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From a doctor specialising in MHTR + methylation...."Niacin speeds up COMT which is one reason why it also may be useful. If one speeds up COMT, then things like dopamine and epinephrine get broken down faster. Niacin also is a ‘sponge’ for methyl groups, namely SAMe, because SAMe is required to metabolize niacin." COMT is Catechol-O-Methyltransferase enzyme.I know this goes against a number of us who feel we are low in dopamine. I can understand why our body is flooded with it during sex/arousal, but why if it is not broken down properly it would it make up feel days later like we are low in it.
May be POIS is a genetic disease like this: http://en.wikipedia.org/wiki/Carnitine_palmitoyltransferase_II_deficiency#Diagnosis
Quote from: gabin on 25/12/2012 12:16:27May be POIS is a genetic disease like this: http://en.wikipedia.org/wiki/Carnitine_palmitoyltransferase_II_deficiency#DiagnosisPerhaps it is but it's not Carnitine Palmitoyltransferase deficiency as if it was, I'd have CC instead of AA at http://www.snpedia.com/index.php/Rs28936673One of the benefits of getting your genes tested is you can rule out a lot of genetic diseases. I think POIS sufferers have a mast cell disorder brought about by methylation problems, probably low levels of BH4 / tetrahydrobiopterin. Also those with MAO A deficiency may have higher levels of serotonin, reduced levels of oxytocin and, hence, higher levels of prolactin following an orgasm. All without having an actual tumour causing the prolactinaemia. Read http://www.ncbi.nlm.nih.gov/pubmed/14514683This is interesting too. http://www.autismcoach.com/Articles.asp?ID=262and http://circres.ahajournals.org/content/101/8/752.full