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A quick note about levitra and oxytocin for those who are taking it as a treatment for POIS. The increase in oxytocin only happens during sexual stimulation. Not sure why this is, but that's what the article I read said that linked oxytocin increase to PDE-5 inhibitors(levitra, viagra, cialis). If an increase in oxytocin is what is responsible for lessening the effects of POIS... if you take PDE-5 inhibitors after orgasm you will not get an increase in the levels of oxytocin!!! This is probably why demografx and whoa had more sever symtoms when they took levitra after orgasm....because the mediating effects of PDE-5 inhibitors only work when you take the pill before sexual stimulation. If you don't, you don't get an increase in oxytocin. So just remember....take the pill first...then do the deed!!!! - and as always, make sure you have a doctors approval(disclaimer:)
Last night I had an NE (it seemed somewhat small), and today I had zero POIS effects. I am still consuming raw garlic so I can't say if fenugreek is responsible or not, but I am hopful that it turns out to be of assistance.
Good job Tarkington. I try Reduce the cortisol release all the time but paradoxically i try to boost cortisol the day after ejaculation Oxytocin modulates stress hormones as cortisol and ACTH.
Good article, Chewbacca. You have linked Levitra and oxytocin.
Fantastic post hurray on oxytocin and fenugreek. It was something I always wondered about from both a POIS and CFS aspect. There is a well known doctor who has success with some of his patients by giving them oxytocin, but it didnt seem that it worked for all his patients. When I enquired about it with my CFS doc he didnt seem to see the connection in regards to immunity + it was a hormone that had a clrear role for women but not really for men. I didn't push on it as it required regular (I think daily) IV injections. Something like oxcytocin would explain the differences in pois between the sexes. Also its role in social anxiety and appetite helps to support it case, and Chewbacca's post linking it to ED meds was great in helping to make the connection to Levitra.I've read a couple of articles on it and I get conflicting info on fenugreek. Some say it mimics oxytocin and others say its synergestic and others say it stimulates the pituitary to produce more. Depending on how it works we could get variable results. I've started to trial it.I've been thinking more on nitric oxide and I'm not so sure now. When I was younger I could hang a wet towel off my boner, and if I had an orgasm, the refactory period was under an hour and I was good to go again. To me this indicates a very healthy level of NO. If we were wiping out our NO levels then it would make sense that POIS would get worse as we get older and that does not seem to be the case.Its annoying how many symptoms and circumstances are not quite the same for everyone. Some people get fever like effect, some people get diarrhea, neither of which I get. Then some people say ejeculation is a big deal and other say not (for me its not) and then some say an all out orgasm is worse and others say its better (I'm the latter).
John, if you never "escaped" POIS in the past with "small NE" this would be a good sign! (I never escaped it <<real tears).
Well I didn't wake up with female breasts this morning, this is good.  Last night I had an NE (it seemed somewhat small), and today I had zero POIS effects. I am still consuming raw garlic so I can't say if fenugreek is responsible or not, but I am hopful that it turns out to be of assistance. Good stuff Tarkington, nice to hear you had some positive results. When I tried Relora I was very sensitive to it. It aggrivated my insomnia so I gave up on it.