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after sex, poor memory, confusion, nausea, weakness, body low vision is difficult to remember the words weak muscles ...
From a doctor specialising in MHTR + methylation...."Niacin speeds up COMT which is one reason why it also may be useful. If one speeds up COMT, then things like dopamine and epinephrine get broken down faster. Niacin also is a ‘sponge’ for methyl groups, namely SAMe, because SAMe is required to metabolize niacin." COMT is Catechol-O-Methyltransferase enzyme.I know this goes against a number of us who feel we are low in dopamine. I can understand why our body is flooded with it during sex/arousal, but why if it is not broken down properly it would it make up feel days later like we are low in it.
May be POIS is a genetic disease like this: http://en.wikipedia.org/wiki/Carnitine_palmitoyltransferase_II_deficiency#Diagnosis
Quote from: gabin on 25/12/2012 12:16:27May be POIS is a genetic disease like this: http://en.wikipedia.org/wiki/Carnitine_palmitoyltransferase_II_deficiency#DiagnosisPerhaps it is but it's not Carnitine Palmitoyltransferase deficiency as if it was, I'd have CC instead of AA at http://www.snpedia.com/index.php/Rs28936673One of the benefits of getting your genes tested is you can rule out a lot of genetic diseases. I think POIS sufferers have a mast cell disorder brought about by methylation problems, probably low levels of BH4 / tetrahydrobiopterin. Also those with MAO A deficiency may have higher levels of serotonin, reduced levels of oxytocin and, hence, higher levels of prolactin following an orgasm. All without having an actual tumour causing the prolactinaemia. Read http://www.ncbi.nlm.nih.gov/pubmed/14514683This is interesting too. http://www.autismcoach.com/Articles.asp?ID=262and http://circres.ahajournals.org/content/101/8/752.full
As i read in Dr's Waldinger announcement he said that when the semen is in the testis there is no problem and only after an ejaculation the symptoms began.In my case things are slightly different..Yes i have the POIS symptoms after an O (mostly mental symptoms) but the weird thing is that there is no symptom after an nocturnal emission..I dont get it..Nocturnal emission is an ejaculation right ? So why there are no symptoms after this
Quote from: chris 18 on 27/12/2012 13:05:14As i read in Dr's Waldinger announcement he said that when the semen is in the testis there is no problem and only after an ejaculation the symptoms began.In my case things are slightly different..Yes i have the POIS symptoms after an O (mostly mental symptoms) but the weird thing is that there is no symptom after an nocturnal emission..I dont get it..Nocturnal emission is an ejaculation right ? So why there are no symptoms after thisHi chris 18. Nocturnal emissions caused less symptoms for me because they occurred during sleep which is a healing time. Perhaps this is what is happening in your case as well.About niacin, it is true that many of our members have benefited from this vitamin including myself. Most of the discussion about it has been at our main forum at poiscenter.com. Here is one post that partly describes our usage of niacin for POIS: newbielink:http://poiscenter.com/forums/index.php?topic=75.msg692#msg692 [nonactive]There is a specific protocol you must follow if you want to use niacin for POIS. The first step is buying the right kind (nicotinic acid) and making sure that it is not the "no-flush" type. Also make sure it is not niacinamide or slow-release. We have had the greatest benefit with the flush type so you will want to have the niacin flush, which is a hot-itchy feeling in your skin and your skin will turn reddish for a short period. It's safest to start with 50mg if you are concerned about this flush. Most of our members need about 200mg to get the flush. You should take the dose about an hour before orgasm and wait for the flush to happen about half an hour later and orgasm as the flush is beginning to die off or just after it goes away. If you can't get a flush with 200mg then you will need to fast for about 5 hours prior to dosage to make sure you take it on an empty stomach. After your niacin arrives immediately wrap it in plastic or something air-tight or else it will become less effective - For instance I didn't wrap mine up even though I always closed the bottle and after a few months I now need 500mg to flush where as originally I only needed 200mg. Taking it more often will cause tolerance and probably make it less effective as well, but I've only taken it a few times over the past year so I haven't had that problem.Taking niacin after an orgasm usually doesn't help much for us. So you will want to take it before an orgasm as I described above.Here is a post that summarized each individual member's experience with niacin (Recorded are 21 positive experiences and 6 negative): newbielink:http://poiscenter.com/forums/index.php?topic=235.msg2958#msg2958 [nonactive]The flush is considered completely safe and you can google "niacin flush" to verify this. There is a slight concern of liver damage, but doctors sometimes prescribe up to 1,000mg of niacin daily for short periods to lower cholesterol so I'm sure that taking 200-400mg once a week would be completely fine.
A few of us have gotten our DNA analyzed. In fact, there have been three of us in total so far- kurtosis, nomore2013, and me. CertainlyPOIS is also submitting his saliva for testing soon. There's a lot of benefit to have this testing done, but the main benefit is to eventually have enough data (sample size of 10-20 of us) for a researcher to examine and make inferences with some degree of confidence. Ultimately, the goal is for this researcher to locate specific mutations that we all have in common that could explain pois. With just 3 samples right now we've identified some similarities of certain defects and other issues, but 3 is obviously not enough to draw any conclusions. With some more samples we can get a better picture of all this and try to figure out what it means.The testing costs btwn $120 and $180 after shipping costs of the saliva sample to the lab. If you think you might be interested in having your dna analyzed and contributing to this project, please shoot me a pm and I can give you some more details. Thanks guys.