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Any men with POIS after a vasectomy? Just wondering if that helps any. Just vasectomy.
I am very happy to see the wealth of info you have at the bottom of the welcome email. It is truly refreshing to find this group.
I'll be brief as I have not much time: I don't see us making the target this year UNLESS we get more people to donate who are NOT POIS sufferers, i.e. sympathizers. The most amazing fund drives I've seen on the internet occur on the site reddit.com A group (under the banner of atheists giving to charity) raised something like $200k in a day. Big stuff happens when you crowdsource it. If I were to head it up, I'd go along the lines that most reddit users are males who often celebrate the action of masturbation (search "fapping") or just sex in general. If we could get some large-scale sympathy from that crowd, we could potentially see a lot of micro-donations. Now they are a skeptical bunch, so any plea will have to be well written and backed up.I have to go, I hope there is some discussion on this when I'm back!
This morning i took 100mg Niacin and the reaction really scared me! This is the second time i take Niacin. The first time i also took 100mg and had the facial flushing and noticed something different in my breathing, but everything was OK.But this time it was a totally different story. I took it 1 hour and a half - 2 hours to take effect, on an nearly-empty stomach. At first i noticed difficulty breathing, and the facial flush was very strong, i was scared of so much blood going into my head. Also, i felt severe pain in my stomach area. Luckily, the effect went away in 5-10 mins. So, why did i had this strong reaction to Niacin this time? Is it normal? Now i'm afraid of taking it again. Could it mean i had a lot of histamine to burn?
So nice feel some aceptance after 19 years of trying to find things your own, and having pretty much given up on most doctors.
There's been some good chats over there already!
I wasn't too keen on cognitive behavioral therapy either, however, the neurologists tell me that the results actually alter the brain. And that this is supported by functional MRI's. Quite honestly, given that the Imitrex they have prescribed has provided much needed and unexpected relief, I am more than willing to follow their recommendations.
Thanks for the valuable information Pharaoh and congratulation you have found relive for your POIS!To me the link between Niacin and Imitrex looks logical.When we orgasm the body have extensive need in serotonin to reward us for perpetuation of the species activity with a mood of goodness and happiness. Probably these high level of serotonin after orgasm have not only the role of making mood of happiness, but also some other roles that need to be carried out after orgasm, or otherwise the body will be subject to POIS symptoms.Serotonin is synthesized from tryptophan by the body, and Niacin is synthesized from tryptophan by the body. Now if we have too low level of tryptophan, or if we have malfunction of synthesis of serotonin from tryptophan or if we have bad absorption of serotonin, then as a result of an orgasm we will have lack of serotonin utilization after orgasm. Now if we supply the body with Niacin prior to orgasm, then the body will have excess of Niacin and will have no need to convert part of tryptophan to Niacin and hence it will be able to convert more tryptophan to serotonin.The Imitrex is a serotonin receptors agonist:http://en.wikipedia.org/wiki/SumatriptanHence Imitrex allows the body to better utilize the serotonin it has which is needed after orgasm.So, those POISers, who have normal synthesis of tryptophan to serotonin, but have lack of tryptophan (due to issues with digestion), find themselves to be relieved by Niacin. Those POISers, who have other problems in the chain of tryptophan absorption and serotonin production, find Niacin inefficient.Victor
QuoteSumatriptan is structurally similar to serotonin (5HT), and is a 5-HT (types 5-HT1D and 5-HT1B) agonist. The specific receptor subtypes it activates are present on the cranial arteries and veins. Acting as an agonist at these receptors, Sumatriptan reduces the vascular inflammation associated with migraine.Is inflammation causing a run out of serotonin and then tryptophan and then vitamin B3 ?
Sumatriptan is structurally similar to serotonin (5HT), and is a 5-HT (types 5-HT1D and 5-HT1B) agonist. The specific receptor subtypes it activates are present on the cranial arteries and veins. Acting as an agonist at these receptors, Sumatriptan reduces the vascular inflammation associated with migraine.
"The Science of Orgasm" author responded to my inquiry about their recently published Rutgers University (NJ) study of fMRI's of female orgasm.Dear Demografx,Thank you for your interest in our research. I have attached a copy of the poster that we presented. The ipad on the poster contained the video of the fMRI animation of brain activity related to orgasm. It can be viewed on You Tube.Please let me know if you have questions or comments about our poster.Barry R Komisaruk, Ph.D.If anyone wishes to see the attached poster he presented, PM me your regular (@) email address. Demo.
I'm looking forward to seeing the people at Hopkins and I will most definitely provide updates. I wasn't too keen on cognitive behavioral therapy either, however, the neurologists tell me that the results actually alter the brain. And that this is supported by functional MRI's. Quite honestly, given that the Imitrex they have prescribed has provided much needed and unexpected relief, I am more than willing to follow their recommendations.
So....I was in a busy cafe with my laptop today and thought I could get away with checking poiscenter.com, expecting the usual innocuous homepage with poiscenter.com in tiny letters to appear. But no.....Post Orgasmic Illness Syndrome (P.O.I.S.)!!!!!!Nice work on the new homepage Daveman thanks! ( no seriously, its coming together well)I did my best to look like a doctor who studies such things!
Quote from: B_Jim on 22/01/2012 14:06:48QuoteSumatriptan is structurally similar to serotonin (5HT), and is a 5-HT (types 5-HT1D and 5-HT1B) agonist. The specific receptor subtypes it activates are present on the cranial arteries and veins. Acting as an agonist at these receptors, Sumatriptan reduces the vascular inflammation associated with migraine.Is inflammation causing a run out of serotonin and then tryptophan and then vitamin B3 ?B3 is also involved as a precursor in the histamine chain. And could well be like Victor says, if you have the pre-cursor and can't use it, the solution is one, but if you are low in production of the pre-cursor the solution is the other.Diabetes is that way. There are two types of insulin, one in which the body lacks insulin, and another where the body has enough but doesn't know how to use it. Two completely different solutions, same final result.So in POIS, I think that's what we are looking at.It's incredible what we can do as lay-people, isn't it!!??
What they think happens in a migraine is that the vessels at the base of the head constrict, this causes the vessels higher up in the head to dilate as a compensatory mechanism to counteract for the decrease blood flow, this dilation causes the headache. The triptians selectively bind to 5ht receptors and cause the dilated vessels in the upper head to constrict, which relieves the headache.
Thanks a lot for writing to Dr. Komisaruk Demo, great to know he is studying fMRI's in men and that we are in touch with him.
Thanks Martin. Omega3 caps (sardines and maquerels oil ? )didn't help me. I want to try astaxanthin but it's expansive
I don't want to wait until late 2013 or 2014 before we can get dedicated (NORD-funded) POIS research under way. At the moment, that is the best we are heading for. We've got 2 months to get to our NORD target this year and save ourselves from waiting this long. We've had some very generous donations recently but some of these are to be made over a period of months. I'm certainly no less grateful to the donors for this fact but it does mean the current NORD pledge tally can be misleading as it uses the total that will be donated by 2013, not by March this year. We are still currently not in a good position to make the March deadline this year. To me it looks like we're half way at best.After we reach our $33500 target, it'll likely be some months before a researcher is appointed to work on POIS through NORD. It may be some time after this that work finally begins. I believe I'm right in saying that we really need to make the March 2012 deadline (2 months time) if we're going to see any benefits from NORD funded research within the next two years. There isn't a quick fix. But it'll be quicker if we begin now. Also, things will cost more in years to come. $33500 might not be the minimum required in future years, it might be more. We have some things that help some of us (eg. Niacin, immunotherapy) at the moment. But these are not cures so far or 100% effective treatments. And we still don't know what causes POIS. We have much better theories than we used to and even evidence for some of them but all POIS sufferers are not the same and what works for some doesn't work for others. We need to push this if we're going to help everyone. We need to know what POIS is, what causes it, what varieties of POIS there are and use this to get as close as possible to being cured/ being POIS-free. For us and for future sufferers.2 months is all we have. So far I have pledged $500. On the condition that we make the March 2012 deadline, I'm upping my pledge to $1500. (seriously, no clappy applause gifs for this please, lets just get that total)
Doctors are saying that vitamin D as in fish and other diet elements requires sunlight to fully integrate into the body.Obviously excess must be avoided but they are saying we are tending to go to extremes that other way, especially with children.In winter I think we should look for a source of ultra-violet, in combination with the high-D foods or even vitamin supplements. Maybe not necessary to develop a full tan, but one 5 min session per week.Also, especially for those who are finding that niacin has little effect, try bolstering it with Vitamin-C and iron. These specifically help in the production of 5-htp which is a precursor to serotonin. And or if we are low in those elements could explain partly why niacin isn't working.
I find the Niacinamide works for me very well and this is comes without much of a flush, sometimes I feel a small one, but then again I take 1000mg... this almost gets rid of the brain fog and flu..... BUT!!!!! I need to find something to help with the DRIVE.... I have no drive, I just want to sit and do nothing, I have no enthusiasm at all.... I am self employed, I have a line up of paying contracts, I am totally out of money, so you would think you could work at these paying contracts..... nope, I can not find any motivation to do almost anything..... its very bad.....I have been reading this forum and have not noted much about fixing this part of the problem.PS.