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This is all very interesting to me as i have been using niacin for the last few months with some success.Furthermore, all the seasonal allergies i have from February - May have not affected me this year AT ALL since i have been taking Niacin, this is unheard of. Also i have previously had a strong allergic reaction to tartrazine - blotchy purple upper torso and head with dizziness and heat. I also seem to react badly to plants containing phenols.Does this make sense given what you have posted above?
I tested the Vitamin B6 level and it was the upper average ! I did not check neither the B3 nor the C.
If increased homocysteine or methylmalonic acid levels and a normalization of these metabolites in response to replacement therapy are used as diagnostic criteria for vitamin B12 deficiency, approximately 50 percent of these patients have serum vitamin B12 levels above 200 pg per mL.1 This observation suggests that use of a low serum vitamin B12 level as the sole means of diagnosis may miss up to one half of patients with actual tissue B12 deficiency. Other studies have shown similar findings, with the rate of missed diagnosis ranging from 10 to 26 percent when diagnosis is based on low serum vitamin B12 levels alone.
kurtosis, you have the highest level of comprehension I have come across re: pathology of vit. B6 deficiency here. Would you be willing to help write this r/askscience post I am helping start, as well as perhaps answer questions that people at r/askscience will ask? I have some education in this stuff, but I am struggling with cognition from PIOS AND transitioning between antipsychotics. Come to the poiscenter.com forums if you are going to help, it's a more organized format for this. Find our Vitamin B6 topic under "General Alternative Causes"Thanks!
Dang! I just set up a monthly recurring donation on the NORD site and got an error. I will try again later. Waiting for the site administrators to check out the error. Anyway, I've been a silent reader of this forum for the past year. I was overjoyed to see that I wasn't the only one with this crazy illness. To keep things short:My age: 30 yrsStart of POIS: Age 11 (19 years living with it, worsened as I got older)Symptoms: Dermatitis, Acute back pain (like acid flowing through my spine), brain fog, severe irritability and anger, anxiety, severe fatigue, digestive issues (tightness in the lower left side of my abdomen, like a knot), fingers and toes get really cold also.Duration of symptoms: 3-4 weeks (no joke, I wish it only lasted a few days)When I was 11 and O'ed the first time, I started getting dermatitis, and had to start taking claritine to reduce the itching all over my body. This still happens everytime I have an O. Two months ago, I abstained for 5 weeks (don't know how the heck I did it, especially with having my wife in bed every night). I was determined to try it. Then I couldn't hold it any longer, I was going out of my mind. I took 250 mg of niacin and had sex while I was having a flush. I felt like I was having sex on a bed full of broken glass, wasn't pleasant at all. The next 2 days were the best days of my life, I was clear headed, had so much energy, I was very happy and just didn't know how to handle all that energy. I'm too used to having low motivation to do anything. Anyway, the symptoms started coming back again after the 2 amazing days, so I tried some more niacin, but it didn't work that time. I'm now seeing a Urologist that has some knowledge of this illness. He told me I have low testosterone levels (~202, normal is above 300 I think). He also recommended I see an endocrinologist to check out my adrenal gland since I apparently have low cortisol levels. He prescribed some Clomiphene (clomiphene citrate) which is supposed to raise my testosterone levels slowly, even though it clearly states that this medication is for women. I will see him again in 6 weeks and will give an update if anything great comes out of this. I will try niacin again, but this time I'll give it 45 minutes AFTER the flush, like someone mentioned on this post. By the way, I live in Atlanta. If anyone else lives in Atlanta, the Urologist's name is Dr Wayland Hsiao at the Emory University. He's a really enthusiastic person.
All I can say on this V B6 issue is WOW you guys.Gives me goosebumps!I KNOW we're on to something!It would also be great if we could somehow reduce what has just been said down into something we can get our mind around (for the less technical of us), although you've already gone a long way to helping digest it all.It's important that we can see that "SOMEBODY" understands at least, so THANKS you guys.We could split off a couple of threads over on poiscenter as work areas and summary areas. Of course we will be sure that there's access here too.I think we are on to something too, it seems to make a lot of sense, its complex to understand but food allergies and previous iBS and the fact that my seasonal allergies seem to have disappeared and POIS improvement with niacin supplements all point to this negative feedback loop and B3 and B6 deficiency causing POIS.
So, what is happening with Daniel? Has he achieved to regain normal Vitamin B-6 levels with the supplement, and is his body now able to convert tryptophan into niacin, so the chain is not disrupted anymore(for some time) when he has an Orgasm? This is what Daniel told us several months ago:Hey guys,I think that I am cured. The last eight weeks I had orgasms 99% free of symptoms.(...) This winter I took vitamine B pills (B1, B6 and B12). Every day one for 3 weeks. These pills made me feel much better, I felt much more clear in my head. Additionally, I took every day one fenugreek capsule. After 3 weeks I quited with the vitamine B (you can get an overdose of B6, so I thought to take care with this) and I also quited with the fenugreek. I did not get orgasms in this period, simply because I had so much work to do at my job, I could not afford to have one.Then, after one or one and half week I started vitamine B again, every week 2 or 3 pills. So every second day. Some weeks after that I addionally started my fenugreek again. I now take two capsules every morning after my breakfast. I was following this for about 4 or 5 weeks. First I could get every week an orgasm without any problem. And now I can get two orgasms in two days without any problem! More orgasms induced some symptoms which disappeared during the day. But I think, I will improve more so this will also be possible in the future. I also avoid stressful situations as much as possible, I think this is important.My life improved a lot, having an orgasm without any problem, it is really great. I hope that everybody with this disease will be cured, because it is pretty much like hell.http://poiscenter.com/forums/index.php?topic=346.0