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CBD appears to have pharmacological profile similar to that of atypical antipsychotic drugs as seem using behavioral and neurochemical techniques in animal models. Additionally, CBD prevented human experimental psychosis and was effective in open case reports and clinical trials in patients with schizophrenia with a remarkable safety profile.
Could cannabis use normalize dopamine function?
The antipsychotic properties of CBD can prevent psychosis:
Is CBD a partial dopamine receptors agonist ? https://www.ncbi.nlm.nih.gov/pubmed/16258853
Quote from: tkadm30 on 19/03/2016 10:15:25Could cannabis use normalize dopamine function?In individuals with presynaptic striatal dopamine dysfunction? .... Not likely.
What are the implications of D2 partial agonism? Aripiprazole binds to the D2 receptor with the same affinity than dopamine, but has a lower intrinsic efficacy, so the response it triggers is lower than dopamine but higher than an antagonist.
The effects of cannabinoids on dopamine function are poorly understood. Does THC and anandamide act as dopamine system stabilizers (DSS) ?
Quote from: tkadm30 on 18/03/2016 20:43:47The effects of cannabinoids on dopamine function are poorly understood. Does THC and anandamide act as dopamine system stabilizers (DSS) ?I will have a go at answering for you, if the amount of dopamine released is released at the same magnitude because it is being induced by the smoker, is that not the rate the body gets use to in being a stable rate?
Dopamine-mediated stimulation of proliferation is dependent on ciliary neurotrophic factor (CNTF), which is known to promote proliferation in the SVZ (Emsley and Hagg, 2003; Yang et al., 2008). A recent study has proposed that dopamine induces proliferation through Akt and extracellular signal-regulated kinase 1/2 signaling, whereas other studies suggest that dopamine stimulates the release of epidermal growth factor (EGF), which is known to promote proliferation of neural stem cells (Reynolds and Weiss, 1996; O'Keeffe et al., 2009; Lao et al., 2013).