/grandparents/close family members with Alzheimers:

Kurtosis
martin88
hurray
Defsync

Is there anyone else? This is enough for me to contact an Alzheimers research center at Harvard about this "coincidence" in hopes that some correlation may bring insight to either condition.

Interesting joint study on the testosterone levels of older men with Alzheimers. University of Hong Kong and St. Louis University in Missouri.
http://www.sciencedaily.com/releases/2010/10/101005171202.htm
So saying there might be a relationship between a disease with a set of sexual / hormonal symptoms and alzheimers isn't that much of a stretch. Someone should want to publish about this!

While you're asking the question about Alzheimers, then could you ask the question about Parkisons also?
I'm not aware of any relatives who have had it but it's interesting given some of the treatments people have suggested boost dopamine levels, in theory.

[martin88]

We never know what we can get from having POIS cases studied at Harvard, if it goes till there.
Alzheimer is very frequent with aging so we would have to prove it's more frequent in POIS families.

My experience with niacin months ago was not very long so what I'll say about it might be wrong.
I took 25mg after orgasm --> no effect on POIS but I had a good sleep during the afternoon wich is unusual for me.
I took 100mg before orgasm --> I had premature ejaculation (I usually have a feeling of PE but there it was real PE). This time niacin helped my POIS but not all symptoms. I definitely had improved thinking and focus, less brain fog. However I still had full physical fatigue and exhaustion.

Happy new year to everyone!!!
Hope we'll make some new progress.

[Starsky]

READ THIS ARTICLE: http://jpet.aspetjournals.org/content/327/3/665.full.pdf

ABOUT HISTAMINE: Methylnicotinate had a weak effect on inducing histamine release from human mast cells,
whereas niacin did not increase rat plasma histamine levels. Moreover, the H1-receptor antagonists brompheniramine,
chlorpheniramine, diphenylhydramine, and ketotifen did not block niacin-induced skin temperature increases. Combined,
these results suggest that histamine is not involved in niacininduced flush


I think Demografx was taking Aspirine to reduce the flush. Aspirie inhibits the effect of prostaglandins, but taking aspirine and niacin didnt make a difference for him so i think prostaglandins are not important. What is left is SEROTONIN. The effect of serotonin can be blocked by taking antihistamines, so i think thats the explanation of Observers case. What my allergist said, histamine and serotonin have the same group of receptors and serotonin can bind to histamine receptors(dont know to which ones) and could work as an antihistamine.

[demografx]

Happy new year !



(Inappropriate    ? )

Perfect, B_Jim! 

[Omen 30]

Hi kurtosis, my grandmother,her two brothers all are having alczimers and I have always had the feeling that the alczimers has got something to do with my pois...my granny is around 90 years age...

[daveman]

Happy new year !



(Inappropriate    ? )

Perfect, B_Jim! 

If we can make as much advance this coming year as we have this year, I'll be a happy man. If we can actually reach our donations goal, I'd have to take niacin all year!!

Have a POIS free New Year. I "celebrated" last night, and thanks to niacin, I'll even be enjoying a late New Years party tonight!!

[demografx]

Happy new year !



(Inappropriate    ? )

Perfect, B_Jim! 

If we can make as much advance this coming year as we have this year, I'll be a happy man. If we can actually reach our donations goal, I'd have to take niacin all year!!

Have a POIS free New Year. I "celebrated" last night, and thanks to niacin, I'll even be enjoying a late New Years party tonight!!

And I second THAT!!

[rock27]

HAPPY HAPPY NEW YEAR TO ALL POIS-ERS!

May 2012 bring happiness and health to all. That we will conquer.
I wish all to have a (normal) life and (normal sexual) relations in 2012.

[demografx]

Rock, wonderful New Year's POIS sentiment!!

[kurtosis]

Happy new year to you and your families. I haven't been on this forum long but I'm very excited about the progress and the energy displayed by all. If we can do this much with POIS, just imagine how much we can achieve without it.  Let's make that our goal for 2012.