[thedoc (OP)]

The role of cannabis-detecting receptors in brain development is becoming
clearer.
Read a transcript of the interview by clicking here

or [chapter podcast=1000899 track=14.10.31/eLife_Podcast_10.14_1002898.mp3] Listen to it now[/chapter] or [download as MP3]

[tkadm30]

The brain's own cannabinoids, also called endocannabinoids, are important lipid signaling molecules which mediate synaptic function. The brain respond to intracellular THC delivery by activation of CB1 receptors mediating retrograde endocannabinoid signaling and releasing endocannabinoids to neurons via astrocytes. Neuron-astrocytes communication is an important method of endocannabinoid mobilization.

[annie123]

I would like to know why my brain does not react to cannabis. I have tried edibles and they have no effect. lately I tried some caramels amounting to 30mg of TCH -THC? or whatever - the stuff that make syou high- and had no effect whatever.Why?

[chris]

Maybe you were taken for a ride and sold elephant dung - quite literally sh1t - or some such; drug dealers don't tend to subscribe to codes of ethical trading or the consumer marketing act, I've heard...

[tkadm30]

I would like to know why my brain does not react to cannabis. I have tried edibles and they have no effect. lately I tried some caramels amounting to 30mg of TCH -THC? or whatever - the stuff that make syou high- and had no effect whatever.Why?

Males and females regulates cannabinoid-induced energy homeostasis differently:

- pmid 19427130

Females regulates brain energy homeostasis through estrogen-mediated attenuation of CB1 receptor:

- pmid 19758570
- pmid 22538462

This might help identifying sex differences in endocannabinoid mediated neurotransmission through proopiomelanocortin (POMC) synapses.

[annie123]

I don't know what the pm etc means.
No I was not sold rubbish. I bought it at one of the several medicinal marihuana shops  here in  BC (Canada) where medical marihuana is allowed when sanctioned by a doctor. And no it had not had the active ingredient taken out. I did look online to see if others had this problem and apparently they do, but don't know why.
perhaps when our sunny days Prime Minister has legalized it for recreational use as well I may get to try a wider variety of things such as the patch to see if anything else works, because i don't want to smoke it. But I still would like to know why it had no effect.

[tkadm30]

As a female your body produces estrogen. Estrogen prevent the effects Cannabis is doing to the brain.

[annie123]

Then why do females get high at all?
Anyway, my body doesn't produce estrogen. I have to take it artificially and when I stopped taking it to see what would happen it didn't make any difference.

[tkadm30]

Then why do females get high at all?

Sex differences in endocannabinoid signaling and distribution of CB1 receptors in the brain may provide
females with higher sensitivity to THC due to estrogen levels. Your lack of estrogen may explain your indifference to cannabis.

[tkadm30]

I just love how THC emancipate my mind from toxic chemicals we breathe and eat. The power of THC to neutralize oppression from the outer world is priceless. Our brains react to cannabis like eating chocolate; It's a powerful antidepressant and antiinflammatory medicine with obvious neuroprotective function.

We should protect organic cannabis cultivation to ensure its perennity and the understanding of its pharmacology;

The knowledge of cannabis science is missing from education, and its effects on the brain are still poorly understood and stonewalled by modern psychiatry. If psychiatry is not a religion then it must properly educate psychiatrists about the use of cannabis as a psychiatric treatment.
 

[evan_au]

I just love how THC emancipate my mind from toxic chemicals we breath and eat.

THC stops your mind from worrying about toxic chemicals (or any number of potentially worrying things, like the pedestrian who is about to step off the kerb in front of your car....).

However, it does not stop your liver from worrying about toxic chemicals we breathe and eat, which will still kill you just as effectively whether or not you have THC in your system.

Nor does it does not stop your lungs from worrying about toxic chemicals we breathe, which are probably more prevalent from air that has just passed through a marijuana joint.

[tkadm30]

THC stops your mind from worrying about toxic chemicals (or any number of potentially worrying things, like the pedestrian who is about to step off the kerb in front of your car....).

However, it does not stop your liver from worrying about toxic chemicals we breathe and eat, which will still kill you just as effectively whether or not you have THC in your system.

Nor does it does not stop your lungs from worrying about toxic chemicals we breathe, which are probably more prevalent from air that has just passed through a marijuana joint.

Agreed. However the toxicity of THC is fairly low compared to others combustion-derived nanoparticles
and fluoride.