[horizon]

i will not consider the fight against pois over until i am actually cured, or am being thoroughly and effectively treated for for pois symptoms. i will continue to pursue my own theory of removing GnRH from my system with the T/P male birth control.  maybe i will beat Dr. doctor waldinger to the finish line

i still have T/P on my mind as a potential future option.

Although I was disappointed to hear it doesnt create "dry" orgasms- the fluid still leaves your body at orgasm, and needs replemishing
its only sperm it stops... which is such a small percentage of the overall fluid
...it still could cure pois though..?..

[horizon]

I'd be very interested to find out what Dr.Waldinger's treatment for Restless Genital Syndrome is?
Although it is not pois ...
it could be in the same "family"
and treatments could be similar

[demografx]

i will not consider the fight against pois over until i am actually cured, or am being thoroughly and effectively treated for for pois symptoms. i will continue to pursue my own theory of removing GnRH from my system with the T/P male birth control.  maybe i will beat Dr. doctor waldinger to the finish line

Laurac, I love your attitude!!

[demografx]

i still have T/P on my mind as a potential future option.

I think it's one of the most exciting options on the table right now.

[demografx]

In terms of reasearchers do we want to wait for dr waldingers article or do we want keep looking. When sending out letters do we want to mention dr waldingers progress.

I don't think we can afford to wait. But I wouldn't mention Dr Waldinger's progress.

I had the same question- thanks...

Just to elaborate, we don't really know anything more specific about POIS progress at this time.

But as I mentioned in my first reply, if we know another interested researcher, we could always offer to put them together. It would be their decision to collaborate or not. I hope this clarifies.

demo, you are totally correct, we should not mention Dr. Waldinger at all, nor should we put another researcher in touch with him, i think he probably has his own research under control. also, researchers may feel it is a waste of time if we tell them that another doctor has solved the problem already, which we dont know is true yet anyways.  i dont think Dr. Waldinger has any plans to collaborate with others until his papers are peer reviewed and published. we should give him 4 months or so, if we have not heard from him before that time demo should attempt to resume contact with him to check in.

Excellent!

 

[horizon]

On the lines of the P/T discussion, we could have a discussion on a
LHRH analog/Testosterone combination...if stopping signals to the testicles is an answer.
..or even "Total androgen blockade"+ TRT.

LHRH analogs are the chemical equivalent of orchiectomy. TRT would level things I would imagine.

This possible pois cure comes with a caution tag as I dont know enough about it whether it would work.
info on use in cancer treatment
http://www.upmccancercenters.com/cancer/prostate/hormonedrugtherapy.html#ADJUV

[horizon]

i will not consider the fight against pois over until i am actually cured, or am being thoroughly and effectively treated for for pois symptoms. i will continue to pursue my own theory of removing GnRH from my system with the T/P male birth control.  maybe i will beat Dr. doctor waldinger to the finish line

laurac, have you or anybody looked into
GnRH antagonist drugs, or
GnRH agonist drugs

[horizon]

Yes, I believe there may prove a link with Restless Genital Syndrome, in the sense it is believed to be caused by
an irregularity in sensory nerves
and I believe POIS is another example of an irregularity in sensory nerves.
My nerves especially down-below certainly feel 'restless' in POIS, and as a result prehaps my body is fighting hard not to have another orgasm.
(Anyways, if there is a link Waldinger is the man to spot it or not, being the expert on both).

Theres no known cure for RGS although its sometimes be reduced by the use of antidepressants, antiandrogenic agents and anaesthetising gels etc.

[daveman]

i will not consider the fight against pois over until i am actually cured, or am being thoroughly and effectively treated for for pois symptoms. i will continue to pursue my own theory of removing GnRH from my system with the T/P male birth control.  maybe i will beat Dr. doctor waldinger to the finish line

Laurac,

For my money you have one of the most promising lines on the forum, and it isn't too far from several others here.

Whether it be GnRH, FH, FSH or even sperm that is the antagonist, it's a similar mecanism that could be aleviated by the solution.

So don't stop and wait by any means. []

[daveman]

Yes, I believe there may prove a link with Restless Genital Syndrome, in the sense it is believed to be caused by
an irregularity in sensory nerves
and I believe POIS is another example of an irregularity in sensory nerves.
My nerves especially down-below certainly feel 'restless' in POIS, and as a result prehaps my body is fighting hard not to have another orgasm.
(Anyways, if there is a link Waldinger is the man to spot it or not, being the expert on both).

Theres no known cure for RGS although its sometimes be reduced by the use of antidepressants, antiandrogenic agents and anaesthetising gels etc.

There was a link posted by pyropeach some time back, to an article in Scientific American that eludes to the inflamation of the menigus (nerve linings), that would produce POIS type symptoms. This inflamation not only effects the nerves, but the linings of the brain, potencially producing the brain fog and concentration problems.

The inflamation is caused by some kind of disactivation of normal auto-immune inflamation suppresant characteristics of certain white blood cells.

The article doesn't say how this could happen, just that when it happens, one suffers brain fog and concentration problems and pain, all of which are the product of erroneous swelling which would normally be suppressed.

Sounded really familiar to me.

[horizon]

Yes, I believe there may prove a link with Restless Genital Syndrome, in the sense it is believed to be caused by
an irregularity in sensory nerves
and I believe POIS is another example of an irregularity in sensory nerves.
My nerves especially down-below certainly feel 'restless' in POIS, and as a result prehaps my body is fighting hard not to have another orgasm.
(Anyways, if there is a link Waldinger is the man to spot it or not, being the expert on both).

Theres no known cure for RGS although its sometimes be reduced by the use of antidepressants, antiandrogenic agents and anaesthetising gels etc.

There was a link posted by pyropeach some time back, to an article in Scientific American that eludes to the inflamation of the menigus (nerve linings), that would produce POIS type symptoms. This inflamation not only effects the nerves, but the linings of the brain, potencially producing the brain fog and concentration problems.

The inflamation is caused by some kind of disactivation of normal auto-immune inflamation suppresant characteristics of certain white blood cells.

The article doesn't say how this could happen, just that when it happens, one suffers brain fog and concentration problems and pain, all of which are the product of erroneous swelling which would normally be suppressed.

Sounded really familiar to me.

To be honest, this is the area I am hoping Dr.Waldinger will enlighten us on- what is happening with the nerves.

[Vandemolen3]

What's P/T?

[demografx]

What's P/T?

Progesterone/testosterone

[lauracostis]

i will not consider the fight against pois over until i am actually cured, or am being thoroughly and effectively treated for for pois symptoms. i will continue to pursue my own theory of removing GnRH from my system with the T/P male birth control.  maybe i will beat Dr. doctor waldinger to the finish line

laurac, have you or anybody looked into
GnRH antagonist drugs, or
GnRH agonist drugs

you could use GnRH antagonist drugs to do the same thing, but i think there are many side effects. and you would have to replace your testosterone anyways because those drugs stop their production.  you might as well use the P/T combo, patients who used it in the studies did not report any side effects. what i mean is that no one noticed any change in their life, it is always possible that there may be long term effects from using hormone augmentation over an extended period of time. the answer to this question is the same as with females and their birth control, we have been using it for a long time now,it is listed as generally safe, but it is almost impossible to link anything directly to it.

[demografx]

****************************************************************************************

Journal of Sexual Medicine (JSM) opportunity

1. JSM (ISSM official publication) reaches 2,047 individuals, including scientists, biologists, endocrinologists, family practitioners, gynecologists, internists, neurologists, physiologists, psychiatrists, psychologists, sex therapists, urologists and other heathcare clinicians.

2. JSM can offer a 30 day posting of our ad for $270. (Advertising to recruit a researcher to study our POIS Forum data). It would appear here:
http://www3.interscience.wiley.com/journal/118495964/home/professional_opportunities.htm
(See "Professional Opportunities")

3. JSM states that "based on our June numbers, the Journal of Sexual Medicine served approximately 96,000 impressions so there is significant web traffic."

4. One other Forum member has PM'ed me, willing to contribute funds to this ad.

5. Is anyone else here interested? []


****************************************************************************************

[demografx]

CASE REPORT
Postorgasm Illness Syndrome—A Spectrum of Illnesses
Jane Ashby, MRCP, and David Goldmeier, MRCP
Genitourinary Medicine (GUM)/Human Immune deficiency Virus (HIV), Imperial College, St. Mary's Hospital, London, UK
Correspondence to  Jane Ashby, MRCP, GUM/HIV, Imperial College, St Mary's Hospital, Praed Street, W2 1NY London, UK. Tel: 07930384735; Fax: 0044 207 886 6974; E-mail: jane.ashby@imperial.nhs.uk
Copyright © 2010 International Society for Sexual Medicine

KEYWORDS
Postorgasm Illness Syndrome • Fatigue • POIS • Neurobiochemical Sequelae of Orgasm

ABSTRACT
Introduction. We describe two men with marked symptoms following orgasm. In each case, the symptoms were consistent with those found in postorgasm illness syndrome (POIS).

Aim. Further elucidation of the cause of the patients' symptoms.

Methods. Both cases were investigated for causes of POIS with biochemical, hormonal, neurological, autonomic, cardiological, and psychological workup.

Results. Extensive investigation did not reveal a major organic cause for these patients' symptoms. Detailed history revealed likely differing etiologies in each case. In one case, the symptom picture suggested cytokine release, and, in fact, the patient subjectively improved by 80% on taking nonsteroidal anti-inflammatory drugs just prior to and for a day or two after orgasm. The other case appeared to have an ethnic/cultural etiology that was associated with the "Dhat" syndrome.

Conclusion. The apparent differing etiologies/clinical associations of these cases highlight the need for careful history, examination, and investigations in patients presenting with POIS. We recommend that each case needs individual consideration and investigation, and treatment needs to be tailored to the likely cause. It seems likely that POIS represents a spectrum of syndromes of differing etiologies. Further research into the neurobiochemical sequelae of orgasm will be useful in understanding the pathological processes in these cases. Ashby J, and Goldmeier D. Postorgasm illness syndrome—A spectrum of illnesses. J Sex Med 2010;7:1976–1981.
http://www3.interscience.wiley.com/journal/123304654/abstract

(I just wrote to Ms Ashby, the author, thanking her for the POIS study and making her aware of us, if she isn't already. I recall writing to her in the past).

[pyropeach]

Did I/we miss seeing this???

CASE REPORT
Postorgasm Illness Syndrome—A Spectrum of Illnesses
Jane Ashby, MRCP, and David Goldmeier, MRCP
Genitourinary Medicine (GUM)/Human Immune deficiency Virus (HIV), Imperial College, St. Mary's Hospital, London, UK
Correspondence to  Jane Ashby, MRCP, GUM/HIV, Imperial College, St Mary's Hospital, Praed Street, W2 1NY London, UK. Tel: 07930384735; Fax: 0044 207 886 6974; E-mail: jane.ashby@imperial.nhs.uk
Copyright © 2010 International Society for Sexual Medicine

KEYWORDS
Postorgasm Illness Syndrome • Fatigue • POIS • Neurobiochemical Sequelae of Orgasm

ABSTRACT
Introduction. We describe two men with marked symptoms following orgasm. In each case, the symptoms were consistent with those found in postorgasm illness syndrome (POIS).

Aim. Further elucidation of the cause of the patients' symptoms.

Methods. Both cases were investigated for causes of POIS with biochemical, hormonal, neurological, autonomic, cardiological, and psychological workup.

Results. Extensive investigation did not reveal a major organic cause for these patients' symptoms. Detailed history revealed likely differing etiologies in each case. In one case, the symptom picture suggested cytokine release, and, in fact, the patient subjectively improved by 80% on taking nonsteroidal anti-inflammatory drugs just prior to and for a day or two after orgasm. The other case appeared to have an ethnic/cultural etiology that was associated with the "Dhat" syndrome.

Conclusion. The apparent differing etiologies/clinical associations of these cases highlight the need for careful history, examination, and investigations in patients presenting with POIS. We recommend that each case needs individual consideration and investigation, and treatment needs to be tailored to the likely cause. It seems likely that POIS represents a spectrum of syndromes of differing etiologies. Further research into the neurobiochemical sequelae of orgasm will be useful in understanding the pathological processes in these cases. Ashby J, and Goldmeier D. Postorgasm illness syndrome—A spectrum of illnesses. J Sex Med 2010;7:1976–1981.
http://www3.interscience.wiley.com/journal/123304654/abstract

(I just wrote to Ms Ashby, the author, thanking her for the POIS study and making her aware of us, if she isn't already. I recall writing to her in the past).

WHOA, where'd you find this?!?!  This definitely should be on the website, and I'm going to try and get a copy.  Oh, and btw, I'm in the States now back from China...talk about culture shock/jetlag.

[demografx]

Welcome back, Pyro!!

[demografx]

I have the correct email for Ms Ashby, author of the above article. She auto-replied that she will be back August 2!

[demografx]

Thanks, B_Jim! Yes, I was very happy to find it too. I found the abstract while I was researching our possible POIS Forum advertisement to find a researcher in The Journal of Sexual Medicine (JSM), the publication of ISSM (International Society for Sexual Medicine).

It was Published Online: February 26, 2010. Journal of Sexual Medicine. Six (6) pages.

I will try to re-contact Ms. Jane Ashby, the author, when she returns August 2, to St. Mary's Hospital, in London.