[0002ppdnuos]

That would make sense. Once b6 and b3 levels were high enough to reduce the number of allergic reactions, his body could balance the amount of neurotransmitters it made and, perhaps, reduce the amount of receptors for catecholamines such that he's less "jumpy".
However, the b1, b6, b12 combination seems a bit specific. Did he say what pills he was taking and what amounts of these b vitamins were in each? I know Merck pharmaceutical produce(d?) a b-complex called neurobion forte with the specific ratio of B1 100mg, B6 200 mg, B12 200mcg. This pill is/was sold in Asia and was sometimes prescribed to people with b vitamin deficiencies by family doctors. It would be interesting to learn more from Daniel about how he ended up taking this specific combination.

The name of the pill he takes is Hidroxil.
I can't remember the ratio of the ingredient, but it can be easily found online.

[kurtosis]

That would make sense. Once b6 and b3 levels were high enough to reduce the number of allergic reactions, his body could balance the amount of neurotransmitters it made and, perhaps, reduce the amount of receptors for catecholamines such that he's less "jumpy".
However, the b1, b6, b12 combination seems a bit specific. Did he say what pills he was taking and what amounts of these b vitamins were in each? I know Merck pharmaceutical produce(d?) a b-complex called neurobion forte with the specific ratio of B1 100mg, B6 200 mg, B12 200mcg. This pill is/was sold in Asia and was sometimes prescribed to people with b vitamin deficiencies by family doctors. It would be interesting to learn more from Daniel about how he ended up taking this specific combination.

The name of the pill he takes is Hidroxil.
I can't remember the ratio of the ingredient, but it can be easily found online.

Found it, thanks.
250 mg Vitamin B1 (thiamine hydrochloride)
250 mg Vitamin B6 (pyridoxine hydrochloride)
0.5 mg vitamin B12 (hydroxocobalamin)

That's a big dose. Many 1000% above RDA I think.

[Starsky]

What about B1? Is tihis vitamin important in sexual reactions?

[B_Daniel]

Symptoms: ..... fingers and toes get really cold also......

Take 1000mg pills of fish oil, 2-3 times a day for 6wks and u should see great improvement on the cold fingers/toes.  At least I did.

[Lapanique]

Symptoms: ..... fingers and toes get really cold also......

Take 1000mg pills of fish oil, 2-3 times a day for 6wks and u should see great improvement on the cold fingers/toes.  At least I did.

Thanks B_Daniel, I'll give that a try once I'm done testing some other vitamins/medicine: niacin, saw palmetto, vitamin B-complex, claritine (this one is a must for me because of my dermatitis/allergic reaction from having an O).  I'm trying not to take too many at once.  It's kinda crazy the number of pills/medication that we take just to try to find even a slight relief. 

[daveman]

So, what is happening with Daniel? Has he achieved to regain normal Vitamin B-6 levels with the supplement, and is his body now able to convert tryptophan into niacin, so the chain is not disrupted anymore(for some time) when he has an Orgasm? This is what Daniel told us several months ago:


Hey guys,

I think that I am cured. The last eight weeks I had orgasms 99% free of symptoms.

(...) This winter I took vitamine B pills (B1, B6 and B12). Every day one for 3 weeks. These pills made me feel much better, I felt much more clear in my head. Additionally, I took every day one fenugreek capsule.

After 3 weeks I quited with the vitamine B (you can get an overdose of B6, so I thought to take care with this) and I also quited with the fenugreek. I did not get orgasms in this period, simply because I had so much work to do at my job, I could not afford to have one.
Then, after one or one and half week I started vitamine B again, every week 2 or 3 pills. So every second day. Some weeks after that I addionally started my fenugreek again. I now take two capsules every morning after my breakfast. I was following this for about 4 or 5 weeks.

First I could get every week an orgasm without any problem. And now I can get two orgasms in two days without any problem! More orgasms induced some symptoms which disappeared during the day. But I think, I will improve more so this will also be possible in the future.
I also avoid stressful situations as much as possible, I think this is important.
My life improved a lot, having an orgasm without any problem, it is really great. I hope that everybody with this disease will be cured, because it is pretty much like hell.

http://poiscenter.com/forums/index.php?topic=346.0

That would make sense. Once b6 and b3 levels were high enough to reduce the number of allergic reactions, his body could balance the amount of neurotransmitters it made and, perhaps, reduce the amount of receptors for catecholamines such that he's less "jumpy".
However, the b1, b6, b12 combination seems a bit specific. Did he say what pills he was taking and what amounts of these b vitamins were in each? I know Merck pharmaceutical produce(d?) a b-complex called neurobion forte with the specific ratio of B1 100mg, B6 200 mg, B12 200mcg. This pill is/was sold in Asia and was sometimes prescribed to people with b vitamin deficiencies by family doctors. It would be interesting to learn more from Daniel about how he ended up taking this specific combination.

The only problem that I have, is that pretty much everything fits, except that I don't have allergies. (Other than a reaction to whatever *down there* when I orgasm).

My whole "package" swells afterwards. I might say prostate, but it's more. Everything from the empididymis (that soft tissue on the testicles) up through the tubes leading upwards, through the prostate to the lower bladder area all swell up. With niacin the swelling is less, but no POIS.

[lauracostis]

It’s often mentioned that Niacin doesn’t work for everyone, and it could well be, BUT I have worked recently with at least 3 people on a one to one basis to help with the use of niacin, and it is a VERY precise process. If it’s not done JUST RIGHT, it doesn’t work. So I’m certain that many who have tried it and failed have just not applied the “rules” correctly and given up too soon.

It’s really worth trying to make it work, because when it works it’s amazing. I suggest that if you are one of those for which it hasn’t worked, that you get in contact with one of us on a one on one to try to see if you can’t make it work. I haven’t spoken to any of the others yet about this, but I’m sure ObserverCenter for instance would be glad to help out.

If you are one for which it works, perhaps you can volunteer here to receive PMs to help guide someone through. They are just simple things that one might miss or “do wrong”, but they make all the difference in the world.

It would be a shame to be suffering when it isn’t necessary.

Besides, if it is just a procedural thing, then we can move one step closer to understanding the mechanisms. If it’s just procedural but we think it’s a non-compatibility, then we understand the mechanism improperly. We misunderstand the reason for it not working in some.

Yeah, you are right Dave. The procedure should be followed VERY precisely, otherwise it won't work. This was the reason I thought that Niacin injection doesn't help me, when I have tried it very first time. But it helped me when I attempted to try it second time, in a month, because of despair. Also body needs to adapt to Niacin, very first intakes results in discomfort feelings in various areas, like area of stomach, heart or head.

I think there is also a possibility that tablets won't work for some, because of insufficient digestion. Flush effect is a good marker to determine whether Niacin digested good or not so good.

Anyone please feel free to send me a PM if you want a one to one guidance and support in trying Niacin.

Victor

You can purchase injectable nicotinic acid with a doctors prescription from any compounding pharmacy in the united states.  I had my doctor write an order for 100mg/1ml concentration.  If injected into the correct subcutaneous site, I have had a flush in less than 2 minutes. 

[kurtosis]

So, what is happening with Daniel? Has he achieved to regain normal Vitamin B-6 levels with the supplement, and is his body now able to convert tryptophan into niacin, so the chain is not disrupted anymore(for some time) when he has an Orgasm? This is what Daniel told us several months ago:


Hey guys,

I think that I am cured. The last eight weeks I had orgasms 99% free of symptoms.

(...) This winter I took vitamine B pills (B1, B6 and B12). Every day one for 3 weeks. These pills made me feel much better, I felt much more clear in my head. Additionally, I took every day one fenugreek capsule.

After 3 weeks I quited with the vitamine B (you can get an overdose of B6, so I thought to take care with this) and I also quited with the fenugreek. I did not get orgasms in this period, simply because I had so much work to do at my job, I could not afford to have one.
Then, after one or one and half week I started vitamine B again, every week 2 or 3 pills. So every second day. Some weeks after that I addionally started my fenugreek again. I now take two capsules every morning after my breakfast. I was following this for about 4 or 5 weeks.

First I could get every week an orgasm without any problem. And now I can get two orgasms in two days without any problem! More orgasms induced some symptoms which disappeared during the day. But I think, I will improve more so this will also be possible in the future.
I also avoid stressful situations as much as possible, I think this is important.
My life improved a lot, having an orgasm without any problem, it is really great. I hope that everybody with this disease will be cured, because it is pretty much like hell.

http://poiscenter.com/forums/index.php?topic=346.0

That would make sense. Once b6 and b3 levels were high enough to reduce the number of allergic reactions, his body could balance the amount of neurotransmitters it made and, perhaps, reduce the amount of receptors for catecholamines such that he's less "jumpy".
However, the b1, b6, b12 combination seems a bit specific. Did he say what pills he was taking and what amounts of these b vitamins were in each? I know Merck pharmaceutical produce(d?) a b-complex called neurobion forte with the specific ratio of B1 100mg, B6 200 mg, B12 200mcg. This pill is/was sold in Asia and was sometimes prescribed to people with b vitamin deficiencies by family doctors. It would be interesting to learn more from Daniel about how he ended up taking this specific combination.

The only problem that I have, is that pretty much everything fits, except that I don't have allergies. (Other than a reaction to whatever *down there* when I orgasm).

My whole "package" swells afterwards. I might say prostate, but it's more. Everything from the empididymis (that soft tissue on the testicles) up through the tubes leading upwards, through the prostate to the lower bladder area all swell up. With niacin the swelling is less, but no POIS.

What you're describing could be an allergy. 
There have been many posts about people suffering allergy-like symptoms. Sometimes these are described as flu-like symptoms but it can be very difficult to distinguish between fatigue, runny nose and streaming eyes caused by flu and an allergy. Indeed, if the immune system is weakened and you come in contact with the flu virus, you might develop a flu.

I think there were some questions in the survey about allergies but it might be work a recap. It would be useful if posters could say whether they have experienced allergy symptoms in the past and whether they fit into the following categories?

- pollen / hay fever
- respiratory condition such as asthma
- sinusitis
- food allergy
- medication allergy
- animal hair allergy
- dust allergy
- insect bite / sting allergy
- mould allergy
- dermatitis or adult acne.

Also mention if you have digestive discomfort or a diagnosed condition such as IBS.

It would be good to know when did the allergy start?

[observercenter]

- pollen / hay fever  -- YES, but a mild one
- respiratory condition such as asthma -- YES, had an asthma attack when i was a child
- sinusitis -- YES
- food allergy -- kiwifruit
- medication allergy -- Maybe...
- animal hair allergy -- YES!
- dust allergy -- Definitely: YES!(I think it is the worse)
- insect bite / sting allergy -- NO
- mould allergy -- NO
- dermatitis or adult acne. -- YES, when i was a child.

Also mention if you have digestive discomfort or a diagnosed condition such as IBS.
NO.

It would be good to know when did the allergy start?
From the very first moment i could remember. I have POIS since i was -18- years old.

[kurtosis]

Thanks observercentre. I'll add my details.

- pollen / hay fever
No.

- respiratory condition such as asthma
Yes, asthma.

- sinusitis
Yes.

- food allergy
Yes, gluten.

- medication allergy
no.
 
- animal hair allergy
not obvious.

- dust allergy
no.

- insect bite / sting allergy
no.

- mould allergy
Yes.

- dermatitis or adult acne.
Yes.

Also mention if you have digestive discomfort or a diagnosed condition such as IBS.
Yes.

It would be good to know when did the allergy start?

No obvious allergies until 15 years old. Allergies and POIS since.

[demografx]

It’s often mentioned that Niacin doesn’t work for everyone, and it could well be, BUT I have worked recently with at least 3 people on a one to one basis to help with the use of niacin, and it is a VERY precise process. If it’s not done JUST RIGHT, it doesn’t work. So I’m certain that many who have tried it and failed have just not applied the “rules” correctly and given up too soon.

It’s really worth trying to make it work, because when it works it’s amazing. I suggest that if you are one of those for which it hasn’t worked, that you get in contact with one of us on a one on one to try to see if you can’t make it work. I haven’t spoken to any of the others yet about this, but I’m sure ObserverCenter for instance would be glad to help out.

If you are one for which it works, perhaps you can volunteer here to receive PMs to help guide someone through. They are just simple things that one might miss or “do wrong”, but they make all the difference in the world.

It would be a shame to be suffering when it isn’t necessary.

Besides, if it is just a procedural thing, then we can move one step closer to understanding the mechanisms. If it’s just procedural but we think it’s a non-compatibility, then we understand the mechanism improperly. We misunderstand the reason for it not working in some.

Yeah, you are right Dave. The procedure should be followed VERY precisely, otherwise it won't work. This was the reason I thought that Niacin injection doesn't help me, when I have tried it very first time. But it helped me when I attempted to try it second time, in a month, because of despair. Also body needs to adapt to Niacin, very first intakes results in discomfort feelings in various areas, like area of stomach, heart or head.

I think there is also a possibility that tablets won't work for some, because of insufficient digestion. Flush effect is a good marker to determine whether Niacin digested good or not so good.

Anyone please feel free to send me a PM if you want a one to one guidance and support in trying Niacin.

Victor

You can purchase injectable nicotinic acid with a doctors prescription from any compounding pharmacy in the united states.  I had my doctor write an order for 100mg/1ml concentration.  If injected into the correct subcutaneous site, I have had a flush in less than 2 minutes. 

LAURACOSTIS IS A MEDICAL PROFESSIONAL. VICTOR IS VERY EXPERIENCED. PLEASE DO NOT ATTEMPT INJECTING YOURSELF WITHOUT PROFESSIONAL MEDICAL HELP OR YOU CAN CAUSE PERMANENT INJURY TO YOURSELF!

[demografx]

THANK YOU, EDS!

[Lapanique]

What you're describing could be an allergy. 
There have been many posts about people suffering allergy-like symptoms. Sometimes these are described as flu-like symptoms but it can be very difficult to distinguish between fatigue, runny nose and streaming eyes caused by flu and an allergy. Indeed, if the immune system is weakened and you come in contact with the flu virus, you might develop a flu.

I think there were some questions in the survey about allergies but it might be work a recap. It would be useful if posters could say whether they have experienced allergy symptoms in the past and whether they fit into the following categories?

- pollen / hay fever
- respiratory condition such as asthma
- sinusitis
- food allergy
- medication allergy
- animal hair allergy
- dust allergy
- insect bite / sting allergy
- mould allergy
- dermatitis or adult acne.

Also mention if you have digestive discomfort or a diagnosed condition such as IBS.

It would be good to know when did the allergy start?

No to all the categories EXCEPT the last one.  The first time I had an O at 11 I developed dermographism.  Have had it since.  That is definitely an allergic reaction.  I've been taking claritin for 20 years to reduce the itching.

I also developed some serious digestive issues.  About 3 times a year i will have a very painful stomach ache and pass out for a minute or two, with profuse sweating.  Feels like death.  Never had these issues before I ever had an O. 

[demografx]

My POIS also arrived with dermatitis and horribly-feeling "dry" fingertips. For 4 long days with each incident of POIS.

[Habibou]

- pollen / hay fever : NO
- respiratory condition such as asthma : NO
- sinusitis : NO
- food allergy : Lactose en casein intolerance
- medication allergy : dont know yet
- animal hair allergy : NO
- dust allergy : YES
- insect bite / sting allergy : NO
- mould allergy : NO
- dermatitis or adult acne.: less and less

[0002ppdnuos]

Found it, thanks.
250 mg Vitamin B1 (thiamine hydrochloride)
250 mg Vitamin B6 (pyridoxine hydrochloride)
0.5 mg vitamin B12 (hydroxocobalamin)
That's a big dose. Many 1000% above RDA I think.

Exactly.
That's why I dare not try yet.
I'm afraid I'll be dead being poisoned before my POIS is cured.
So, I'm trying brewer's yeast, which has lots of vitamin B and protein.
One quarter teaspoon daily mixed into my coffee.
I'll see how it goes.

[0002ppdnuos]

- pollen / hay fever : NO
- respiratory condition such as asthma : NO
- sinusitis : NO
- food allergy : YES (honey)
- medication allergy : Yes (a kind of antibiotic)
- animal hair allergy : NO
- dust allergy : NO
- insect bite / sting allergy : YES (mosquitoes & ant's bite)
- mould allergy : NO
- dermatitis or adult acne.: NO

[Omen 30]

I have a history of eczema...

[demografx]

Habibou, excellent idea about a case history.

[B_Daniel]

How many of you have had b12 levels measured? Anyone of you had b12 shots? 

See an extract below related to b12 where this person mentions the relationship between sperm and b12

"All sorts of theories get made up when real facts are lacking. The right vitamins make all the difference in the world. If a teaspoon of semen contains as much b12 as a steak it might seem rather magical revitalizing in effect, a powerful sacrement, in a society literally starving for b12."

Thanks for reposting your note. I think we miss important posts all the time so re-posting something that we overlooked and that you found important is very welcomed. To answer your question, I've never had my B12 levels tested, but could prob attach that to my nxt bloodwork pretty easily.  Does a B12 deficiency cause brainfog like we all have in common?  Because I didnt find that in a quick search i did on B12 deficiencies.  Perhaps that's my difficulty in getting on board with this theory.