Is THC a potential antiglutamatergic drug?

  • 2 Replies
  • 384 Views

0 Members and 1 Guest are viewing this topic.

*

Offline tkadm30

  • Neilep Level Member
  • ******
  • 1042
    • View Profile
    • IsotopeSoftware
Is THC a potential antiglutamatergic drug?
« on: 19/07/2016 20:19:08 »
Is THC a potential antiglutamatergic drug?
The bliss of ignorance is deeper in the region of tyranny.

*

Offline chris

  • Neilep Level Member
  • ******
  • 5394
  • The Naked Scientist
    • View Profile
    • The Naked Scientists
Re: Is THC a potential antiglutamatergic drug?
« Reply #1 on: 19/07/2016 22:07:26 »
Why do you ask? I enquire since I am unaware of the pharmacology of the agent at receptors other than cannabinoid receptors; do you have reason for suspecting that it might have affinity at glutamatergic sites?
I never forget a face, but in your case I'll make an exception - Groucho Marx

*

Offline tkadm30

  • Neilep Level Member
  • ******
  • 1042
    • View Profile
    • IsotopeSoftware
Re: Is THC a potential antiglutamatergic drug?
« Reply #2 on: 19/07/2016 23:09:22 »
Why do you ask? I enquire since I am unaware of the pharmacology of the agent at receptors other than cannabinoid receptors; do you have reason for suspecting that it might have affinity at glutamatergic sites?

Have a look at this paper. It seems THC may downregulate glutamate signaling and depresses glutamatergic synaptic transmission. A potential neuroprotective mecanism I suppose to prevent glutamate-induced excitotoxicity?

http://www.ncbi.nlm.nih.gov/pubmed/26987641
The bliss of ignorance is deeper in the region of tyranny.