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Hello every one, I also have this curse..i remember the time and date when i got it. I was 15 years old, and i was (lol) masterbating when BAM i had a panic attack. I had no idea what the **** was happening. In my mind i thought i was dying...and from that point on and 4 years later i still have POIS.I mean, i still have sex i don't have ED or anything..OK here are the symptoms i get after the "dance of death" if you wanna call it that...I have Brain Fog 24/7 i mean that sh1t doesn't go away....only for a few seconds after i orgasm and then it comes back..I've learned how to live with it tho.Mental & physical exhaustion i can still function, but not the way i want to.Just a wile back i had depression for the fact that i have this sh1t and it ain't getting better..depression is gone BTW no meds!!!I have low confidence or i just don't care about stuff anymore, i hate life and i envy every one that is not going trough the pain I'm going through etc..Since the first day i had POIS stress and anxiety started creeping in my life, anxiety is gone but stress is always there. For about 3 years i had no idea what i had, i thought i had a brain tumor, testicular cancer, insanity, depression, i don't know whats worse having this or not knowing what i had.This is all for now if yall have any questions, i am happy to answer them.
Quote from: hazey on 27/01/2010 02:31:14I have an appointment with a supposedly very good Dr who specializes in Thyroid/Adrenal, hormones and anti-aging. I want to get the below tests done prior to my consultation.Can anyone think of anything else I should be getting tested and when would be best to have the collection done. Day 1, Day 2 after OThanks.Blood Test===========Total+Free/Bio TestosteroneLH+FSHEstradiol(E2)SHBGProlactinDHEACostisolIGF-1ProgetesteroneDht,TSH, Free T3, Free T4, Reverse T3Magnesium(+ adrenalinecrp)?Saliva Test===========Cortisol (Morning, noon, evening, night)Estriol, Estradiol, Eestrone,ProgesteroneTestosteroneDHEANeurotransmitter Test=====================SerotoninAcetylcholineDopamineGABAHistamine
I have an appointment with a supposedly very good Dr who specializes in Thyroid/Adrenal, hormones and anti-aging. I want to get the below tests done prior to my consultation.Can anyone think of anything else I should be getting tested and when would be best to have the collection done. Day 1, Day 2 after OThanks.Blood Test===========Total+Free/Bio TestosteroneLH+FSHEstradiol(E2)SHBGProlactinDHEACostisolIGF-1ProgetesteroneDht,TSH, Free T3, Free T4, Reverse T3Magnesium(+ adrenalinecrp)?Saliva Test===========Cortisol (Morning, noon, evening, night)Estriol, Estradiol, Eestrone,ProgesteroneTestosteroneDHEANeurotransmitter Test=====================SerotoninAcetylcholineDopamineGABAHistamine
And I also don't wish to increase the dose, yet, which keeps me at low-normal.
In elderly males, the coordinate release of LH and testosterone became asynchronous despite normal serum levels of these hormones....Our findings suggest that in middle-aged men, less pulsatile testosterone and more LH are secreted at night than in young men, with disruption of the association between testosterone rhythm and REM sleep. The decline in nocturnal testosterone secretion appears to involve a combination of testicular and pituitary hypogonadism.
On a lighter note,Ive wondered, how do people pronounce POIS?Is it like 'po-is', or sounding like 'poise'?
Good question! I don't think it's ever been really discussed on this forum. For myself, I have always pronounced it P-O-I-S (saying the name of each letter, as in the pronunciation of 'TNT'--I suppose both POIS and TNT can have harmful 'explosive' properties!)Quote from: daveyboy on 21/02/2010 12:06:29On a lighter note,Ive wondered, how do people pronounce POIS?Is it like 'po-is', or sounding like 'poise'?
Quote from: demografx on 20/02/2010 16:14:06 And I also don't wish to increase the dose, yet, which keeps me at low-normal. my T is also at low normal and I have severe POIS. I'm wondering if I can have an erratic T secretion, maybe T is not what it should be during the night. I don't have a refreshing sleep during POIS. Maybe we need something like a 24h T test, or a constant monitoring test during sleep.QuoteIn elderly males, the coordinate release of LH and testosterone became asynchronous despite normal serum levels of these hormones....Our findings suggest that in middle-aged men, less pulsatile testosterone and more LH are secreted at night than in young men, with disruption of the association between testosterone rhythm and REM sleep. The decline in nocturnal testosterone secretion appears to involve a combination of testicular and pituitary hypogonadism.http://cat.inist.fr/?aModele=afficheN&cpsidt=14951476
Martin, excellent point! 10mg Androderm T-patch daily brought me within normal range. Which helped my POIS, but I wanted more (greedy me )...so I asked for a 50% increase to 15mg - and THAT worked much better!I asked for the increase because I experimented and took 15mg when POIS started, and that helped.
-my trial with phosphatidylserine didn't bring relief. Only a very small improvement (slightly nerve tonic).Fenugreek was more effective (30% improvement for POIS), but with inconsistent results.Appetite was increased a lot on it, and sexual frequency was increased which I don't like.-good I didn't see the endo yet, I'll be able to ask for a progesterone test. Norethisterone seems to be androgenic and anti estrogenic (source: BIAM).
You will need to find an enlightend doctor to assist you with 'low normal levels'. A sports medico or anti-aging medico would likely be better than an endo or regular GP/MD. I had symptoms of low testosterone for years and and got low readings. I was told I was too young to take TRT (yeah better to take it when you are retired than during the peak years of your life) or that I was low but still just in the normal range (thats fine ..you are with 95% of the male population....no I'm in the bottom 5% of the bell curve) It was only after many years that I had a doc who measured my free T levels that where quite low, who finally did something about it. Make sure your Endo requests 'free testosterone' test. While TRT has not cured pois for me, I definitely feel better for it.As I was lead to believe, the normal ranges one sees on pathology reports are statistically based on the results of past patient blood tests. This would mean the 'normal' range would be skewed on the low side because the majority of T tests would be performed on men who are fatigued & not feeling well and are visiting their doctor and not strapping fit healthy guys who have no need to visit a doctor. If your girlfriend goes to the doctor to request estrogen for birth control, she's out in 5 with a script, but when it comes to testostene...
Martin88I have been using phosphatidylserine and I also have to report disappointment..also just the slightest improvement. I was 50% strength. I had tried it back in the late 90s and noticed a cognitive boost with a different brand that I could get anymore.Fenugreek I tried and was very impressed the first week but its effect faded after that. I have not tried it for quite a while. I would have loved to have gotten an appetite boost. Good luck with your endo.
I'm not sure what this means as to the potential relationship between norethisterone and cancer(no human studies done), but I thought I would post this link to be on the safe side:http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s139nore.pdf
edit: also not sure how this affects progesterone
about progesterone as dangerous, remember that hundreds of millions of people have been taking it for the last 20 years on a daily basis for birth control and many other things.
Symptoms Which Might Indicate a B12 Deficiency Vitamin B12 deficiency can cause unusual neurological symptoms such as tremor, gait disturbance, severe pain, and can mimic MS (multiple sclerosis) or even Parkinsonís Syndrome. The physical signs and symptoms can often mimic other diseases and the diagnosis is frequently missed. An excellent book on the topic is: Could it Be B12? An Epidemic of Misdiagnosis by Sally M. Pacholok, R.N. and Jeffrey J Stuart, D.O. (1) B12 deficiency damages the myelin sheath around the nerve fibers, this is a soft fatty insulating material which is also damaged in demyelinating diseases such as multiple sclerosis. Mental Changes: Irritability, apathy, sleepiness, paranoia, personality changes, depression (including post-partum depression), memory loss, dementia, cognitive dysfunction or deterioration, fuzzy thinking, psychosis, dementia, hallucinations, violent behavior, in children; autistic behavior, developmental delay. Neurological Signs and Symptoms: Abnormal sensations (pain, tingling, and/or numbness of legs, arms trunk or anywhere),diminished sense of touch, pain or temperature (may mimic diabetic neuropathy Charcot foot), loss of position sense, weakness, clumsiness, tremor, any symptoms which may mimic parkinson's or multiple sclerosis, spasticity of muscles, incontinence, paralysis, vision changes, damage to optic nerve (optic neuritis). Vascular Problems: Atherosclerotic vascular disease is increased by B12 deficiency including; Coronary artery disease, TIAs, CVA, heart attack, heart failure, claudication, all associated with elevated homocysteine levels caused by B12 deficiency.
QuoteI'm not sure what this means as to the potential relationship between norethisterone and cancer(no human studies done), but I thought I would post this link to be on the safe side:http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s139nore.pdfThanks for reposting this link Demo. It's obviously a very important potential risk to be aware of. Dr Dexter reported in his paper that Merck, the manufacturers of the drug, confirmed there were no known harmful side effects of norethisterone in (human) males. In the light of the National Toxicology Program's conclusions that you linked to, one is left wondering about long-term usage and its important to be aware of both reports.(It should also be said that lots and lots of substances have been found to have carcinogenic effects, including many substances found in everyday foodstuffs and even chlorine that is used to treat drinking water. The carcinogenic risk from such substances seems to depend a lot on the concentration of that substance in the body which can accumulate over time with long-term use/ingestion. I don't know how the carcinogenic risk of norethisterone would compare to say a substance found in shampoo or any of a host of other apparently carcinogenic substances we ingest everyday. Tea can have carcinogenic and anti-cancer properties! It's a minefield! I guess it's up to the individual to assess what an acceptable level of risk is but the information available to make that decision seems to be difficult to interpret and sometimes conflicting).Incidentally, if anyone wants an idea of the range of carcinogens we encounter everyday you can start with this google search:http://www.google.com/search?q=carcinogen+everyday+food&rls=com.microsoft:en-gb:IE-SearchBox&ie=UTF-8&oe=UTF-8&sourceid=ie7&rlz=1I7GGLL_en
Quote from: demografx on 22/02/2010 23:59:24 edit: also not sure how this affects progesteroneFurther to my post above, if norethisterone is a synthetic version of progesterone and is carcinogenic, one might also expect naturally occuring progesterone to be carcinogenic and that does indeed seem to be the case!! (though not necessarily proven in humans)http://www.google.com/search?q=progesterone+carcinogenic&rls=com.microsoft:en-gb:IE-SearchBox&ie=UTF-8&oe=UTF-8&sourceid=ie7&rlz=1I7GGLL_enProgesterone also has anti-cancer properties!:http://www.google.com/search?q=progesterone+inhibits+cancer&rls=com.microsoft:en-gb:IE-SearchBox&ie=UTF-8&oe=UTF-8&sourceid=ie7&rlz=1I7GGLL_enWhich just goes to show how careful you need to be when assessing risks of chemicals! This MAY mean that norethisterone is no more carcinogenic than the progesterone produced by a normal body and might even have anti-cancer properties too!
Demo,I'm wondering if you have had your homocystine levels checked?...wondering if B12 might be the root cause...What do you think?...... The symptoms do line up with many of our complaints.
If we look steroid hormones synthesis :We have Demo's succes with testo on the right,Agjchs 's succes with DHEA right side,scientific study succes with progesterone on the left side.But progesterone can be converted to the right side by hydroxyprogesterone/androstenedione pathway if needed (I suppose in Pois).Some of us find stress (cortisol) makes the Pois stronger, and some guys are healed with Relora (less cortisol, more DHEA).
[From list of John's B12 deficiency characteristics]The "abnormal sensations" could relate to your fingertips problem.
Laurac, I've done extensive blood tests, is there another name for B12-testing/results?
Testing for the Diagnosis of B12 Deficiency Most doctors do not test for B12, and even they do a blood test, they do the standard serum B12 which is unreliable.