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I would NOT recommend trying to isolate any significant quantity of atropine! (or any of the other alkaloids in datura stromnium)If you do try to isolate atropine from jimson weed, just be VERY careful. While it is used as medicine, it is also highly toxic (lethal) to those who don't need it, or at doses higher than prescribed. Toxic effects can begin to manifest as low as 33 µg/kg (2.5 mg for a 75 kg person), and can be fatal at significantly higher dosages. You will need gloves and a jacket and eye protection (it can be absorbed through your skin, and some of the compounds required for purification aren't so friendly either.)