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READ THIS ARTICLE: http://jpet.aspetjournals.org/content/327/3/665.full.pdfABOUT HISTAMINE: Methylnicotinate had a weak effect on inducing histamine release from human mast cells,whereas niacin did not increase rat plasma histamine levels. Moreover, the H1-receptor antagonists brompheniramine,chlorpheniramine, diphenylhydramine, and ketotifen did not block niacin-induced skin temperature increases. Combined,these results suggest that histamine is not involved in niacininduced flushI think Demografx was taking Aspirine to reduce the flush. Aspirie inhibits the effect of prostaglandins, but taking aspirine and niacin didnt make a difference for him so i think prostaglandins are not important. What is left is SEROTONIN. The effect of serotonin can be blocked by taking antihistamines, so i think thats the explanation of Observers case. What my allergist said, histamine and serotonin have the same group of receptors and serotonin can bind to histamine receptors(dont know to which ones) and could work as an antihistamine.
Happy new year to you and your families. I haven't been on this forum long but I'm very excited about the progress and the energy displayed by all. If we can do this much with POIS, just imagine how much we can achieve without it. Let's make that our goal for 2012.
Quote from: traderwithpois on 25/12/2011 03:40:07Curious if there is a link between marijuana (neurotransmitter depletion) and pois for some peopleI think it would be worthwhile to study marijuana's effect on POIS in a responsible research study.Medicinal marijuana research has been deemed worthy of study of other illnesses, why not POIS?It has been classed by some as an "active placebo", highly susceptible to the participant's mood as well as the setting or environment he is in.So there's a possibility it could work on some people, and backfire on others. But worth studying, I think.
Curious if there is a link between marijuana (neurotransmitter depletion) and pois for some people
Hi Acronym, Are you taking Niacin also? For me, that seems to be making a big difference. I'm guessing niacin in the morning releases serotonin which has an anti-depressant effect. I'm also walking more as I've more energy. Perhaps the combination of the pyroluric treatment at night and the niacin in the morning and increased exercise is producing a kind of positive feedback loop. All I can say is that I feel much better since I started taking the niacin and the ZMA. There are 2 other factors I can think of. 1) I never have more than 1 O a week anymore. Too much hassle and I rarely get NE's so that's not a problem for me. 2) I drink chlorella most days which I'm told is good at chelating copper out of the body. The first few days felt a bit odd and this makes me very "regular" but I think it may have helped me make progress with the pyroluric treatment this time. The other sign that something is working is a fungal infection has cleared up. I remembered at the time that the "holistic doctor" had said such infections thrived in bodies where there was a poor copper balance. She seemed to suggest that some people store copper in the tissues but their blood plasma copper was low due to some misfiring enzymatic reaction. I must download a few papers on this as I thought it sounded like crap at the time. I guess sometimes we dismiss good advice if we don't like the packaging There's no doubt these supplements have made a difference to my clarity of thought and level of energy.
That's interesting as the ZMA supplement is supposed to boost testosterone levels and I find that other activities that are supposed to boost testosterone production, such as lifting weights, also reduce the symptoms. It always struck me as odd as boosting testosterone makes me more inclined to want to have an O but then seems to reduce the effects of one. But what worried me about that was adrenal fatigue. Eventually, the aggressive exercise regime made me feel burnt out. Have you ever had tests for vitamin and mineral deficiencies. Hair analysis for example?
I just spoke on the phone with the center at Harvard.http://alzheimersweekly.com/content/alzheimers-disease-research-center-harvard-medical-school They want me to put together an email describing the correlation between POIS, relatives who have Alzheimers, and the similarity in mental symptoms one gets from POIS to the symptoms one gets from Alzheimers.This is who I am to send the email to:http://madrc.mgh.harvard.edu/liang-yap-phdSo I am going to ask one last time, just in case, do any of your relatives, for those who have POIS, have or had Alzheimer's? If you dont know for sure, please check and post here if so. After a few days I will compose the email and send it out.
Hey guys, nocturnal emissions are something we all struggle with, mostly because we cannot prepare for them. Does anyone know of an optimum supplement combination to take?
Also chlorella helps me. I have always had stomach/bowel troubles (started same time as pois). The brand that was the best for me is no longer on the market, and all the other brands are not as potent and are mixed with spearmint which I hate. I take the suisse brand now, but I just don't get the boost I used to. In relation to the stomach/bowel aspect to pois, I have for many years taken a product called Blooms Herb-a-lax, once every 2 weeks on and off over periods when I felt rotten, and I would have a boost in health for the next week afterwards, greatly reduced pois for any O within the next 3 days. Having had fecal tests at Melb Uni Bio21 institute that showed high levels of a number of undesirable bacteria, I am sure this is the reason why it helps. I don't think this issue causes pois, but the toxic load aggravates the tiredness, brain fog & nuero symptoms. Something others here who have bowel/digestive problems might want to give a go, though its not a solution just a remedy. Resolving the 'undesirable bacteria' issue has was not so straight forward unfortunately, and I am about to push a follow up program with a new doctor on this in a month.
Hi demografxI sorted through most of the messages on the link to the other fourm and just wanted to clarify something as there was a lot to sort though...When the funding goal is reached will it be directed towards cause or cure or is that still to be decided along the way? Not that the former excludes the latter of course. A precis of the situation would be good to encourage donations.
Quote from: badgerstripe on 02/01/2012 13:29:15Hi demografxI sorted through most of the messages on the link to the other fourm and just wanted to clarify something as there was a lot to sort though...When the funding goal is reached will it be directed towards cause or cure or is that still to be decided along the way? Not that the former excludes the latter of course. A precis of the situation would be good to encourage donations.Badgerstripe,Very good question!The whole research process, not only at NORD but throughout the medical industry, goes through several stages. In our case, we are at the very first stage. POIS is new and for the most part little known, so this first phase, the seed phase, is required to establish POIS as something real!Although to us $33,500 sounds like a LOT of money, in terms of research, it's peanuts. Normally it wouldn't be enough to do hardly anything, but thanks to NORD, with their whole infrastructure built to manage rare disorders, they are in a position to get the best for the money, where administration costs and management boards of the highest level are shared between all of the projects at all levels.Research is very complex, and must follow a very strict protocol. Controlling a project must be done within the strictest of ethics and must guarantee, true and real dedication to the actual cause. This seems logical, but very often research projects with lesser ethics and guidelines may try to cut corners and dedicate potentially to parallel anomalies of a condition because it better suits the investigator's needs.So one of the greatest restrictions in working with NORD is that the MAC, a highly experienced board of medical researchers creates the research project and makes the final selection of investigators based on what they see as the best solution to the cause. We cannot specify preferences or even what we feel to be the best approaches. THEY are the experienced ones in doing medical research, and know what is best for the cause.The curricula of the members of the MAC are extraordinary.At the seed level, it will probably be necesary to establish as a minimum "what is POIS". If nothing else is found, and I feel that we will see much more than that, the answer to this question will very valuable to us. In this moment, we don't know what it is. We fight even between ourselves because of this. We can be lead off far too easily into some dead end street because of this.POIS symptoms parallel many other maladies, and at least two times a month we have new members saying, "because of our symptoms maybe we have so-and-so and not POIS". We desperately need the answer to the question, "what is POIS". Without knowing what it is, we won't know the cause, without knowing the cause, we won't know the cure.BUT, there's nothing that says that finding "what it is" won't directly lead us to what causes it and maybe what even cures it.We are the only POIS group in the world raising funds for research. We are a BIG group of POIS sufferers and have more potential for gathering information and knowledge about POIS than anyone else in the world. NO researcher, not one in the world, has as much access to information on POIS as we do. Not one of them has a collective feel for POIS as we do, we just don't know how to put it all in real and researched medical perspective.So what we want to do, is involve our group in the provision of solid information about POIS. We can't sway or influence them, nor do we wish to. None of us would want to take the responsibility of directing a serious investigation down a mistaken path based on only a gut feeling. But what we can do is show them more information than they may have access to, tell them how POIS feels, how and when it shows it's ugly face, basically give them a very good starting base.As we've seen, no POIS researcher knew about niacin before us. Most still don't, and those that do have found out from us. We can't tell them that niacin is the solution, but we can make them aware of it and how it seems to work. they can take it from there.In this way, we hope to cut years off of the investigation.We will be puting together a format for the recompilation of this information. The more thorough and professional it is the better. It would need medical back up, reliable internet sources, perhaps blood test and controls. We will look for a format that is common in the medical industry and open threads on SMF to produce these "reports". A true investigation cannot overlook this kind of information during it's formative phases.So to make a story short. We don't know exactly the form the investigation will take, except that the best approach will be taken. We can inform and provide input, I think this will be of tremendous value in our case to give the investigation the best kickstart possible.
I tend to try and stay active in the gym and such. After activity like basketball I usually feel weak and shake, Jittery.. Feels like it could be hypoglycemia type symptoms but I'm not sure. Does anyone else feel this and what can be done about it?Thanks all.Jon.
Thanks DavemanThat was the kind of update and summary i was looking for and makes me much more comfortable about donating (though it won't be this month, maybe in a month or so!)My understanding of what you say is that *the end goal of the research IS to find a solution to POIS* but there are steps along the way, the first of which is to establish scientifically that the condition really exists. Is that right?I have looked at the NORD website and it seems like a really solid scientific and ethical organisation. I agree that our forum can't steer the investigation but i hope, as you say, that they look closely at our experiences of POIS and remedies to get to solutions more quickly than without our experiences.I am still experimenting with the Niacin and results are mixed, i will post some more of my experimenting when i have a few more Os under it's influence.