Why do only IgG antibodies cross the placenta into a developing baby?

  • 1 Replies

0 Members and 1 Guest are viewing this topic.


Offline thedoc

  • Forum Admin
  • Administrator
  • Sr. Member
  • *****
  • 513
    • View Profile
shannon m howell asked the Naked Scientists:
   If IgG antibodies and albumin can cross the cell membrane by pinocytosis, why is this not the case of all antibody therapeutics?
What do you think?
« Last Edit: 31/08/2016 20:04:26 by chris »


Offline chris

  • Neilep Level Member
  • ******
  • 5424
  • The Naked Scientist
    • View Profile
    • The Naked Scientists
This is because the trophoblast cells, that make up the placenta, switch on - from about 29 weeks - specific receptors called Fc-gamma. These recognise IgG antibody and move it across the trophoblast layer and into the foetal circulation. But receptors for other classes of immunoglobulin - such as IgM - are not expressed by the trophoblast cells and so there is no mechanism for them to move across and into the baby.
I never forget a face, but in your case I'll make an exception - Groucho Marx