Can Pyriproxyfen cause microencephaly?

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Offline syhprum

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Can Pyriproxyfen cause microencephaly?
« on: 15/02/2016 11:22:22 »
It has been reported that there is an overlap between the areas where many cases of microcephaly have been reported and where Pyriproxyfen has been used.
« Last Edit: 15/02/2016 17:09:21 by chris »
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Offline chris

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Re: Can Pyriproxyfen cause microencephaly?
« Reply #1 on: 15/02/2016 17:12:58 »
Pyriproxifen is a larvicidal chemical added to water to prevent mosquitoes breeding. It has been added to water supplies in Brazil for about the last 18 months. Some have claimed that the presence of this chemical can cause microcephaly, although the Brazilian government have refuted this claim.

Here's an update on the story: http://www.telegraph.co.uk/news/worldnews/zika/12157747/Zika-virus-Brazil-dismisses-link-between-larvicide-and-microcephaly.html
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Offline exothermic

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Re: Can Pyriproxyfen cause microencephaly?
« Reply #2 on: 15/02/2016 22:34:16 »
From a pharmacodynamic standpoint.... I'm thinking it's merely coincidental, as the mutagenicity/teratogenicity profile of pyriproxyfen clearly indicates it's not the culprit.

Principles and Methods of Toxicology, Fifth Edition
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Harvard School of Public Health

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Offline exothermic

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Re: Can Pyriproxyfen cause microencephaly?
« Reply #3 on: 15/02/2016 23:20:18 »
More non-mutagenic/teratogenic data:

WHO SPECIFICATIONS AND EVALUATIONS FOR PUBLIC HEALTH PESTICIDES
PYRIPROXYFEN
phenoxyphenyl (RS)-2-(2-pyridyloxy)propyl ether


webcache.googleusercontent.com/search?q=cache:aVHmqULYTRQJ:www.who.int/whopes/quality/en/pyriproxyfen_eval_specs_WHO_jul2006.pdf+&cd=1&hl=en&ct=clnk&gl=us

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Offline exothermic

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Re: Can Pyriproxyfen cause microencephaly?
« Reply #4 on: 16/02/2016 00:05:07 »
In terms of the etiology of microcephaly, new research has identified pathogenic mutations in the MCPH1 & CASC5 genes, as well as mutations in SPATA5.

MCPH1 mutation
ncbi.nlm.nih.gov/pubmed/26192461

CASC5 mutation
ncbi.nlm.nih.gov/pubmed/26626498

SPATA5 mutation
ncbi.nlm.nih.gov/pubmed/26299366

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Offline tkadm30

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Re: Can Pyriproxyfen cause microencephaly?
« Reply #5 on: 16/02/2016 12:12:47 »
Sounds like a diversion to create confusion about the origins of the microencephaly...

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