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Well for a start there's the problem of tissue penetration. Phages are all well and good if they can reach the site of infection. But in the context of meningitis, for example, where the bugs are within the meninges, access becomes a problem. The antibiotic molecules used are extremely small and have excellent CNS penetration. In the context of a life threatening infection you do not mess around, nor allow the worry of some subsequent diarrhoea influence your choice of therapy. I've seen a man with bacterial meningitis go from alert, conscious and able to share a joke, to barely rousable with a rash spreading in front of my eyes. Another 30 minutes and he would have been irretrievable. As it was a regular doses of intravenous broadspectrum antibiotics saved his life. And he didn't get any diarrhoea either !I am a big supporter of phage therapy but everything has its place and it should not be used just because it is new.(By the way, the inter-bacterial signalling you are referring to, cannnabinoid, is called "quorum sensing".)Chris"I never forget a face, but in your case I'll make an exception" - Groucho Marx