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Great work Demografx!I think we should send to1) http://rarediseases.info.nih.gov/2) e-mail/post a letter to AACE President3) e-mail the endocrine project.It could be the same letter for each (with small modifications: e.g. a sentence at the beginning of each letter explaining why we decided to write to that particular organization). At a glance, http://rarediseases.info.nih.gov/ shows the most promise. The WHO letter would serve as a good template. How about we aim to have these letters sent out by this time next week? I can offer some editorial/writing assistance on Mon,Tues.emphasis mine for draft deadline to CP
Just found this and had never read this before..... anyone else miss this....I found it at http://forum.mesomorphosis.com/mens-health-forum/post-orgasmic-illness-syndrome-134261293.htmlThey did not say this is the answer.... they just found it interesting....QUOTE:This is called orgasmic stress (OS) induced by excessive conversion of dopamine-norepinephrine-epinephrine in the brain and adrenal glands under the sympathetic nervous function for you to achieve orgasm. Action of Norepinephrine and Epinephrine on the sympathetic alpha receptor causes constriction of blood vessels upon orgasm. Excessive norepinephrine and epinephrine (excessive stress and anxiety) will eliminate the relaxation hormone prostaglandin E-1, resulting in tension in the rear brain, neck and shoulders where the norepinephrine and epinephrine neurons are very dense. Neck and shoulders have the densest neuro-hormone epinephrine and norepinephrine receptors in the body, followed by the urogenital areas (uterus, ovaries, vagina, clitoris, penis, testicles, and prostate), digestive tract and head skin. That is why stress, anxiety and panic can cause neck and shoulder pains and face cramp, urinary incontinence, infertility, prostate/uterine/ovarian tumors/cancers, prostate enlargement, erectile dysfunction (impotence and frigidity), digestive dysfunction, stomach cramps, and even hair loss(yes! Stress causes hair loss!). Excessive orgasm can produce Orgasmic Stress, resulting in these problems too. If you have a good blood circulation, excessive neurohormones Norepinephrine and Epinephrine can be dispersed out of the local tissues, then metabolized by the liver and expelled by the kidneys to the bladder. The un-metabolized neurohormones can also stimulate the bladder and urethral sympathetic nerves. A low level of DHEA and androstenedione / estrogen will also cause excessive sympathetic nervous functions. Nausea is due to excessive epinephrine (sympathetic nervous functions) in the digestive systems - digestive stress.Your body's responses to orgasmic stress out are the same as your work stress out. The difference is that the orgasmic stress occurs instantaneously upon orgasm and during sexual tension (extreme arousal), but both orgasmic and work stresses can last very long. To solve the orgasmic headache and nausea Orgasmic Stress), you have to1. reduce the dopamine-norepinephrine-epinephrine conversion in the brain and adrenal medulla, and the epinephrine level in the bloodstream (who can do those? 5-HTP and Kava Kava!);2. partially block the sympathetic alpha receptors;3. increase the DHEA/androstenedione (for balancing testosterone and estrogen!) levels;4. increase the acetylcholine and serotonin levels to modulate the sympathetic function for orgasm - de-stress the body for orgasm;5. partially inhibit the acetylcholine re-uptaking in the synapses and power the parasympathetic nervous functions to balance the sympathetic functions that induce stress against the cardiovascular, digestive, liver, kidney and adrenal functions;6. increase the prostaglandin E-1 (PGE-1) production in the local tissues by increasing the DHEA, acetylcholine (and its neurochemicals), and androstenedione levels;7. Improve the local blood circulation by massage to quickly remove epinephrine and norepinephrine from the local tissues and to quickly replenish the local tissues with the nutrients, oxygen, DHEA/androstenedione and neurochemicals for the synthesis of PGE-1. Heating the local tissues can also promote the PGE-1 production to release the pulling or constriction pain. Massaging and heating on the neck and shoulders can extensively affect the PGE-1 concentration in the brain stem.Note that Massaging and Heating the low abdomen, low back and tail bone can do the same effects on the PGE-1 production for release of the PMS or orgasmic/post-orgasmic pains or cramps in the low abdomen, low back/tailbone, and pelvic floor PS
Thanks Demo for your work. Here is an additional way you can go :In this study (which is very interesting) there are some names and email of people to contact :http://www.ncbi.nlm.nih.gov/pubmed/11760788If they want, I think these doctors can really know how to help us because they already have done similar studies.A problem we'll face, even if we have a researcher, is to be able to regroup a good number of pois sufferers to participate.Do you think it could be possible to organize research on pois in several labs? Ex: One researcher gives some directives to our own endo to organize the research.
Fascinating study, Martin. But I don't see where the emails are.
You didn't tell me I had to open my eyes and look!! 
I just wanted to respond to this because it was something that looked like it could go into the compendium...but excessive conversion to dopamine to norepinephrine to epinephrine, based on my biochemistry classes, doesn't make too much scientific sense. Although I suppose it is possible (by a super long shot) that we overexpress the enzyme between dopamine and norepineprine and underexpress the enzyme between norepinephrine and epinephrine, which might cause a buildup of norepinephrine to abnormal levels and cause POIS.
Martin, the prolactin article is interesting. My endo says that we don't really understand the role of prolactin in men. In women, it's obvious (lactation).
We just hit 200 Pages! There must be a significance to that somewhere!!! 
Pois Sufferer,5000 posts is a lot! Maybe when we'll be to 50000 posts we'll finally find a reason and a cure for pois !If possible I wanted to know more about your Ativan experience, does this work everytime ? And are you taking this immediately after release? Thanks
I get really bad sometimes with very scary inability to talk.... and also very odd dizzy, sort of a head ache, very hard to describe feeling in my brain!
martin88,What dosage of ATIVAN? Is it the type you swallow or the one you put under your tongue? I use the under the tongue type it only takes 10-20 minutes to kick in, and 1mg, I jave tried the swallowing type at at 1mg for that type I do not get the same results, not as good. (I weigh 200lbs if that makes a difference to dosage)If I take 2mg all at once I can start to not remember things that happened for the next 8-10 hours! So its rare for me to go above 1mg.PS
Quote from: demografx on 19/06/2009 03:38:51We just hit 200 Pages! There must be a significance to that somewhere!!! There is... 25 posts per page 200 pages or... 5000 posts!PS.
[Just in case my precedent post was misinterpreted (it was edited also), I'd like to add that I'm not for any form of censure here. I think that anyone without exception is welcome here to express whatever he thinks to be relevant ]
Quote from: martin88 on 21/06/2009 22:40:37[Just in case my precedent post was misinterpreted (it was edited also), I'd like to add that I'm not for any form of censure here. I think that anyone without exception is welcome here to express whatever he thinks to be relevant ]Martin, generally I would agree with you. But from past experience, I feel that there are exceptions: (1) spammers, i.e., blatant advertisers (2) ad hominem attacks on other forum members (3) outright quackery (dangerous medical suggestions or totally false medical information) (4) "street language", e.g., referring to human anatomy, sex, etc. is inappropriate in a Science forum, (5) acting against the interest of the forum, e.g., misrepresentational letters to organizations purporting to be the "voice" of this forum.I have taken appropriate action in all these cases, which has generally been supported by the members here as well as Naked Science Forum administrators.But I think you're right that opposing points of view should generally be tolerated, which is the spirit of a forum.
many thanks for your involvement as a moderator, which I know is not always an easy task!
Question... I find it very difficult to "abstain" for more than 3 days. I get very tense, I find it difficult to focus, and my thoughts become less fluent -- as does my writing. This isn't the same as POIS, I imagine it's somewhat common for people who have gone long periods of time, but it's probably related. It's severe enough that my productivity decreases, even when I am trying my best to focus.I'm wondering if anyone else had trouble with this? I hear about people going weeks, a month, or even months without release. Do you start to feel really agitated after a week?
Question... I find it very difficult to "abstain" for more than 3 days. I get very tense, I find it difficult to focus, and my thoughts become less fluent -- as does my writing. This isn't the same as POIS, I imagine it's somewhat common for people who have gone long periods of time, but it's probably related. It's severe enough that my productivity decreases, even when I am trying my best to focus.
sorry to cut in like this guys, but I gotta ask if anyone has any blood test data on ACTH levels (Adrenocorticotropic hormone); I think I'm close to a comprehensive theory that can be supported by data.
My last post was on 6/17 and today is the first day I feel good again. My wife approached my to have sex today, we did but in the first time in 21 years of marriage I purposely did not have an orgasm because I did not want to fell like gargage again. POIS sucks!!!