[apostate801]

Do you stir the initial sample?  Any idea how long a frozen sample is good for?

[Willem]

Do you stir the initial sample?  Any idea how long a frozen sample is good for?

I do stir the initial sample before freezing to make sure it's liquified.  After a few weeks the frozen sample starts to look freezer burned and doesn't chip off as easily, so I replenish at least once per month. 

[Quasar]

For those who have stomach bloatness and diarrhea while in Pois, take a look at this: http://webcache.googleusercontent.com/search?q=cache:o98SZodJiyYJ:ibdcrohns.about.com/cs/ibs/a/dealibsd.htm+ibs+dehydration&cd=2&hl=es&ct=clnk&gl=es

I notice my skin A LOT more drier when i have Pois, and my stools lose consistency. It is known that diarrhea can cause dehydration.

I also notice much less Pois symptoms if i have the O. with an empty stomach.

What medication/natural alternative could prevent the diarrhea and bloatness in Pois? If we achieve that, we may also prevent dry skin.

BTW,

I've found this from a user named "john1234" in an acne subject board: http://www.acne.org/messageboard/Masturbation-Restriction-t210949.html&st=40

"day 15.

Wow, besides the red marks, i have realized that I've come a freaking long way since my depressed state since day 1.

1. my dry skin is eliminated
2. no active bumps
3. mood is up
4. regaining energy (feel young again.)"

I think there's a lot of people with Pois out there....

[Quasar]

So, i've been reading about IBS, stomach bloatness and diarrhea, and one of the more successful approaches is to first take Rifaximin for a few days/weeks. It is a very safe antibiotic that kills bad gastrointestinal bacteria. http://en.wikipedia.org/wiki/Rifaximin

Then, recolonize the gut with probiotics. Here you have a comparison between them: http://en.wikipedia.org/wiki/Probiotics

I think this strategy could be useful for Pois members who have stomach discomfort, pain or bloatness, and it's not dangerous to try.

I also have been reading about Ischemic colitis and crhon's disease. Here you have a pic that could explain why Pois could affect the gastrointestinal system: http://allaboutim.webs.com/Ischemic%20Colitis.jpg

That is if we consider Pois is a kind of migraine/vascular disease.

[demografx]

Mellivora, B_Daniel, Willem, Limejuice, Habibou and all: your concerns are well expressed and legitimate. Daveman and I will bring this up with Stefanie when she returns from a leave of absence in a few weeks. Many thanks for speaking your mind!

Demo

Willem  and others, we haven't forgotten about your concerns over the NORD fund. We're working out alternatives as this is being written. Many thanks for your patience!

[pois1]

Has anyone experimented with treatments after POIS starts?  So I had an O last night then today I took 500mg of Niacin.  I had the flush and felt some improvement over the symptoms but ended up with some lightheadness.  It felt like POIS was still there and was returning after some time.  Then I thought about how if this is an allergy, maybe Benadryl would help.  I took an aspiring and Benadryl and felt some improvement after a few hours.

[Quasar]

Has anyone experimented with treatments after POIS starts?  So I had an O last night then today I took 500mg of Niacin.  I had the flush and felt some improvement over the symptoms but ended up with some lightheadness.  It felt like POIS was still there and was returning after some time.  Then I thought about how if this is an allergy, maybe Benadryl would help.  I took an aspiring and Benadryl and felt some improvement after a few hours.

After Pois has started, it's very difficult to abort it, because it presents with a lot of symptoms. You may improve some of the symptoms, but a lot of us here think that it's more difficult to abort it, than to prevent it.

I experienced with Niacin before and Niacin after Pois. And Niacin before Pois helped me more.

I also tried Paracetamol after Pois, and it helped.

[Vincent M]

fenugreek + garlic/green tea work pretty well to abort POIS for me. Same with saw palmetto. However they work better if taken before orgasm.

[pois1]

Had another O and this time I immediately took Benadryl and aspirin.  I feel surprisingly good given two Os so close to each other.  I'll have to try the green tea/fenugreek.

[GoingCrazy]

Had another O and this time I immediately took Benadryl and aspirin.  I feel surprisingly good given two Os so close to each other.  I'll have to try the green tea/fenugreek.

I took a Benadryl last time I had POIS.  It made me really tired and I could tell it stayed in my system for about 2 days, I just took one pill.

Is there anybody here that has heavy heartbeats at night?  Seems that especially right before bed I experience heavy heartbeats.  It will beat and than stop for a moment longer than beat again but much heavier, than return to a normal heavy heartbeat.

[Quasar]

Had another O and this time I immediately took Benadryl and aspirin.  I feel surprisingly good given two Os so close to each other.  I'll have to try the green tea/fenugreek.

I took a Benadryl last time I had POIS.  It made me really tired and I could tell it stayed in my system for about 2 days, I just took one pill.

Is there anybody here that has heavy heartbeats at night?  Seems that especially right before bed I experience heavy heartbeats.  It will beat and than stop for a moment longer than beat again but much heavier, than return to a normal heavy heartbeat.

I also get that. I think it's called PVC's. It's usually a benign condition. People get them when they are nervous, or sometimes if you are low in some minerals (magnesium, potasium...).

I get more PVC's when i'm under Pois. I also get more orthostatic hypotension when i'm under Pois.

[WeEndThemAll]

Who is the admin on the new forum poiscenter, the registration process needs to bee faster it take to much time to get approved by the administrator.

[Guthrie]

Hi all, an update on my experiences with niacin.  When I first took the niacin (about a month and a half ago), I did so with 300 mg, and had a flush that lasted about one hour.  The next day, my POIS was reduced to about 15-20%.  So that was promising. 

But, I thought that a one-hour flush seemed a little bit long.  So, in subsequent attempts, I only took 100 mg or 200 mg.  This still produced a full flush, but one that didn't last as long.  However, with these, I found that my POIS-reduction was not as significant.  So that made me think that maybe the niacin wasn't working for me.

But then, on Friday night, I decided to try 300 mg again.  This time, I had an O about 2 hours after taking the niacin, and then the next day, my POIS was reduced to about 15-20% again. 

This makes me think that perhaps simply 'experiencing the flush' may not be the sole factor to consider -- one can achieve the flush with lower doses (100 mg/200 mg), but it may be that that the higher (300 mg) dose may be doing other things as well.  (E.g., perhaps, using up greater stores of histamine, so that one has a less-strong histamine reaction in response to O.) 

So, I think this could be an important thing to consider: 'achieving a flush vs. not achieving a flush' is not the only thing going on, and so we should not focus just on that.  Rather, a flush could simply be an outward sign of something else that the niacin is doing, and while a lower dose may still achieve the flush, it may not be as effective at doing that 'something else.' 

And, it could be the case that if that 'something else' is something like using histamine stores (or something similar), it could be that the niacin could still have that same effect, even if one built up a tolerance to the flush-effect.  In this case, it might be possible that taking niacin every day could be helpful for POIS, even if that lessened the effect of the flush in particular.

What do others think? 

[Quasar]

Hi all, an update on my experiences with niacin.  When I first took the niacin (about a month and a half ago), I did so with 300 mg, and had a flush that lasted about one hour.  The next day, my POIS was reduced to about 15-20%.  So that was promising. 

But, I thought that a one-hour flush seemed a little bit long.  So, in subsequent attempts, I only took 100 mg or 200 mg.  This still produced a full flush, but one that didn't last as long.  However, with these, I found that my POIS-reduction was not as significant.  So that made me think that maybe the niacin wasn't working for me.

But then, on Friday night, I decided to try 300 mg again.  This time, I had an O about 2 hours after taking the niacin, and then the next day, my POIS was reduced to about 15-20% again. 

This makes me think that perhaps simply 'experiencing the flush' may not be the sole factor to consider -- one can achieve the flush with lower doses (100 mg/200 mg), but it may be that that the higher (300 mg) dose may be doing other things as well.  (E.g., perhaps, using up greater stores of histamine, so that one has a less-strong histamine reaction in response to O.) 

So, I think this could be an important thing to consider: 'achieving a flush vs. not achieving a flush' is not the only thing going on, and so we should not focus just on that.  Rather, a flush could simply be an outward sign of something else that the niacin is doing, and while a lower dose may still achieve the flush, it may not be as effective at doing that 'something else.' 

And, it could be the case that if that 'something else' is something like using histamine stores (or something similar), it could be that the niacin could still have that same effect, even if one built up a tolerance to the flush-effect.  In this case, it might be possible that taking niacin every day could be helpful for POIS, even if that lessened the effect of the flush in particular.

What do others think? 

Yes, it's perfectly possible. Niacin has been studied as a potential migraine preventive agent, and in those studies is usually taken every day for few months, and usually at higher doses than 100 mg. But be cautious, because Niacin at high doses can be toxic.

Take a look at this:

" It is not known if PGD2 causes vasodilation of the intracranial arteries, but niacin's ability to abort acute migraine headaches suggests that this might be what is occurring. Old reports cited by Bicknell and Prescott [24], demonstrate that niacin does indeed cause vasodilation of the cerebral and spinal vessels, and that intravenous administration increases the rate of intracranial blood flow in human beings for 20–60 minutes without any significant change in blood pressure. Unfortunately, there have not been more recent reports examining the effects that niacin has upon cerebral blood flow in human subjects."

"Some of the reports did demonstrate prophylactic benefits when niacin was administered orally every day. It is now recognized that a deficit of mitochondrial energy metabolism (i.e., impaired mitochondrial phosphorylation potential) plays a role in the pathogenesis of chronic migraine headaches [28]. Niacin maintains adequate mitochondrial energy metabolism by increasing substrate availability to complex I [29], and this is how it might function as an effective prophylactic agent for migraine prevention. Two other nutritional agents (riboflavin and coenzyme Q10) augment complex I of the mitochondrial respiratory chain, and have been subjected to clinical trials demonstrating their effectiveness for the prevention of migraine headaches [30-32]. A deficit of mitochondrial energy metabolism may play a role in the pathogenesis of migraine. Since niacin improves mitochondrial energy metabolism by increasing substrate availability to complex I, it might also be an effective agent for migraine prevention."

[Vincent M]

The only thing about fenugreek is I can't take it before bed cuz it'll keep me up all night. If I take it around 1pm I'll be able to go to sleep by midnight. So I generally take 2 pills in the morning and 2 around noon.

[Guthrie]

Yes, it's perfectly possible. Niacin has been studied as a potential migraine preventive agent, and in those studies is usually taken every day for few months, and usually at higher doses than 100 mg. But be cautious, because Niacin at high doses can be toxic.

Actually, I think we should be more specific with regard to claims about 'high doeses of Niacin'.  Obviously, it is important to be cautious in taking any supplement.  However, in pretty much all the different sources I've looked at, the 'liver-risky' dosage is often listed at 3 g (= 3000 mg) per day.  The lowest number that I've seen anywhere for a 'liver-risky' dosage is 1 g (= 1000 mg) per day.  On top of that, it is specifically the slow-release form of niacin that has the most risks for the liver.  As such, from what I've read, it seems that taking up to 1000 mg per day of the 'regular' (i.e. 'flushing') variety of niacin does not appear to be dangerous for the liver.  And so 300 mg per day would certainly seem to fall well within this non-risk range.

If I'm wrong about this, please correct me -- we shouldn't gloss over risks, but we also should avoid over-stating them.

[Starsky]

The only thing about fenugreek is I can't take it before bed cuz it'll keep me up all night. If I take it around 1pm I'll be able to go to sleep by midnight. So I generally take 2 pills in the morning and 2 around noon.

I noticed it too but now after a month of taking i can take how much i want before bedtime and i sleep very well.

[demografx]

We shouldn't gloss over risks, but we also should avoid over-stating them.

Guthrie, excellent point to remember for ALL dosing trials and experiences!

[Quasar]

I've got a question: is it equally effective to take Niacin (or any other vitamin) alone, than to take a B-complex that contains the same quantity of Niacin?

[Guthrie]

I've got a question: is it equally effective to take Niacin (or any other vitamin) alone, than to take a B-complex that contains the same quantity of Niacin?

I would think that in principle the Niacin could still be effective if taken in a B-complex.  However, I think that the form of niacin in most B-complex vitamins is nicotinamide, i.e. the non-flushing type -- so it might be that factor, rather than the presence of other vitamins, that might make B-complex less effective for niacin-treatment of POIS. 

Has anyone on the forum done comparison tests between regular niacin and nicotinamide, to see if the latter has any effect on POIS?