[Limejuice]

I find it interesting that hormones testosterone (Demo's cure) and progesterone are both manufactured in the testies. This could suggest that the 'disease' is really an organ issue, and also could identify other possible cures or the testing of other hormones produced in the testies.

[daveman]

(i dont get the theory of it yet, can someone try and explain it? .. you know, why the female hormone needs bumping up in pois..i get kinder get the low testosterone theory/relate to that more...mmm..

Thought I saw something there about how progesterone during pregnancy helps to prevent rejection of the fetus. Think I've seen some links between progesterone and swelling in men (probably women too). And then there was the Scientific American article that showed how swelling of the meninge that can cause symptoms similar to POIS. It's pretty complicated so I'm still trying to find more information and piece things together.

Not sure what the profesional explanations might be though.

[demografx]

I find it interesting that hormones testosterone (Demo's cure) and progesterone are both manufactured in the testies. This could suggest that the 'disease' is really an organ issue, and also could identify other possible cures or the testing of other hormones produced in the testies.

(1) I agree, Limejuice, something is "up" in that department (no pun intended)

(2) I wonder if we should re-think urology as a possible avenue, and also try to recruit researcher(s) from that field?

Anyone else agree/disagree?

[Limejuice]

Unfortunately I only have the one prescription of progesterone so my testing for an optimal schedule will be limited.  What I know so far is that it works for me according to the schedule I posted (which is similar to the schedule in the article...but slightly different).  In comparing the person in the article to me, were different in that I need more progesterone and at a different interval.  This observation would lead me to believe that if progesterone works for others that they need to understand the dosage and time interval that fits their needs best.

We are all treading new territory so much that no documentation on prescriptions has been written for POIS. I feel we need to cautiously understand what we need (such as reviewing the side-effects and interactions like Demo posted).

My progesterone levels were never tested - it was prescribed based off an article.

My intake is really irregular in that sometimes I take specifically before O and sometimes I'll take a random 5mg.

Why do you ask?

What would you say is a good overall regimine then, now that you've experimented a bit, and if you had to try to formalize a program?

[Limejuice]

RE:  #2 - I agree we should!

I find it interesting that hormones testosterone (Demo's cure) and progesterone are both manufactured in the testies. This could suggest that the 'disease' is really an organ issue, and also could identify other possible cures or the testing of other hormones produced in the testies.

(1) I agree, Limejuice, something is "up" in that department (no pun intended)

(2) I wonder if we should re-think urology as a possible avenue, and also try to recruit researcher(s) from that field?

Anyone else agree/disagree?

[prism]

I find it interesting that hormones testosterone (Demo's cure) and progesterone are both manufactured in the testies. This could suggest that the 'disease' is really an organ issue, and also could identify other possible cures or the testing of other hormones produced in the testies.

ah ok, i didnt know this about progesterone and testicles.
now this is making more sense to me.

I would love to know all the hormone testicles are involved in making and to what extent.


(also, from the article, although i dont suffer from PSAS i did relate to number three as in it fits my reason for my pois cause-
3. Neurologic Types of PSAS - either due to a neurologic defect caused by a subtle injury, or due to an altered neurotransmitter response)

isnt it a shame you cant take T in pill-form too?

[lauracostis]

I find it interesting that hormones testosterone (Demo's cure) and progesterone are both manufactured in the testies. This could suggest that the 'disease' is really an organ issue, and also could identify other possible cures or the testing of other hormones produced in the testies.

ah ok, i didnt know this about progesterone and testicles.
now this is making more sense to me.

I would love to know all the hormone testicles are involved in making and to what extent.


(also, from the article, although i dont suffer from PSAS i did relate to number three as in it fits my reason for my pois cause-
3. Neurologic Types of PSAS - either due to a neurologic defect caused by a subtle injury, or due to an altered neurotransmitter response)

isnt it a shame you cant take T in pill-form too?

the ovaries and testies both produce androgens, estrogens, and progestins in varying amount in males and females. they are controlled by the release of tropic hormones LH, and FSH by the posterior pituitary gland.

[lauracostis]

since we dont really know if progesterone is really safe or not?  if you just wanted to take progesterone a few times a month, that would probably be safe.  if you wanted to have sex every day, then you would be significantly altering your progesterone levels by daily augmentation of progesterone.  that would worry me a little bit

[prism]

Well theres plenty of books on the pros and cons of hormone replacement including many on progesterone.
I doubt getting pois every week is that safe either.
I agree theres loads of personal research to consider before going on HRT.
I dont like the idea of using a female hormone..Im not that manly looking as it is! (+ my car parking skills are dreadful as they are!!)

[demografx]

I dont like the idea of using a female hormone..Im not that manly looking as it is! (+ my car parking skills are dreadful as it is!!)

Haha! And before you know it, you'll be asking strangers for directions! []

[demografx]

Fantastic!!! [re Mayo Clinic]

Can you believe.....Mayo has 6,000 people employed in Research!

In addition to writing to Mayo Clinic Endocrinologists:

              Dr. Eberhardt

              Dr. Rizza

I wrote to:

              Dr Kendall Lee, neurosurgery

I also wrote to:

              Dr. Noseworthy, President/CEO of Mayo Clinic.

I immediately got an auto-reply that Dr Noseworthy was out-of-town and to contact one of his 3 assistants. So I wrote to each of his 3 assistants, writing that, "Dr. Noseworthy suggested that I contact you in his absence....................." []

I also wrote to other top people at the Mayo Clinic:

              William Rupp, M.D.,        Vice President and CEO

              Nina M. Schwenk, M.D.,     Vice President

              Victor F. Trastek, M.D.,   Vice President and CEO

              Shirley A. Weis,           Vice President and CAO

RE:  #2 - I agree we should! [seek out urologist researchers]

OK, Limejuice, I went with your reply and contacted 3 Urology Researcher/Professors at The Mayo Clinic.

              Dr. Paul Andrews

              Dr. Donald Tindall

              Dr. Ajay Nehra   (sexual dysfunction)

Everyone: keep your fingers crossed! If this works, we owe Defsync a McDonald's treat for suggesting it []

[strawberryman]

I think a cardiologist might be helpful too . . .

[demografx]

Because of BP?

[lauracostis]

I doubt getting pois every week is that safe either.

pois has damaged my body, doing heroin once a week is probably better for your body than doing pois once a week.

[demografx]

UCSF Medical Center Urology Research

Sent a letter to 2 Senior Research Professors asking them to please help us study POIS:

            James F. Smith, MD, MS

            Ira Sharlip, MD

[demografx]

Laurac, I agree. POIS can be vicious and lifedraining!

[martin88]

Good to send emails, thanks.

I think that doing some tests for progesterone level before supplementing
can help to know if the body's own production has been impaired by the treatment.

not sure this is really helpful:

according to the following study, the way amino acids are used by the body
can be modified with progesterone:
link

progesterone causing anemia. (It's only one case here but it's important to check with doctor for other side effects)
http://www.ncbi.nlm.nih.gov/pubmed/7986730

[daveman]

I doubt getting pois every week is that safe either.

pois has damaged my body, doing heroin once a week is probably better for your body than doing pois once a week.

What damage have you seen, and irreversible?

I feel, aside from the regular symptoms that are transitory, that my body suffers in the joints and soft tissues. Initially swelling, but any joints that are used more often during POIS seem to be damaged beyond the POIS period, and I get the feeling, more permanently. Particularly old workout injuries (my case very old[]).

[daveman]

Very interesting link, and in Wiki no less!

http://en.wikipedia.org/wiki/Progesterone

I can see where a deficiency could produce some of our symptoms.

Although possibly not too related, I'm still looking for a link between sperm fired immune responses and imbalances that could cause abnormal swelling (of meninges and connective tissues).

[demografx]

daveman, I asked Marnia Robinson, a sexual-relationship author, consultant and friend of this forum about your question. Her reply:


"Hi,

Tell Dave to think about visiting this site and contacting David Wise: http://www.pelvicpainhelp.com/. Wise seems a very humble, thoughtful man, and might be able to shed some light on possible research of an immune system response after ejaculation.

Also, Dave may find this little item of interest: http://www.reuniting.info/science/androgens_immune_suppressant_antechinus "