Post Orgasmic Illness Syndrome (POIS)

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5550 on: 11/09/2009 04:41:20 »
http://www.anxietyinsights.info/overactive_brain_endorphin_system_linked_to_depression.htm

just found this, overactive endorphin system?  Maybe endorphins released during sexual climax results in this system to overactivate?

It is "a pain killer 3x more effective than morphine"

And I do realize that when in POIS I get these "good" feelings associated with the terrible POIS feeling, maybe endorphin release followed by my brain trying to get off the "drug" is what causes POIS.  Almost too many ideas.
« Last Edit: 11/09/2009 04:52:51 by goingcrazy »

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5551 on: 11/09/2009 04:42:26 »
goingcrazy

whoever answered must have minute grey matter for giving an answer like that.

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Offline Itsmebutwho?

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5552 on: 11/09/2009 10:48:35 »
Is it possible to have sex/masturbate (ejaculate) wrong way?

I have had many years many of these POIS symptoms, depression, very low mood, foggy mind, very introverted, very bad weakness in my body and mind, coldness, flu like feeling, concentration problems, pains everywhere in body, allergy symptoms and so on... all after 1-2 days from ejaculation. And recovery has taken always few days if i stay without ejaculating those days.

I have tried many solutions from here, totally changed how i eat and had lot of exercise, without much help. Well, i feel healthier but the POIS symptoms havent disappeared.

I also tested my testosterone levels, the result: 15.... quite low but not below limit.

Last few months i have been thinking that why i have had sometimes couple of weeks' periods that i havent felt POIS symptoms much at all. I noticed that during those days i have been masturbating different way, i have made it slowly, teasing myself, not letting ejaculation come fast.

I also noticed during these last months that i can ejaculate/masturbate/have sex different way than i have had done during my whole age. Most of my times i have masturbated/had sex as being very consciously what i have been doing as having sex or masturbated. I have controlled my body.

But now i have noticed, my body can do those things automatically, without i make my body do it. I usually use homemade vagina if im masturbating. Most of my times i have put my penis in and start to move my body and kept moving it. But now... I have noticed if i want to have sex, i put my penis in and hold it still, and watch some sexy babes, my body actually starts to move by itself, without i consciously do it by myself. I dont actually need to do it by myself, my body does it for me. All i need to do it just watch and enjoy.

How it all goes:

I put my penis into vagina, i may make some conscious movements by myself and watching something hot same time. I dont usually do it long time. I just stop or slow down my pace, relax my body/pelvis, then it happens, my body seems want to do it. My penis needs to get just little touch from the vagina around it and it makes my body move back and forward. I dont need to do it by myself. I let my body do so, and i keep watching my sexual objects.

There comes a point when my breath begins to get faster, and thats very important point. The point makes my body move faster and faster, my breath gets also faster and faster. I start to loose time and space, my body begins to get good feeling. Things around me blurs, my eyes which first wandered around on woman's body, actually goes out of control, and locks on usually woman pelvis/vagina. My body does it automatically, without i do anything, crazy speed and the breath feels also so weird...so fast, not normal what i have experienced during my past years as having sex/masturbated. Then i get my orgasm, it feels so great and relief... whats more, i really feel good after ejaculation.... that havent happened most of times my past years... And the good feel just continues.... Next day i feel still good, no much sadness, no much depression, and i have energy....im able to think..... it feels weird...

But if i do it fast way, consciously, and control my masturbation/sex moment ... the result is POIS symptoms.

I have kept thinking why it is so...? Does my body release more testosterony this way? And the 'wrong' way does something else/bad to my body?

Is the key just let animal insticts come alive, let off the control?  [:)]
« Last Edit: 11/09/2009 11:48:06 by Itsmebutwho? »

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Offline Z_one

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5553 on: 11/09/2009 21:33:09 »
Hello everyone,

I am new to the forum, though have been following up closely on it since a couple of months now....I am a 30 years old male and  POIS sufferer since almost 6 years.. yet I only truly understood what was happening to me when I discovered this forum one year ago and thus putting an end to endless speculations, doubts and assumptions......mostly and like many POIS sufferers, I had to endlessly explain, convince, repeat to doctors that what was happening to me was not psychological but physiological….thankfully now there is enough proof and thanks to this great forum that POIS is 100% real !

Though i have seen many propositions going from Fenugreek to Rerola as remedies as well as POIS theories such as nerodrelanine and auto-immune diseases….one thing is sure not everybody is alike and in my opinion they might be more than one cause that are all inter-related and leading to the same problem yet all post orgasmic,,,,

Meanwhile,

I was wondering whether anyone has tried "black seed oil" (Nigella Sativa}  ?.....I personally take two large spoons of it just at the beginning of my symptoms and it seems to be a great boost overall; especially if combined with any light juice such as lemon or orange juice.....mostly if taken continuously in safe doses and in intervals...I noticed that it considerably decreases overall symptoms (I would say by 75%) as well as recovery time by half....(From one week to three days)… I watch out, since too much of it can cause kidney disease just like too much of anything,,,,,

Also, and as obvious as it might sound....through trial and error...I got to notice the great benefits of a sunbath for a couple of hours,,,,i have done some research and found that sunrays have great healing benefits on the endocrine and immune systems and are often underestimate from fear of skin cancers....it accelerates healing and recharges the body with energy and mood.....I personally have found sunbaths very beneficial in decreasing recovery time....and boost overall energy...of course that is not an option for those living in cold weather countries; unless they take a break to Cuba or Dubai after each POIS.... [8D]...


In addition ,I noticed again and through trial and error and some logic...that a fully loaded banana milk shake with some whey protein & bee pollen or honey greatly assists the body in recovering from the symptoms and mostly reduces compulsive eating disorder since ....Whey in particular has many immune friendly properties if taken in reasonable amounts as well as provides the body with fullness and satiety,,,, So I think you might have guessed it , on weekends while I am half dead on the side of the pool, I always ask for a fully loaded banana milk shake with HONEY PLZ! 

Anyway, I am personally a great believer that for every illness there is a cure….yet if the cure if not directly pointed out by God must be digged  out by humans….As such I  like many others have declared war against POIS and I am gathering every bit and piece from this forum  and going to present all of  it to my GP & endocrinologist on Monday,,,,,,(Already done some blood tests waiting for results,,,,) I will sure post anything relevant once I finish my diagnosis…..

Last but not least....I just would like to remind everybody about the great health risks that herb supplements can cause....especially in what concerns drug-herb and herb-herb interaction....I recklessly took an anti-histamine drug combined with a couple of herbs and almost died that day from my symptoms....also too many herbs can slowly kill your kidneys or liver without you noticing the early stage symptoms….and therefore too much trial and errors might have fatal consequences….

Finaly, I personally would like to thank the initiators of this forum including all those who shared their stories whether fully cured or not…..also special thanks to Girlwind for that great video on youtube,,,,I truly think that if each and every POIS sufferer including myself  does enough noise to create awareness for this life ruining illness,,,,,that media, specialists, doctors, health associations will look even more seriously into POIS and hopefully thrive to find us a clear concise definite answer and a cure that would cause all of us an orgasmic scream of joy !!

Kind regards,
« Last Edit: 11/09/2009 21:53:30 by Z_one »

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Offline lauracostis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5554 on: 11/09/2009 23:19:32 »
demografx

is the levitra your taking just for erectile dysfunction or is it for pois, what dosage do you take? how and when do you take it.  i know that levitra dialates blood vessels and stimulates conversion of cyclic gmp.  it works on many other areas of the body, dialting consricted vessels in the lungs. 

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Offline Z_one

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5555 on: 12/09/2009 00:10:23 »
Check out this : Bodybuilding.com Forums > More General Categories > Misc. > Why do people try to stop fapping?

Look up for the great posts by Devil_Z , I am sure the key to the solution is there,,,,

Z.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5556 on: 12/09/2009 04:16:20 »
Check out this : Bodybuilding.com Forums > More General Categories > Misc. > Why do people try to stop fapping?

Look up for the great posts by Devil_Z , I am sure the key to the solution is there,,,,

Z.

Can't find it, they may have taken it off or something, can you give us a link?

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5557 on: 12/09/2009 05:15:24 »

demografx

is the levitra your taking just for erectile dysfunction or is it for pois, what dosage do you take? how and when do you take it.  i know that levitra dialates blood vessels and stimulates conversion of cyclic gmp.  it works on many other areas of the body, dialting consricted vessels in the lungs. 


Laurac, at one time I thought Levitra was "the cure" for POIS (for me). But I was taking testosterone injections at the time, so I might have misattributed what was working. Then the Levitra started to "fade" as a cure, but my testosterone use was also dwindling and then eventually discontinued.

Back then, and now, the primary reason for taking it was for ED.

Now, daily testosterone patches 15mg, appear to cure my POIS 75% to 90% per episode. Eight months since I've been on this treatment.

One theory I have is that - even if we're not low on testosterone, a boost might work nevertheless, for some people. I have just increased my dose 50%, with doc's approval. I just wrote to my endo to get his opinion on my theory.
« Last Edit: 12/09/2009 06:16:09 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5558 on: 12/09/2009 05:25:27 »

itsmebutwho? and Z_one, welcome to the POIS thread of The Naked Science Forum!




Here are some POIS resources which may be helpful to you:

Our new POIS Information Website, built by "mat780", is here:
http://sites.google.com/site/poiswebsite/

Please see "B_Jim"'s POIS Summary of All Cases, here as well as others on the Web. This includes remedies that we have tested, and results.
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

"Girlwind" has created an excellent POIS Video:
http://www.youtube.com/watch?v=UWBxAUC9k1g

And filling out the POIS survey created by "Counterpoints" will enable you to share POIS information and details with others here. This will also enable us to work more easily with outside researchers by having more organized data available about us:
http://pois.olympe-network.com/

POIS Research Study

We have a copy of the first and only study on POIS by Dr. Marcel Waldinger,MD and Dr. David Schweitzer, MD.

If you want a copy (PDF), send me a Private Message with your regular email address and I'll send you back the PDF.

To send a Private Message, click on "Messages" at the top of this page. At the Messages page, click on "New Message". From that point on, it works just like posting a message here, except that it only goes to the person(s) you designate.

Remember to put a quote around my name, i.e., "demografx".


New York Times article,

January 20, 2009
Mind
Sex and Depression: In the Brain, if Not the Mind
By RICHARD A. FRIEDMAN, M.D.
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

In addition to serving our own informational interests, the resources listed above can be useful for you to show the medical world - which often shows little understanding and is sometimes skeptical of our condition - that POIS has scientific underpinnings and that POIS is not "just another psychological problem" related to sex - to be treated by the psychiatric/psychotherapist community. This can help fight the immediate reaction of some: IT'S NOT "ALL IN OUR HEADS"!

Also, it can be helpful when dealing with medical professionals to point out the successful existence of our rapidly growing forum for over 2 years, which has attracted over 150 POIS sufferers worldwide who have posted here, plus more than 350,000 page visits. Not bad for a rare malady!

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5559 on: 12/09/2009 05:26:56 »

itsmebutwho? and Z_one, this post might help you find information about POIS that we have already discussed, by tailoring a Google search to this forum:


SEARCH THE FORUM WITH GOOGLE

We have an overwhelming amount of data: over 2 years' worth of posts from 150+ Forum members, and an additional 150 POIS sufferers found on the Internet, but not on this forum.

In the Google search box, type
whatever-it-is-you're-interested-in-finding-out[space]POIS[space]site:http://www.thenakedscientists.com/

for example, I tried
demografx POIS site:http://www.thenakedscientists.com/

and 1,000+ results came up for "demografx" within the Forum.

be careful with spaces (you can use them before the word "site") and no-spaces (everything after the word "site")

Google even provides you results with the Message# for each result. But Message #'s do change, so be patient and look for the approximate Message#.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5560 on: 12/09/2009 05:31:39 »

Testosterone does not help my pois. im on shots 2x a wk and my level is 789 but still have the symptoms after orgasms. I also take an estradoil blocker now, becuase T converts rapidly into estrogen. my level was 105 a year ago, so i assumed thats why i felt so bad after orgasm. It wasnt the answer. Im a 47 yr old male.


My injections didn't work well either and my endo explained that the injections "spike" then drop precipitously, which is why I was put on patches. Patches (worn 24/7) simulate the way testosterone naturally flows throughout the system steadily, rather than violently swinging up, down and out - as my endo believes is the case with injections.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5561 on: 12/09/2009 07:18:45 »

One theory I have is that - even if we're not low on testosterone, a boost might work nevertheless, for some people. I have just increased my dose 50%, with doc's approval. I just wrote to my endo to get his opinion on my theory.


Reply from my endocrinologist: "Blood levels may not reflect tissue sensitivity - so the only way to tell is to test that hypothesis."

What got me thinking about this is that 8 years ago, desperately seeking a cure for my POIS, I contacted a well-known sexology-researcher in Czechoslovakia, and his immediate reply to me - without knowing whether or not I was testosterone-deficient - was...."testosterone!"
« Last Edit: 12/09/2009 07:21:23 by demografx »

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Offline pauliebaby61

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5562 on: 12/09/2009 15:00:50 »
demografx----
I have used androderm patches, but they did not work and  severly burned my skin. I also used compounded T and Testim, both DID NOT work and never boosted my T level like the injections do.Testim made me really nauseaous for days---terible product imo
I now do .375cc of T 2x a week and take a pill that blocks the conversion into estrogen. I seem to feel more manly and confident now and have tons of facial and body hair growth, which i never had before. I could try a higher dose, but i dont see it affecting the pois symptoms. It seems to mimic a depletetion of something, and then it slowly builds up over 1-2 weeks.


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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5563 on: 12/09/2009 15:41:50 »
Paulie, many thanks for sharing that! As I mentioned, my theory may only apply to some sufferers...or maybe none.

But I find it hard to believe that I'm the only one whose POIS can benefit from testosterone.

Paulie, can you please explain, "It seems to mimic a depletetion of something, and then it slowly builds up over 1-2 weeks."?

Thanks again!
« Last Edit: 12/09/2009 15:48:20 by demografx »

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5564 on: 12/09/2009 16:13:30 »
Does anybody have an idea towards why POIS is worse in the morning?  (at least for me)

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Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5565 on: 12/09/2009 21:33:51 »
well taking copper after an O doesnt help. even with ADD meds softening the blow. what a terrible week at work... even got taken before the boss for screwing up. what do you say to him? "uh sorry I got POIS after having an O last weekend" ROFL

well POIS has made it into a 2009 book about intimacy

http://books.google.com/books?id=88EU4S8BhtoC&pg=PT125&lpg=PT125&dq=post+orgasmic+illness+syndrome&source=bl&ots=AAF1fQY8Yk&sig=VjbIa3HEljV3UmQQ98xaEO_2XYw&hl=en&ei=if6rSrTWEZLSMuCm2PIN&sa=X&oi=book_result&ct=result&resnum=29#v=onepage&q=post%20orgasmic%20illness%20syndrome&f=false

though after the mention of POIS she says "the usual cure" is to have more O's.

lol

(looks around naked scientists forums)

hmmmm i missed that "usual" cure somewhere....

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5566 on: 12/09/2009 23:07:28 »

Does anybody have an idea towards why POIS is worse in the morning?  (at least for me)


Mine's worse in the evening. My no-POIS/low-energy time is evening.

Maybe your no-POIS/low-energy time is morning?

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5567 on: 12/09/2009 23:16:40 »

well POIS has made it into a 2009 book about intimacy

http://books.google.com/books?id=88EU4S8BhtoC&pg=PT125&lpg=PT125&dq=post+orgasmic+illness+syndrome&source=bl&ots=AAF1fQY8Yk&sig=VjbIa3HEljV3UmQQ98xaEO_2XYw&hl=en&ei=if6rSrTWEZLSMuCm2PIN&sa=X&oi=book_result&ct=result&resnum=29#v=onepage&q=post%20orgasmic%20illness%20syndrome&f=false

though after the mention of POIS she says "the usual cure" is to have more O's.

lol

(looks around naked scientists forums)

hmmmm i missed that "usual" cure somewhere....


The author, "reuniting" aka Ms. Marnia Robinson, is a good friend of this Forum, she has been extremely supportive of us. Counterpoints and 1-2 others have reported the cure you mentioned, which is intermittent, i.e., it doesn't always succeed.

I just recently posted about the book:


Interesting new book

Marnia Robinson, aka "reuniting" has been a POIS Forum member for quite some time and has contributed quite a bit to us. She and her husband are world-class experts in sexual relationships. Her new book looks like it might give us some more insight into POIS:
http://www.reuniting.info/cupids_poisoned_arrow


                       

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5568 on: 13/09/2009 01:13:34 »

Does anybody have an idea towards why POIS is worse in the morning?  (at least for me)


Mine's worse in the evening. My no-POIS/low-energy time is evening.

Maybe your no-POIS/low-energy time is morning?

In the morning I wake up and just cannot "focus", and still feel like I'm dreaming for about an hour or two after I wake up.  No-Pois?  Sometimes when I wake up it feels like POIS has recharged itself during sleep, but so has my body.  Very awkward feeling.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5569 on: 13/09/2009 07:13:44 »

No-Pois?


No-POIS: meaning a day when we're not in-POIS or recovering, i.e., a "normal" day.

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Offline Pronobis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5570 on: 13/09/2009 11:58:25 »
URGENT DANDRUFF

Hi everybody,

I have posted a similar question several times but I haven't got a right answer.
I have a dandruff since a year ago. I have got some product and I can treat it easily. But after each ejaculation it comes back in worst way (some hours after the ejaulation). Please tell me if you have the same problem and could it be due to POIS.
Thanx

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Offline Z_one

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5571 on: 13/09/2009 14:58:06 »
Thx "Demografx" and "B_Jim" for the welcome.....

"Goingcrazy" I tried inserting the link but the forum is not accepting it...maybe it's too long or something,,,,,though B_jim has successfully accessed it, therefore I don't think they removed it !


Z.
« Last Edit: 13/09/2009 15:02:15 by Z_one »

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5572 on: 13/09/2009 17:20:29 »
I don't know if by chance or not, but stretching my neck out and rotating it circularly seemed to actually calm me down a bit during POIS.

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Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5573 on: 13/09/2009 17:38:26 »
hmm a couple things in this I havent heard of, like ACTH-MSH peptides and opioid peptides

The neurophysiology of the sexual cycle.

from:http://www.ncbi.nlm.nih.gov/pubmed/12834016

"The cycle of sexual activity in men and women occurs in 4 phases--excitation, plateau, orgasm, resolution--which are guided by sexual desire. Male sexual activity is characterized by erection, seminal emission and ejaculation (orgasm), whereas female sexual activity is characterized by vaginal lubrication, erection of the clitoris and orgasm. These responses are under the control of numerous central and peripheral neural systems. The central supraspinal systems are mainly localized in the limbic system (olfactory nuclei, medial preoptic area, nucleus accumbens, amygdala, hippocampus etc.), in the hypothalamus and its nuclei (paraventricular and ventromedial nuclei). Neural information travels through the brain stem, the medulla oblongata, the spinal cord and the autonomous nervous system to the genital apparatus. While we have very detailed knowledge of the neural mechanism, which controls the function of the male and female genital organs, in particular those mediating erection, very little is known of the central mechanism involved. Nevertheless, several neurotransmitters and neuropeptides, such as dopamine, glutamic acid, nitric oxide, oxytocin, ACTH-MSH peptides, are known to facilitate sexual function, while serotonin, gamma-aminobutyric acid (GABA) and opioid peptides reduce it. At the level of the paraventricular nucleus a group of oxytocinergic neurons projecting to extra-hypothalamic brain areas, including the spinal cord, have been identified, which facilitate erectile function and copulation when activated and reduce both when inhibited. Although the majority of results, which have clarified the mechanisms involved, have been performed in males, it is believed that similar mechanisms are also operative in females."

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5574 on: 14/09/2009 01:35:26 »
any body ever try that querctin supplement, it is suppose to be antihistamine and help with energy. I think studies on it is still early though.
http://www.umm.edu/altmed/articles/quercetin-000322.htm

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Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5575 on: 14/09/2009 23:00:46 »
I was listening to NPR today about chemo-brain (info here: http://www.cancerhelp.org.uk/help/default.asp?page=40136)

symptoms:
    * Memory loss – forgetting things that you normally remember     
    * Difficulty thinking of the right word for a particular object     
    * Difficulty following the flow of a conversation     
    * Trouble concentrating or focusing on one thing     
    * Difficulty doing more than one thing at a time (multi tasking)     
    * More difficulty doing things you used to do easily, such as adding up in your head     
    * Fatigue (tiredness and lack of energy)     
    * Confusion     
    * Mental fogginess

okay why am i mentioning this, well Jim mentioned cytokines before... the doctor being interviewed said that some of the people who exhibit these symptoms have high level of cytokines in their blood. And they dont know why the cytokines could be causing them.

There exists a Cytokine panel of blood testing that can be done, like this one: http://www.lef.org/Vitamins-Supplements/ItemLCCYT/Cytokine-Panel---IL1b-IL6-IL8-TNF-Alpha-Blood-Test.html

The Cytokines in chemo-therapy result from an auto-immune response. Maybe for some of us the POIS is a auto-immune reaction triggering large amounts of these cytokines to be released. Once I have the health insurance again, I am definitely doing to get this panel done after a few O's (god that will be a crappy week at work lolz =)

Even in healthy males, studies (like this one: http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=79409&Ausgabe=230291&ProduktNr=224176) have shown that an O causes an immuno reaction by the human body.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5576 on: 14/09/2009 23:08:51 »
Defsync, how come those individuals dont experience POIS?



More info about cranberry...

I O'd about a week and 2 days ago and symptoms are slow in diminishing.  I just started drinking cranberry juice again and it almost brings about more POIS symptoms.  I don't know what is going on.  It could be helping or it could be hurting me.

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Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5577 on: 14/09/2009 23:30:31 »
Defsync, how come those individuals dont experience POIS?

dont know for sure, tho from the looks of it the immuno reaction is very very low, compared to what the cancer patients experience post-chemo

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Offline Finally

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5578 on: 15/09/2009 04:10:32 »
I was listening to NPR today about chemo-brain (info here: http://www.cancerhelp.org.uk/help/default.asp?page=40136)

symptoms:
    * Memory loss – forgetting things that you normally remember     
    * Difficulty thinking of the right word for a particular object     
    * Difficulty following the flow of a conversation     
    * Trouble concentrating or focusing on one thing     
    * Difficulty doing more than one thing at a time (multi tasking)     
    * More difficulty doing things you used to do easily, such as adding up in your head     
    * Fatigue (tiredness and lack of energy)     
    * Confusion     
    * Mental fogginess

okay why am i mentioning this, well Jim mentioned cytokines before... the doctor being interviewed said that some of the people who exhibit these symptoms have high level of cytokines in their blood. And they dont know why the cytokines could be causing them.

There exists a Cytokine panel of blood testing that can be done, like this one: http://www.lef.org/Vitamins-Supplements/ItemLCCYT/Cytokine-Panel---IL1b-IL6-IL8-TNF-Alpha-Blood-Test.html

The Cytokines in chemo-therapy result from an auto-immune response. Maybe for some of us the POIS is a auto-immune reaction triggering large amounts of these cytokines to be released. Once I have the health insurance again, I am definitely doing to get this panel done after a few O's (god that will be a crappy week at work lolz =)

Even in healthy males, studies (like this one: http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=79409&Ausgabe=230291&ProduktNr=224176) have shown that an O causes an immuno reaction by the human body.

When I am in POIS I notice swelling in my Lymph nodes especially under the arms and the neck.  This occurs even If I don't ejaculate.
Also have a fever feeling in back neck and face.  Always felt like an immune reaction.  Like when fighting a bad cold or flu.


Purchasing the LEF panel will probably not be reimbursed by insurance so make sure you check first.  I paid for mine because I trust them and I don't trust the people in my health care plan.

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Offline Dean93

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5579 on: 15/09/2009 20:14:48 »
Does anyone think that it's worthwhile or even helpful to do a "colon cleanse" before starting a supplement for better absorption? Not some brand name cleanse, just something simple like psyllium husk, for an effect similar to goingcrazy's from eating very little during cranberry testing.

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Offline Dean93

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5580 on: 15/09/2009 21:19:11 »
Throughout all the years that I've had POIS it has changed a lot. The most notable change is that I have a lot less brain fog. I think this happened after taking relora. After my brainfog-less POIS episode while on relora, I haven't had the same brain fog that I always had. When I say brain fog, I'm referring mostly to derealization. This "brain fog", to me, was like an actual "pseudo-physical" thing, like an actual fog in my head, not just a loss of concentration. It is the thing that would make me pick up an actual physical object and say "Is this real?", "Is this actually there?". I felt entirely detached from the world around me, like i couldn't reach out and touch someone. That doesn't happen anymore, but I think it has kind of screwed up my gauge of what is normal. Now out of POIS I don't know if I have just a little brainfog, or If that's just "baseline" for me. Things aren't completely clear, visually, to me, even out of POIS. The question I ask myself when holding an object now is "How close am I supposed to feel to this?"

If I rub my eyes, It gets a little better, so I'm thinking it might be physical. Perhaps its my glasses...I don't know.

Another note is that, compared to when I was a freshman in highschool, my POIS episodes are now less "desperate" than they were back then. I'm going to go ahead and attribute that to having had it longer and being "jaded", but mostly to having found this forum, putting a name to it and knowing that there is some hope for a cure. Thank you to John, who started this thread and everyone that works to keep it going. I don't know what would have done without it even for only 2 years!
« Last Edit: 15/09/2009 21:20:48 by Dean93 »

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5581 on: 15/09/2009 22:26:17 »
Throughout all the years that I've had POIS it has changed a lot. The most notable change is that I have a lot less brain fog. I think this happened after taking relora. After my brainfog-less POIS episode while on relora, I haven't had the same brain fog that I always had. When I say brain fog, I'm referring mostly to derealization. This "brain fog", to me, was like an actual "pseudo-physical" thing, like an actual fog in my head, not just a loss of concentration. It is the thing that would make me pick up an actual physical object and say "Is this real?", "Is this actually there?". I felt entirely detached from the world around me, like i couldn't reach out and touch someone. That doesn't happen anymore, but I think it has kind of screwed up my gauge of what is normal. Now out of POIS I don't know if I have just a little brainfog, or If that's just "baseline" for me. Things aren't completely clear, visually, to me, even out of POIS. The question I ask myself when holding an object now is "How close am I supposed to feel to this?"

If I rub my eyes, It gets a little better, so I'm thinking it might be physical. Perhaps its my glasses...I don't know.

Another note is that, compared to when I was a freshman in highschool, my POIS episodes are now less "desperate" than they were back then. I'm going to go ahead and attribute that to having had it longer and being "jaded", but mostly to having found this forum, putting a name to it and knowing that there is some hope for a cure. Thank you to John, who started this thread and everyone that works to keep it going. I don't know what would have done without it even for only 2 years!

Yes, compared to last year for me I'm probably 1.5 - 2 times better.  I'm pretty sure that if we stay on this track it might eventually disappear.  I feel EXACTLY the same as you, about the brain fog and everything.  I'm just following John21's celibacy and hopefully it will go away within the years.  I think we can bring ourselves out of this.  I view this disease as another form of depression that if we commit 100% we can come out of.  Diet and exercise and non-orgasm, I have hope, could beat it.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5582 on: 15/09/2009 22:27:44 »
For me I was thinking that yes it could possibly be hormonal, I've practically had POIS the same amount of time that I've had acne, and my acne is slowly diminishing, hence POIS is getting better... At least for me.

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Offline THISFORUMROCKS!

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5583 on: 16/09/2009 08:57:39 »
So for B_JIMS's summary of POIS cases and others interested I just wanted to note since I have not specifically in the past that I have had the common POIS symptoms as described in the POIS website to a significant extent, of both the mental and physical varieties:

"Extreme mental fatigue, difficulty concentrating, inability to comprehend/retain what is read, shortened attention span, loss of speech fluency, cloudy mindedness, headache, anxiousness, and depression are most commonly experienced by those in the first category.  Those in the second category commonly have diarrhea, constipation, muscle aches, sweatiness, cold spells, feeling hot, physical fatigue, and restlessness."
AKA [:0] [xx(] [:(!] [:-'(] [>:(] [:(]

Of course, once I figured this out about a year or two ago I undertook the immense mental task of committing to no more O's.

So now after 8 months of no O's I know this makes the biggest difference- obviously, but more easily said than done. Then again sometimes I feel similar symptoms to a much less lesser degree from time to time, even with no O. For example if some hottie walks by and my mind wanders a bit too much- no O but it seems to activate some process regardless.
   
I figure I have had POIS symptoms for about 15 years; since I was young. It has significantly impacted my social life, family relations, work relations. I have tried several antidepressants and ADD medications with no benefits. I know I have POIS, but additionally have strong suspicions that I may have LYME and CELIAC. I had a vitamin D deficiency which was resolved and something good for others to avoid. I have GILBERT syndrome. I had a salivary "performance" test done by Body Balance that indicated testosterone outside and above normal range, cortisol outside and below normal range and DHEA within normal range. I had a hair analysis mineral check done by Body Balance that indicated Antimony, Lead, Mercury, Cobalt, Copper, and Zinc were all "outdide range" above the normal reference range. Most notably my lead and mercury levels appeared ridiculously high. I had been eating a bunch of fish but I don't know if that completely explains that or not. A later blood test showed mercury levels at just above normal range. Without multiple tests it is hard to know how accurate the above ones were, but I hope you found this interesting.



Some 5 important things I have learned about mitigating POIS to summarize till we find the cause/cure:
-No "O"!
-An upbeat mental attitude helps, including having this forum for support.
-Nutrition and moderate exercise are key.
-Proper sleep including enough hours and regular to bed and wake up times.
-Relaxation techniques whether it be deep breathing, massage, meditation, whatever.

Sure, the above may seem obvious or unrelated to POIS specifically depending on how you look at it, BUT I think that all things related to general health can have an impact on POIS. POIS seems to be able to aggravate and exploit/feed off any existing health issues, whether mental or physical, so the fewer other health problems the better.

And finally, I may have some zany POIS theories from time to time, but they are all with good intention...   

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Offline THISFORUMROCKS!

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5584 on: 16/09/2009 09:27:29 »
Also of interest: I have consistently in the past noted the POIS related symptom of having EXREMELY RED, IRRITATED, DRY eyes.

This is more of a minor inconvenience relative to the other POIS issues, though it can make me  [:(!] when  [:o)]'s don't take me seriously, and wrongly assume that I am a care-free pot smoker who is constantly stoned, even at work  [:0] [xx(] [B)].
« Last Edit: 16/09/2009 09:29:59 by THISFORUMROCKS! »

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Offline devastated

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5585 on: 16/09/2009 13:03:47 »
Dear friends,

You cannot begin to imagine how glad I am that I discovered you. My warmest congratulations on your efforts and contribution to clarifying what the POIS syndrome is and how it can be dealt with. I'm 34 years old male from Greece and since very early in my life I was suffering from this condition. I knew somehow that I couldn't be a unique case and more people were suffering from this as well.

Although the information gathered in these 200+ thread pages is invaluable, the webmasters should really consider organising it a bit better. Lots of info is buried in an endless frustrating pile of posts...it's nearly impossible to read everything in a row unless I bookmark each time the last page where I stopped reading.

I came across this thread almost at the same time with this forum: http://recover.forumup.org (it requires free registration). I think it relates to some Dr Lin, but the posts pinpointing the symptoms and possible cure appear quite accurate.

I'll use all the info I gathered so far in order to describe my own symptoms:

    * Headaches or pains to the back of the neck that can extend to migraines - due to excessive inflammatory hormone prostaglandin E-2 release and excessive dopamine/norepinephrine-epinephrine conversion in the brain after the acetylcholine, serotonin and GABA nervous system due to sexual exhaustion.
    * Depression, stress, anxiety and emotional instability (Mood Swing) - due to deficiency of the neurotransmitters acetylcholine, dopamine, serotonin add GABA
    * Attention Deficiency and Absence mind (losing mind concentration and memory) - due to the deficiency of the brain's neurotransmitters serotonin and acetylcholine - memory protection failure or insufficient memory.
    * Intense cognitive impairments (lack of judgement ability, diffuculty to evaluate a situation, confusion, brain fog, tendecy make many random mistakes and repeat them over and over again, difficulty to learn from mistakes, difficulty to adopt to new environments / conditions, depersonalisation / derealisation, panic attacks. In extreme cases temporary inability to find the right words to express my thoughts or to read out loud properly without making repetitive mistakes, inability to show any form of self-discipline for long periods of time)
    * Fatigue, tiredness and exhaustion - the parasympathetic nervous recharging/healing system is out of order; the pituitary releases excessive prolactin to shut down the testicular function.
    * Visual snow / sunlight sensitivity - due to disorders of the nervous sensing (acetylcholine nervous) and amplifier (dopamine nervous) circuits, a deficiency of the serotonin/GABA nervous modulation in retina, excessive stress hormones, or a poor retinal blood circulation or an arterial constriction due to deficiency of prostaglandin E-1 or/and Nitric oxide or sympathetic nervous action on the beta receptors
    * Tinnitus / buzzing right ear - reasons possibly same as above
    * Weak immunity - neuro-immune disorder resulting from the deficiency of the neurotransmitters acetylcholine and dopamine. For example, easy to catch cool or get sick and requiring a longer time to get recovery from sickness
    * Increased hair loss during that period / decoloring (premature white hair).
    * Short breathing and irregular cardiovascular output (sympathetic) / can extend to slight arrythmia - a weakening brain's acetylcholine/serotonin and parasympathetic/vagus nervous function.
    * Sleeping disorder and its associated symptoms- due to the deficiency of serotonin and melatonin, both of which are synthesized by the pineal gland with GABA and norepinephrine, or due to excessive pituitary LH and FSH hormones in an attempt to revive a weak/dying testicular/ovarian function. This causes a deficiency hGH and excessive inflammatory hormone prostaglandin E-2 release into the bloodstream, an undercharging of the parasympathetic nervous system, and an excessive sympathetic nervous fire (Flight or Fight), resulting in back/joint/ligament pains or cramps, urinary or bowel incontinence as a result of no or insufficient healing (restoration) power (prostaglandin E-1) in the organs, muscles, ligaments and joints.
    * Excessive Sweating - the sympathetic/epinephrine nervous fires burning the entire body due to an constantly excessive dopamine/norepinephrine-epinephrine conversion in the hypothalamus and adrenal medulla.
    * Muscle Tremors/Twitching (especially at the solar plexus when I yawn) - due to deficiency of dopamine and acetylcholine
    * Occassional numbing of arms and legs.
    * Nasal allergy (especially at night)
    * Dry and irritable skin and eyes
    * Gland swelling around the neck
    * Increased smegma secretion on face and hair
    * Persistent back pains

Symptoms used to last from 3-4 days when I was younger and well rested. Now that I'm married and need to work for over 9 hours per day (which means I tire myself much more), they can extend to as far as 7-9 days becoming much more intense in comparison to the past, making my life a complete nightmare... It is like you become a zombie: your whole organism collapses in multiple unbearable and frustrating ways. In times, it totally ruins my social life / personal development. Even though I have limited the frequency of intercourse to once per week, most of the times it's not enough for complete recovery and symptoms mound and pile up (meaning new symptoms add up to previous not fully recovered condition). This results to a chronic condition: some symptoms persist more and are almost always there (although in a subtler form) - they only subside if I abstain from sex for over 2 weeks (which at least for me is *very* hard). Usually the 3rd day after orgasm is the worst (when organism strives for serious replenishment), where all symptoms reach their peak and migraine is almost certain to occur.  Throughout these years I have discovered that that symptom intensity is definately proportional to the intensity of orgasm & amount of lost semen + the amount of time that has elapsed since the previous ejaculation.

And some history: Unfortunately for me, I began masturbation as early as 6-7 years old (soon afterwards I began experiencing visual snow). However, If I exclude only small periods at my teens, I never masturbated as frequently as daily or many times per day. The usual pattern was 2-3 times / week max. I'm uncertain whether this was enough for me to suffer such severe drainage or there is some inherent gene / dna defect at work here (which might be common for most of us). I tend to conclude towards the latter.

My wife happens to be a biologist and by reading the kind of substances some of you guys take, she went berzerk: "Substances like DHEA are really heavy stuff. If they aren't sure what they're doing, they might be imparing their organism in various ways". I'm really hesitant to fill my body with dopamine, testosterone, serotonin, melatonin, DHEA, GABA, Acetylcholine and the rest, in fear of causing further irrecoverable damage to my health due to unknown side effects of mixing all these things together. Has it really worked for you? Has any doctor told you it is safe enough? For the time being the only non-medicine treatment that has visible for me is combination of celibacy, good diet and sleep. However I need a normal sexual life like most of the people, without having to wait for entire weeks... it's like a vice circle of torture: experience orgasm and you'll suffer...try to abstain and you'll suffer again.

Thank you very much for your patience. Any questions are more than welcome.



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Offline Dean93

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5586 on: 16/09/2009 19:58:40 »

Although the information gathered in these 200+ thread pages is invaluable, the webmasters should really consider organising it a bit better. Lots of info is buried in an endless frustrating pile of posts...it's nearly impossible to read everything in a row unless I bookmark each time the last page where I stopped reading.



I'd like to add that an easy way to get around the thread (if you know what page that you want to go to) is to divide the page that you want to go by 4 and typing that number into the URL after "6576." Add zeros to make make the number 4 digits long and omit decimal points. If you really want to be precise, you can subtract 25 from the last two digits. Otherwise you can just skip that step, and go back one back, as without it you will be taken a page ahead of the page that you wanted.

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Offline lauracostis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5587 on: 16/09/2009 20:24:57 »
spermatogenesis:

after ejaculation, or when sperm levels fall below 20 million, "activin" stimulates the hormone "FSH" which starts sperm production.  when sperm levels reach desired amount by testis, inhibin is released shutting off "fsh".  its possible that either fsh or activin may be responsible for pois symptoms.  activin and fsh are both  proteins, so they could be the most likely culprit if the auto immune system is the problem.  the more O's you have the greater the sperm deficit, and the more activin and fsh you will have in your system.  as sperm count gradually rises activin will start to taper off, and inhibin will start taking over and block release of "fsh".  there will always be small amounts of activin in your system because sperm storage life in testis is about 90 days, after that they are destroyed and need to be replaced.  in a 24 hour period (without ejaculation)small amounts of activin and fsh are released to replace 1/90th of sperm.  this could be the reason why we never totally recover from pois.



Activin and inhibin are two closely related protein complexes that have opposing biological effects. Activin enhances FSH biosynthesis and secretion,Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis,[1] metabolism, homeostasis, immune response, wound repair,[2] and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.[3]

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Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5588 on: 16/09/2009 21:29:21 »
spermatogenesis:

after ejaculation, or when sperm levels fall below 20 million, "activin" stimulates the hormone "FSH" which starts sperm production.  when sperm levels reach desired amount by testis, inhibin is released shutting off "fsh".  its possible that either fsh or activin may be responsible for pois symptoms.  activin and fsh are both  proteins, so they could be the most likely culprit if the auto immune system is the problem.  the more O's you have the greater the sperm deficit, and the more activin and fsh you will have in your system.  as sperm count gradually rises activin will start to taper off, and inhibin will start taking over and block release of "fsh".  there will always be small amounts of activin in your system because sperm storage life in testis is about 90 days, after that they are destroyed and need to be replaced.  in a 24 hour period (without ejaculation)small amounts of activin and fsh are released to replace 1/90th of sperm.  this could be the reason why we never totally recover from pois.


FOr me the POIS exists from the "feel-good" sensation of an O, whether ejac occurs or not. Interesting ideas though.

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Offline John21

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5589 on: 16/09/2009 21:37:19 »
Devastated,

Welcome to the forum.

Quote
I'm really hesitant to fill my body with dopamine, testosterone, serotonin, melatonin, DHEA, GABA, Acetylcholine and the rest, in fear of causing further irrecoverable damage to my health due to unknown side effects of mixing all these things together

I second that notion. I dabble with supplements that I have researched and consider safe but taking substances that the body produces such as melatonin and DHEA sounds very questionable to me. Hormonal supplementation should only be taken as prescribed by a qualified doctor IMO.  I agree that the information could be presented better, and I think some of our members are working on a website with POIS summary info. If I were you I would simply glean through the pages and only zero in on topics that interest you, or simply search for that info. I hope you find something useful here, even if it is only our support.
« Last Edit: 16/09/2009 21:38:55 by John21 »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5590 on: 16/09/2009 22:08:22 »


Although the information gathered in these 200+ thread pages is invaluable, the webmasters should really consider organising it a bit better.


We're trying. Below are some baby steps we've taken towards improving the organization of our 5,000+ posts.

Your command of English is superb. Did you study the language elsewhere?


devastated, welcome to the POIS thread of The Naked Science Forum!




Here are some POIS resources which may be helpful to you:

Our new POIS Information Website, built by "mat780", is here:
http://sites.google.com/site/poiswebsite/

Please see "B_Jim"'s POIS Summary of All Cases, here as well as others on the Web. This includes remedies that we have tested, and results.
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

"Girlwind" has created an excellent POIS Video:
http://www.youtube.com/watch?v=UWBxAUC9k1g

And filling out the POIS survey created by "Counterpoints" will enable you to share POIS information and details with others here. This will also enable us to work more easily with outside researchers by having more organized data available about us:
http://pois.olympe-network.com/

POIS Research Study

We have a copy of the first and only study on POIS by Dr. Marcel Waldinger,MD and Dr. David Schweitzer, MD.

If you want a copy (PDF), send me a Private Message with your regular email address and I'll send you back the PDF.

To send a Private Message, click on "Messages" at the top of this page. At the Messages page, click on "New Message". From that point on, it works just like posting a message here, except that it only goes to the person(s) you designate.

Remember to put a quote around my name, i.e., "demografx".


New York Times article,

January 20, 2009
Mind
Sex and Depression: In the Brain, if Not the Mind
By RICHARD A. FRIEDMAN, M.D.
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

In addition to serving our own informational interests, the resources listed above can be useful for you to show the medical world - which often shows little understanding and is sometimes skeptical of our condition - that POIS has scientific underpinnings and that POIS is not "just another psychological problem" related to sex - to be treated by the psychiatric/psychotherapist community. This can help fight the immediate reaction of some: IT'S NOT "ALL IN OUR HEADS"!

Also, it can be helpful when dealing with medical professionals to point out the successful existence of our rapidly growing forum for over 2 years, which has attracted over 150 POIS sufferers worldwide who have posted here, plus more than 350,000 page visits. Not bad for a rare malady!
« Last Edit: 17/09/2009 05:36:57 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5591 on: 16/09/2009 22:10:01 »
devastatated, this post might help you find information about POIS that we have already discussed, by tailoring a Google search to this forum:


SEARCH THE FORUM WITH GOOGLE

We have an overwhelming amount of data: over 2 years' worth of posts from 150+ Forum members, and an additional 150 POIS sufferers found on the Internet, but not on this forum.

In the Google search box, type
whatever-it-is-you're-interested-in-finding-out[space]POIS[space]site:http://www.thenakedscientists.com/

for example, I tried
demografx POIS site:http://www.thenakedscientists.com/

and 1,000+ results came up for "demografx" within the Forum.

be careful with spaces (you can use them before the word "site") and no-spaces (everything after the word "site")

Google even provides you results with the Message# for each result. But Message #'s do change, so be patient and look for the approximate Message#.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5592 on: 16/09/2009 22:17:06 »

sometimes I feel similar symptoms to a much less lesser degree from time to time, even with no O. For example if some hottie walks by and my mind wanders a bit too much- no O but it seems to activate some process regardless.


In my case, I have had excessive physical/mental/emotional reactions to jet lag (I rarely fly any more), and alcohol (I quit). Does anything else besides NHS (new hottie syndrome [;D]) affect you?

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5593 on: 17/09/2009 03:10:32 »
Has any body put more thought into this chemo brain thing, their symptoms match to closely with pois.  and the way the patients describe their situation it resembles to much of what we are going through. 
    When i looked at science daily it talked about different activity in brain.

The PET scans show a link between chemo-brain symptoms and lower metabolism in a key region of the frontal cortex," explained Silverman, a member of UCLA's Jonsson Comprehensive Cancer Center. "We found that the lower the patient's resting brain metabolism rate was, the more difficulty she had performing the memory test."

The scans revealed that blood flow to the frontal cortex and cerebellum spiked as the chemotherapy patients performed the memory tests, indicating a rapid jump in these brain regions' activity level.

"The same area of the frontal lobe that showed lower resting metabolism displayed a substantial leap in activity when the patients were performing the memory exercise," said Silverman. "In effect, these women's brains were working harder than the control subjects' to recall the same information."

Finally, the researchers discovered that women who underwent hormonal therapy in addition to chemotherapy displayed changes to their basal ganglia, a part of the brain that works to bridge thought and action. On average, these women showed an 8 percent drop in resting metabolism in this brain region.

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5594 on: 17/09/2009 03:14:13 »
report on using claritin.

I used it  an hour before orgasm and also used it the next day without any noticeble results. 

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5595 on: 17/09/2009 04:26:04 »

spermatogenesis:

after ejaculation, or when sperm levels fall below 20 million, "activin" stimulates the hormone "FSH" which starts sperm production.  when sperm levels reach desired amount by testis, inhibin is released shutting off "fsh".  its possible that either fsh or activin may be responsible for pois symptoms.  activin and fsh are both  proteins, so they could be the most likely culprit if the auto immune system is the problem.  the more O's you have the greater the sperm deficit, and the more activin and fsh you will have in your system.  as sperm count gradually rises activin will start to taper off, and inhibin will start taking over and block release of "fsh".  there will always be small amounts of activin in your system because sperm storage life in testis is about 90 days, after that they are destroyed and need to be replaced.  in a 24 hour period (without ejaculation)small amounts of activin and fsh are released to replace 1/90th of sperm.  this could be the reason why we never totally recover from pois.



Activin and inhibin are two closely related protein complexes that have opposing biological effects. Activin enhances FSH biosynthesis and secretion,Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis,[1] metabolism, homeostasis, immune response, wound repair,[2] and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.[3]


I like this. I have felt strongly for some time that my POIS has been associated with "sperm regeneration": When I'm feeling "empty" of semen, POIS ravages. When I'm "full", I feel great.

Testosterone therapy has sped up my regeneration, cutting back my devastating symptoms from 4 days to 1.

This, of course, needs empirical verification.

Anyone: any more ideas on how to get outside researchers to study us and POIS?
« Last Edit: 17/09/2009 05:32:55 by demografx »

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5596 on: 17/09/2009 04:43:21 »
For the infection idea, i do find myself in a better mood after being in a sauna for 5-10 minutes.  I'm not "cured" or anything, it is just a definite positive reaction though.  Sauna's are supposed to help rejuvenate the body and help with chronic infections.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5597 on: 17/09/2009 04:45:29 »
Has any body put more thought into this chemo brain thing, their symptoms match to closely with pois.  and the way the patients describe their situation it resembles to much of what we are going through. 
    When i looked at science daily it talked about different activity in brain.

The PET scans show a link between chemo-brain symptoms and lower metabolism in a key region of the frontal cortex," explained Silverman, a member of UCLA's Jonsson Comprehensive Cancer Center. "We found that the lower the patient's resting brain metabolism rate was, the more difficulty she had performing the memory test."

The scans revealed that blood flow to the frontal cortex and cerebellum spiked as the chemotherapy patients performed the memory tests, indicating a rapid jump in these brain regions' activity level.

"The same area of the frontal lobe that showed lower resting metabolism displayed a substantial leap in activity when the patients were performing the memory exercise," said Silverman. "In effect, these women's brains were working harder than the control subjects' to recall the same information."

Finally, the researchers discovered that women who underwent hormonal therapy in addition to chemotherapy displayed changes to their basal ganglia, a part of the brain that works to bridge thought and action. On average, these women showed an 8 percent drop in resting metabolism in this brain region.

I'm trying to find your post but i am just too impatient now, I believe it had something to do with cytokines?  Maybe.  For me POIS happenned after a terrible 2 years of coffee caused stress.  Stress that I've never dealt with before in my life.  Maybe this causes orgasm to release more cytokines.  I am not sure, we need some concrete evidence.  Is there anything you can take to test this idea?

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5598 on: 17/09/2009 06:07:34 »

Question to all:

If you had your pick of an individual(s) or an institution, who would you like to see study us and POIS?

If you'd prefer to PM me with a reply that's fine, as is a casual post.

Thanks!

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Offline mellivora

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5599 on: 17/09/2009 11:55:56 »
As I posted about a month ago, I had some blood tests a while back. These tests were not done while I was feeling symptoms. I still think I need to do a before and after test. I have an endocrinologist appointment at the end of October.
Basically my results for Testosterone, Prolactin, FSH, SHBG, Cortisol and thyroid were all normal. My LH was 'slightly low' - I wonder if that's just something to do with a relatively low frequency of orgasm compared to a normal non-sufferer.

I'd like to see the actual numbers to see where within 'normal' range I was and also to check exactly which testosterone test was carried out (I asked for total, free, bioavailable). I should be able to discuss all this at my endocrinology appointment. Also I think its important to do both before  symptoms and during POIS symptoms tests so hopefully my endo will help me with this.

Trying cranberries. has anyone had any apparent results from dried cranberries? They seem to be easier to get hold of