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...I have no doubt that Levitra is powerful and effective for you. But you say it's only a 50-75% cure.
So it [Fenugreek] is still very successful for me!
http://www.sciencedaily.com/releases/1999/06/990617072302.htm [Links inactive - To make links active and clickable, login or click here to register]The track we are following with cortisol seems like a very plausible path because this articles supports high cortisol level for short period affects memory functions.
I understand that you'll probably have to find the [university endocrinology] boss there to ask how to initiate a research! Obviously anything we can try to be able to start something will be very welcome.
Quote from: martin88 on 20/11/2008 20:40:15...I have no doubt that Levitra is powerful and effective for you. But you say it's only a 50-75% cure.Martin, if I took 20 mg (I take 10mg now) I suspect it would be a 100% POIS cure. It's risky but I might do it. Do you (or anyone else) have an opinion about that?
Hi, haven't posted for a bit due to not having internet access.The fenugreek supplements are still working very well - I am taking 3 capsules of Solgar fenugreek before and after orgasm, as well as having a protein-heavy meal shortly after. On a couple of occasions the POIS symptoms have hardly happened at all, on a couple more they have been very substantially reduced (70%). On one occasion when I left out the protein meal and did not take fenugreek after the event, the POIS effects were only partly alleviated.So it is still very successful for me!
Quote from: martin88 on 20/11/2008 20:40:15I understand that you'll probably have to find the [university endocrinology] boss there to ask how to initiate a research! Obviously anything we can try to be able to start something will be very welcome.I think winning over the endocrinologist I'm working with might be more beneficial. They all have stellar reputations and can "fight" for a particular project/grant, etc. I'm taking it a step at a time. First step is to see what they can do for me as a POIS patient!
Perhaps cortisol has an important function in sleep. As I mentioned before, I had insomnia the nights following orgasm. And others have mentioned that Relora has actually caused insomnia. So I definitely see a connection between sleep and cortisol and orgasm.
Demo you know the [Levitra] manufactured doses are 2.5 mg, 5 mg, 10 mg, and 20 mg of vardenafil. Are you experiencing negative side-effects at 10mg? How risky would trying 20 mg once, be? The latter question might be best suited for a doctor but you've done the research I'm sure. What are your thoughts?
I've ran several google searchs and couldn't find symptoms for low prolactin. Does anyone know what these symptoms are?
Thanks for the welcome B_Jim and Demo, I feel fortunate to find so many posters who are attacking the problem with a logical and open minded approach. I get a sense that there's no real panacea here but rather a good mix of remedies that need experimentation. No need to worry though Demo, I have no intention of experimenting with any drug without proper medical supervision!I haven't had time to read through the entire thread yet so I'm reluctant to ask any questions out of courtesy but I was wondering if testosterone levels had been abandoned as a possible cause and if so why? I ask because I notice a proportional rise in libido to decline in my symptoms of POIS. Was I wrong to think of testosterone as the primary agent here?Thanks again everyone.
...The two main issues endocrinologists deal with are diabetes and thyroid problems. Many of them focus almost exclusively on diabetes, because there are more medicines to play with, so it attracts more interest, and of course more money. And as far as the thyroid issue goes, most endocrinologists are VERY CONSERVATIVE and ENTRENCHED in strong opinions about thyroid tests and treatments."Endocrinologists are the accountants of medicine," writes Mary Shomon. "They love numbers and many are more comfortable reading lab charts and numbers off blood test results than interacting with patients or engaging in creative problem-solving.So be fore-warned! AND definitely be prepared!
RE MY SEEING A UNIVERSITY ENDOCRINOLOGIST (December 2)I'm also going by a consensus that has been reached by a number of people here at this forum, that an endocrinologist sifting through all of our posts/data can only be beneficial. And from nearly two years ago when this forum was started off by John21, that's been the consistent first choice of medical professional to assist us all. But I will heed your warning. I just hope that I meet with an anomaly. A good one!If I am treated well and logically (I will share my experience with you all) I will try to get us to a next step of either hopping on to an existing clinical trial or some research study (Government, private, or pharmaceutical) as a "POIS subset" or seeing if we can somehow get some assistance in sifting through this huge mass of data known as The POIS Forum. I don't know about you, but my head is SPINNING with all the good POIS theories, individual forum members' experiences, forum members' drug/supple-ment trials, etc. that whiz by every day on our computer screens! B_Jim, Counterpoints and others have done superb distillation work, but we need some more synthesis, summarization, hypothesis/testing, etc. by a medical professional(s). Naturopathic or any other form of testing that can yield POIS relief is most welcome as well.At this stage, I think we all need to keep it very simple. This is merely ONE more step that we are trying out amongst MANY attempts we have made to get professional outside help. And frankly, we're not exactly blazing any trails; we are a small group with a rare malady, not top-of-mind for the medical research community at large! And so far, what this particular discussion really boils down to is...that I have a doctor's appointment 
Don't get me wrong, I think it's a great idea to see an endocrinologist. I'm just sharing with you what I have been told by some other patients (with CFS and thyroid issues) and what I've read about this branch of medicine. I think it would DEFINITELY serveyou well to be VERY WELL PREPARED for that visit, with as much of your own personal medical data as possible...
Demografx: Extreme physical exhaustion does not sound like a sign of high cortisol to me (though I could be wrong, and a better answer would not be so simple)...
Quote from: tarkington on 21/11/2008 21:25:17Perhaps cortisol has an important function in sleep. As I mentioned before, I had insomnia the nights following orgasm. And others have mentioned that Relora has actually caused insomnia. So I definitely see a connection between sleep and cortisol and orgasm.There is definitely a connection between adrenal health and insomnia. Check out the article below.http://www.nutritionalmedicine.org.uk/phdi/p1.nsf/supppages/franklin?opendocument&part=6 [nofollow]
Quote from: Counterpoints on 23/11/2008 00:36:40Demografx: Extreme physical exhaustion does not sound like a sign of high cortisol to me (though I could be wrong, and a better answer would not be so simple)...Counterpoints, that's exactly my concern. I would recommend that the cortisol path be examined concomitantly with the fatigue path. I, for one, am typical of the fatigue-as-primary-symptom crowd. I think you're more in the cognitive-impairment-as-primary group.
A few things I want to put out there.1. Personally, I've quite the opposite of insomnia while experiencing POIS symptoms. In fact, for several hours afterward, I can barely keep my eyes open. 2. Sleep is one of the things that, for me, "heals" the symptoms.3. On the occasions where I only get 1 or 2 hours of sleep, I feel physical/mental fatigue similar to POIS even if I did not orgasm beforehand (or beforecoital - ability to come up with bad puns isn't harmed).OK, I'm both then - severe physical and mental fatigue.
Also there was an other person who was helped with Levitra, sorry I don't remember who. It would be helpful to have an answer (just to be sure) to the following: were you taking other meds with Levitra?
on 17/10/2008 08:32:56...she prescribed me Levitra - which is why I felt obliged to register and post here today. On Levitra, I can confirm that the POIS symptoms were lessened dramatically post-orgasm. Even after an awesome load, I can still get up and do things. I don't feel paralyzed. However, I've never masturbated with Levitra and only used it for a short while until I was comfortable with my girlfriend - So my testing was limited.
It's good to remember when we are addressing the issue of fatigue that the brain is actually part of the body. So mental fatigue in a certain respect is physical fatigue, just in a different location.http://www.pnas.org/content/99/16/10237.full [Links inactive - To make links active and clickable, login or click here to register]
Like Whoa when i use relora, i tend to get sleepy. When i started using it, all i did was sleep. But now i don't fall asleep as easily but when i go to sleep, it is scarily deep. 3 hrs of sleep feels like i have slept for days in terms of intense dreaming.
It's written "more than 140 cases of pois" in the front of the forum but there is only a few filled forms for now.
Can someone suggest a good, short definition of POIS that I can give to my endocrinologist?
Why don't you just use the [POIS] definition that's on my YouTube video...
Also if someone has a good article concerning SSRI or SNRI and cortisol..
I am a 24 year old healthy male with no health problems whatsoever.
My mother died in a hospital because the epinephrine they gave in the ER wouldn't work because her doctor had upped the dose of high blood pressure medicine.
Quote from: martin88 on 23/11/2008 03:41:19Also if someone has a good article concerning SSRI or SNRI and cortisol..I asked a psychiatrist friend. Awaiting reply.
Martin ,FYI, I found this by "advanced googling":Levitra site:http://www.thenakedscientists.com
Quote from: demografx on 23/11/2008 17:30:47Martin ,FYI, I found this by "advanced googling":Levitra site:http://www.thenakedscientists.comA chance it was not too far. Sorry Whoa, I have too much e-mails to treat, my memory is full. It would be great to know if you took other meds with Levitra.
I forget if I mentioned this before... I am wondering if prepubescent sex could have caused damage somehow to the developing system. I began before I could produce any semen, it wasn't until sometime later that I ejaculated after masturbation. Girlwind has also told us how she began at a very young age. Was anyone else here sexual before puberty was complete?
[Is there] a good article concerning SSRI or SNRI and cortisol[?]...
I agree with you Demografx. Whether it's regarding POIS or CFS, I don't feel it's helpful to look back at our childhood years with an attitude of blame for an adult onset medical condition. First of all, I don't thing there's anything wrong with children experimenting with their bodies sexually, as many, if not most, healthy curious children do. Child orgasms can begin as early as 5 months of age. (Read the Kinsey research from the 1950's, the report from Life Planning Education in Washington DC or Sigmund Freud's "Infant Pleasure Potentials.") Secondly, if childhood or teenage sexual activity doesn't become consistently excessive, then it's most likely a NON-issue as a contributor to POIS. Even if it is excessive... who knows IF that might be factor.
Quote from: John21 on 24/11/2008 00:38:34I forget if I mentioned this before... I am wondering if prepubescent sex could have caused damage somehow to the developing system. I began before I could produce any semen, it wasn't until sometime later that I ejaculated after masturbation. Girlwind has also told us how she began at a very young age. Was anyone else here sexual before puberty was complete?I began at a very young age too, around 11. I would orgasm and not even ejaculate.
Yeah, there appears to be three different levels of scope to look at our research- Broad (society level)- finding the cause, a cure, and help preventing additional cases of POIS- Intimidate (POIS community level) - find the cause and a cure or temporary relief for POIS- Narrow (individual level) - finding temporary reliefFrom my observation, the forum people that have been around the longest are primarily looking at the intermediate level and touching on the broad level (by seeking professional medical advice). Others have had tremendous success at the individual level with OTC supplements. IMO we need both chiefs and Indians researching and pooling our information to give us the best chance for success at any level (which we seem to be doing).