Post Orgasmic Illness Syndrome (POIS)

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Offline gondal4

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17350 on: 23/11/2012 16:31:16 »
i dont understand what you people mean by "flush".explain in simple terms

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17351 on: 24/11/2012 03:45:05 »
i dont understand what you people mean by "flush".explain in simple terms

First of all you get the flush from using niacin and not from pois.

The flush occurs after about 30 mins after using niacin on an empty stomach. the flush involves redding of the skin and very intense itching sensation you would not be able to stop scratching your body for about 30 mins.  And then the sensation subsides.
It is generally considered safe.  Dont be scared of it.
« Last Edit: 24/11/2012 04:03:48 by CertainlyPOIS »

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17352 on: 24/11/2012 03:54:21 »

That is the only way that

Just an update,

It is after 14 days start taking the calcium channel blockers (Flunarizine hydrochloride). I have an o at the 10th day, 11th day, and 14th day (twice).  My all cognitive symptoms such as lack of mental clarity, Stammering, anxiety, difficulty in thinking, burning sensation are reduced extremely and presently running without Herbal life and Neem. Only taking the above medicine.  The only problem remaining is excess dreaming at night and abnormal breathing.

Hence, it is working superbly.  Now my social life has changing, I am calm, cool and started to present papers & seminars in office. My life totally changed.   I met doctor yesterday and he told that it is only 20 to 30% of recovery and it takes around 3 months for complete recovery from this.  But I am in a feeling that I have recovered 70% as my cognitive symptoms disappeared. 

Waiting in next 3 months, how my life will be after complete recovery.

Request you to consult your doctor and as per his guidance take the above mentioned tablet. Its working.  Initially I shared only herbal remedies with temprovery sucess and without scientific reason.  Finally I have shared my success with scientific medicine with reason for clear of POIS. 

My next proposed findings with the help of this forum and my doctor:
a) I want to know how the Testerone replacement theraphy reduce symptoms (cured)for demo and other person in this forum.  (What is the link between TRT and Calcium Channel Blocker)
b) What is the link between Niacin and Calcium Channel Blocker.
c) How Neem has stopped my POIS for 2 months and then how low diet food (without morning breakfast and dinner  and Herbal life) has helped me in some how temprovery blocking of POIS.

Please try this medicine for atleast 20 days (under guidance of doctor) and see the results.   Please don't expect result in first week. 


Hi Natan, I'm taking flunarizine for two day now. Even if I'm taking citalopram since 6 years for anxiety, my doctor don't find any problem for me taking flunarizine. Here in Canada, flunarizine is not use anymore but still available. So, i'll wait ( we'll wait, my wife and me) and I will give news after two weeks.

nice.
« Last Edit: 24/11/2012 04:02:22 by CertainlyPOIS »

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Offline JACKMAN

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17353 on: 25/11/2012 01:26:37 »
yo guys, im 21 and i have  symptoms you guys have described.

i feel really weak, agitated and nauseous, also my penis feels tight and my prostrate feels to be fighting the flow of semen, (this could be physical) after ejaculation but for from what ive read i dont suffer as bad as some of you, my symptoms usually last about 15-20mins but in that time i feel like death, so of course has depressed me for a while, and it is quite hard to explain to partners why you cant go through with it avoiding sexual contact altogether,
when i have ejaculated with partners i have felt really cold towards them and do not want to be touched. sometimes i feel that my symptoms dont last long enough for me to worry as much but people dont know how we feel so cant understand.

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Offline JACKMAN

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17354 on: 25/11/2012 01:56:14 »
yo guys, im 21 and i have  symptoms you guys have described.

i feel really weak, agitated and nauseous, also my penis feels tight and my prostrate feels to be fighting the flow of semen, (this could be physical) after ejaculation but for from what ive read i dont suffer as bad as some of you, my symptoms usually last about 15-20mins but in that time i feel like death, so of course has depressed me for a while, and it is quite hard to explain to partners why you cant go through with it avoiding sexual contact altogether,
when i have ejaculated with partners i have felt really cold towards them and do not want to be touched. sometimes i feel that my symptoms dont last long enough for me to worry as much but people dont know how we feel so cant understand.
must add that when i have nighttime emissions i dont get any of these symptoms.

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Offline Prancer

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17355 on: 25/11/2012 05:55:36 »
yo guys, im 21 and i have  symptoms you guys have described.

i feel really weak, agitated and nauseous, also my penis feels tight and my prostrate feels to be fighting the flow of semen, (this could be physical) after ejaculation but for from what ive read i dont suffer as bad as some of you, my symptoms usually last about 15-20mins but in that time i feel like death, so of course has depressed me for a while, and it is quite hard to explain to partners why you cant go through with it avoiding sexual contact altogether,
when i have ejaculated with partners i have felt really cold towards them and do not want to be touched. sometimes i feel that my symptoms dont last long enough for me to worry as much but people dont know how we feel so cant understand.

Hey jackman, welcome! Really interesting to hear that your symptoms only last 15-20 minutes.

If you have any questions, feel free to ask one of us and we will try to get your answer for you. :)

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Offline John21

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17356 on: 25/11/2012 12:25:08 »
If POIS is a histamine problem I wonder if it might be possible to take an anti-histaime some time before and perhaps after sex to prevent the symptoms, without being on it full time. Has anyone experimented with anti-histamines besides nathan? I know the histamine theory has been kicked around for years, GoingCrazey had some success with Clairitin. Has anyone else benefited from anti-histamines besides Nathan and GC?

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Offline Over it

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17357 on: 26/11/2012 07:45:02 »
Surprise, surprise, the Doxycycline has not cured me. But the relief it gave me from symptoms was very real, until I copped a severe bout of POIS before I had even finished the second and final week of my perscription (go figure). I am very eager to hear more from user Coreman, particularily so after coming across a breif discussion about sustained, elevated prolactin levels in a post by user Mellivora in 2007 (see page 2 of this thread).

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17358 on: 26/11/2012 21:05:24 »
If POIS is a histamine problem I wonder if it might be possible to take an anti-histaime some time before and perhaps after sex to prevent the symptoms, without being on it full time. Has anyone experimented with anti-histamines besides nathan? I know the histamine theory has been kicked around for years, GoingCrazey had some success with Clairitin. Has anyone else benefited from anti-histamines besides Nathan and GC?

If you are going by kurtosis theory then normal antihistamines would not be enough because they dont cross BBB well and dont go after the histamine3 receptors which are connected to cognition problems.
You can try his proposed combination to deactivate histamine by increasing methylation.

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Offline acronym

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17359 on: 27/11/2012 20:42:27 »
If POIS is a histamine problem I wonder if it might be possible to take an anti-histaime some time before and perhaps after sex to prevent the symptoms, without being on it full time. Has anyone experimented with anti-histamines besides nathan? I know the histamine theory has been kicked around for years, GoingCrazey had some success with Clairitin. Has anyone else benefited from anti-histamines besides Nathan and GC?

If you are going by kurtosis theory then normal antihistamines would not be enough because they dont cross BBB well and dont go after the histamine3 receptors which are connected to cognition problems.
You can try his proposed combination to deactivate histamine by increasing methylation.
Its possible the methylation cylcle in us is not normal. It would be great if we could all do gene testing for this, but it is not cheap.
Here are a couple of links for those interested in methylation that may see something interesting in relation to their health. I know it was interesting for me because a number of liver supps and methylation supps I have taken have made me worse over the years. It can explain why for some of us why diet changes play a role in feeling better...but its tricky to 2nd guess.

http://www.mthfrsupport.com/1/post/2012/05/other-gene-mutations-that-must-be-addressed-before-starting-an-mthfr-protocol.html
http://www.heartfixer.com/AMRI-Nutrigenomics.htm
« Last Edit: 27/11/2012 20:50:18 by acronym »

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17360 on: 28/11/2012 03:39:39 »
If POIS is a histamine problem I wonder if it might be possible to take an anti-histaime some time before and perhaps after sex to prevent the symptoms, without being on it full time. Has anyone experimented with anti-histamines besides nathan? I know the histamine theory has been kicked around for years, GoingCrazey had some success with Clairitin. Has anyone else benefited from anti-histamines besides Nathan and GC?

Yes, claritin did help me, I was definitely better taking claritin than nothing at all.  When I took claritin most and sometimes all of the mental symptoms were gone, but they were delayed for about a day, but that makes sense because I took a claritin 24hr.  So even after orgasm, and taking an antihistamine, the reaction still was occurring but I wouldn't feel it, and when the claritin stopped working I felt it.

I also wanted to note that after taking a heavy dose of aspirin for POIS I've had one of the worst episodes to date.  It is now day 4 and I still feel like I am in day 1, although it did offer relief when I first took it.  Aspirin's blood-thinning affect can last for a long time.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17361 on: 28/11/2012 03:49:26 »
I was also thinking about trying a "mast cell stabilizer" it prevents histamine, prostaglandins and leukotrienes from being released by mast cells, instead of just an antihistamine.  Here is a link I found.

http://www.urticare.com/Treatments/Mast+Cell+Stabilisers.html

Imagine if the same applied to POIS; "An additional feature that has been noticed with Ketotifen is that in the vast majority of patients who have become asymptomatic on Ketotifen if the medication is continued for some 4 months or so, a significant proportion of patients remain well after that without any further treatment being required."

Tell me what you guys think.  I did notice they have some side effects, but I may still give them a try.

On second note after researching them some more they do seem a little extreme, for ketotifen you have to be on it for some months for it to work, it's also used for asthma patients.
« Last Edit: 28/11/2012 04:17:46 by GoingCrazy »

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17362 on: 28/11/2012 04:16:54 »
When it comes down to it, that's what I believe my POIS is.  A combination of histamine, prostaglandins and Leukotrienes working on my brain in response to orgasm.  That's probably why antihistamines make me feel better, but not 100% because there is still prostaglandins and leukotrienes that cause a reaction.  The only bad thing about taking medication to help it is they are used by your body in other processes, unrelated to POIS, and also used in the brain for other purposes.  We need to do some more research on these things. I'd like to find possible medication for all or seperate medications for each.

The only thing that confuses me is after I've been celibate for a while I kind of get irritable, but that can be due to lack of release correct?

And also, I'd like to comment on a possible remedy during POIS.  It is one a day vitacraves gummies + immunity support.  One possible reason it helps is because of its selenium content.  It definitely puts me into a better mood.
« Last Edit: 28/11/2012 04:26:34 by GoingCrazy »

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Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17363 on: 28/11/2012 12:27:32 »
When it comes down to it, that's what I believe my POIS is.  A combination of histamine, prostaglandins and Leukotrienes working on my brain in response to orgasm.  That's probably why antihistamines make me feel better, but not 100% because there is still prostaglandins and leukotrienes that cause a reaction.  The only bad thing about taking medication to help it is they are used by your body in other processes, unrelated to POIS, and also used in the brain for other purposes.  We need to do some more research on these things. I'd like to find possible medication for all or seperate medications for each.

The only thing that confuses me is after I've been celibate for a while I kind of get irritable, but that can be due to lack of release correct?

And also, I'd like to comment on a possible remedy during POIS.  It is one a day vitacraves gummies + immunity support.  One possible reason it helps is because of its selenium content.  It definitely puts me into a better mood.

I'm getting the genetic testing done. I have to know for definite which genes are mutated so I can come up with a methylation treatment that works with me. There's so much stuff to factor in. COMT, HNMT, MTHFR, MTR, BHMT, DAO etc. I don't think there are silver bullets but I do believe that something like ketitofen may help. Prostaglandin and histamine are released from mast cells so a mast cell stabiliser seems a good starting point for any treatment.

It all depends whether the POIS is caused by an inability to restore homeostasis after an O which may be obvious from looking at genes controlling deactivation of histamine via methylation (for instance) OR whether we simply have too many mast cells (some form of mastocytosis). I don't know but I want to know as much about my own DNA to help answer the question!

Clarityn D worked for my worst POIS and I believe it's the combination of anti-histamine and pseudoephedrine that yielded those results.

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Offline nomore2013

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17364 on: 28/11/2012 17:10:41 »
i took claritin-d 3 times already, and every time it worked.

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Offline nomore2013

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17365 on: 28/11/2012 17:56:13 »
claritin-d, contains loratadine and pseudoephedrine. pseudoephedrine acts as a vasoconstrictor, which is weird, because i thought we were supposed to be looking for vasodillators like b3-niacin, niacinimide.

can you take pseudoephedrine and niacinimide at the same time?

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Offline Prancer

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17366 on: 28/11/2012 19:12:28 »
I had some temporary success with loratadine (claritin), but then my symptoms kicked in big time next day. I haven't tried claritin-d yet.
Pseudoephedrine acts like a stimulant, and I know that caffeinated soft drinks like colas seem to help me a lot. I want to give claritin-d a try.

Last month I abstained for about 2 weeks and seemed to feel somewhat better, but I'm still very inconclusive about whether abstaining for a long time actually clears my symptoms up, which bothers me. I remember hearing that some sufferers had to wait over a month or 2 before starting to feel normal again. I want to abstain while trying all these remedies for as long as possible (for months hopefully), and if I STILL have pois symptoms after all that, well then that would suck.  :\

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Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17367 on: 28/11/2012 19:58:01 »
I had some temporary success with loratadine (claritin), but then my symptoms kicked in big time next day. I haven't tried claritin-d yet.
Pseudoephedrine acts like a stimulant, and I know that caffeinated soft drinks like colas seem to help me a lot. I want to give claritin-d a try.

Last month I abstained for about 2 weeks and seemed to feel somewhat better, but I'm still very inconclusive about whether abstaining for a long time actually clears my symptoms up, which bothers me. I remember hearing that some sufferers had to wait over a month or 2 before starting to feel normal again. I want to abstain while trying all these remedies for as long as possible (for months hopefully), and if I STILL have pois symptoms after all that, well then that would suck.  :\

Clarityn D isn't a long term treatment I'm afraid. My doctor advised against me taking it much but I have chronic sinus problems that go with my POIS and it has a decongestant effect.

Pseudoephedrine is a stimulant which encourages the body to produce adrenaline / epinephrine. This reduces the level of histamine, similar to the way getting an epi-pen injection counteracts a severe allergic reaction.
You're basically shocking your system out of the POIS state. Yeah, it works but, as I said, I can't see this being a long term solution but it does feel a lot better than POIS :)

Good to know it works though, especially if you have an NE before an important meeting or exam. For some people the natural mast cell stabiliser Quercetin might work great. It's a mild COMT inhibitor however, so if someone had a COMT issue (one or 2 mutations of the COMT gene) then it would inhibit and already slow catecholamine clearing mechanism. This would be really bad to combine with something like a dopamine or norepinephrine reuptake inhibitor. It may cause mania. DO NOT DO IT.

If you're not taking that kind of anti-depressant then you could give it a go. The other option it ketotifen. It might be a h1 antihistamine but it's the mast cell stabilisation you want most.
http://en.wikipedia.org/wiki/Ketotifen
Again, this is something your doctors could prescribe.
Like I've said, I think most of the symptoms are caused by inflammation mediated by mast cell release. Most of it histamine. You can clear histamine by increasing methylation (which may actually improve the POIS sufferers quality of life in every way if they have a specific methylation genetic problem) or improving mast cell stability via quercetin, ketotifen, cromolyn etc.

It all depends on genetics, the other drugs or supplements the person is taking, severity of POIS etc.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17368 on: 29/11/2012 03:36:19 »
I had some temporary success with loratadine (claritin), but then my symptoms kicked in big time next day. I haven't tried claritin-d yet.
Pseudoephedrine acts like a stimulant, and I know that caffeinated soft drinks like colas seem to help me a lot. I want to give claritin-d a try.

Last month I abstained for about 2 weeks and seemed to feel somewhat better, but I'm still very inconclusive about whether abstaining for a long time actually clears my symptoms up, which bothers me. I remember hearing that some sufferers had to wait over a month or 2 before starting to feel normal again. I want to abstain while trying all these remedies for as long as possible (for months hopefully), and if I STILL have pois symptoms after all that, well then that would suck.  :\

I think the time I feel the best is the time furthest from my last "O" and that I still don't feel sexually frustrated. 

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17369 on: 29/11/2012 03:37:56 »
claritin-d, contains loratadine and pseudoephedrine. pseudoephedrine acts as a vasoconstrictor, which is weird, because i thought we were supposed to be looking for vasodillators like b3-niacin, niacinimide.

can you take pseudoephedrine and niacinimide at the same time?

I'm not so sure about the vasodilating/vasoconstricting effect, but more on its effect on histamine and other inflammatories.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17370 on: 29/11/2012 03:45:14 »
Kurtosis, can you take claritin-D and still fall asleep after?  I know you mentioned the pseudoephedrine as a stimulant.  I guess I haven't tried that either, I tried the claritin 24 hour, and like Prancer said you sometimes feel it the next day.  Do you get the same reaction of feeling POIS the next day?



And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.
« Last Edit: 29/11/2012 03:51:12 by GoingCrazy »

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Offline John21

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17371 on: 29/11/2012 10:50:17 »
Kurtosis, can you take claritin-D and still fall asleep after?  I know you mentioned the pseudoephedrine as a stimulant.  I guess I haven't tried that either, I tried the claritin 24 hour, and like Prancer said you sometimes feel it the next day.  Do you get the same reaction of feeling POIS the next day?



And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.

I have had insomnia for many years, maybe around 12 years now. It is sleep maintenance insomnia where I wake in the middle of the night and sometimes have difficulty getting back to sleep. Stress is a definite contributor, if not the sole reason. What form of insomnia do you have GC?

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Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17372 on: 29/11/2012 12:38:45 »
Kurtosis, can you take claritin-D and still fall asleep after?  I know you mentioned the pseudoephedrine as a stimulant.  I guess I haven't tried that either, I tried the claritin 24 hour, and like Prancer said you sometimes feel it the next day.  Do you get the same reaction of feeling POIS the next day?



And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.

Yeah, I can still sleep but I find I can sleep through most things. My biggest problem with sleeping is the amount of mucous I produce which sometimes makes me snore so loudly I wake myself up. Quercetin reduced this in the past. Sometimes if I eat 2 apples, it has a similar effect and I think that's because there's quercetin in them.
Interesting open journal article on quercetin here. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033805

Had 2 O's yesterday and feel pretty good. I didn't take anything after them. I just woke up, had my NADH and some fish oil (stuff gives me no fishy burps and no stomach pain unlike some products).
I've a bit of a cold which seems like an actual cold as opposed to POIS but apart from that, pretty good.

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Offline JACKMAN

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17373 on: 30/11/2012 17:07:23 »
i read something today about mens virility today, and it said how not ejacualting when you should be, when you should be reaching climax is shocking your system and messing up your nervous system which in can turn make you impotent or far less virile. so i experienced that recently with a woman, and it hasnt happened before to me, so im guessing i should just go through with it and it would help in the future or is my POIS due to me not always climaxing when i should of done, and my body inturn reacting like this when i do climax. it all could be complete nonsense.

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Offline Prancer

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17374 on: 01/12/2012 20:54:29 »

And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.

For me, I don't have any problem staying asleep, but I go to bed very late, like 1 or 2 am. I'm usually very tired in the morning because of the late bedtime but I believe mainly because of pois.

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Offline Coreman

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17375 on: 02/12/2012 16:16:47 »
HI, Im back after 24 days of BROMOCRIPTINE treatment.

PRANCER was right: it's too early to break out the champagne...

I am getting a little better, but not to the level I expected.


MY AGENDA:
Firstly, I'm seeing the specialist in 2 days who may prescribe CLOMIFENE CITRATE this time.

"CLOMIFENE CITRATE has been found very effective in the treatment of secondary male hypogonadism in many cases.[3] This has shown to be a much more attractive option than testosterone replacement therapy (TRT)" -  Wikipedia.


Secondly, I'm waiting for an MRI test to face the fact if  I  have
a PROLACTINOMA tumor. (A prolactinoma is a noncancerous pituitary tumor that produces a hormone called prolactin)

I'll  report back on the result of the MRI test and progress!

Cheers,

COREMAN.




Citation:
-----------------------

That sounds like some pretty good news Coreman. Although it's early, I'm already getting excited! Please keep us up to date on any new developments. Thanks a lot and good luck!
 - Prancer

PS: Let's give it the 2-week rule that B_Daniel suggested (wait couple weeks and see if you are still cured or feeling much better) before we really break out the champagne!

-------------------------
You're right, Prancer. Thanks! I'll give it a 2 weeks' go!
Coreman.

-------------------------
Dear Demografx and Others!
Iíve been having a BREAKTHROUGH  !!!
(Me: a member for 5 years, suffering from POIS for 10 years.)

To put it short, Iím diagnosed with Hyperprolactinaemia, taking pills and getting way better!  :)
newbielink:http://en.wikipedia.org/wiki/Hyperprolactinaemia [nonactive]

The results of my lab tests:
(performed after a release):
Total Testo: 4,2 seriously under the range of 8,6 Ė 26
Prolactine:   1646 (!!) seriously over the range of 86-324

Taking Bromocriptine for 5 days, and feeling much better !!! :)

I met an Endocrinologist with profound knowledge.
->an adenoma tumour (so called prolactinoma) is suspected.
-> I am enlisted for an MRI test to check whether I really have prolactinoma.
Cheers!! Iím over the moon now! :)

Coreman."
----------------------------
« Last Edit: 02/12/2012 16:18:34 by Coreman »

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Offline Ninjagasm

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17376 on: 02/12/2012 18:19:54 »
I'm a new user so I apologize if somebody said this already...
Okay so I used to expierence severe to mild brain fog and intense fatigue everytime I orgasmed. I started taking a Vitamin B-100 Complex 100mg for the fatigue before I orgasmed and two tablets of Lecithin 120 mg for the brain fog before and after orgasm. Been "cured" ever since. Once again we are all different and react to different medication/supplements. Hope this helped :)
« Last Edit: 02/12/2012 18:26:23 by Ninjagasm »

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Offline Ninjagasm

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17377 on: 02/12/2012 18:23:13 »
Oh and I'm pretty sure the key is to have a orgasm atleast 3-5 times a week or your body will never get used to the POIS. I used to be scared to orgasm because of the symptoms so I would only have one once a week. Its only been 3 days but so far so good.

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Offline Prancer

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17378 on: 02/12/2012 21:59:36 »
I'm a new user so I apologize if somebody said this already...
Okay so I used to expierence severe to mild brain fog and intense fatigue everytime I orgasmed. I started taking a Vitamin B-100 Complex 100mg for the fatigue before I orgasmed and two tablets of Lecithin 120 mg for the brain fog before and after orgasm. Been "cured" ever since. Once again we are all different and react to different medication/supplements. Hope this helped :)

Welcome ninjagasm, and thank you for sharing what's helped you! I'm happy to hear you are feeling better. :)

I bought a lecithin supplement after hearing your success story. You're right that we're all different so I'm not getting overly excited, but I'm still highly optimistic with every new supplement I try. (By the way, I now officially have amassed A LOT of different supplements. Those that don't know I have pois think that I've become a dr. oz aficionado.) I don't mind experimenting with new supplements because one day I might try the perfect one!

On another matter, for those that get pois or feel worse after a hot shower, I think I found something that helps me and might help you too. Basically I just switched my hair dryer from one that uses mainly HEAT with little air flow to dry hair to one that uses a lot of air flow and not as much heat. I have found that this has helped not only to save time by drying my hair faster, but also to eliminate most of the symptoms I felt. In my case, it might have actually been the heat from the hair dryer against my scalp that was causing most of the symptoms. So yeah, just wanted to throw that out in case someone was having a similar problem. K, bye for now!

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Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17379 on: 02/12/2012 22:17:50 »
Peopple with urticaria sometimes use a hot shower to release histamine. It feels better after a while. It all depends on the length of the shower.
See http://en.wikipedia.org/wiki/Urticaria

and more specifically http://en.wikipedia.org/wiki/Cholinergic_urticaria
I think POIS is similar to this but without the hives. I've had some rosacea but my body certainly doesn't become covered in hives. Anyway, the connection between the 2 is mast cell release of histamine etc.

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Offline nathan123

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17380 on: 04/12/2012 16:33:50 »
Just an update,

Its been after one month and one week after starting Calcium channel blocker. 

Now my intensity and frequency of the pois is reduced by great extent.  I can say approximately 60 to 70% of intensity of my POIS is reduced. 

Another interesting fact from my last 3 weeks is I will get symptoms now when I have orgasm.  I had even tried daily 4 o .  But no symtoms.  But if in case I go to bed at late night say 12 or 1, POIS symoms back but,intensity of pois is very low and will be cured in just 2 days. 

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Offline Habibou

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17381 on: 04/12/2012 21:20:36 »
that s great it is working for you for the moment Nathan !
Do you know if the 150 patients of PCH or POIS got totally cured with the flunarizine dihydrochloride?

I will start the same treatment in 3 days for over 3 months, under the supervisiory control of my GP.

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Offline Ninjagasm

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17382 on: 05/12/2012 00:36:32 »
that s great it is working for you for the moment Nathan !
Do you know if the 150 patients of PCH or POIS got totally cured with the flunarizine dihydrochloride?

I will start the same treatment in 3 days for over 3 months, under the supervisiory control of my GP.

I apologize for being a lazy bastard, but can you guys please summarize exactly what this calcium supplement or what ever it is your talking about???? Thank youuuu!

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Offline Ninjagasm

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17383 on: 05/12/2012 00:39:02 »
and whats the logic behind using it??

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17384 on: 05/12/2012 06:36:13 »
I have a confusion about whether I have POIS or Post Coital headche and for my condition doctor told that it is a Post Coital headche illness.  So, please explain me whether my problem is a POIS by seeing the following symtoms.  By Calcium Channel blocker, my POIS has clearing now, so I want to discuss with doctor on POIS vs Post Coital headche illness. 

When I am in POIS, I have the following symtoms,

a) Brain fog, low concentration, low memory, Fatigue, burning in head, confusion
b) Depression
c) Burning eyes,
d) feeling imbalance in head
e) Abnormal breathing
f) High Anxiery
g) Difficult to have eye contact
h) Stammerting at the great extent
i) Imbalance in sleep and excessive dreaming
j) Emotional imbalance
h) Very rare occasion I also had throat infection.
and I don't get any flu and physical symtoms.
These symtoms will be there for atleast one months and very difficult to remove when attacked.  Upto last 2 months, my symtoms as explained above.  Please clarifiy to me.

you have pois. Do you even get any headaches after orgasm.
you can crosscheck your symptoms with dr waldingers symptoms list and you will see your symptoms match alot of the symptoms.

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Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17385 on: 05/12/2012 09:32:16 »
and whats the logic behind using it??

Pretty much the exact opposite of a calcium supplement. Indeed, I think some people have gotten confused and started taking extra calcium which would make things worse. 
Calcium channel blockers are described here
http://en.wikipedia.org/wiki/Calcium_channel_blocker
They are used to reduce blood pressure, prevent epileptic seizures or to reduce frequency or severity of migraines. I don't know whether they're safe to use long term but the argument is that POIS symptoms (and this sounds reasonable to me) are actually similar to post coital headache.

Nathan is using this http://en.wikipedia.org/wiki/Flunarizine
Which is both an anti-histamine and a cerebrovascular dilator, i.e. it relaxes blood vessels in your brain See http://dpic.org/sites/default/files/pdf/DIR_CCBs.pdf

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Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17386 on: 06/12/2012 05:00:19 »
fyi: I've been using DAOsin for a couple weeks and it hasn't helped my digestion issues at all.
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17387 on: 06/12/2012 06:54:13 »
Kurtosis, can you take claritin-D and still fall asleep after?  I know you mentioned the pseudoephedrine as a stimulant.  I guess I haven't tried that either, I tried the claritin 24 hour, and like Prancer said you sometimes feel it the next day.  Do you get the same reaction of feeling POIS the next day?



And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.

I have had insomnia for many years, maybe around 12 years now. It is sleep maintenance insomnia where I wake in the middle of the night and sometimes have difficulty getting back to sleep. Stress is a definite contributor, if not the sole reason. What form of insomnia do you have GC?

Usually when I sleep, it's like I cannot "relax", sort of my brain doesn't shut off, and I can't get into the mood of calmness/relaxation.  Sometimes I'll wake up in the middle of the night sweating and nervous, so it almost seems like a symptom of anxiety, but I don't know if POIS is the cause or something else.

But recently I've been sleeping well just by taking vitamin C in the morning (Ester C), I think its reaction with histamine is causing me to sleep better throughout the night even though I take it in the morning.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17388 on: 06/12/2012 06:55:35 »
I'm a new user so I apologize if somebody said this already...
Okay so I used to expierence severe to mild brain fog and intense fatigue everytime I orgasmed. I started taking a Vitamin B-100 Complex 100mg for the fatigue before I orgasmed and two tablets of Lecithin 120 mg for the brain fog before and after orgasm. Been "cured" ever since. Once again we are all different and react to different medication/supplements. Hope this helped :)

Do you have any other symptoms besides brain fog?

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Offline Ninjagasm

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17389 on: 07/12/2012 05:39:39 »

Do you have any other symptoms besides brain fog?
[/quote]

Intense fatigue, headache, very irritable, mentally unstable in general, insomnia, feeling of intense heat, my pain tolerance goes down, if i go to the gym the amount of weight I can lift goes down about 25 pounds, anxiety

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Offline Kingkong

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17390 on: 07/12/2012 23:33:30 »
Hi everybody, I have good news. I've tried flunarizine (sibelium) as Nathan. I'M taking 10 mg each days since november 19th. On december 5th I had an O for the first time since two month. I had a normal night of 8 hours. The nightmares were very light. When I wook up the 6th, it was difficult but not as usually when I'm having an O. I was tired the 6th at work. I`m working in an office. Yesterday the 6th, I had a second O. I went to bed at 20 o'clock because I was very tired and I wake up at 6 this morning. So I sleep 10 hour last night. I would say that all my symptoms were gone by 10 o'clock this morning. Yesterday, I could felt a physical fatigue but about 50% mental fatigue that I have usually. Yesterday, I could felt my ganglion a bit but today absolutly nothing. IT's a lot more efficient than NIACIN. Today I had no irritability at all and no mental problem. It's a very big succes for me. I'M must say that the first 10 day that I began to take Sibelium, I was sleeping 10 hour a day and I was tired. But now it's OK. My doctor told me that by 8 weeks of taking Sibelium, I will be very hungry and could take 10-20 pounds. I will have to control myself not to eat too much. I'm continuing to take flunarizine and I 'll give more news later. I'm 53 yers old and I never felt good like that since 14 year the after I had an O. As I wrote on november 20th on this site, I'm taking citalopram for many years. Maybe i't for that reason that I was so tired de first 10 days of taking flunarizine.

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17391 on: 08/12/2012 02:29:58 »
Hi everybody, I have good news. I've tried flunarizine (sibelium) as Nathan. I'M taking 10 mg each days since november 19th. On december 5th I had an O for the first time since two month. I had a normal night of 8 hours. The nightmares were very light. When I wook up the 6th, it was difficult but not as usually when I'm having an O. I was tired the 6th at work. I`m working in an office. Yesterday the 6th, I had a second O. I went to bed at 20 o'clock because I was very tired and I wake up at 6 this morning. So I sleep 10 hour last night. I would say that all my symptoms were gone by 10 o'clock this morning. Yesterday, I could felt a physical fatigue but about 50% mental fatigue that I have usually. Yesterday, I could felt my ganglion a bit but today absolutly nothing. IT's a lot more efficient than NIACIN. Today I had no irritability at all and no mental problem. It's a very big succes for me. I'M must say that the first 10 day that I began to take Sibelium, I was sleeping 10 hour a day and I was tired. But now it's OK. My doctor told me that by 8 weeks of taking Sibelium, I will be very hungry and could take 10-20 pounds. I will have to control myself not to eat too much. I'm continuing to take flunarizine and I 'll give more news later. I'm 53 yers old and I never felt good like that since 14 year the after I had an O. As I wrote on november 20th on this site, I'm taking citalopram for many years. Maybe i't for that reason that I was so tired de first 10 days of taking flunarizine.

I looked it up and that is one of the side effects of sibelium.
Also do you have any physical symptoms like fatigue,and fluelike symptoms.

Not saying this because of flunarizine success with some. But my first true O with another person produce the most most worst worst headache ever. I dont know how to explain it " the pain level felt like i busted a vein in my head and that pain lasted all day i couldnt get out of bed."
The only problem is, it only happened that time and never since.  And i did not notice any pois symptoms untill about three months from that day.
« Last Edit: 08/12/2012 07:14:10 by CertainlyPOIS »

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17392 on: 08/12/2012 03:00:49 »
according to this it looks like calcium channel blocker act differently in the body.
And Flunarizine and nimodipine are the only ones who pretty much just affect the brain.
http://dpic.org/sites/default/files/pdf/DIR_CCBs.pdf

if you trying this you should probabbly stick to just flunarizine.

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Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17393 on: 08/12/2012 10:02:04 »
Pseudoephedrine is a stimulant which encourages the body to produce adrenaline / epinephrine. This reduces the level of histamine, similar to the way getting an epi-pen injection counteracts a severe allergic reaction.
You're basically shocking your system out of the POIS state. Yeah, it works but, as I said, I can't see this being a long term solution but it does feel a lot better than POIS :)

Reallly good point Kurtosis! For the last month, it's become increasingly obvious to me that POIS is, at its heart, a histamine problem. As confirmation of this, ive found that foods high in histamine make me feel worse, and supplements that break down histamine, like Sam-E, make me feel a lot better!!

The only part of this theory that was still bugging me though was understanding why caffeine and ritilin make me feel better. What does that have to do with too much histamine? 

As u so precisely explain above, adrenaline clears histamine instantly, giving us relief. And then as u also wrote in another post, this explains why we get worn out so easily, mentally and physically. All day every day we have a high level of adrenaline in order to fight the high histamine.  Consequently, we have adrenal fatigue from using too much adrenaline all the time!  it makes so much sense!

I found a website a guy wrote about his problems breaking down histamine. Youll see how eerily familiar it sounds to pois.  It also explores this link with adrenaline (also know  as epinephrine).

Clip from guy's blog:
Adrenaline (Epinephrine) is the only chemical that can quickly eliminate histamine in a person. So called "antihistamines" like Benadryl only work to block some of your body's histamine receptors relieving some histamine related symptoms, they do not remove histamine. If you do go into anaphylactic shock where your organs essentially shut down, it is essential that you are injected with adrenaline immediately to counteract the dangerously high histamine level and prevent death. My histamine level was very high but not dangerous. My body tried in vain to reduce this high level of histamine to a normal level, by releasing abnormally large quantities of adrenaline into my blood stream. This created nervous energy and sometimes even panic attacks if the spikes were large enough. The body normally has a certain amount of adrenaline that increases and decreases slightly to balance your body's histamine level. In its attempt to reduce my histamine level, my body would essentially use up all my adrenaline (as shown by my blood test). This would leave me feeling anywhere from moderately tired to frighteningly exhausted. Its probably difficult to imagine being so drained of energy that it would actually scare you, but it happened to me frequently. My high histamine level also caused my Meniere's like symptoms, as well as difficulty thinking, focusing, and remembering things.
« Last Edit: 08/12/2012 10:32:37 by B_Daniel »
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.

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Offline kurtosis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17394 on: 08/12/2012 11:37:32 »
Quote
This would leave me feeling anywhere from moderately tired to frighteningly exhausted. Its probably difficult to imagine being so drained of energy that it would actually scare you, but it happened to me frequently

And epinephrine is made from norepinephrine and that's made from dopamine so the effort reduces available dopamine, possibly leading to lower metabolites of dopamine in the urine (e.g. DOPAC).

That's what I think anyway but I'm going to hold out until I see the genetic tests before making a decision about how best to deal with this. If there's no obvious methylation problem that could be affecting breakdown of histamine then possibilities include too many mast cells or mast cell instability (so a mast cell stabiliser may be the answer) or another possibility is, genuinely, a parasitic infection of some sort which may lead to increased histamine levels, impaired digestion and other problems that could account for POIS.

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Offline Prancer

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17395 on: 08/12/2012 17:24:27 »
If someone were to use an epinephrine auto injector (like EpiPen), would this instantly clear his pois symptoms? I'm just wondering & not recommending that anyone try this by the way.

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17396 on: 08/12/2012 18:37:59 »
If someone were to use an epinephrine auto injector (like EpiPen), would this instantly clear his pois symptoms? I'm just wondering & not recommending that anyone try this by the way.

Counterpoint tried this and it didnt work for him.

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Offline Kingkong

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17397 on: 08/12/2012 19:58:00 »
Hi everybody, I have good news. I've tried flunarizine (sibelium) as Nathan. I'M taking 10 mg each days since november 19th. On december 5th I had an O for the first time since two month. I had a normal night of 8 hours. The nightmares were very light. When I wook up the 6th, it was difficult but not as usually when I'm having an O. I was tired the 6th at work. I`m working in an office. Yesterday the 6th, I had a second O. I went to bed at 20 o'clock because I was very tired and I wake up at 6 this morning. So I sleep 10 hour last night. I would say that all my symptoms were gone by 10 o'clock this morning. Yesterday, I could felt a physical fatigue but about 50% mental fatigue that I have usually. Yesterday, I could felt my ganglion a bit but today absolutly nothing. IT's a lot more efficient than NIACIN. Today I had no irritability at all and no mental problem. It's a very big succes for me. I'M must say that the first 10 day that I began to take Sibelium, I was sleeping 10 hour a day and I was tired. But now it's OK. My doctor told me that by 8 weeks of taking Sibelium, I will be very hungry and could take 10-20 pounds. I will have to control myself not to eat too much. I'm continuing to take flunarizine and I 'll give more news later. I'm 53 yers old and I never felt good like that since 14 year the after I had an O. As I wrote on november 20th on this site, I'm taking citalopram for many years. Maybe i't for that reason that I was so tired de first 10 days of taking flunarizine.

I looked it up and that is one of the side effects of sibelium.
Also do you have any physical symptoms like fatigue,and fluelike symptoms.

Not saying this because of flunarizine success with some. But my first true O with another person produce the most most worst worst headache ever. I dont know how to explain it " the pain level felt like i busted a vein in my head and that pain lasted all day i couldnt get out of bed."
The only problem is, it only happened that time and never since.  And i did not notice any pois symptoms untill about three months from that day.

Yes I was very tired the first 10 day that I took Sibelium. But gradualy, the fatigue and the fluelike symptom's diseapar. Flunarizine takes two months to reach full efficient. I'm trusting my doctor when he told me that was no contraindication to take this drugs. He his 64 years old and he prescribed flunarizine a lot for headache in the past. For him is a good drug even because he had no problem in the past whit his patient taking flunarizine.

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Offline Kingkong

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17398 on: 08/12/2012 20:24:01 »
i took claritin-d 3 times already, and every time it worked.
I've tried claritin during two week two month ago and I had no benifit using that. It gave me ligh headache only.

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Offline B_Daniel

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #17399 on: 08/12/2012 22:01:49 »
If someone were to use an epinephrine auto injector (like EpiPen), would this instantly clear his pois symptoms? I'm just wondering & not recommending that anyone try this by the way.

Counterpoint tried this and it didnt work for him.

Did he?  Certainly, will you share with us the quote from the forum where he says he tried it??  I searched the forum for Epipen and saw Counterpoints say that he owned one, but didn't see him say that he had ever used it.  Unfortunately we can't ask him because somebody banned him.

I've never used an epipen, and they're dangerous to try when not absolutely necessary so don't be a hero, but I'm fairly confident we'd feel instantly better.  Anyone else have experience with an epipen??
« Last Edit: 08/12/2012 22:29:38 by B_Daniel »
2-5 days, 80% cognitive, tongue-tied, brain fog, lose track of thoughts mid conversation, anxiety, dry eyes, irritable, fatigue.  Believer of both auto-immune AND regeneration theories.  My sessions are much shorter when I've gone 2 wks without.