[Animus]

Dr. Waldinger's term, "allergy" has never sat right with me.

Nope, me neither.

Me neither... Perhaps "allergy" is a shorthand in an evolving investigation.

Is this a new article or is it a review of the publication of dr. Waldinger? It's from Nature. Written by Suzanne J. Farley. 

http://www.nature.com/nrurol/journal/v8/n3/full/nrurol.2011.17.html

If it's new? Does anyone has an account?

Hyper-reactive immune response is the term they are using here. I'm very interested to read this article. Thanks for posting it, Van.

[Vandemolen3]

Maybe Rock27 can post the article? Or give a summary.

[daveman]

Hyper-reactive immune response sounds much better!

[pyropeach]

Can anyone answer these questions? does anyone else wonder them too?

1. Are there any other known allergies that last for 7 days after exposure and have similar symptoms?
2. Why don't women with semen allergies react in the same way as men with POIS?

I'm not saying you could answer them, but maybe speculate...
Seeing the wheal size photographs are convincing in support of the allergy theory.

You can't compare the female body with the male body. The male urethra and the vas deferens are not the same as oviduct.
And women with semen allergy have a few symptoms that are the same as POIS.

This makes intuitive sense, especially given the acidic properties of womens' bodies in those areas that may alter the allergens (ie render them harmless).  When within a man, proteins and whatnot in the semen remain in their basic environment (semen), but who knows how they get altered perhaps even denatured when thrown into an acidic environment.  It might drastically change the way these allergens are dealt with by our immune system.  Not to mention, maybe all these women are just not allergic to what we are allergic to in the semen...I wonder if girlwind might have experienced this and have more information. 

[Vandemolen3]

This makes intuitive sense, especially given the acidic properties of womens' bodies in those areas that may alter the allergens (ie render them harmless).  When within a man, proteins and whatnot in the semen remain in their basic environment (semen), but who knows how they get altered perhaps even denatured when thrown into an acidic environment.  It might drastically change the way these allergens are dealt with by our immune system.  Not to mention, maybe all these women are just not allergic to what we are allergic to in the semen...I wonder if girlwind might have experienced this and have more information. 

And who knows what effect the ova have on the semen in relation with an allergy. The ova is a womans own liquid. So that could have another effect when a POIS-patient comes in contact with the ova of a woman during sex.

[CertainlyPOIS]

Women also have more progesterone that can mean something.
I get a burning sensation at my lower back when i have done one to many.
i also listed some of the symptoms dr waldinger noted that are similar to other allergy reactions.
Eyes Burning/red injected eyes 20 44
Blurred vision 10 22
Watery/irritating/running/itching eyes 12 27
Dry/sensitive/painful eyes/pressure on
eyes
9 20
Nose Congestion nose 14 31
Watery/snotty/runny nose/sneezing 15 33
Throat Dirty taste in mouth/dry mouth 5 11
Tickling cough/hoarse voice/sore throat 5 11

this two links talk about people with allergic rhitnitis complaining about cognitive problems.
http://www.annallergy.org/article/S1081-1206(10)62273-9/abstract
http://www.acaai.org/allergist/allergies/Types/rhinitis/Pages/allergic-diseases-cognitive-impairment.aspx

[Animus]

This makes intuitive sense, especially given the acidic properties of womens' bodies in those areas that may alter the allergens (ie render them harmless).  When within a man, proteins and whatnot in the semen remain in their basic environment (semen), but who knows how they get altered perhaps even denatured when thrown into an acidic environment.  It might drastically change the way these allergens are dealt with by our immune system.  Not to mention, maybe all these women are just not allergic to what we are allergic to in the semen...I wonder if girlwind might have experienced this and have more information. 

And who knows what effect the ova have on the semen in relation with an allergy. The ova is a womans own liquid. So that could have another effect when a POIS-patient comes in contact with the ova of a woman during sex.

This is interesting:
It seems that men can suffer from the same semen allergy which women suffer from when exposed to semen, despite the differences in anatomy, acidity, etc... If you read this explanation of semen allergy, you will see that the symptoms for men and women are grouped together.
It does say that symptoms vary, but are characterized by certain ones.

Here is an interesting link on semen allergy:
http://www.wellness.com/reference/allergies/semen-allergy/symptoms-and-causes

[demografx]

"When somebody masturbates, is [sic] committing a crime against nature..."

Please! Quotes like this have no place in a Science Forum! Your post has been deleted.

ps - Animus' stage name is Frank, not Frick.  []

[demografx]

Hyper-reactive immune response sounds much better!

Ditto!

[demografx]

Dr. Waldinger's term, "allergy" has never sat right with me.

Nope, me neither.

Me neither... Perhaps "allergy" is a shorthand in an evolving investigation.

Or perhaps one day my Benadryl will kick in and my 20% POIS will be gone. []

[demografx]

The new POIS Forum link:

www.POISCenter.com/forums/index.php

[Animus]

Anyways...I can surely attest to experiencing no symptoms as soon as I feel like my sperm supply has fully regenerated...

I can attest to that feeling too.

Well it sure seems like it. But you can't take your sperm count in your head! LOL

I was not taking my sperm count in my head. I was sensing a legitimate biological feeling, which I had grown attuned to and aware of. Perhaps the cause of that feeling is unknown, and "illusory" as demo has suggested. However, it is legitimate, and has a legitimate cause.

Reflecting on my earlier posts, I hedged a little more than I should have about "subjective" and "feeling".

After 35 years of this, it's way more than "illusory".

When I "feel" semen is low (early regeneration), the ejaculate is....LOW VOLUME.

When I "feel" semen is high (late stage regen), the ejaculate is.....HIGH VOLUME.

And no, I didn't use a measuring cup. Just trust me, ok? []



The above data have been independently verified by Bernie L. Madoff, Butner Correctional Facility, NC.

YES, exactly! Me too!  []
I could even add in that POIS symptom levels corresponded too.

When I "feel" semen is low (early regeneration), the ejaculate is....LOW VOLUME- and the POIS symptoms are at a High.

When I "feel" semen is high (late stage regen), the ejaculate is.....HIGH VOLUME- and the POIS symptoms are Low.

[demografx]

Daveman, I feel badly about our overposting on regen, but I honestly feel this is going somewhere and NOT round in circles. It feels like a tiny piece of the puzzle is ADDED each time we discuss this. But I know it must appear tedious to you and some others. Many thanks for your patience.

[demografx]

The new POIS Forum link:

www.POISCenter.com/forums/index.php

[Habibou]

We can check the dosage of the semen antibody in our blood stream, I learnt it was possible (perhaps already talked there)  :  Ig A, Ig E, Ig M, Ig G

It depends on the persons... Perhaps our different symptoms are due to the different dosage of those Ig towards semen :

1- anti-sperme IgG= C'est une immunoglobuline monomérique qui peut être retrouvée dans les sécretions du tractus génital de l'homme et de la femme. Il s'agit de grosses molécules que ne traversent pas la muqueuse; ainsi, la concentration d'anti-sperme IgG dans le sperme et dans le mucus cervical est < 1%, sa concentration dans le sérum. Cette concentration est trop basse pour permettre l'agglutination du sperme dans l'éjaculat et dans le mucus cervical.

2-anti-sperme IgM= C'est une immunoglobine pentamérique . Ces molécules sont plus grosses que l'IgG, et de ce fait, ne passe pas la barrière cellulaire.

3-anti-sperme IgA= Les anticorps agglutinants du sperme dans le sperme et mucus cervical sont de type IgA (Kremer et Jager, 1992). Ils sont fabriqués dans la muqueuse cervicale (Schumacher, 1988) et l'épididyme . En effet, les anticorps IgA, (à la différence de l'IgG), présents dans les spermatozoïdes et le mucus cervical, sont responsables des troubles d'interaction entre le sperme et le mucus cervical.

Google translate :

1 - anti-sperm IgG = immunoglobulin is a monomer that can be found in the genital tract secretions of man and woman. These are large molecules that do not cross the mucosa, so the concentration of IgG anti-sperm in semen and cervical mucus is <1%, its concentration in serum. This concentration is too low to allow agglutination of sperm in the ejaculate and in the cervical mucus.

2-Anti-Sperm IgM = immunoglobulin is a pentamer. These molecules are larger than IgG, and therefore do not pass the cell barrier.

3-IgA anti-sperm antibodies agglutinating = sperm in semen and cervical mucus are of type IgA (Kremer and Jager, 1992). They are manufactured in the cervical mucus (Schumacher, 1988) and epididymis. Indeed, IgA antibodies (in contrast to the IgG), present in sperm and cervical mucus, are responsible for disorders of interaction between sperm and cervical mucus.

4- IgE = more known for women ( local redness, burining)
       and also Gulf War Syndrome  = Ig E against own semen    (I guess you talked about it earlier too : http://en.wikipedia.org/wiki/Gulf_War_syndrome) just the wiki article but I read more about it.

[demografx]

Habibou,, very interesting!

[Animus]

Animus, thank you!

I left out that most important part, i.e., my POIS severity goes up and down in direct proportion to "semen fullness" (or lack of same)!

Daveman, I feel badly about our overposting on regen, but I honestly feel this is going somewhere and NOT round in circles. It feels like a tiny piece of the puzzle is ADDED each time we discuss this. But I know it must appear tedious to you and some others. Many thanks for your patience.

Yes, I'm sorry I've been complicit in this too! []
I also feel a little reckless...
The next few weeks are very busy for me- so I'll check in when I can. Wish me luck!

[demografx]

Good luck, Animus!

[demografx]

[lauracostis]

Daveman, I feel badly about our overposting on regen, but I honestly feel this is going somewhere and NOT round in circles. It feels like a tiny piece of the puzzle is ADDED each time we discuss this. But I know it must appear tedious to you and some others. Many thanks for your patience.

Demo, I thought you do not have any sperm to regenerate in the first place.