Post Orgasmic Illness Syndrome (POIS)

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5750 on: 08/10/2009 20:29:33 »
I looked at old test result and saw that my free testosterone is way below normal for any age.
19 pg/ml   35- 155pg/ml  I dismissed it because urologist told me my total was to high then
but that that i took that blood test i started recovery faster than usual.

2nd test free testosterone is low but not out of range but total T very close to lower range.

if put these these two test together, do you guys think it will warrant some attention.


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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5751 on: 08/10/2009 22:22:17 »

demografx, I don't know why you were taking reglan (metochlopramide)[sic] daily, which is very good accompanied with acetaminophen to treat headaches with nausea by the way, but it's a secret to no one that metochlopramide increases prolactin level. Why? because it's a dopamine antagonist. Even a fist [sic] year med student would know that. And this prolactin stimulating effect has precisely been used to induce lactation in women!


Again, I said it's not well known or studied in men, not women. As I mentioned earlier, prolactin's role in women is widespread common knowledge.

And I have indeed talked to endocrinologists and some bright med school students who confirm it's rarely studied. In men, prolactin is basically ignored.

Yes, I heard all about the reglan/dopamine antagonist scenario from one expert...who had to look it up. The rest basically were not concerned about hyperprolactinemia. Except for prolactin partially being responsible for the low libido. But that was being treated very well.

I cured the high prolactin count and went from 90 to 9.

Paulrx, it's a highly specialized world we live in, and I don't fault the physicians and others I consulted for not knowing more about prolactin.

I'm sure you'll agree that it's impossible for any one physician or health care provider to keep up with the explosive growth in worldwide data, studies, treatments, etc. My endo, for example, specializes, as many do, in this case diabetes.

The miracle is that my endo was politically brave enough to take on POIS!


All the drugs I mentioned [including bromocriptine] have [a] very safe profile.


Bromocriptine - - Combined with MAO inhibitors:  Dangerous rise in blood pressure; When driving: Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs. (From MD Advice).

I don't often see the word "danger" when side effects are mentioned.

Prolonged use:

May lead to uncontrolled movements of head, face, mouth, tongue, arms or legs. (same source)

Bromocriptine is an anti-Parkinson's disease drug. That alone scares me. Even if taken once a year.

Back to the medical world's knowledge base, read up on this forum's history with health care providers, and you'll see the decades long struggle of getting ANY doctor to take notice of our POIS! And when they do, they often just refer us to shrinks...because "it's all in our heads"!

What I'm saying is that, until serious scientific research happens, we have some very primitive problems to deal with.
« Last Edit: 09/10/2009 17:53:07 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5752 on: 08/10/2009 22:33:11 »

Your friend is a biochemist, not a biophysicist.


Ph.D. in Biophysics from the University of Chicago.


(1) POIS is obviously a major neuro-endocrine anomaly...(2) POIS is not due to a serotonin imbalance...(3) (prolactin) just initiate(s) a cascade when the prolactin spike is above a certain threshold...



Not proven!

Besides, we have found in our 3 years here that there are many varieties of POIS, as different as night from day.


To conclude, 5-HTP would not be a cure for POIS.


Which type of POIS?

Paulrx, I respectfully urge you to review at least some of the massive history we've accumulated here. Some of your statements reflect a gap. We have worked with an impressive group of medical/technical people both within and outside this forum, such as my Harvard friend.

Learn what we have found.

But you do have some ideas to add to our growing list of plausible ideas, perhaps for future testing. Thank you for that.
« Last Edit: 10/10/2009 08:34:16 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5753 on: 08/10/2009 23:50:29 »

I looked at old test result and saw that my free testosterone is way below normal for any age.
19 pg/ml   35- 155pg/ml  I dismissed it because urologist told me my total was to high then
but that that i took that blood test i started recovery faster than usual.

2nd test free testosterone is low but not out of range but total T very close to lower range.

if put these these two test together, do you guys think it will warrant some attention?


Definitely, CC!

My endo and a previous urologist and a previous GP, all had no problem (eventually, when I promised to stop screaming  [;D]) to increase my dose, even when my T was "normal". But I emphatically urged that I wanted this treatment for POIS and not for insufficient testosterone. And I kept insisting! And some of this insistence was back in the day when fear was widespread about T and cancer. So I just agreed to any kind of monitoring they wanted to do. And yes, I told them I was desperate. But without a wild gleam in my eye. [:)]

And I also cited the internationally well-respected Czech researcher whom I found and consulted with, after 20-30 years of dark, dead-end alleys, and his firm conclusion was: testosterone-for-POIS! This was around the time that Dr Waldinger's study first came out in 2002.

I worried that "Professor Czech" was possibly crazy but I-just-didn't-care! If someone told me cyanide.....no, forget that [:D]
« Last Edit: 09/10/2009 00:18:45 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5754 on: 09/10/2009 00:12:46 »

I believe most the POIS sufferers are wrongly assuming that orgasm is the culprit, it's more likely the ejaculation [is].


So we'll have to change our name to PEIS? Won't that offend the PENIS people??? [;D]
« Last Edit: 09/10/2009 00:19:49 by demografx »

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5755 on: 09/10/2009 01:18:17 »

I believe most the POIS sufferers are wrongly assuming that orgasm is the culprit, it's more likely the ejaculation [is].


So we'll have to change our name to PEIS? Won't that offend the PENIS people??? [;D]

Like some others on here, POIS arises from the good feeling of sex, whether orgasmic or not for me.

I also think that POIS is not relatively a new condition.  Maybe even people thousands of years ago had this disease.  Maybe even 50 years ago, internet sites like this were unavailable.  But I think that some people actually cured their POIS without using sites such as these.  Say if you had this disease for 5 years and cured it, say abstinence was the main cause to slow healing, would you than search the internet about post orgasmic illness if you didn't have it anymore?  Certainly for me the more POIS I have the more I am on this site.  I just can't believe this would be a new condition

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5756 on: 09/10/2009 17:23:54 »

I believe most the POIS sufferers are wrongly assuming that orgasm is the culprit, it's more likely the ejaculation [is].


So we'll have to change our name to PEIS? Won't that offend the PENIS people??? [;D]

Like some others on here, POIS arises from the good feeling of sex, whether orgasmic or not for me.

I also think that POIS is not relatively a new condition.  Maybe even people thousands of years ago had this disease.  Maybe even 50 years ago, internet sites like this were unavailable.  But I think that some people actually cured their POIS without using sites such as these.  Say if you had this disease for 5 years and cured it, say abstinence was the main cause to slow healing, would you than search the internet about post orgasmic illness if you didn't have it anymore?  Certainly for me the more POIS I have the more I am on this site.  I just can't believe this would be a new condition

Asian populations were writing about "POIS" 5,000 years ago! (as postorgasmic, serious loss of energy and poor physical/mental state).

One thing that puzzles me is that from reading about Asian medicine, "POIS" symptoms seem to be widespread, but here in the U.S. and in Western countries, POIS seems to be rare.

Anyone have an idea, why is POIS rare here but widespread over there? Is it our embarrassment over sex, preventing us from talking about it?

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5757 on: 09/10/2009 21:58:04 »

I asked my psychiatrist today what she thought of the fact that Asian populations have seemingly enormous writing and discussion and symptom-description on "POIS" compared to us here in the West. She thinks that Asian populations just might be more genetically susceptible to POIS. Makes sense to me: there are illnesses that are disproportionately found in other populations; African-American, Ashkenazi Jewish, etc.

Perhaps we here would do well to find out what mainstream Asian medicine (not the naturopathic, "chi" alternative therapies which have not shown us much)  has to say about POIS!

Anyone have a thought about that?
 
« Last Edit: 09/10/2009 22:08:44 by demografx »

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Offline Dean93

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5758 on: 10/10/2009 03:25:54 »
That was my thought Demo, but although POIS may be similar, or identical, to its equivalent in Asia, their names are certainly not the same. Does anyone have any knowledge that could help bridge the gap? Search terms perhaps?

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5759 on: 10/10/2009 05:30:46 »

Thanks, Dean! Search terms, yes, excellent idea. I just emailed Pyropeach, who is in China, to see if he can help.

FWIW, Google in China is http://www.google.cn
« Last Edit: 10/10/2009 06:07:35 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5760 on: 10/10/2009 06:02:53 »
Just ran across these articles, interesting POIS reference material from 2005 and 2006 that I haven't seen before.

Co-edited by the "Founder of POIS", Dr. Marcel Waldinger. It's a special issue on Ejaculatory Disorders: 14 articles. From the World Journal of Urology: http://www.springerlink.com/content/v575n5775g64/?p=e663345222fb416bb3dd0f785fcc8eb9&pi=27

Another World Journal of Urology article of interest:
"Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence"
http://www.springerlink.com/content/1elxf861chc5p9jv/?p=ae214cf7feac435cb19b25ee60ae15c1&pi=0

I'll send these to Counterpoints for possible POIS Wikipedia inclusion.
« Last Edit: 10/10/2009 06:09:01 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5761 on: 10/10/2009 06:41:07 »


Would anyone here be interested in my approaching a testosterone manufacturer (like Androderm/Watson Pharmaceuticals) to see if they would be interested in conducting research, clinical trials into the use of testosterone as a way to alleviate POIS - for low- testosterone and normal-testosterone POIS sufferers alike? Feel free to post your answer here or to send me a Private Message.


Today I initiated contact with Watson Pharmaceuticals (WP). No email, just a cold telephone call. Friday afternoon is not an ideal time to do that, but I just felt like "let's do it already!".

I left one message (to return my call), but I tried calling back several times.

So far, it seems like we have 4-5 people here interested if I can get them interested. If you are (see the quote above from my earlier post), let me know if you haven't already! Thanks.

Will keep you posted on progress (or lack thereof) with WP.
« Last Edit: 10/10/2009 08:23:53 by demografx »

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Offline Defsync

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5762 on: 10/10/2009 14:48:24 »

I asked my psychiatrist today what she thought of the fact that Asian populations have seemingly enormous writing and discussion and symptom-description on "POIS" compared to us here in the West. She thinks that Asian populations just might be more genetically susceptible to POIS. Makes sense to me: there are illnesses that are disproportionately found in other populations; African-American, Ashkenazi Jewish, etc.

Perhaps we here would do well to find out what mainstream Asian medicine (not the naturopathic, "chi" alternative therapies which have not shown us much)  has to say about POIS!

Anyone have a thought about that?
 

To be honest i think it has to do with the asians (more specifically chinese) historically being able to detect very slight balances and functions within the body that western medicine seems to have skipped over. Now I dont believe in chi or anything, but I do believe their take on chi is a slight metaphysical interpretation of concrete nervous structures and relations within the human body. For example, they say they can feel your palm/hand and know where "distress" is in your body. Some organs can be in distress without conscious pain registering, though there may be other painless nerve signals being sent that manifest themselves in small almost imperceptible clenching of muscles in the hand.

Thousands of years ago Chinese monks were able to figure out that even in a normal person, by not having any sex, a male can have a slight increase in his intellectual function. When a monkish order has a few millennium to sit around and think about crap, you'd be surprised what revelations they can come up with =P

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Offline John21

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5763 on: 10/10/2009 17:02:17 »
Update

I had an NE early in the week and again I had no immediate cognative changes, yet later in the week I did have some loss of function plus emotional irritation (what I have referred to as Phase B)

(As I have previously explained my typical POIS episodes consisted of severe cognative changes which lasted several days to a week, followed by days of feeling "burnt out". By burnt out I mean mentally degraded, like my mind is slowed down and I therefore can't perform mentally as well and feel quite stupid. This state is quite different from the state of emotional burn out, in which a person is emotionally exhausted. In my "Phase B" I am simply slow on the draw and struggle because of it.)

The bacterial/virus ideas now sound doubtful in light of my continuing symptoms, mild as they may be. It has been suggested that my chastity could be responsible for healing my system such that the severity is reduced, and this does sound plausible to me. But still I won't rule anything out.

Again I am wondering whether my current tamer form of POIS is actually more widespread than is recognized. If it wasn't for my years and years of suffering severely in the days following sex I don't think that I would make the association between my mental ability and emotional state five days afterward. Maybe some people's "bad days" are similar to my Phase B.  Maybe this is what the Chinese monks figured out.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5764 on: 10/10/2009 20:34:37 »
John, what a coincidence, I just spoke yesterday to my shrink about the difficulty of connecting the dots between sex and symptoms, ESPECIALLY when symptoms are delayed.  I know it took me  and others here, YEARS to recognize!

Our relationship-expert-forum-member "reuniting" also feels that "tamer POIS" might be more widespread.

That bodes well for our getting research funding!

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Offline bruxe

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5765 on: 10/10/2009 21:52:12 »
hi
i'm new here
i'm so happy  to join you
i'm  from belgium 27y male  (sorry my english isn't so good)
yes, i 'm a Pois sufferer, it caused me many probleme in my life (separation,depression,weaknes....)
this syndrome destroyed me life, i live alone no girlfriend no wife  no masturbation ...

Symptoms:
1)normal sexual life with woman "orgasme" every day or 4 at 5 time per week

-Strong fatigue
-Low mental energy
-very low motivation
-big anxiety and social phobia
-headache
-feeling little hot
-many Muscular cramp...i can't stretch
-lose my haire
-backache
-prostate ache when i piss
- kidney ache
-my skin pricks me  everywhere and any time
-probleme with my eyes i cant open its morning i must use my hand
-nightmare
-big brain fog non stop 24/24 7/7 
-my hand and my body shake like a mini "parkinson syndrome"
-palpitation
-weak blood pressure
-ache in testicles
-no erection after orgasme
-premature ejaculation
-I feel hungry all the time
-probleme digestivea "gas"
-articulation probleme "knee"
.
.
.
2-- alone abstinence 1 week

-nightmare  still 2 day after orgasme
-I feel hungry 1day
-palpitation  1day
-Strong fatigue 3day
-very low motivation 3day
-my skin pricks me  everywhere and anytime  4day
-big brain fog non stop 24/24  6day 
-feeling little hot 1 day
-headache 4 day

3-- alone abstinence 2 weeks

-nightmare  still 1 day after orgasme
-I feel hungry  1day
-palpitation  1day
-Strong fatigue 1day
-very low motivation 2day
-my skin pricks me  everywhere and any time  2day
-big brain fog non stop 24/24  2day 

3-- alone abstinence3 weeks

-nightmare  still 1 day after orgasme
-I feel hungry  1day
-palpitation  1day
-not Strong fatigue
-low motivation
-not big brain fog non stop 24/24  1day 

4--never tried 4 weeks abstinence

solution
i never found a solution of my probleme
but
i do sport for increase level  dopamine an testosterone
café and salt for more blood presure

i will begin two treatments next week  "Phosphatidylserine" and  "Magnesium chloride"
I hope it will works for me.

 Thank you
« Last Edit: 10/10/2009 22:27:14 by bruxe »

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Offline Finally

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5766 on: 10/10/2009 22:14:02 »
Hello guys,

I think I have solution not to cure POIS but to totally bypass it. It's called male multiple orgasm. There're techniques out there to achieve what's often referred as to dry orgasm. In other words, by learning how to have orgasm without ejaculation, you would totally bypass POIS.
I encourage you to visit a board called www.malemultiple.org where all the techniques and experiences are discussed freely. I'll also ask the moderators there if we can start a specific thread on POIS and MMO.
I truly believe that this is the way to go to combat this awful POIS!

Paul

yeah i can do that but it doesnt work for me, as i've stated before whatever causes the "feel good" sensation, with or without ejac, causes my POIS

I have found that although reaching ejaculation results in the most severe POIs symptoms sexual stimulation will cause a moderate amoun of symptoms lasting a shorter time but over a length of time will form a cumulative effect.
Since taking herbal and other natural  supplements I have reduced the severity and duration(from about 4 days to 1).

Temperature:  I noticed about 1-1.5 degree F increase in body temperature both under the toungue and underarm.  Testing the groin area it was the same in and put of POIS.

I am looking into the possible effect of Quercetin(on order) on POIs symptoms.  I was wondering if anyone has tried this?

Another Thing I have noticed.  I bought some Dried Ginger(coated with sugar) basically as a snack and noticed some positive reults with muscle stifness and fatigue.


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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5767 on: 10/10/2009 22:18:18 »
hey guys, anybody think that POIS could just be a symptom of depression?  I feel like the more abstinent I am and the more I live my life the more non-depressed I am, and I just had 2 orgasms without the POIS that I used to have, probably half times as better.  I think that the depressed brain cannot handle sex, this is what causes POIS.  Plus there is a lot of correlation between depression and not wanting sex.  Maybe we can think ourselves out of this.  My parents were telling me that by just adjusting the way you think can have a great deal of changes on your body chemistry.  Just an idea.  The addiction thing is still in my mind.
« Last Edit: 10/10/2009 22:51:26 by goingcrazy »

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Offline Counterpoints

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5768 on: 10/10/2009 23:12:11 »
hi
i'm new here
i'm so happy  to join you
i'm  from belgium 27y male  (sorry my english isn't so good)
yes, i 'm a Pois sufferer, it caused me many probleme in my life (separation,depression,weaknes....)
this syndrome destroyed me life, i live alone no girlfriend no wife  no masturbation ...

Symptoms:
1)normal sexual life with woman "orgasme" every day or 4 at 5 time per week

-Strong fatigue
-Low mental energy
-very low motivation
-big anxiety and social phobia
-headache
-feeling little hot
-many Muscular cramp...i can't stretch
-lose my haire
-backache
-prostate ache when i piss
- kidney ache
-my skin pricks me  everywhere and any time
-probleme with my eyes i cant open its morning i must use my hand
-nightmare
-big brain fog non stop 24/24 7/7 
-my hand and my body shake like a mini "parkinson syndrome"
-palpitation
-weak blood pressure
-ache in testicles
-no erection after orgasme
-premature ejaculation
-I feel hungry all the time
-probleme digestivea "gas"
-articulation probleme "knee"
.
.
.
2-- alone abstinence 1 week

-nightmare  still 2 day after orgasme
-I feel hungry 1day
-palpitation  1day
-Strong fatigue 3day
-very low motivation 3day
-my skin pricks me  everywhere and anytime  4day
-big brain fog non stop 24/24  6day 
-feeling little hot 1 day
-headache 4 day

3-- alone abstinence 2 weeks

-nightmare  still 1 day after orgasme
-I feel hungry  1day
-palpitation  1day
-Strong fatigue 1day
-very low motivation 2day
-my skin pricks me  everywhere and any time  2day
-big brain fog non stop 24/24  2day 

3-- alone abstinence3 weeks

-nightmare  still 1 day after orgasme
-I feel hungry  1day
-palpitation  1day
-not Strong fatigue
-low motivation
-not big brain fog non stop 24/24  1day 

4--never tried 4 weeks abstinence

solution
i never found a solution of my probleme
but
i do sport for increase level  dopamine an testosterone
café and salt for more blood presure

i will begin two treatments next week  "Phosphatidylserine" and  "Magnesium chloride"
I hope it will works for me.

 Thank you

bruxe,

Welcome.  You may want to get a pituitary MRI, with contrast.  It seems that a pituitary adenoma/abnormality might be the cause of these symptoms. 

Several people here have reported one.

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Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5769 on: 11/10/2009 00:09:36 »
Hi Bruxe, I can feel your stress! Social phobia + solitude, I don't know how you can deal with this.

About asian debate, I think pois was also mentionned in western countries. Hippocrates (the father of medicine), Aristotle, and more recently Tissot and very probably a lot more were all convinced of a disease caused by orgasm or semen loss. Without mentionning the catholic religion.. and now us!

Demo, nice job with the pharm company.
I spent 15 years making theories, talking to MDs, trying supplements to cure POIS, with results but not enough. After 15 years I stopped and accepted the fact.. till I found this forum.
Even the famous people mentionned above knew POIS was real but couldn't prove it. That's why I think we absolutely need to be more dedicated to find researchers, otherwise we'll stay in darkness for the rest of our life, like other had been in the past.
All theories mentionned here are very welcome, and I like a lot to read them, but we'll NEVER know for sure without a good research.
« Last Edit: 02/11/2009 23:01:29 by martin88 »

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Offline hurray

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5770 on: 11/10/2009 01:57:12 »

Paulrx, your ideas are very interesting. Was it just the post-ejac solo-neurochemical-manifestation or something else that brought you to the prolactin theory? Your idea caught my attention because I panicked for months about my sky-high prolactin (10X reference range) and found myself to be my own doctor because no one knows anything about prolactin in men! I cured it by quitting reglan, which I found in wikipedia to often cause prolactin increase. Amazingly, none of my top physicians were aware of that. Again, male prolactin sdeems to be ignored by the medical community.

Do you think an (f)MRI at orgasm could reveal an abnormally high prolactin spike? Or maybe we just need to do a routine hormonal lab test immediately after orgasm to tell the story. Then perhaps we can do a comparison of those results with a non-POIS "normal" individual also at orgasm. Statistical reliability would of course require more than just 2 individuals.


I think that there could well be some truth in the prolactin theory.

The main wikipedia entry on dopamine suggests that there may well be a balance between dopamine and prolactin - more dopamine means less prolactin, more prolactin means less dopamine.

http://en.wikipedia.org/wiki/Dopamine#Regulating_prolactin_secretion

Quote
Regulating prolactin secretion
Dopamine is the primary neuroendocrine inhibitor of the secretion of prolactin from the anterior pituitary gland. [12] Dopamine produced by neurons in the arcuate nucleus of the hypothalamus is secreted into the hypothalamo-hypophysial blood vessels of the median eminence, which supply the pituitary gland. The lactotrope cells that produce prolactin, in the absence of dopamine, secrete prolactin continuously; dopamine inhibits this secretion. Thus, in the context of regulating prolactin secretion, dopamine is occasionally called prolactin-inhibiting factor (PIF), prolactin-inhibiting hormone (PIH), or prolactostatin. Prolactin also seems to inhibit dopamine release, such as after orgasm, and is chiefly responsible for the refractory period.

This goes back to a theory about POIS that we've discussed - the better the "quality" of orgasm, the less severe the symptoms of POIS are.

It stands to reason that better quality orgasms release more dopamine, which in turn inhibits the prolactin release, and possibly neutralises the symptoms of POIS.

Anybody think there may be something in this?

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Offline hurray

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5771 on: 11/10/2009 02:15:44 »
This article suggests a link between increased testosterone and increased dopamine!

http://linkinghub.elsevier.com/retrieve/pii/S0361923097002116

Therefore, one means by which testosterone may promote copulation is by upregulating nitric oxide synthesis in the MPOA, which in turn enhances dopamine release.

Could this be why testosterone works for you, demografx?

Good work with Watson Pharmaceuticals Demo, hope you can make a breakthrough!
« Last Edit: 11/10/2009 02:24:06 by hurray »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5772 on: 11/10/2009 03:18:35 »

Just ran across these articles, interesting POIS reference material from 2005 and 2006 that I haven't seen before.

(1)  ...


(2) Another World Journal of Urology article of interest:
"Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence"
http://www.springerlink.com/content/1elxf861chc5p9jv/?p=ae214cf7feac435cb19b25ee60ae15c1&pi=0

I'll send these to Counterpoints for possible POIS Wikipedia inclusion.


My mistake! The 2nd reference (listed above) of the two WJU references that I mentioned in my earlier post, was posted by Martin here...twice!

Martin has also added the research physician's email address to our database for POIS funding/research outreach for this forum.

Sorry, Martin, and thanks very much for all your help!

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5773 on: 11/10/2009 03:26:53 »

This article suggests a link between increased testosterone and increased dopamine!

http://linkinghub.elsevier.com/retrieve/pii/S0361923097002116

Therefore, one means by which testosterone may promote copulation is by upregulating nitric oxide synthesis in the MPOA, which in turn enhances dopamine release.

Could this be why testosterone works for you, demografx?

Good work with Watson Pharmaceuticals Demo, hope you can make a breakthrough!


THANX, hurray! This makes perfect sense!

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Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5774 on: 11/10/2009 14:11:51 »
Sorry, Martin, and thanks very much for all your help!
No problem!

Maybe promising for POIS, a new form of antidepressant without sexual side effect :
http://en.wikipedia.org/wiki/Agomelatine

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Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5775 on: 12/10/2009 01:19:27 »
Androgen receptors in the brain

There is a correlation with all our symptoms:
We know POIS symptoms are similar to those of T deficiency.
-As mentionned in the following study, androgen receptors are important for cognitive function  and this is interesting for us, a test seems to exist (?):
http://www.biomedexperts.com/Abstract.bme/14573323/Androge n_receptor_CAG_repeat_polymorphism_is_associated_with_cogn itive_function_in_older_men
Quote
BACKGROUND: Androgen receptors are located throughout the  brain, especially in regions involved with learning and  memory. Different lengths of a CAG (glutamine) repeat  polymorphism in exon 1 of the androgen receptor gene may  influence androgen action, with longer repeat lengths  conferring decreased androgen sensitivity. METHODS: We  sought to determine if this CAG polymorphism was  associated with cognition in older men. RESULTS: Among 301  community-dwelling white men (mean age, 73.0 +/- 7.1),  greater CAG repeat length was associated with lower scores  on three cognitive tests (p <.05 for all). In addition, 12  participants (9.8%) had cognitive impairment in the low  tertile of CAG repeat length whereas 29 (16.3%) had  cognitive impairment in the two higher tertiles (odds  ratio = 1.8; 95% confidence interval =.9-3.7).  CONCLUSIONS: Research should be directed at identifying  the mechanism for this association and to determine if  treatment with testosterone prevents cognitive decline.

-An other study links sexual satiation with decreased  androgen receptors :
http://cat.inist.fr/?aModele=afficheN&cpsidt=14700097
Quote
Abstract
Male sexual behavior is regulated by limbic areas like the  medial preoptic nucleus (MPN), the bed nucleus of the  stria terminalis (BST), the nucleus accumbens (nAcc) and  the ventromedial hypothalamic nucleus (VMN). Neurons in  these brain areas are rich in androgen receptors (AR) and  express FOS-immunoreactivity in response to mating. In  many species sexual satiation, a state of sexual behavior  inhibition, is attained after multiple ejaculations. The  mechanisms underlying sexual satiation are largely  unknown. In this study we show that sexual activity  reduces androgen receptor immunoreactivity (AR-ir) in some  of the brain areas associated with the control of male  sexual behavior, but not in others. Thus, one ejaculation  reduced the AR-ir in the MPN and nAcc, but not in the BST  and VMN. Copulation to satiation, on the other hand,  reduced AR-ir in the MPN, nAcc and VMN, and not in the  BST. The AR-ir reduction observed in the MPN of sexually  satiated rats was drastic when compared to that of animals  ejaculating once. Serum androgen levels did not vary after  one ejaculation or copulation to exhaustion. These data  reveal that sexual activity reduces AR in specific brain  areas and suggest the possibility that such a reduction  underlies the sexual inhibition that characterizes sexual  satiety.

-The nucleus accumbens, part of the brain where androgen  receptors are altered is involved in anxiety disorder. (largely present in POIS)
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T02-4B8BJYG-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1043712564&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=96b267e21e9a097f0dce3dfa0b4a43f4
Quote
Abstract
We considered clinical observations in patients with  obsessive–compulsive- and anxiety-disorders, who underwent  bilateral anterior capsulotomy, as well as anatomical and  pathophysiological findings. Based on these  considerations, we choose the shell region of the right  nucleus accumbens as target for deep brain stimulation  (DBS) in a pilot-series of four patients with severe  obsessive–compulsive- and anxiety-disorders. Significant  reduction in severity of symptoms has been achieved in  three of four patients treated. Clinical results as well  as a 15-O-H2O-PET study, perfomed in one patient during  stimulation, speak in favour of the following hypothesis.

As a central relay-structure between amygdala, basal  ganglia, mesolimbic dopaminergic areas, mediodorsal  thalamus and prefrontal cortex, the accumbens nucleus  seems to play a modulatory role in information flow from  the amygdaloid complex to the latter areas. If disturbed,  imbalanced information flow from the amygdaloid complex  could yield obsessive–compulsive- and anxiety-disorders,  which can be counteracted by blocking the information flow  within the shell region of the accumbens nucleus by deep brain stimulation.

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Offline martin88

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5776 on: 12/10/2009 13:59:28 »
This goes back to a theory about POIS that we've discussed - the better the "quality" of orgasm, the less severe the symptoms of POIS are.
It stands to reason that better quality orgasms release more dopamine, which in turn inhibits the prolactin release, and possibly neutralises the symptoms of POIS.
Anybody think there may be something in this?
I don't remember about this theory, too much data here :) What you say is very possible. Some people have more energy and feel better after orgasm. For me the very good orgasms can cause the worst POIS episodes. Maybe because prolactin is also increased. We had a discussion about this study : "The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety"  http://www.ncbi.nlm.nih.gov/pubmed/16095799

It seems possible that if POIS sufferers have an existing problem with low dopamine, even a normal secretion of prolactin will decrease dopamine enough to cause problems.

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5777 on: 12/10/2009 18:11:57 »
do you guys know why different labs have different ranges for the same test but also have same units for example.

quest diagnotstic
total testosterone
250 - 1100 ngdl

AEL
280 -1070 ng/dl

labcorp
175-781 ng/dl

it is like that for free testoterone and this is the one without bioavailable.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5778 on: 12/10/2009 22:41:41 »
This goes back to a theory about POIS that we've discussed - the better the "quality" of orgasm, the less severe the symptoms of POIS are.
It stands to reason that better quality orgasms release more dopamine, which in turn inhibits the prolactin release, and possibly neutralises the symptoms of POIS.
Anybody think there may be something in this?
I don't remember about this theory, too much data here :) What you say is very possible. Some people have more energy and feel better after orgasm. For me the very good orgasms can cause the worst POIS episodes. Maybe because prolactin is also increased. We had a discussion about this study : "The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety"  http://www.ncbi.nlm.nih.gov/pubmed/16095799

It seems possible that if POIS sufferers have an existing problem with low dopamine, even a normal secretion of prolactin will decrease dopamine enough to cause problems.


Martin, I think that what hurray means by "the very good [quality] orgasm" is not necessarily the explosive/exciting one but the orgasm that is more entwined with the "quality of the relationship".

Hurray, can you clarify?
« Last Edit: 12/10/2009 23:45:04 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5779 on: 12/10/2009 23:47:04 »

do you guys know why different labs have different ranges for the same test but also have same units for example.

quest diagnotstic
total testosterone
250 - 1100 ngdl

AEL
280 -1070 ng/dl

labcorp
175-781 ng/dl

it is like that for free testoterone and this is the one without bioavailable.


I noticed that too on mine. No clue.

I googled the question, here are some "answers":
http://www.google.com/search?hl=en&source=hp&q=why+different+labs+have+different+ranges%3F&btnG=Google+Search&aq=f&oq=&aqi=
 
« Last Edit: 13/10/2009 00:11:01 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5780 on: 13/10/2009 00:03:25 »

hi
i'm new here
i'm so happy  to join you
i'm  from belgium 27y male  (sorry my english isn't so good)
yes, i 'm a Pois sufferer, it caused me many probleme in my life (separation,depression,weaknes....)
this syndrome destroyed me life, i live alone no girlfriend no wife  no masturbation ...


Bruxe, since we at this forum have some strong theories of POIS and hormonal imbalance, maybe the Belgian Endocrine Society can help you find an endocrinologist who is familar with sexual problems:
http://www.endocrinesociety.be/
« Last Edit: 13/10/2009 00:05:36 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5781 on: 13/10/2009 00:16:45 »

hey guys, anybody think that POIS could just be a symptom of depression?


In my case, I don't think so.

Why?

Over many, many years.............

I have felt "down".............................strong POIS

I have felt "up" (even elated)..............strong POIS

"Up" includes periods of my life with AND without effective antidepressant medication.
« Last Edit: 13/10/2009 00:18:38 by demografx »

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Offline lauracostis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5782 on: 13/10/2009 00:35:43 »
This goes back to a theory about POIS that we've discussed - the better the "quality" of orgasm, the less severe the symptoms of POIS are.
It stands to reason that better quality orgasms release more dopamine, which in turn inhibits the prolactin release, and possibly neutralises the symptoms of POIS.
Anybody think there may be something in this?
I don't remember about this theory, too much data here :) What you say is very possible. Some people have more energy and feel better after orgasm. For me the very good orgasms can cause the worst POIS episodes. Maybe because prolactin is also increased. We had a discussion about this study : "The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety"  http://www.ncbi.nlm.nih.gov/pubmed/16095799

It seems possible that if POIS sufferers have an existing problem with low dopamine, even a normal secretion of prolactin will decrease dopamine enough to cause problems.


Martin, I think that what hurray means by "the very good [quality] orgasm" is not necessarily the explosive/exciting one but the orgasm that is more entwined with the "quality of the relationship".

Hurray, can you clarify?

this prolactin stuff is very interesting, but for the people who say that sexual excitement, or any kind of intense excitement can cause pois like symptoms, the following statement would negate this theory. "prolactin levels were unaffected by sexual arousal, increases in plasma prolactin during sexual stimulation are orgasm-dependent, suggesting that prolactin may regulate a negative-feedback sexual-satiation mechanism".  then again we do have pois, which means there is somthing physioloicaly wrong/different with are bodies.

the study said that blood was drawn automatically by a machine at intervals during/after masterbation. i think somthing like this could tell us what is intiating this negative cascade of effects in our bodies.  it would at least tell us if our bodies are working the same way during sexual stimulation/orgasm as every body else.

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Offline GoingCrazy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5783 on: 13/10/2009 05:15:07 »
I was wondering if somebody could take Benadryl allergy and/or motrin to see if they have relief of at least some their symptoms.  Something is helping me but I'm not sure what it is.
I am taking vitamin B's, chelated magnesium, calcium magnesium, and motrin.  Even rhodiola rosea.  I've also been stretching my neck out and rotating it (not sure if that's really helping me or not). 
But I would like if somebody has either motrin or benadryl allergy to take some and tell me how you feel, if you don't feel a difference it just cancels those out for me.  I don't think it is the vitamins I'm taking, even though I really "felt" the good feeling of vitamin B after I haven't taken it in a long time.  Thank you

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5784 on: 13/10/2009 05:51:46 »

Laurac, interesting about prolactin. For a VERY long time I was running around this planet with sky-high prolactin (10X the norm). I can't make heads or tails out of it meaning anything though (for me).

I notice a number of people saying that arousal-only can create POIS. For me, it's the opposite: if I'm aroused yet don't take it to "the next step", I feel stronger and more positive. I've seen this sentiment repeated by other people a number of times in my reading over the years.

Interesting opposites in people!

« Last Edit: 14/10/2009 16:30:58 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5785 on: 13/10/2009 05:59:25 »

Mat, many thanks for updating the POIS website this last weekend!
http://sites.google.com/site/POISwebsite/

Your work is very much appreciated.

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Offline Danny_Boy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5786 on: 13/10/2009 06:25:08 »
Dear guys,

I was very busy during the summer, so I only had time to come now.

* Different lab ranges: this is simple. There are no nationwide standards on ranges, so each lab has to do their own research on this. They take volunteers, measure their whatever (T, glucose...) and do the statistics. However, with a different distribution of the values in different volunteer groups, you get sometimes very different result - for example in Prague, Czech republic (where I live) we have two labs, where the boundary for becoming hypohomo-cysteinemic is 11 in one and 12,... in the other, so your diagnosis basically depends on which lab you are sent to.

* Prolactin/dopamine: I have myself taken Mucuna pruriens, which is a plant rich in L-DOPA (the very thing used to treat Alzheimer's sufferers), that the body converts directly to dopamine and..with no effect on POIS. However, my prolactin level was in the low normal on a blood test, so maybe folks who have higher prolactin could use Mucuna. It is dirt cheap at swansons.

* Just an addition of mine to the theory of lauracostis here: in the axons (the output pathways of neurons) the signal spreads by a long cascade of Na/K pumps. So if there is some problem with bioelectricity (gradients and stuff), I can imagine, that this must have a great impact on the brain.

* The CHI stuff: I have myself been a great believer of this. I can testify that properly done Qi Gong exercises are energizing and boost me both physically and mentally, and that I get weaker with each O. On the other hand I have never experienced any relief from TCM designed diet. However, I also believe, that chi is just a nickname for something to be discovered later (like "bioelectricity") or stuff. The connection of O´s and losing energy is quite clumsy, because as probably many more guys here, if I have sex and don´t come, I feel some POIS-like stuff too. Namely, my limbs get really cold and I get a slightly empty feeling in the head. So in my view, it will have something to do with neurotransmitters to.

* My experience in the last months: I started taking something called DMAE. It is naturally occurring in fish and has the ability to raise neurochemicals. Together with practising the above mentioned QiGong practise and doing a 20 mins cardio at least 2x a week, I managed to reduce my POIS symptoms to being slightly dumb the very day of a NE, however even in this state of dumbness I am much better mentally that I used to be in my best days some 3-4 months ago. Dieting is extremely important - as someone here said that pasta doesn´t make them feel good and they are always hungry...I used to be the same hungry before I started eating fats on a regular basis. Also, when I eat pasta, pastry of other grain-stuff, I get literally debilitated for a day - a noticeable weakness in muscles, a noticeable brain fog etc, even though an allergy test did not reveal any reaction to gluten. So if you want to check another thing, try to go gluten-free for a month.

In the mean time, I am going to try fenugreek and cranberries, so that we have another test subject:)

Take care and keep up the good sense of humor present in this forum,
D.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5787 on: 13/10/2009 07:28:26 »

American Society of Andrology
http://www.andrologysociety.com/


Thanks to Mat780, for recommending that we make the ASA aware of our condition. I just sent an outreach letter to the President, asking for any guidance in studying POIS..

Let's hope for a reply!

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5788 on: 13/10/2009 23:58:37 »
Watson Pharmaceuticals

We got a great reception today! [:)]

The woman I spoke to demonstrated that by writing up our conversation and circulating it to several departments.

She went to our forum site here as we spoke. She asked to see Dr Waldinger's paper and I will send it tonight, along with other POIS links of interest.  I said Waldinger's paper adds credibility when we show it to our physician and that a "Watson Study Of POIS" would help too, especially with endocrinologists.

No promises, but I do feel good about this one.

She also said I'm a great spokesman for POIS [:)] But personally, I think Johnny Depp would do better!

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5789 on: 14/10/2009 00:45:54 »
Watson Pharmaceuticals

We got a great reception today! [:)]

The woman I spoke to demonstrated that by writing up our conversation and circulating it to several departments.

She went to our forum site here as we spoke. She asked to see Dr Waldinger's paper and I will send it tonight, along with other POIS links of interest.  I said Waldinger's paper adds credibility when we show it to our physician and that a "Watson Study Of POIS" would help too, especially with endocrinologists.

No promises, but I do feel good about this one.

She also said I'm a great spokesman for POIS [:)] But personally, I think Johnny Depp would do better!


Fantastic job on that. 

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Offline CertainlyPOIS

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5790 on: 14/10/2009 00:47:34 »
* Different lab ranges: this is simple. There are no nationwide standards on ranges, so each lab has to do their own research on this. They take volunteers, measure their whatever (T, glucose...) and do the statistics. However, with a different distribution of the values in different volunteer groups, you get sometimes very different result - for example in Prague, Czech republic (where I live) we have two labs, where the boundary for becoming hypohomo-cysteinemic is 11 in one and 12,... in the other, so your diagnosis basically depends on which lab you are sent to.


adding to that.   

on testosterone the labs use different testing methods which also influences the results and ranges.  So it is better to stick with one lab to avoid confusion.

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Offline hurray

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5791 on: 14/10/2009 01:03:06 »
Thanks for the responses martin and laura, plenty of food for thought!

Quote
Martin, I think that what hurray means by "the very good [quality] orgasm" is not necessarily the explosive/exciting one but the orgasm that is more entwined with the "quality of the relationship".

Hurray, can you clarify?

The word "quality" was partly to acknowledge that some orgasms produce more/less POIS symptoms than others. Counterpoints has referred to "good" and "bad" orgasms, with the good ones actually alleviating his symptoms. According to the POIS website, one sufferer was cured when he started a new relaionship - perhaps the altered brain chemistry of being newly in love can help mitigate the effects of POIS.

Wikipedia says this about dopamines effect on prolactin:

http://en.wikipedia.org/wiki/Dopamine

Quote
Regulating prolactin secretion
Dopamine is the primary neuroendocrine inhibitor of the secretion of prolactin from the anterior pituitary gland. [12] Dopamine produced by neurons in the arcuate nucleus of the hypothalamus is secreted into the hypothalamo-hypophysial blood vessels of the median eminence, which supply the pituitary gland. The lactotrope cells that produce prolactin, in the absence of dopamine, secrete prolactin continuously; dopamine inhibits this secretion. Thus, in the context of regulating prolactin secretion, dopamine is occasionally called prolactin-inhibiting factor (PIF), prolactin-inhibiting hormone (PIH), or prolactostatin. Prolactin also seems to inhibit dopamine release, such as after orgasm, and is chiefly responsible for the refractory period.

It seems that there is normally an equilibrium between dopamine and prolactin.

It's possible that the milder POIS symptoms that some people get from sexual stimulation without orgasm are caused by the above effect - after stimulation, dopamine levels drop below their normal baseline, allowing some prolactin secretion to take place. People with a higher baseline of dopamine would not be affected.

Another possibility is that in some people, high dopamine orgasms causes a huge initial release of prolactin to compensate, draining the brains store of prolactin. Once dopamine levels return to normal, there is not enough prolactin left to trigger the symptoms of POIS. A lower dopamine orgasm would trigger a smaller prolactin release, leaving enough prolactin left for the subsequent prolactin secretion to trigger full-blown POIS symptoms. One danger would be that a high dopamine orgasm could lead to an individuals supply of dopamine being exhausted rather than the prolactin supply, which would lead to an extremely unpleasant bout of POIS.

That's my attempt to pin the blame for the whole POIS monster on dopamine/prolactin  [;)] - I would welcome any thoughts on this!

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Offline hurray

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5792 on: 14/10/2009 01:08:21 »
Great work Demo - thanks for putting more time and effort into our cause, it would be wonderful to see further research into POIS taking place as a result of this!

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Offline mat780

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5793 on: 14/10/2009 01:14:44 »
Watson Pharmaceuticals

We got a great reception today! [:)]

The woman I spoke to demonstrated that by writing up our conversation and circulating it to several departments.

She went to our forum site here as we spoke. She asked to see Dr Waldinger's paper and I will send it tonight, along with other POIS links of interest.  I said Waldinger's paper adds credibility when we show it to our physician and that a "Watson Study Of POIS" would help too, especially with endocrinologists.

No promises, but I do feel good about this one.

She also said I'm a great spokesman for POIS [:)] But personally, I think Johnny Depp would do better!



These are terrific news!

If we keep on working this hard we will have good news soon!!!

I feel proud of the people on this Forum. It makes me hopeful   [:D]


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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5794 on: 14/10/2009 01:47:32 »

Thanks, everybody, and I agree with Mat, there's much reason to be hopeful!

ps - Watson Pharmaceuticals is the 5th largest pharmaceutical company in the United States:
http://en.wikipedia.org/wiki/Watson_Pharmaceuticals
« Last Edit: 14/10/2009 01:55:01 by demografx »

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Offline lauracostis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5795 on: 14/10/2009 03:31:07 »
I was wondering if somebody could take Benadryl allergy and/or motrin to see if they have relief of at least some their symptoms.  Something is helping me but I'm not sure what it is.
I am taking vitamin B's, chelated magnesium, calcium magnesium, and motrin.  Even rhodiola rosea.  I've also been stretching my neck out and rotating it (not sure if that's really helping me or not). 
But I would like if somebody has either motrin or benadryl allergy to take some and tell me how you feel, if you don't feel a difference it just cancels those out for me.  I don't think it is the vitamins I'm taking, even though I really "felt" the good feeling of vitamin B after I haven't taken it in a long time.  Thank you
motrin/ibprophen gives me some relief from intial symptoms during first cupple days, expecialy right after o. alieve/naproxen sodium gives me better relief.

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Offline lauracostis

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5796 on: 14/10/2009 03:37:21 »
Watson Pharmaceuticals

We got a great reception today! [:)]

The woman I spoke to demonstrated that by writing up our conversation and circulating it to several departments.

She went to our forum site here as we spoke. She asked to see Dr Waldinger's paper and I will send it tonight, along with other POIS links of interest.  I said Waldinger's paper adds credibility when we show it to our physician and that a "Watson Study Of POIS" would help too, especially with endocrinologists.

No promises, but I do feel good about this one.

She also said I'm a great spokesman for POIS [:)] But personally, I think Johnny Depp would do better!

good job demo your on the ball right now

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5797 on: 14/10/2009 04:46:31 »

CCconfucius, if you (and Danny_Boy) wish, maybe you could speak with Peter Weiss, he's the original Czech researcher I spoke with who strongly recommended testosterone to me for POIS. He was highly recommended by a foremost sex researcher at Johns Hopkins University. If you want his email address, please PM me.
« Last Edit: 14/10/2009 06:53:04 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5798 on: 14/10/2009 06:57:42 »

Mat, very nice color scheme on "updated and "new" on the website!

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #5799 on: 14/10/2009 20:29:20 »
POIS Resource List:


I just sent this info to Watson Pharmaceuticals (with a letter). Feel free to use these items to send out to anyone you wish, so that they can better familiarize themselves with POIS:

 

POIS research study: Dr Marcel Waldinger
(if you don't have PDF, get one from demografx)

POIS Forum member survey database:
http://pois.olympe-network.com/

POIS video:
http://www.youtube.com/watch?v=UWBxAUC9k1g

POIS Forum Compendium:
http://sites.google.com/site/POISwebsite/

POIS Forum:
http://www.thenakedscientists.com/forum/index.php?topic=6576.0

POIS Information website:
http://sites.google.com/site/POISwebsite/

POIS wikipedia:
http://en.wikipedia.org/wiki/Postorgasmic_illness_syndrome

NY Times article:
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

OR---------

IF YOU WANT TO USE ABBREVIATED URL's/LINKS:

(before sending, remove the spaces in tinyurl links)



POIS research study: Dr Marcel Waldinger
(If you don't have PDF, get one from demografx)

POIS Forum member survey database:
http://pois.olympe-network.com/

POIS Video:
h t t p : / / t i n y u r l . c o m / y g 8 9 3 g j

POIS Forum Compendium:
http://sites.google.com/site/POISwebsite/

POIS Forum:
h t t p : / / t i n y u r l . c o m / d 3 u v 8 8

POIS Information website
http://sites.google.com/site/POISwebsite/

POIS wikipedia:
h t t p : / / t i n y u r l . c o m / y g e x b 3 r

NY Times article
h t t p : / / t i n y u r l . c o m / y g f w g k 4

« Last Edit: 15/10/2009 07:37:57 by demografx »